DK3295941T3 - Fremgangsmåde til fremstilling af form a af grapiprant - Google Patents

Fremgangsmåde til fremstilling af form a af grapiprant Download PDF

Info

Publication number: DK3295941T3
Authority: DK; Denmark
Prior art keywords: grapiprant; procedure; making
Prior art date: 2014-03-06

Application number

DK17193737.8T

Other languages

English (en)

Inventor

Tamara Newbold

Melissa Smith

Christopher Seekamp

Robert Wenslow

Xia Lu

Original Assignee

Aratana Therapeutics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-03-06

Filing date

2015-03-05

Publication date

2020-08-24

2015-03-05 Application filed by Aratana Therapeutics Inc filed Critical Aratana Therapeutics Inc

2020-08-24 Application granted granted Critical

2020-08-24 Publication of DK3295941T3 publication Critical patent/DK3295941T3/da

Links

HZVLFTCYCLXTGV-UHFFFAOYSA-N 1-[2-[4-(2-ethyl-4,6-dimethylimidazo[4,5-c]pyridin-1-yl)phenyl]ethyl]-3-(4-methylphenyl)sulfonylurea Chemical compound CCC1=NC2=C(C)N=C(C)C=C2N1C(C=C1)=CC=C1CCNC(=O)NS(=O)(=O)C1=CC=C(C)C=C1 HZVLFTCYCLXTGV-UHFFFAOYSA-N 0.000 title 1
229950004517 grapiprant Drugs 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Neurology (AREA)
Physical Education & Sports Medicine (AREA)
Oncology (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurosurgery (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Led Devices (AREA)
Crystals, And After-Treatments Of Crystals (AREA)
Ceramic Products (AREA)
Inorganic Insulating Materials (AREA)

DK17193737.8T 2014-03-06 2015-03-05 Fremgangsmåde til fremstilling af form a af grapiprant DK3295941T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201461949006P	2014-03-06	2014-03-06
US201461996961P	2014-07-30	2014-07-30
EP15758500.1A EP3113773B1 (en)	2014-03-06	2015-03-05	Crystalline forms of grapiprant

Publications (1)

Publication Number	Publication Date
DK3295941T3 true DK3295941T3 (da)	2020-08-24

Family

ID=54016295

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK19156369.1T DK3511000T3 (da)	2014-03-06	2015-03-05	Krystallinsk form x2 af grapiprant
DK17193737.8T DK3295941T3 (da)	2014-03-06	2015-03-05	Fremgangsmåde til fremstilling af form a af grapiprant
DK15758500T DK3113773T3 (da)	2014-03-06	2015-03-05	Krystallinske former af grapiprant

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK19156369.1T DK3511000T3 (da)	2014-03-06	2015-03-05	Krystallinsk form x2 af grapiprant

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK15758500T DK3113773T3 (da)	2014-03-06	2015-03-05	Krystallinske former af grapiprant

Country Status (16)

Country	Link
US (1)	US9265756B2 (da)
EP (4)	EP3511000B1 (da)
JP (2)	JP6535683B2 (da)
KR (2)	KR101697914B1 (da)
CN (11)	CN107501262A (da)
AU (1)	AU2015227064B2 (da)
CA (10)	CA2997692A1 (da)
DK (3)	DK3511000T3 (da)
ES (3)	ES2919346T3 (da)
MX (2)	MX367376B (da)
NZ (3)	NZ733234A (da)
PL (3)	PL3113773T3 (da)
PT (3)	PT3295941T (da)
RU (1)	RU2638931C1 (da)
TW (1)	TWI537270B (da)
WO (1)	WO2015134797A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US12109218B2 (en)	2014-12-09	2024-10-08	Aratana Therapeutics, Inc.	Compositions of grapiprant and methods for using the same
TWI664969B (zh)	2014-03-06	2019-07-11	雅瑞塔那醫療公司	格拉匹綸(ｇｒａｐｉｐｒａｎｔ)組合物及其使用方法
CN112292128A (zh)	2018-04-16	2021-01-29	阿瑞斯医疗有限公司	Ep4抑制剂和其用途
US20210315909A1 (en) *	2018-07-11	2021-10-14	Arrys Therapeutics, Inc.	Polymorphic compounds and uses thereof
IL280051B2 (en) *	2018-07-11	2024-03-01	Arrys Therapeutics Inc	EP4 inhibitors and their synthesis
US11254675B2 (en) *	2019-08-12	2022-02-22	Cadila Healthcare Limited	Process for preparation of grapiprant
WO2021226162A1 (en)	2020-05-05	2021-11-11	Arrys Therapeutics, Inc.	Ep4 antagonists and their use in the treatment of proliferative diseases
CN116283959A (zh) *	2021-12-10	2023-06-23	江苏慧聚药业股份有限公司	格拉匹纶新晶型及其制备

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HN2001000224A (es)	2000-10-19	2002-06-13	Pfizer	Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti - inflamatorios y analgesicos.
AU2006221699A1 (en) *	2005-03-11	2006-09-14	Pfizer Inc.	Crystal forms of an imidazole derivative
EP2270000B1 (en) *	2005-05-23	2015-07-29	Novartis AG	Crystalline and other forms of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one lactic acid salts
JP5069752B2 (ja) *	2006-12-15	2012-11-07	グラクソグループリミテッド	Ｅｐ４受容体アゴニストとしてのベンズアミド誘導体
CN102149384B (zh) *	2008-08-14	2014-08-20	南京奥昭生物科技有限公司	作为ep4受体拮抗剂的杂环酰胺衍生物
CN103702995B (zh)	2011-05-18	2016-04-13	拉夸里亚创药株式会社	4-{[4-({[4-(2,2,2-三氟乙氧基)-1,2-苯并异噁唑-3-基]氧}甲基)哌啶-1-基]甲基}-四氢-2h-吡喃-4-羧酸的多晶型形式

2015
- 2015-03-05 CA CA2997692A patent/CA2997692A1/en not_active Abandoned
- 2015-03-05 CN CN201710831540.8A patent/CN107501262A/zh active Pending
- 2015-03-05 CN CN201710831743.7A patent/CN107540671A/zh not_active Withdrawn
- 2015-03-05 US US14/639,916 patent/US9265756B2/en active Active
- 2015-03-05 CA CA3168877A patent/CA3168877A1/en active Pending
- 2015-03-05 PT PT171937378T patent/PT3295941T/pt unknown
- 2015-03-05 MX MX2016011023A patent/MX367376B/es active IP Right Grant
- 2015-03-05 AU AU2015227064A patent/AU2015227064B2/en active Active
- 2015-03-05 EP EP19156369.1A patent/EP3511000B1/en active Active
- 2015-03-05 ES ES19156369T patent/ES2919346T3/es active Active
- 2015-03-05 ES ES17193737T patent/ES2816057T3/es active Active
- 2015-03-05 JP JP2016555827A patent/JP6535683B2/ja active Active
- 2015-03-05 CN CN201710831494.1A patent/CN107573339A/zh not_active Withdrawn
- 2015-03-05 PT PT191563691T patent/PT3511000T/pt unknown
- 2015-03-05 CA CA2997746A patent/CA2997746A1/en not_active Abandoned
- 2015-03-05 PL PL15758500T patent/PL3113773T3/pl unknown
- 2015-03-05 NZ NZ733234A patent/NZ733234A/en unknown
- 2015-03-05 ES ES15758500T patent/ES2755396T3/es active Active
- 2015-03-05 EP EP15758500.1A patent/EP3113773B1/en active Active
- 2015-03-05 CN CN201710832196.4A patent/CN107759589A/zh active Pending
- 2015-03-05 CA CA3105571A patent/CA3105571A1/en active Pending
- 2015-03-05 CA CA2997741A patent/CA2997741A1/en not_active Abandoned
- 2015-03-05 RU RU2016139096A patent/RU2638931C1/ru active
- 2015-03-05 PT PT157585001T patent/PT3113773T/pt unknown
- 2015-03-05 CA CA2997718A patent/CA2997718A1/en active Pending
- 2015-03-05 CA CA2997694A patent/CA2997694C/en active Active
- 2015-03-05 DK DK19156369.1T patent/DK3511000T3/da active
- 2015-03-05 CA CA2941019A patent/CA2941019A1/en not_active Withdrawn
- 2015-03-05 CN CN202110197159.7A patent/CN113087705A/zh active Pending
- 2015-03-05 KR KR1020167024256A patent/KR101697914B1/ko active Active
- 2015-03-05 WO PCT/US2015/019043 patent/WO2015134797A1/en not_active Ceased
- 2015-03-05 MX MX2018003837A patent/MX388969B/es unknown
- 2015-03-05 CN CN201710832416.3A patent/CN107759590A/zh not_active Withdrawn
- 2015-03-05 CN CN201580002716.8A patent/CN105764508A/zh active Pending
- 2015-03-05 PL PL17193737T patent/PL3295941T3/pl unknown
- 2015-03-05 CA CA2997703A patent/CA2997703A1/en not_active Abandoned
- 2015-03-05 TW TW104107082A patent/TWI537270B/zh active
- 2015-03-05 DK DK17193737.8T patent/DK3295941T3/da active
- 2015-03-05 PL PL19156369.1T patent/PL3511000T3/pl unknown
- 2015-03-05 CN CN201710832497.7A patent/CN107759591A/zh not_active Withdrawn
- 2015-03-05 DK DK15758500T patent/DK3113773T3/da active
- 2015-03-05 NZ NZ733225A patent/NZ733225A/en unknown
- 2015-03-05 KR KR1020177000896A patent/KR101771385B1/ko active Active
- 2015-03-05 EP EP19156370.9A patent/EP3520790A1/en not_active Withdrawn
- 2015-03-05 CA CA2997697A patent/CA2997697A1/en not_active Abandoned
- 2015-03-05 EP EP17193737.8A patent/EP3295941B1/en active Active
- 2015-03-05 CN CN201910653673.XA patent/CN110256426A/zh active Pending
- 2015-03-05 NZ NZ724923A patent/NZ724923A/en unknown
- 2015-03-05 CN CN201710831795.4A patent/CN107501263A/zh not_active Withdrawn
- 2015-03-05 CN CN201710831735.2A patent/CN107400132A/zh not_active Withdrawn
2017
- 2017-11-10 JP JP2017217662A patent/JP2018065819A/ja active Pending

Also Published As

Publication number	Publication date
CA2997694A1 (en)	2015-09-11
NZ724923A (en)	2018-03-23
PL3295941T3 (pl)	2020-11-16
EP3511000A1 (en)	2019-07-17
CA2997697A1 (en)	2015-09-11
MX367376B (es)	2019-08-16
JP6535683B2 (ja)	2019-06-26
PT3511000T (pt)	2022-05-25
EP3113773A4 (en)	2017-05-10
US20150250774A1 (en)	2015-09-10
TWI537270B (zh)	2016-06-11
CN107400132A (zh)	2017-11-28
JP2018065819A (ja)	2018-04-26
PT3295941T (pt)	2020-08-25
WO2015134797A1 (en)	2015-09-11
CA2997746A1 (en)	2015-09-11
KR101697914B1 (ko)	2017-01-18
MX388969B (es)	2025-03-20
KR20170008889A (ko)	2017-01-24
CN110256426A (zh)	2019-09-20
CN107759590A (zh)	2018-03-06
KR101771385B1 (ko)	2017-08-24
CA2997692A1 (en)	2015-09-11
EP3295941A1 (en)	2018-03-21
CA3168877A1 (en)	2015-09-11
AU2015227064A1 (en)	2016-10-27
CA2997718A1 (en)	2015-09-11
EP3511000B1 (en)	2022-04-27
NZ733225A (en)	2018-03-23
EP3113773B1 (en)	2019-09-18
DK3113773T3 (da)	2019-11-18
CA2997694C (en)	2021-04-06
CN107540671A (zh)	2018-01-05
KR20160106779A (ko)	2016-09-12
CN107759589A (zh)	2018-03-06
CA2941019A1 (en)	2015-09-11
CN107501262A (zh)	2017-12-22
EP3520790A1 (en)	2019-08-07
AU2015227064B2 (en)	2017-05-11
US9265756B2 (en)	2016-02-23
CA3105571A1 (en)	2015-09-11
ES2919346T3 (es)	2022-07-26
CN105764508A (zh)	2016-07-13
ES2755396T3 (es)	2020-04-22
PL3511000T3 (pl)	2022-08-22
PT3113773T (pt)	2019-11-12
PL3113773T3 (pl)	2020-05-18
CN107501263A (zh)	2017-12-22
EP3113773A1 (en)	2017-01-11
CN113087705A (zh)	2021-07-09
CA2997703A1 (en)	2015-09-11
NZ733234A (en)	2018-08-31
CN107573339A (zh)	2018-01-12
ES2816057T3 (es)	2021-03-31
CA2997741A1 (en)	2015-09-11
MX2016011023A (es)	2016-11-28
CN107759591A (zh)	2018-03-06
RU2638931C1 (ru)	2017-12-19
EP3295941B1 (en)	2020-07-22
JP2017507161A (ja)	2017-03-16
TW201538500A (zh)	2015-10-16
DK3511000T3 (da)	2022-05-30

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