DK3252142T3 - Transformeret svamp med øget ergothionein produktivitet og en fremgangsmåde til produktion af ergothionein - Google Patents
Transformeret svamp med øget ergothionein produktivitet og en fremgangsmåde til produktion af ergothionein Download PDFInfo
- Publication number
- DK3252142T3 DK3252142T3 DK15880177.9T DK15880177T DK3252142T3 DK 3252142 T3 DK3252142 T3 DK 3252142T3 DK 15880177 T DK15880177 T DK 15880177T DK 3252142 T3 DK3252142 T3 DK 3252142T3
- Authority
- DK
- Denmark
- Prior art keywords
- ergothionein
- productivity
- producing
- increased
- transformed fungus
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
- C12N9/1007—Methyltransferases (general) (2.1.1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/01—Methyltransferases (2.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y208/00—Transferases transferring sulfur-containing groups (2.8)
- C12Y208/01—Sulfurtransferases (2.8.1)
- C12Y208/01007—Cysteine desulfurase (2.8.1.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungi isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/66—Aspergillus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/66—Aspergillus
- C12R2001/665—Aspergillus awamori
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/66—Aspergillus
- C12R2001/685—Aspergillus niger
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/66—Aspergillus
- C12R2001/69—Aspergillus oryzae
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015017328 | 2015-01-30 | ||
| JP2015157444 | 2015-08-07 | ||
| PCT/JP2015/086301 WO2016121285A1 (ja) | 2015-01-30 | 2015-12-25 | エルゴチオネイン生産能が増強された形質転換糸状菌及びエルゴチオネインの製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3252142T3 true DK3252142T3 (da) | 2022-01-03 |
Family
ID=56542917
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15880177.9T DK3252142T3 (da) | 2015-01-30 | 2015-12-25 | Transformeret svamp med øget ergothionein produktivitet og en fremgangsmåde til produktion af ergothionein |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10760107B2 (da) |
| EP (2) | EP3985100A1 (da) |
| JP (1) | JP6246953B2 (da) |
| CN (2) | CN113773971A (da) |
| DK (1) | DK3252142T3 (da) |
| WO (1) | WO2016121285A1 (da) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6932354B2 (ja) | 2015-08-07 | 2021-09-08 | キッコーマン株式会社 | セレノネインの製造方法 |
| JP6263672B1 (ja) * | 2016-02-29 | 2018-01-17 | 長瀬産業株式会社 | エルゴチオネインの発酵生産 |
| JP2018130091A (ja) * | 2017-02-17 | 2018-08-23 | 国立大学法人 筑波大学 | 植物体、食品、培養物、肥料及び製造方法 |
| WO2019004234A1 (ja) | 2017-06-27 | 2019-01-03 | 三菱ケミカル株式会社 | エルゴチオネインの製造方法 |
| WO2019163767A1 (ja) * | 2018-02-23 | 2019-08-29 | 長瀬産業株式会社 | エルゴチオネインの製造方法 |
| JP7185213B2 (ja) * | 2018-03-02 | 2022-12-07 | 国立大学法人 筑波大学 | エルゴチオネイン合成微生物、及びエルゴチオネインの製造方法 |
| CN109554414B (zh) * | 2018-11-09 | 2020-07-31 | 华南农业大学 | 金针菇基因Fvegt1、Fvegt2和Fvegt3在合成麦角硫因中的应用 |
| CN112011464B (zh) * | 2019-05-31 | 2021-12-28 | 浙江华睿生物技术有限公司 | 一种用于生产麦角硫因的里氏木霉 |
| CA3145979A1 (en) | 2019-07-10 | 2021-01-14 | Kureha Corporation | Plant growth regulator and method for promoting plant growth |
| CN110607286B (zh) * | 2019-08-21 | 2021-02-19 | 华南农业大学 | 灰树花麦角硫因基因Gfegt1和Gfegt2在合成麦角硫因中的应用 |
| US12421533B2 (en) | 2019-11-27 | 2025-09-23 | Nanjing Nutrabuilding Bio-Tech Co., Ltd. | Ean B mutants and their uses |
| ES3036445T3 (en) | 2020-01-09 | 2025-09-18 | Kureha Corp | Method for producing novel microorganisms and ergothioneine |
| JP6864131B1 (ja) * | 2020-03-04 | 2021-04-28 | 長瀬産業株式会社 | Ｌ−エルゴチオネイン含有組成物 |
| CN112301013B (zh) * | 2020-11-03 | 2022-11-08 | 深圳瑞德林生物技术有限公司 | 复合酶及其在制备麦角硫因中的应用 |
| JP7710862B2 (ja) * | 2021-03-04 | 2025-07-22 | キッコーマン株式会社 | エルゴチオネイン高含有麹菌固体発酵物、並びにその製造方法 |
| CN114085782B (zh) * | 2021-11-23 | 2023-10-24 | 深圳中科欣扬生物科技有限公司 | 一种来源于曲卓木天然热泉的麦角硫因合成基因及其开发应用 |
| CN114277042A (zh) * | 2021-12-29 | 2022-04-05 | 内蒙古金达威药业有限公司 | 一种高产麦角硫因的圆红冬孢酵母重组表达菌株及其构建方法和应用 |
| CN118574922A (zh) * | 2022-01-05 | 2024-08-30 | 株式会社吴羽 | 新型微生物、新型微生物的培养物或提取物以及麦角硫因的生产方法 |
| JP7450959B2 (ja) * | 2022-01-07 | 2024-03-18 | シャメン オアミック バイオテック カンパニー リミテッド | 酵母菌およびそのエルゴチオネイン製造における用途 |
| CN116515785A (zh) * | 2022-01-24 | 2023-08-01 | 上海医药工业研究院有限公司 | 亚砜合酶及其在制备麦角硫因或其中间体中的应用 |
| CN114606170B (zh) * | 2022-03-07 | 2023-07-18 | 深圳中科欣扬生物科技有限公司 | 一种基于CRISPR-Cas9的麦角硫因生物合成方法及应用 |
| CN116855467A (zh) * | 2022-05-03 | 2023-10-10 | 中国科学院上海有机化学研究所 | 一种化学-酶偶联方法用于合成麦角硫因 |
| WO2023234307A1 (ja) * | 2022-05-31 | 2023-12-07 | キッコーマン株式会社 | エルゴチオネイン生産性を高めるように改変された核酸、並びに遺伝子改変された微生物 |
| JP2024006089A (ja) * | 2022-06-30 | 2024-01-17 | 宮崎県 | エルゴチオネインを含有する発酵物の製造方法及びエルゴチオネインの製造方法 |
| AR130564A1 (es) | 2022-09-27 | 2024-12-18 | Kureha Corp | Agente para mejorar la tolerancia al estrés ambiental en una planta y método para mejorar la tolerancia al estrés ambiental en una planta |
| EP4621043A4 (en) | 2022-11-18 | 2026-04-15 | Kureha Corp | NEW MICROORGANISM, NEW CULTURE OR MICROORGANISM EXTRACT, AND PROCESS FOR THE PRODUCTION OF ERGOTHIONEIN |
| CN116769850B (zh) * | 2023-05-09 | 2026-04-03 | 南京工业大学 | 一种双阶段调控提高麦角硫因生产效率的方法 |
| CN116926103B (zh) * | 2023-07-14 | 2024-01-19 | 合曜生物科技(南京)有限公司 | 一种高产麦角硫因的圆红冬孢酵母工程菌的构建方法及其应用 |
| CN117431198A (zh) * | 2023-07-27 | 2024-01-23 | 上海锐康生物技术研发有限公司 | 一种微氧或厌氧条件下产麦角硫因的重组基因工程菌及其制备方法和用途 |
| AR134099A1 (es) | 2023-10-16 | 2025-12-03 | Kureha Corp | Método para tratar una planta, formulación, propágulo de una planta, método para cultivar una planta, y plántula de trasplante |
| AR134410A1 (es) | 2023-11-21 | 2026-01-14 | Kureha Corp | Agente para mejorar la recuperabilidad de daño y formulación para mejorar la recuperabilidad de daño de la planta, método para mejorar la recuperabilidad de daño de la planta, cuerpo de la planta y agente para mejorar la tolerancia al estrés físico de la planta |
| AR134409A1 (es) | 2023-11-21 | 2026-01-14 | Kureha Corp | Mejorador de tolerancia al estrés abiótico de una planta, método para mejorar la tolerancia al estrés abiótico, formulación para mejorar la tolerancia al estrés abiótico, producto para mejorar la tolerancia al estrés abiótico, y planta |
| CN117736957B (zh) * | 2023-12-26 | 2024-05-10 | 广州同隽医药科技有限公司 | 产麦角硫因的基因工程菌及其在生产麦角硫因中的应用 |
| CN119307523B (zh) * | 2024-12-13 | 2025-02-18 | 中国农业科学院生物技术研究所 | 一种提高麦角硫因生物合成产量的EgtE-TS蛋白的编码基因、EgtE-TS蛋白、重组表达载体和重组菌及其应用 |
| CN121538143B (zh) * | 2026-01-20 | 2026-04-10 | 北京绿色康成生物技术有限公司 | 生产麦角硫因的重组微生物、重组表达载体及制备麦角硫因的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5327732B2 (da) | 1971-12-16 | 1978-08-10 | ||
| JPS5231025B2 (da) | 1972-10-16 | 1977-08-12 | ||
| EP0672161B1 (en) * | 1992-11-05 | 1999-09-22 | Xyrofin Oy | Recombinant method and host for manufacture of xylitol |
| JP3148455B2 (ja) | 1993-04-08 | 2001-03-19 | キッコーマン株式会社 | 変異型ピルビン酸脱水素酵素複合体のｅ１蛋白質 遺伝子及び変異型ピルビン酸脱水素酵素複合体のｅ１蛋白質 |
| JP2005176602A (ja) | 2001-12-27 | 2005-07-07 | National Institute Of Advanced Industrial & Technology | 麹菌遺伝子 |
| JP2007222055A (ja) | 2006-02-22 | 2007-09-06 | Noda Inst For Scient Res | 染色体領域欠失株の作製方法 |
| JP5231025B2 (ja) | 2008-01-10 | 2013-07-10 | 国立大学法人名古屋大学 | 菌糸体培養によるエルゴチオネインの製造方法 |
| JP2011239681A (ja) | 2008-09-19 | 2011-12-01 | Kikkoman Corp | 麹菌アルカリプロテアーゼプロモーター |
| JP4865083B1 (ja) | 2010-11-19 | 2012-02-01 | 幸子 清水 | エルゴチオネインの製造方法 |
| JP2013034416A (ja) | 2011-08-05 | 2013-02-21 | Kikkoman Corp | 重複ゲノム領域を有する菌 |
| EP2935603A4 (en) * | 2012-12-21 | 2016-07-13 | Pinghua Liu | ERGOTHIONEINE PRODUCTION THROUGH METABOLIC ENGINEERING |
| JP6932354B2 (ja) | 2015-08-07 | 2021-09-08 | キッコーマン株式会社 | セレノネインの製造方法 |
-
2015
- 2015-12-25 WO PCT/JP2015/086301 patent/WO2016121285A1/ja not_active Ceased
- 2015-12-25 CN CN202110970819.0A patent/CN113773971A/zh active Pending
- 2015-12-25 DK DK15880177.9T patent/DK3252142T3/da active
- 2015-12-25 JP JP2016571827A patent/JP6246953B2/ja active Active
- 2015-12-25 EP EP21200700.9A patent/EP3985100A1/en active Pending
- 2015-12-25 US US15/533,215 patent/US10760107B2/en active Active
- 2015-12-25 CN CN201580074637.8A patent/CN107250347B/zh active Active
- 2015-12-25 EP EP15880177.9A patent/EP3252142B1/en active Active
-
2020
- 2020-04-27 US US16/859,072 patent/US11186855B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP6246953B2 (ja) | 2017-12-13 |
| JPWO2016121285A1 (ja) | 2017-08-24 |
| CN107250347B (zh) | 2021-09-07 |
| WO2016121285A1 (ja) | 2016-08-04 |
| US20200318147A1 (en) | 2020-10-08 |
| EP3252142A4 (en) | 2018-06-27 |
| EP3252142A1 (en) | 2017-12-06 |
| US11186855B2 (en) | 2021-11-30 |
| CN113773971A (zh) | 2021-12-10 |
| US10760107B2 (en) | 2020-09-01 |
| US20170321235A1 (en) | 2017-11-09 |
| EP3252142B1 (en) | 2021-11-03 |
| EP3985100A1 (en) | 2022-04-20 |
| CN107250347A (zh) | 2017-10-13 |
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