DK3295149T3 - Fremgangsmåde og apparat til måling af rheologiske egenskaber for Newtonske og ikke-Newtonske fluida - Google Patents
Fremgangsmåde og apparat til måling af rheologiske egenskaber for Newtonske og ikke-Newtonske fluida Download PDFInfo
- Publication number
- DK3295149T3 DK3295149T3 DK16724344.3T DK16724344T DK3295149T3 DK 3295149 T3 DK3295149 T3 DK 3295149T3 DK 16724344 T DK16724344 T DK 16724344T DK 3295149 T3 DK3295149 T3 DK 3295149T3
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- Prior art keywords
- fluid
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- microchannel
- rheometer
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
- G01N11/02—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by measuring flow of the material
- G01N11/04—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by measuring flow of the material through a restricted passage, e.g. tube, aperture
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F1/00—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow
- G01F1/56—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using electric or magnetic effects
- G01F1/64—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using electric or magnetic effects by measuring electrical currents passing through the fluid flow; measuring electrical potential generated by the fluid flow, e.g. by electrochemical, contact or friction effects
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Fluid Mechanics (AREA)
- Electrochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Claims (12)
1. Apparat til måling af rheologiske egenskaber for Newtonske og ikke-Newtonske fluida, omfattende: Mindst et mikro-rheometer (1), omfattende en mikrokanal (2) med en indgang (4), en udgang (5) og en sensor-matrix, anbragt langs mikrokanalen (2) for at måle rheologiske egenskaber af et fluidum (7), der strømmer gennem mikrokanalen (2); hvorved senso-rmatrixen omfatter et antal elektrodepar (8, 8') med en kendt fysisk placering langs mikrokanalen (2), hvorved de to elektroder i hvert elektrodepar er anbragt vendende mod hinanden i mikrokanalen (2) for at fungere som en elektronisk kontakt, når fluidummet (7) strømmer gennem dem; og et dataopsamlingssystem (10) i forbindelse med sensor-matrixen, omfattende et elektronisk kredsløb, der er forbundet til elektrodeparret (8, 8’) og konfigureret til: detektering af tidspunktet for den elektroniske kontaktdannelse, i det elektroniske kredsløb, for elektrodeparret (8, 8’), når fluidummet (7) passerer forbi, bestemmelse, ud fra tidspunktet for den elektroniske kontaktdannelse og den fysiske placering af elektrodeparrene (8, 8’), af strømningshastigheden for fluidummet (7) i mikrokanalen (2), og bestemmelse af de rheologiske egenskaber for fluidummet (7) under anvendelse af den erhvervede strømningshastighed for fluidummet (7), mikro-rheometerets (1) dimensioner og trykket, hvorved fluidummet (7) indsprøjtes i mikro-rheometeret (1); kendetegnet ved, at i det elektroniske kredsløb for dataopsamlingssystemet (10) er hvert elektrodepar (8, 8’) forbundet til et elektronisk forstærkerkredsløb (11) for at sikre en meget lille elektrisk strøm (IE) gennem kortslutningen, der skabes af fluidummet (7) og elektrodeparret (8, 8’) med henblik på at undgå beskadigelse af fluidummet (7).
2. Apparat ifølge krav 1, hvorved mikrokanalen (2) omfatter en indstrømningssektion (30) ved indgangen (4) og en hovedkanalsektion (31), hvor elektroderne er anbragt, hvorved indstrømnings sektionens (30) tværsnits areal er mindre end hovedkanalsektionens (31) tværsnits areal med henblik på at styre strømningshastigheden for fluidum-fronten (20) inden i hovedkanalen (31).
3. Apparat ifølge et af kravene 1-2, hvorved det ydermere omfatter et mikrorør (16), som er forbundet med mikrokanalens (2) indgang (4), med et tværsnitsareal, der er mindre end mikrokanalens (2) tværsnitsareal, med henblik på at styre fluidum-frontens (20) strømningshastighed i hovedkanalen (31).
4. Apparat ifølge et af kravene 1-3, ydermere omfattende pneumatik-midler (21) til indsprøjtning af fluidummet (7) inden i mikro-rheometeret (1) ved et bestemt tryk.
5. Apparat ifølge et af kravene 1-4, omfattende en matrix af mikro-rheometre (1), som deler en indgang (4), og med mikrokanaler (2) med forskelligt tværsnitsareal, med henblik på samtidig analyse af rheologiske egenskaber for fluidummet (7) ved forskellige forskydningshastigheder.
6. Apparat ifølge et af kravene 1-5, hvorved elektroderne (8, 8’) i mikro-rheometeret (1) har interdigital form.
7. Apparat ifølge et af kravene 1-6, hvorved elektroderne (8, 8’) i mikro-rheometeret (1) har kvadratisk form.
8. Apparat ifølge et af kravene 1-7, hvorved elektroderne (8, 8’) i mikro-rheometeret (1) er placeret på overfladen af et substrat (54), som er fæstnet til mikrokanalen (2).
9. Apparat ifølge krav 8, hvorved substratet (54) er af PET, glas eller et andet substrat, der anvendes ved mikrofabrikation, med henblik på aflejring, fordampning eller printning af elektrodematerialer.
10. Apparat ifølge et af kravene 1-9, hvorved mikro-rheometeret (1) er indrettet med henblik på analyse af biologiske prøveemner og er af biokompatible materialer.
11. Apparat ifølge et af kravene 1-10, hvorved mikro-rheometeret (1) er indrettet til at måle fluidummets (7) viskositet.
12. Fremgangsmåde til måling af rheologiske egenskaber for Newtonske og ikke-Newtonske fluida, omfattende: Indsprøjtning, ved et bestemt tryk, af et fluidum (7) i mikro-rheometeret (1) i et apparat ifølge et af kravene 1-11; detektering af tidspunktet for den elektroniske kontaktdannelse, i det elektroniske kredsløb, for elektrodeparret (8, 8’), når fluidummet (7) passerer forbi; bestemmelse, ud fra tidspunktet for den elektroniske kontaktdannelse og den fysiske placering af elektrodeparrene (8, 8’), af strømningshastigheden for fluidummet (7) inden i mikrokanalen (2), og bestemmelse af de rheologiske egenskaber for fluidummet (7) under anvendelse af den erhvervede strømningshastighed for fluidummet (7), mikro-rheometerets (1) dimensioner og trykket, hvorved fluidummet (7) indsprøjtes i mikro-rheometeret (1);
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15382248.1A EP3093647A1 (en) | 2015-05-14 | 2015-05-14 | Method, apparatus and micro-rheometer for measuring rheological properties of newtonian and non-newtonian fluids |
| PCT/EP2016/060835 WO2016180964A1 (en) | 2015-05-14 | 2016-05-13 | Method, apparatus and micro-rheometer for measuring rheological properties of newtonian and non-newtonian fluids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3295149T3 true DK3295149T3 (da) | 2019-02-18 |
Family
ID=53191627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16724344.3T DK3295149T3 (da) | 2015-05-14 | 2016-05-13 | Fremgangsmåde og apparat til måling af rheologiske egenskaber for Newtonske og ikke-Newtonske fluida |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10386282B2 (da) |
| EP (2) | EP3093647A1 (da) |
| DK (1) | DK3295149T3 (da) |
| ES (1) | ES2709694T3 (da) |
| PL (1) | PL3295149T3 (da) |
| SI (1) | SI3295149T1 (da) |
| WO (1) | WO2016180964A1 (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110035690A (zh) * | 2016-07-19 | 2019-07-19 | 外分泌腺系统公司 | 汗液电导率、容积出汗速率和皮肤电反应设备及应用 |
| WO2018147862A1 (en) | 2017-02-10 | 2018-08-16 | Hewlett-Packard Development Company, L.P. | Determine viscosity of fluids using a capillary channel |
| WO2018204615A1 (en) * | 2017-05-04 | 2018-11-08 | University Of Connecticut | Assembly for measuring the viscosity of fluids using microchannels |
| US20210172848A1 (en) * | 2019-12-10 | 2021-06-10 | King Abdullah University Of Science And Technology | Viscosity sensor for real-time monitoring of tubular conduits and method |
| US11684920B2 (en) * | 2020-07-07 | 2023-06-27 | International Business Machines Corporation | Electrical tracking of a multiphase microfluidic flow |
| CN112973815B (zh) * | 2021-03-09 | 2022-06-03 | 西北大学 | 一种聚集非球形微游泳体的微流管道及一种过滤方法 |
| US12584839B2 (en) | 2021-07-13 | 2026-03-24 | Massachusetts Institute Of Technology | Point-of-use devices and methods for determining rheological properties of samples |
| WO2023047176A1 (en) * | 2021-09-27 | 2023-03-30 | Universidade Do Porto | Microelectrorheometer for characterizing electrorheological fluids |
| DE102024129203A1 (de) * | 2024-10-09 | 2026-04-09 | Netzsch - Gerätebau Gesellschaft mit beschränkter Haftung | Mobile Rheometervorrichtung und Verfahren für die medizinische Diagnostik von menschlichen, tierischen oder pflanzlichen Proben |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2510257A1 (fr) | 1981-07-21 | 1983-01-28 | Centre Nat Rech Scient | Rheometre pour la mesure des caracteristiques de viscosite d'un liquide |
| US5955659A (en) * | 1998-01-13 | 1999-09-21 | Massachusetts Institute Of Technology | Electrostatically-actuated structures for fluid property measurements and related methods |
| US7040144B2 (en) * | 2000-02-23 | 2006-05-09 | Caliper Life Sciences, Inc. | Microfluidic viscometer |
| DE10010539B4 (de) * | 2000-03-03 | 2004-02-05 | Disetronic Licensing Ag | Verfahren zur Affinitätsviskosimetrie und viskosimetrischer Affinitätssensor |
| US7770436B2 (en) | 2001-10-31 | 2010-08-10 | Rheosense, Inc. | Micro rheometer for measuring flow viscosity and elasticity for micron sample volumes |
| US7290441B2 (en) * | 2001-10-31 | 2007-11-06 | Rheosense, Inc. | Micro slit viscometer with monolithically integrated pressure sensors |
| WO2006036833A2 (en) * | 2004-09-24 | 2006-04-06 | The Regents Of The University Of Michigan | A nanoliter viscometer for analyzing blood plasma and other liquid samples |
| US7454988B2 (en) * | 2005-02-10 | 2008-11-25 | Applera Corporation | Method for fluid sampling using electrically controlled droplets |
| DE102006001180B4 (de) | 2006-01-06 | 2010-12-23 | Technische Universität Chemnitz | Rheometer und Auswerteverfahren zur Bestimmung von Fließkurve und Viskositätsfunktion von optisch transparenten Newtonschen und Nicht-Newtonschen Flüssigkeiten |
| FR2907226B1 (fr) * | 2006-10-13 | 2008-12-12 | Rhodia Recherches & Tech | Dispositif d'analyse fluidique,dispositif de determination de caracteristiques d'un fluide comprenant ce dispositif d'analyse,procedes de mise en oeuvre et procede de criblage correspondants |
| JP2008128706A (ja) * | 2006-11-17 | 2008-06-05 | Konica Minolta Medical & Graphic Inc | マイクロチップ検査システム、およびマイクロチップ検査システムに用いるプログラム |
| FR2909293B1 (fr) * | 2006-12-05 | 2011-04-22 | Commissariat Energie Atomique | Micro-dispositif de traitement d'echantillons liquides |
| DE202007018634U1 (de) * | 2007-02-15 | 2009-01-15 | Bayer Technology Services Gmbh | Leitfähigkeitsmessvorrichtung |
| US8306773B2 (en) * | 2007-08-29 | 2012-11-06 | Canon U.S. Life Sciences, Inc. | Microfluidic devices with integrated resistive heater electrodes including systems and methods for controlling and measuring the temperatures of such heater electrodes |
| US8056398B2 (en) * | 2008-02-19 | 2011-11-15 | Kent State University | Broad-range nanoliter rheometer |
| DE102008050326A1 (de) * | 2008-10-07 | 2010-04-08 | Endress + Hauser Gmbh + Co. Kg | Vorrichtung zur Bestimmung und/oder Überwachung einer Prozessgröße eines Mediums |
| GB2485965A (en) | 2010-08-03 | 2012-06-06 | Univ Manchester | Rheometry apparatus for measuring the viscosity and elasticity of liquids |
| US9110026B2 (en) * | 2011-05-05 | 2015-08-18 | Biopico Systems Inc | Microfluidic devices and methods based on massively parallel picoreactors for cell and molecular diagnostics |
| AR082130A1 (es) * | 2011-07-07 | 2012-11-14 | Consejo Nac Invest Cient Tec | Microviscosimetro capilar |
| KR101349796B1 (ko) * | 2012-05-18 | 2014-01-16 | 한국생산기술연구원 | 마이크로 점도계 및 이를 생산하기 위한 제조방법 |
| DE102012210470B4 (de) * | 2012-06-21 | 2015-09-17 | Ihp Gmbh - Innovations For High Performance Microelectronics / Leibniz-Institut Für Innovative Mikroelektronik | MEMS-Mikroviskosimeter |
-
2015
- 2015-05-14 EP EP15382248.1A patent/EP3093647A1/en not_active Withdrawn
-
2016
- 2016-05-13 SI SI201630169T patent/SI3295149T1/sl unknown
- 2016-05-13 ES ES16724344T patent/ES2709694T3/es active Active
- 2016-05-13 PL PL16724344T patent/PL3295149T3/pl unknown
- 2016-05-13 DK DK16724344.3T patent/DK3295149T3/da active
- 2016-05-13 US US15/574,021 patent/US10386282B2/en active Active
- 2016-05-13 WO PCT/EP2016/060835 patent/WO2016180964A1/en not_active Ceased
- 2016-05-13 EP EP16724344.3A patent/EP3295149B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016180964A1 (en) | 2016-11-17 |
| ES2709694T3 (es) | 2019-04-17 |
| US20180299361A1 (en) | 2018-10-18 |
| EP3093647A1 (en) | 2016-11-16 |
| SI3295149T1 (sl) | 2019-04-30 |
| EP3295149B1 (en) | 2018-10-31 |
| US10386282B2 (en) | 2019-08-20 |
| PL3295149T3 (pl) | 2019-07-31 |
| EP3295149A1 (en) | 2018-03-21 |
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