DK3224268T3 - Nye 2'- og/eller 5'-aminosyreesterphosphoramidat 3'-deoxyadenosinderivater som anti-cancerforbindelser - Google Patents

Nye 2'- og/eller 5'-aminosyreesterphosphoramidat 3'-deoxyadenosinderivater som anti-cancerforbindelser Download PDF

Info

Publication number: DK3224268T3
Authority: DK; Denmark
Prior art keywords: sterphosphoramidate; deoxyadenosin; derivatives; new; amino acid
Prior art date: 2014-11-28

Application number

DK15804216.8T

Other languages

English (en)

Inventor

Hugh Griffith

Christopher Mcguigan

Valentina Ferrari

Michaela Serpi

Antunez Carmen Jimenez

Original Assignee

NuCana plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-11-28

Filing date

2015-11-27

Publication date

2019-09-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54771155&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3224268(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2014-11-28 Priority claimed from GBGB1421211.2A external-priority patent/GB201421211D0/en

2015-11-02 Priority claimed from GBGB1519316.2A external-priority patent/GB201519316D0/en

2015-11-27 Application filed by NuCana plc filed Critical NuCana plc

2019-09-02 Application granted granted Critical

2019-09-02 Publication of DK3224268T3 publication Critical patent/DK3224268T3/da

Links

230000001093 anti-cancer Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
OFEZSBMBBKLLBJ-BAJZRUMYSA-N cordycepin Chemical class C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)C[C@H]1O OFEZSBMBBKLLBJ-BAJZRUMYSA-N 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Oncology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

DK15804216.8T 2014-11-28 2015-11-27 Nye 2'- og/eller 5'-aminosyreesterphosphoramidat 3'-deoxyadenosinderivater som anti-cancerforbindelser DK3224268T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB1421211.2A GB201421211D0 (en)	2014-11-28	2014-11-28	Chemical compounds
GBGB1519316.2A GB201519316D0 (en)	2015-11-02	2015-11-02	Chemical compounds
PCT/GB2015/053628 WO2016083830A1 (en)	2014-11-28	2015-11-27	New 2' and/or 5' amino-acid ester phosphoramidate 3'-deoxy adenosine derivatives as anti-cancer compounds

Publications (1)

Publication Number	Publication Date
DK3224268T3 true DK3224268T3 (da)	2019-09-02

Family

ID=54771155

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK15804216.8T DK3224268T3 (da)	2014-11-28	2015-11-27	Nye 2'- og/eller 5'-aminosyreesterphosphoramidat 3'-deoxyadenosinderivater som anti-cancerforbindelser

Country Status (26)

Country	Link
US (3)	US10570168B2 (da)
EP (2)	EP3224268B1 (da)
JP (2)	JP6646668B2 (da)
KR (2)	KR102741202B1 (da)
CN (2)	CN107207554B (da)
AU (2)	AU2015352203B2 (da)
CA (1)	CA2962373C (da)
CL (1)	CL2017001336A1 (da)
CY (1)	CY1122074T1 (da)
DK (1)	DK3224268T3 (da)
EA (1)	EA031727B1 (da)
ES (1)	ES2742167T3 (da)
HR (1)	HRP20191461T1 (da)
HU (1)	HUE046850T2 (da)
IL (4)	IL291927A (da)
LT (1)	LT3224268T (da)
ME (1)	ME03462B (da)
MX (3)	MX375759B (da)
PH (1)	PH12017500944B1 (da)
PL (1)	PL3224268T3 (da)
PT (1)	PT3224268T (da)
RS (1)	RS59264B1 (da)
SG (2)	SG10202009020VA (da)
SI (1)	SI3224268T1 (da)
SM (1)	SMT201900489T1 (da)
WO (1)	WO2016083830A1 (da)

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DK3031812T3 (da)	2011-03-01	2018-09-17	NuCana plc	Kemiske forbindelser
LT3224268T (lt) *	2014-11-28	2019-09-25	NuCana plc	Naujieji 2` ir (arba) 5` aminorūgšties esterio fosforamidato 3`-deoksi adenozino dariniai, kaip priešvėžiniai junginiai
GB201522764D0 (en) *	2015-12-23	2016-02-03	Nucana Biomed Ltd	Formulations of phosphate derivatives
GB201609601D0 (en) *	2016-06-01	2016-07-13	Nucana Biomed Ltd	Phosphoramidate compounds
GB201609600D0 (en) *	2016-06-01	2016-07-13	Nucuna Biomed Ltd	Cancer treatments
GB201709471D0 (en) *	2017-06-14	2017-07-26	Nucana Biomed Ltd	Diastereoselective synthesis of hosphate derivatives
GB201720279D0 (en)	2017-12-05	2018-01-17	Nucana Biomed Ltd	Anticancer compounds
CN110669088B (zh) *	2018-07-02	2023-03-28	成都阿奇生物医药科技有限公司	N-(2-乙基胺)苯磺酰胺基虫草素衍生物及其制备方法和应用
GB201904544D0 (en)	2019-04-01	2019-05-15	NuCana plc	Anticancer compounds
CN111888373A (zh) *	2019-05-05	2020-11-06	上海医药集团股份有限公司	一种虫草素或其药学上可接受的盐的应用
AU2023268725A1 (en)	2022-05-12	2024-12-12	NuCana plc	Cancer treatment with nuc-7738
CN116768949B (zh) *	2022-07-12	2026-03-03	南京工业大学	一种基于3’-脱氧腺苷经化学修饰改性的具有抗癌效应的化合物
GB2627905B (en) *	2022-07-12	2025-06-25	Nanjing University Of Technology	Cordycepin-based derivatized compound with anti-tumor effect
WO2025058573A1 (en) *	2023-09-15	2025-03-20	National Science And Technology Development Agency	Cordycepin derivatives or a pharmaceutically acceptable salt thereof as pan-antiviral agents

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US4357324A (en)	1981-02-24	1982-11-02	The United States Of America As Represented By The Department Of Health And Human Services	Prodrug derivatives of 9β-D-arabinofuranosyl-2-fluoroadenine
GB0317009D0 (en)	2003-07-21	2003-08-27	Univ Cardiff	Chemical compounds
WO2006063149A1 (en) *	2004-12-09	2006-06-15	Regents Of The University Of Minnesota	Nucleosides with antiviral and anticancer activity
GB0505781D0 (en)	2005-03-21	2005-04-27	Univ Cardiff	Chemical compounds
WO2006121820A1 (en) *	2005-05-05	2006-11-16	Valeant Research & Development	Phosphoramidate prodrugs for treatment of viral infection
GB0623493D0 (en)	2006-11-24	2007-01-03	Univ Cardiff	Chemical compounds
US8759318B2 (en)	2009-01-09	2014-06-24	Inhibitex, Inc.	Phosphoramidate derivatives of guanosine nucleoside compounds for treatment of viral infections
EP2393815A4 (en)	2009-02-06	2012-11-21	Rfs Pharma Llc	PURIN NUCLEOSIDE MONOPHOSPHATE PRODRUGS FOR THE TREATMENT OF CANCER AND VIRUS INFECTIONS
JP2012521359A (ja)	2009-03-20	2012-09-13	アリオスバイオファーマインク．	置換されたヌクレオシドアナログおよびヌクレオチドアナログ
AU2011282241B2 (en)	2010-07-19	2015-07-30	Gilead Sciences, Inc.	Methods for the preparation of diasteromerically pure phosphoramidate prodrugs
WO2012040126A1 (en) *	2010-09-22	2012-03-29	Alios Biopharma, Inc.	Substituted nucleotide analogs
NZ607996A (en)	2010-09-22	2014-07-25	Alios Biopharma Inc	Substituted nucleotide analogs
GB201016855D0 (en)	2010-10-06	2010-11-17	Nucana Biomed Ltd	Chemical compounds
DK3031812T3 (da)	2011-03-01	2018-09-17	NuCana plc	Kemiske forbindelser
EP2776438A4 (en) *	2011-11-10	2015-04-29	Inhibitex Inc	SUBSTITUTED PURIN NUCLEOSIDES, PHOSPHORAMIDATE AND PHOSPHORDIAMIDATE DERIVATIVES FOR THE TREATMENT OF VIRUS INFECTIONS
LT3043803T (lt)	2013-09-11	2022-08-10	Emory University	Nukleotidų ir nukleozidų kompozicijos ir jų panaudojimas
CN105934438A (zh)	2013-11-27	2016-09-07	艾登尼克斯药业有限公司	用于治疗肝癌的核苷酸
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LT3224268T (lt)	2014-11-28	2019-09-25	NuCana plc	Naujieji 2` ir (arba) 5` aminorūgšties esterio fosforamidato 3`-deoksi adenozino dariniai, kaip priešvėžiniai junginiai
WO2016145142A1 (en)	2015-03-10	2016-09-15	Emory University	Nucleotide and nucleoside therapeutics compositions and uses related thereto
SMT201800303T1 (it)	2015-05-14	2018-07-17	NuCana plc	Trattamenti per il cancro
GB201522764D0 (en)	2015-12-23	2016-02-03	Nucana Biomed Ltd	Formulations of phosphate derivatives
GB201609602D0 (en)	2016-06-01	2016-07-13	Nucuna Biomed Ltd	Chemical compounds
GB201609601D0 (en)	2016-06-01	2016-07-13	Nucana Biomed Ltd	Phosphoramidate compounds
GB201609600D0 (en)	2016-06-01	2016-07-13	Nucuna Biomed Ltd	Cancer treatments
GB201709471D0 (en)	2017-06-14	2017-07-26	Nucana Biomed Ltd	Diastereoselective synthesis of hosphate derivatives
GB201720279D0 (en)	2017-12-05	2018-01-17	Nucana Biomed Ltd	Anticancer compounds

2015
- 2015-11-27 LT LTEP15804216.8T patent/LT3224268T/lt unknown
- 2015-11-27 RS RSP20191057 patent/RS59264B1/sr unknown
- 2015-11-27 WO PCT/GB2015/053628 patent/WO2016083830A1/en not_active Ceased
- 2015-11-27 ES ES15804216T patent/ES2742167T3/es active Active
- 2015-11-27 CN CN201580063936.1A patent/CN107207554B/zh active Active
- 2015-11-27 CN CN202010794701.2A patent/CN111909231B/zh active Active
- 2015-11-27 SI SI201530848T patent/SI3224268T1/sl unknown
- 2015-11-27 MX MX2017006942A patent/MX375759B/es active IP Right Grant
- 2015-11-27 EA EA201791182A patent/EA031727B1/ru unknown
- 2015-11-27 SG SG10202009020VA patent/SG10202009020VA/en unknown
- 2015-11-27 KR KR1020237021261A patent/KR102741202B1/ko active Active
- 2015-11-27 PT PT15804216T patent/PT3224268T/pt unknown
- 2015-11-27 SG SG11201702369UA patent/SG11201702369UA/en unknown
- 2015-11-27 HU HUE15804216A patent/HUE046850T2/hu unknown
- 2015-11-27 HR HRP20191461 patent/HRP20191461T1/hr unknown
- 2015-11-27 PH PH1/2017/500944A patent/PH12017500944B1/en unknown
- 2015-11-27 JP JP2017528423A patent/JP6646668B2/ja active Active
- 2015-11-27 EP EP15804216.8A patent/EP3224268B1/en active Active
- 2015-11-27 DK DK15804216.8T patent/DK3224268T3/da active
- 2015-11-27 ME MEP-2019-230A patent/ME03462B/me unknown
- 2015-11-27 IL IL291927A patent/IL291927A/en unknown
- 2015-11-27 SM SM20190489T patent/SMT201900489T1/it unknown
- 2015-11-27 AU AU2015352203A patent/AU2015352203B2/en active Active
- 2015-11-27 PL PL15804216T patent/PL3224268T3/pl unknown
- 2015-11-27 US US15/518,527 patent/US10570168B2/en active Active
- 2015-11-27 EP EP19181028.2A patent/EP3683225A1/en active Pending
- 2015-11-27 KR KR1020177014174A patent/KR102548806B1/ko active Active
- 2015-11-27 CA CA2962373A patent/CA2962373C/en active Active
- 2015-11-27 MX MX2020010375A patent/MX394059B/es unknown
2017
- 2017-03-23 IL IL251353A patent/IL251353B/en active IP Right Grant
- 2017-05-24 CL CL2017001336A patent/CL2017001336A1/es unknown
- 2017-05-26 MX MX2022008744A patent/MX2022008744A/es unknown
2019
- 2019-08-13 CY CY20191100874T patent/CY1122074T1/el unknown
- 2019-09-20 AU AU2019232929A patent/AU2019232929B2/en active Active
2020
- 2020-01-10 JP JP2020002722A patent/JP6978524B2/ja active Active
- 2020-02-05 US US16/782,952 patent/US11352387B2/en active Active
- 2020-07-16 IL IL276109A patent/IL276109B/en unknown
2022
- 2022-04-07 IL IL292062A patent/IL292062B2/en unknown
- 2022-06-06 US US17/833,780 patent/US12054510B2/en active Active

Also Published As

Publication number	Publication date
US11352387B2 (en)	2022-06-07
MX394059B (es)	2025-03-24
MX375759B (es)	2025-03-06
CA2962373A1 (en)	2016-06-02
IL276109B (en)	2022-05-01
IL292062A (en)	2022-06-01
AU2019232929A1 (en)	2019-10-10
IL292062B2 (en)	2023-06-01
JP6978524B2 (ja)	2021-12-08
HUE046850T2 (hu)	2020-03-30
KR20170087465A (ko)	2017-07-28
KR20230098915A (ko)	2023-07-04
JP6646668B2 (ja)	2020-02-14
WO2016083830A1 (en)	2016-06-02
MX2017006942A (es)	2017-08-24
CN107207554A (zh)	2017-09-26
SMT201900489T1 (it)	2019-11-13
HRP20191461T1 (hr)	2019-11-15
LT3224268T (lt)	2019-09-25
EP3224268B1 (en)	2019-06-26
KR102741202B1 (ko)	2024-12-19
CL2017001336A1 (es)	2017-12-15
US12054510B2 (en)	2024-08-06
US10570168B2 (en)	2020-02-25
SG10202009020VA (en)	2020-10-29
SG11201702369UA (en)	2017-04-27
US20170253629A1 (en)	2017-09-07
AU2015352203A1 (en)	2017-04-27
AU2019232929B2 (en)	2020-09-10
EP3683225A1 (en)	2020-07-22
US20200181189A1 (en)	2020-06-11
CY1122074T1 (el)	2020-11-25
JP2017535587A (ja)	2017-11-30
AU2015352203B2 (en)	2019-08-15
MX2020010375A (es)	2022-07-19
CA2962373C (en)	2023-04-25
JP2020075928A (ja)	2020-05-21
PT3224268T (pt)	2019-09-04
IL251353A0 (en)	2017-05-29
PH12017500944A1 (en)	2017-11-20
EA031727B1 (ru)	2019-02-28
CN111909231B (zh)	2025-10-17
SI3224268T1 (sl)	2019-10-30
IL291927A (en)	2022-06-01
NZ767066A (en)	2022-03-25
IL276109A (en)	2020-08-31
RS59264B1 (sr)	2019-10-31
PL3224268T3 (pl)	2019-11-29
EA201791182A1 (ru)	2017-09-29
PH12017500944B1 (en)	2023-03-08
NZ730919A (en)	2021-02-26
ES2742167T3 (es)	2020-02-13
KR102548806B1 (ko)	2023-06-27
BR112017011187A2 (pt)	2018-01-02
EP3224268A1 (en)	2017-10-04
US20220306675A1 (en)	2022-09-29
ME03462B (me)	2020-01-20
MX2022008744A (es)	2022-07-27
IL251353B (en)	2020-08-31
CN111909231A (zh)	2020-11-10
CN107207554B (zh)	2020-09-11

Publication	Publication Date	Title
DK3224268T3 (da)	2019-09-02	Nye 2'- og/eller 5'-aminosyreesterphosphoramidat 3'-deoxyadenosinderivater som anti-cancerforbindelser
HUE056634T2 (hu)	2022-02-28	Rákellenes szerekként hasznos szubsztituált karbonukleozid-származékok
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HUE058009T2 (hu)	2022-06-28	1,3-Tiazol-2-il szubsztituált benzamid-származékok
DK3229810T3 (da)	2020-08-17	Phospholipid-ether-analoger som kræftrammende lægemiddelvehikler
DK3130592T3 (da)	2019-11-04	ANALOGER AF 4H-PYRAZOLO[1,5-á]BENZIMIDAZOL-FORBINDELSER SOM PARPINHIBITORER
MA41107A (fr)	2017-10-10	Compositions anti-cancéreuses
LT3226842T (lt)	2021-03-25	Priešvėžinės kompozicijos
LT3226843T (lt)	2021-08-10	Priešvėžinės kompozicijos
HUE054534T2 (hu)	2021-09-28	Piridonszármazék tetrahidropiranil-metil csoporttal
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