DK3307277T3 - Enkeltstrengede oligonukleotider til anvendelse i medicinsk behandling af hudlidelser - Google Patents

Enkeltstrengede oligonukleotider til anvendelse i medicinsk behandling af hudlidelser Download PDF

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Publication number
DK3307277T3
DK3307277T3 DK16734570.1T DK16734570T DK3307277T3 DK 3307277 T3 DK3307277 T3 DK 3307277T3 DK 16734570 T DK16734570 T DK 16734570T DK 3307277 T3 DK3307277 T3 DK 3307277T3
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Denmark
Prior art keywords
medical treatment
skin disorders
stranded oligonucleotides
oligonucleotides
stranded
Prior art date
Application number
DK16734570.1T
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English (en)
Inventor
Holmgren Anna-Lena Spetz
Peter Järver
Annette Sköld
Original Assignee
Tirmed Pharma Ab
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Publication of DK3307277T3 publication Critical patent/DK3307277T3/da

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7125Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/17Immunomodulatory nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/315Phosphorothioates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/3212'-O-R Modification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/34Spatial arrangement of the modifications
    • C12N2310/346Spatial arrangement of the modifications having a combination of backbone and sugar modifications

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK16734570.1T 2015-06-15 2016-06-14 Enkeltstrengede oligonukleotider til anvendelse i medicinsk behandling af hudlidelser DK3307277T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE1550814 2015-06-15
PCT/EP2016/063596 WO2016202779A1 (en) 2015-06-15 2016-06-14 Single-stranded oligonucleotides for use in the medical treatment of skin disorders

Publications (1)

Publication Number Publication Date
DK3307277T3 true DK3307277T3 (da) 2020-12-07

Family

ID=56345083

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16734570.1T DK3307277T3 (da) 2015-06-15 2016-06-14 Enkeltstrengede oligonukleotider til anvendelse i medicinsk behandling af hudlidelser

Country Status (15)

Country Link
US (1) US10626401B2 (da)
EP (1) EP3307277B1 (da)
AU (1) AU2016280663B2 (da)
CA (1) CA2989371C (da)
CY (1) CY1123639T1 (da)
DK (1) DK3307277T3 (da)
ES (1) ES2834906T3 (da)
HR (1) HRP20202066T1 (da)
HU (1) HUE051875T2 (da)
LT (1) LT3307277T (da)
PL (1) PL3307277T3 (da)
PT (1) PT3307277T (da)
RS (1) RS61274B1 (da)
SI (1) SI3307277T1 (da)
WO (1) WO2016202779A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201504124D0 (en) 2015-03-11 2015-04-22 Proqr Therapeutics B V Oligonucleotides
AU2016265457B2 (en) 2015-05-21 2022-06-09 Wings Therapeutics, Inc. Antisense oligonucleotides to treat dystrophic epidermolysis bullosa
GB201714330D0 (en) * 2017-09-06 2017-10-18 Järver Peter Oligonucleotides
US20210047646A1 (en) * 2018-04-09 2021-02-18 The Trustees Of Princeton University Compositions Comprising Immune System Activators and Method of Using Same
WO2022229350A2 (en) 2021-04-30 2022-11-03 Tirmed Pharma Ab Single-stranded oligonucleotides for use in the medical treatment and/or prophylaxis of virus infections
WO2025122871A1 (en) * 2023-12-07 2025-06-12 Northwestern University Multi-armed dendrimeric oligonucleotide nanoarchitectures to target the cyclic gmp-amp (cgas)/cyclic gmp-amp receptor stimulator of interferon genes (sting) pathway

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7807803B2 (en) 2002-07-03 2010-10-05 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US8101345B1 (en) * 2005-03-25 2012-01-24 Isis Pharmaceuticals, Inc. Proinflammatory nucleic acids
WO2008147956A2 (en) 2007-05-25 2008-12-04 Centocor, Inc. Toll-like receptor 3 modulators and uses thereof
US20100040576A1 (en) 2007-12-18 2010-02-18 The Texas A&M University System Modified Oligonucleotides For The Treatment Of Hepatitis C Infection

Also Published As

Publication number Publication date
HUE051875T2 (hu) 2021-04-28
SI3307277T1 (sl) 2021-02-26
EP3307277A1 (en) 2018-04-18
PL3307277T3 (pl) 2021-03-08
RS61274B1 (sr) 2021-01-29
CY1123639T1 (el) 2022-03-24
US20180142246A1 (en) 2018-05-24
LT3307277T (lt) 2020-12-28
AU2016280663B2 (en) 2021-04-29
CA2989371A1 (en) 2016-12-22
PT3307277T (pt) 2020-12-30
ES2834906T3 (es) 2021-06-21
CA2989371C (en) 2024-02-06
US10626401B2 (en) 2020-04-21
HRP20202066T1 (hr) 2021-04-30
WO2016202779A1 (en) 2016-12-22
EP3307277B1 (en) 2020-10-07
AU2016280663A1 (en) 2018-01-18

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