DK3302471T3 - Tetrasubstituerede alkenforbindelser og deres anvendelse - Google Patents
Tetrasubstituerede alkenforbindelser og deres anvendelse Download PDFInfo
- Publication number
- DK3302471T3 DK3302471T3 DK16804153.1T DK16804153T DK3302471T3 DK 3302471 T3 DK3302471 T3 DK 3302471T3 DK 16804153 T DK16804153 T DK 16804153T DK 3302471 T3 DK3302471 T3 DK 3302471T3
- Authority
- DK
- Denmark
- Prior art keywords
- tetra
- substituted alkene
- alkene compounds
- compounds
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/02—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/02—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 2
- C07D317/06—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 2 condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562168581P | 2015-05-29 | 2015-05-29 | |
| US201562168529P | 2015-05-29 | 2015-05-29 | |
| US201562269745P | 2015-12-18 | 2015-12-18 | |
| PCT/US2016/034782 WO2016196346A1 (en) | 2015-05-29 | 2016-05-27 | Tetrasubstituted alkene compounds and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3302471T3 true DK3302471T3 (da) | 2021-11-15 |
Family
ID=57398096
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16804153.1T DK3302471T3 (da) | 2015-05-29 | 2016-05-27 | Tetrasubstituerede alkenforbindelser og deres anvendelse |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US9796683B2 (da) |
| EP (2) | EP3302471B1 (da) |
| JP (1) | JP6325760B1 (da) |
| KR (1) | KR102664618B1 (da) |
| CN (2) | CN113024466A (da) |
| AU (1) | AU2016271126B2 (da) |
| BR (1) | BR112017025546B1 (da) |
| CA (1) | CA2987321C (da) |
| CL (1) | CL2017002996A1 (da) |
| CO (1) | CO2017013432A2 (da) |
| CY (1) | CY1125068T1 (da) |
| DK (1) | DK3302471T3 (da) |
| ES (1) | ES2895511T3 (da) |
| HR (1) | HRP20211542T1 (da) |
| HU (1) | HUE056199T2 (da) |
| IL (1) | IL255765B2 (da) |
| JO (1) | JO3735B1 (da) |
| LT (1) | LT3302471T (da) |
| MA (1) | MA43364B1 (da) |
| MD (1) | MD3302471T2 (da) |
| MX (1) | MX379297B (da) |
| MY (1) | MY186977A (da) |
| PE (1) | PE20181083A1 (da) |
| PH (1) | PH12017502142B1 (da) |
| PL (1) | PL3302471T3 (da) |
| PT (1) | PT3302471T (da) |
| RS (1) | RS62481B1 (da) |
| RU (1) | RU2733741C2 (da) |
| SI (1) | SI3302471T1 (da) |
| SM (1) | SMT202100599T1 (da) |
| TW (1) | TWI704137B (da) |
| UA (1) | UA120882C2 (da) |
| WO (2) | WO2016196346A1 (da) |
| ZA (1) | ZA201707912B (da) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS62481B1 (sr) | 2015-05-29 | 2021-11-30 | Eisai R&D Man Co Ltd | Jedinjenja tetrasupstituisanog alkena i njihova upotreba |
| JP2019535778A (ja) * | 2016-11-24 | 2019-12-12 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 四置換アルケン化合物及び乳がんを治療するためのその使用 |
| JP2019535781A (ja) * | 2016-11-24 | 2019-12-12 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 四置換アルケン化合物及びその使用 |
| CN109790141B (zh) * | 2016-11-28 | 2021-06-11 | 卫材 R&D 管理有限公司 | 吲唑衍生物的盐及其晶体 |
| WO2018170447A1 (en) | 2017-03-16 | 2018-09-20 | Eisai R&D Management Co., Ltd. | Combination therapies for the treatment of breast cancer |
| BR112020023136A2 (pt) | 2018-05-14 | 2021-02-09 | Nuvation Bio Inc. | compostos de alvo de receptor de hormônio nuclear anticâncer |
| WO2019225552A1 (en) * | 2018-05-22 | 2019-11-28 | Eisai R&D Management Co., Ltd. | Salts of indazole derivative and crystals thereof |
| AU2019400398B2 (en) * | 2018-12-17 | 2024-10-03 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Estrogen receptor antagonist |
| CN113811333B (zh) | 2019-05-14 | 2024-03-12 | 诺维逊生物股份有限公司 | 靶向抗癌核激素受体的化合物 |
| JP7608369B2 (ja) | 2019-05-24 | 2025-01-06 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | エストロゲン受容体アルファ阻害剤の経口剤形を用いて癌を治療する方法 |
| US12325696B2 (en) * | 2019-06-19 | 2025-06-10 | Jiangsu Hengrui Medicine Co., Ltd. | Indazole derivative, preparation method therefor, and pharmaceutical application thereof |
| GB2606804B (en) | 2019-07-17 | 2023-12-27 | 2692372 Ontario Inc | Benzenesulfonamide derivatives and uses thereof |
| CN110452177A (zh) * | 2019-09-02 | 2019-11-15 | 南通大学 | 一种5-溴-4-氟-1h-吲唑的合成方法 |
| EP4058464A1 (en) | 2019-11-13 | 2022-09-21 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
| CN115916769B (zh) | 2020-06-28 | 2024-09-10 | 深圳扬厉医药技术有限公司 | 并环吲唑类化合物 |
| EP4240357A1 (en) * | 2020-11-06 | 2023-09-13 | Eisai R&D Management Co., Ltd. | Method of treating breast cancer |
| CN114644615B (zh) * | 2020-12-18 | 2023-11-14 | 江苏恒瑞医药股份有限公司 | 一种吲唑类衍生物的结晶形式及其制备方法 |
| WO2022127904A1 (zh) * | 2020-12-18 | 2022-06-23 | 江苏恒瑞医药股份有限公司 | 一种吲唑类衍生物的药学上可接受的盐、结晶形式及其制备方法 |
| CN114644616B (zh) * | 2020-12-18 | 2023-11-14 | 江苏恒瑞医药股份有限公司 | 一种吲唑类衍生物的药学上可接受的盐、结晶形式及其制备方法 |
| EP4313991A1 (en) | 2021-03-23 | 2024-02-07 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
| WO2022235585A1 (en) | 2021-05-03 | 2022-11-10 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
| CN117440950A (zh) * | 2021-06-27 | 2024-01-23 | 北京盛诺基医药科技股份有限公司 | 一种ERα受体共价结合拮抗剂 |
| CN115960082B (zh) * | 2021-10-13 | 2024-06-07 | 长春金赛药业有限责任公司 | 一种四取代的烯烃化合物、其制备方法及其在医药上的应用 |
| JP7824822B2 (ja) * | 2022-05-31 | 2026-03-05 | 東レ・ファインケミカル株式会社 | エチニル基を有する縮合多環芳香族化合物の製造方法 |
| CN117550980B (zh) * | 2023-12-04 | 2025-12-19 | 宁夏瑞泰科技股份有限公司 | 一种制备n-乙基-1,6-己二胺的方法和由其制得的产品 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3907290A1 (de) | 1989-03-07 | 1990-09-13 | Gerhard Prof Dr Eisenbrand | Steroidhormonrezeptoraffine antitumorwirkstoffe |
| US5552412A (en) * | 1995-01-09 | 1996-09-03 | Pfizer Inc | 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis |
| TW397821B (en) | 1996-04-19 | 2000-07-11 | American Home Produits Corp | 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof |
| US6897231B2 (en) * | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
| WO2007058626A1 (en) * | 2005-11-16 | 2007-05-24 | S*Bio Pte Ltd | Indazole compounds |
| WO2009120999A2 (en) | 2008-03-28 | 2009-10-01 | Olema Pharmaceuticals, Inc. | Use of an endoxifen prodrug for treatment of breast cancer |
| US8063249B1 (en) | 2008-04-25 | 2011-11-22 | Olema Pharmaceuticals, Inc. | Substituted triphenyl butenes |
| CA2775266C (en) | 2009-10-13 | 2013-12-31 | Duquesne University Of The Holy Spirit, A Nonprofit Corporation Organized Under The Laws Of The Commonwealth Of Pennsylvania | Anti-cancer tamoxifen-melatonin hybrid ligand |
| WO2011129837A1 (en) | 2010-04-16 | 2011-10-20 | Olema Pharmaceuticals, Inc. | Use of a 4-hydroxytoremifene prodrug for treatment of breast cancer |
| GB2483736B (en) | 2010-09-16 | 2012-08-29 | Aragon Pharmaceuticals Inc | Estrogen receptor modulators and uses thereof |
| WO2013056178A2 (en) | 2011-10-14 | 2013-04-18 | Foundation Medicine, Inc. | Novel estrogen receptor mutations and uses thereof |
| US9499538B2 (en) | 2012-03-20 | 2016-11-22 | Seragon Pharmaceuticals, Inc. | Estrogen receptor modulators and uses thereof |
| US9365510B2 (en) | 2012-04-16 | 2016-06-14 | British Columbia Cancer Agency Branch | Aziridine bisphenol ethers and related compounds and methods for their use |
| EP2945628B1 (en) | 2013-01-15 | 2020-04-15 | Aragon Pharmaceuticals, Inc. | Androgen receptor modulator in combination with abiraterone acetate and prednisone for treating prostate cancer |
| EA031077B1 (ru) | 2013-06-19 | 2018-11-30 | Серагон Фармасьютикалз, Инк. | Модулятор рецептора эстрогена и его применения |
| BR112015030595A2 (pt) | 2013-06-19 | 2017-07-25 | Seragon Pharmaceuticals Inc | moduladores de receptor de estrogênio de azetidina e usos dos mesmos |
| GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| SG11201607334YA (en) | 2014-03-13 | 2016-10-28 | Hoffmann La Roche | Therapeutic combinations with estrogen receptor modulators |
| WO2016055982A1 (en) | 2014-10-10 | 2016-04-14 | Acerta Pharma B.V. | Quinoline and quinazoline compounds |
| WO2016097071A1 (en) | 2014-12-18 | 2016-06-23 | F. Hoffmann-La Roche Ag | Estrogen receptor modulators and uses thereof |
| RS62481B1 (sr) | 2015-05-29 | 2021-11-30 | Eisai R&D Man Co Ltd | Jedinjenja tetrasupstituisanog alkena i njihova upotreba |
-
2016
- 2016-05-27 RS RS20211306A patent/RS62481B1/sr unknown
- 2016-05-27 BR BR112017025546-4A patent/BR112017025546B1/pt active IP Right Grant
- 2016-05-27 MX MX2017015226A patent/MX379297B/es unknown
- 2016-05-27 MY MYPI2017001740A patent/MY186977A/en unknown
- 2016-05-27 WO PCT/US2016/034782 patent/WO2016196346A1/en not_active Ceased
- 2016-05-27 WO PCT/US2016/034764 patent/WO2016196337A1/en not_active Ceased
- 2016-05-27 EP EP16804153.1A patent/EP3302471B1/en active Active
- 2016-05-27 CN CN202110301494.7A patent/CN113024466A/zh active Pending
- 2016-05-27 PL PL16804153T patent/PL3302471T3/pl unknown
- 2016-05-27 KR KR1020177037820A patent/KR102664618B1/ko active Active
- 2016-05-27 CA CA2987321A patent/CA2987321C/en active Active
- 2016-05-27 CN CN201680043755.7A patent/CN107847498B/zh active Active
- 2016-05-27 JP JP2017560920A patent/JP6325760B1/ja active Active
- 2016-05-27 IL IL255765A patent/IL255765B2/en unknown
- 2016-05-27 US US15/167,373 patent/US9796683B2/en active Active
- 2016-05-27 RU RU2017146408A patent/RU2733741C2/ru active
- 2016-05-27 UA UAA201712962A patent/UA120882C2/uk unknown
- 2016-05-27 SI SI201631340T patent/SI3302471T1/sl unknown
- 2016-05-27 PT PT168041531T patent/PT3302471T/pt unknown
- 2016-05-27 PE PE2017002481A patent/PE20181083A1/es unknown
- 2016-05-27 EP EP21191181.3A patent/EP3981766A1/en not_active Withdrawn
- 2016-05-27 ES ES16804153T patent/ES2895511T3/es active Active
- 2016-05-27 HR HRP20211542TT patent/HRP20211542T1/hr unknown
- 2016-05-27 HU HUE16804153A patent/HUE056199T2/hu unknown
- 2016-05-27 DK DK16804153.1T patent/DK3302471T3/da active
- 2016-05-27 LT LTEPPCT/US2016/034782T patent/LT3302471T/lt unknown
- 2016-05-27 MD MDE20180368T patent/MD3302471T2/ro unknown
- 2016-05-27 AU AU2016271126A patent/AU2016271126B2/en active Active
- 2016-05-27 SM SM20210599T patent/SMT202100599T1/it unknown
- 2016-05-27 MA MA43364A patent/MA43364B1/fr unknown
- 2016-05-27 PH PH1/2017/502142A patent/PH12017502142B1/en unknown
- 2016-05-27 TW TW105116750A patent/TWI704137B/zh active
- 2016-05-29 JO JOP/2016/0102A patent/JO3735B1/ar active
-
2017
- 2017-09-22 US US15/713,107 patent/US10851065B2/en active Active
- 2017-11-21 ZA ZA2017/07912A patent/ZA201707912B/en unknown
- 2017-11-27 CL CL2017002996A patent/CL2017002996A1/es unknown
- 2017-12-27 CO CONC2017/0013432A patent/CO2017013432A2/es unknown
-
2021
- 2021-11-08 CY CY20211100961T patent/CY1125068T1/el unknown
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