DK32989A - Immunoglobulin-konjugater og fremgangsmaade til fremstilling deraf - Google Patents

Immunoglobulin-konjugater og fremgangsmaade til fremstilling deraf

Info

Publication number
DK32989A
DK32989A DK032989A DK32989A DK32989A DK 32989 A DK32989 A DK 32989A DK 032989 A DK032989 A DK 032989A DK 32989 A DK32989 A DK 32989A DK 32989 A DK32989 A DK 32989A
Authority
DK
Denmark
Prior art keywords
procedures
preparing
immunoglobulin conjugates
conjugates
immunoglobulin
Prior art date
Application number
DK032989A
Other languages
English (en)
Other versions
DK32989D0 (da
Inventor
James Jacob Starling
Bennett Coleman Laguzza
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DK32989D0 publication Critical patent/DK32989D0/da
Publication of DK32989A publication Critical patent/DK32989A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6805—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a vinca alkaloid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
DK032989A 1988-01-27 1989-01-26 Immunoglobulin-konjugater og fremgangsmaade til fremstilling deraf DK32989A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14882288A 1988-01-27 1988-01-27

Publications (2)

Publication Number Publication Date
DK32989D0 DK32989D0 (da) 1989-01-26
DK32989A true DK32989A (da) 1989-07-28

Family

ID=22527543

Family Applications (1)

Application Number Title Priority Date Filing Date
DK032989A DK32989A (da) 1988-01-27 1989-01-26 Immunoglobulin-konjugater og fremgangsmaade til fremstilling deraf

Country Status (11)

Country Link
EP (1) EP0326322A1 (da)
JP (1) JPH02152996A (da)
KR (1) KR890011896A (da)
CN (1) CN1034543A (da)
AU (1) AU2878989A (da)
DK (1) DK32989A (da)
HU (1) HU199783B (da)
IE (1) IE890237L (da)
IL (1) IL89043A0 (da)
PT (1) PT89504A (da)
ZA (1) ZA89524B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5094849A (en) * 1988-08-08 1992-03-10 Eli Lilly And Company Cytotoxic antibody conjugates of hydrazide derivatized vinca analogs via simple organic linkers
US5006652A (en) * 1988-08-08 1991-04-09 Eli Lilly And Company Intermediates for antibody-vinca drug conjugates
IL93986A0 (en) * 1989-04-04 1991-01-31 Lilly Co Eli Improvements in and relating to pharmaceutical formulations
ES2049656B1 (es) * 1992-10-08 1994-11-16 Lilly Co Eli Grupos de conjugados de farmacos con anticuerpos.
EP0833663A4 (en) * 1995-05-15 1999-04-07 Constantin A Bona CARBOHYDRATE MEDIATED COUPLING OF PEPTIDES TO IMMUNOGLOBULINES
SE0302324D0 (sv) * 2003-08-28 2003-08-28 Astrazeneca Ab Novel compounds
CN102898523B (zh) * 2012-10-19 2014-06-25 上海师范大学 N-取代四氢吡啶连吲哚-单克隆抗体cd14结合物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0121388B1 (en) * 1983-03-30 1990-06-13 Lilly Industries Limited Immunoglobulin conjugates
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
ZA873600B (en) * 1986-05-27 1988-12-28 Lilly Co Eli Immunoglobulin conjugates
FR2610198B1 (fr) * 1987-02-03 1990-06-15 Ire Celltarg Sa Conjugues d'hydrazide d'alcaloide de vinca lie a une immunoglobuline, procede de preparation et compositions pharmaceutiques en comprenant

Also Published As

Publication number Publication date
PT89504A (pt) 1989-10-04
ZA89524B (en) 1990-09-26
IE890237L (en) 1989-07-27
DK32989D0 (da) 1989-01-26
KR890011896A (ko) 1989-08-23
IL89043A0 (en) 1989-08-15
CN1034543A (zh) 1989-08-09
HU199783B (en) 1990-03-28
JPH02152996A (ja) 1990-06-12
AU2878989A (en) 1989-07-27
HUT48909A (en) 1989-07-28
EP0326322A1 (en) 1989-08-02

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Legal Events

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