DK3309149T3 - 6-Brom-3-hydroxy-2-pyrazincarboxamid-krystal og fremgangsmåde til fremstilling af dette - Google Patents
6-Brom-3-hydroxy-2-pyrazincarboxamid-krystal og fremgangsmåde til fremstilling af dette Download PDFInfo
- Publication number
- DK3309149T3 DK3309149T3 DK16807530.7T DK16807530T DK3309149T3 DK 3309149 T3 DK3309149 T3 DK 3309149T3 DK 16807530 T DK16807530 T DK 16807530T DK 3309149 T3 DK3309149 T3 DK 3309149T3
- Authority
- DK
- Denmark
- Prior art keywords
- pyrazinecarboxamide
- bromo
- hydroxy
- crystal
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562172958P | 2015-06-09 | 2015-06-09 | |
| PCT/JP2016/067114 WO2016199824A1 (ja) | 2015-06-09 | 2016-06-08 | ６－ブロモ－３－ヒドロキシ－２－ピラジンカルボキサミドの結晶およびその製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3309149T3 true DK3309149T3 (da) | 2021-05-31 |
Family
ID=57503297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16807530.7T DK3309149T3 (da) | 2015-06-09 | 2016-06-08 | 6-Brom-3-hydroxy-2-pyrazincarboxamid-krystal og fremgangsmåde til fremstilling af dette |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10266501B2 (da) |
| EP (1) | EP3309149B1 (da) |
| JP (1) | JP6705817B2 (da) |
| CN (2) | CN107635976A (da) |
| CY (1) | CY1124180T1 (da) |
| DK (1) | DK3309149T3 (da) |
| ES (1) | ES2865296T3 (da) |
| HK (1) | HK1248236A1 (da) |
| HR (1) | HRP20211070T1 (da) |
| HU (1) | HUE054654T2 (da) |
| LT (1) | LT3309149T (da) |
| PL (1) | PL3309149T3 (da) |
| PT (1) | PT3309149T (da) |
| SI (1) | SI3309149T1 (da) |
| WO (1) | WO2016199824A1 (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111349049B (zh) * | 2020-02-28 | 2022-11-11 | 江苏阿尔法药业股份有限公司 | 一种法匹拉韦及其中间体的合成工艺 |
| US11780817B2 (en) * | 2020-05-18 | 2023-10-10 | Weaver Labs, LLC | Methods for preparing Favipiravir |
| CN114057656B (zh) * | 2020-08-05 | 2025-11-18 | 广东东阳光药业股份有限公司 | 一种法匹拉韦共晶及其制备方法 |
| CN112851589B (zh) * | 2021-01-25 | 2022-10-11 | 山东邹平大展新材料有限公司 | 一种法匹拉韦中间体6-溴-3-羟基吡嗪-2-甲酰胺的制备方法 |
| CN113461622B (zh) * | 2021-08-11 | 2023-04-07 | 海正药业南通有限公司 | 一种法匹拉韦中间体6-溴-3-羟基吡嗪-2-甲酰胺的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60108724T2 (de) | 2000-02-16 | 2005-06-23 | Toyama Chemical Co. Ltd. | Neue pyrazin-derivate oder salze davon, pharmazeutische zusammensetzungen, die die derivate oder deren salze enthalten und intermediate zu beider herstellung |
| KR101574567B1 (ko) * | 2007-09-27 | 2015-12-07 | 토야마 케미칼 컴퍼니 리미티드 | 6-플루오로-3-히드록시-2-피라진카보니트릴의 유기아민염 및 그 제조법 |
| WO2010087117A1 (ja) * | 2009-01-28 | 2010-08-05 | 日本曹達株式会社 | ジクロロピラジン誘導体の製造方法 |
| JP5739618B2 (ja) | 2009-03-18 | 2015-06-24 | 富山化学工業株式会社 | ３−ヒドロキシ−２−ピラジンカルボキサミドの製造法 |
| JP5559604B2 (ja) | 2009-05-27 | 2014-07-23 | 富山化学工業株式会社 | ３，６−ジクロロ−２−ピラジンカルボニトリルの製造法 |
| CN102775358B (zh) * | 2012-08-22 | 2015-05-27 | 山东齐都药业有限公司 | 6-氟-3-羟基-2-吡嗪酰胺的制备方法 |
-
2016
- 2016-06-08 SI SI201631237T patent/SI3309149T1/sl unknown
- 2016-06-08 LT LTEP16807530.7T patent/LT3309149T/lt unknown
- 2016-06-08 CN CN201680033471.XA patent/CN107635976A/zh active Pending
- 2016-06-08 HR HRP20211070TT patent/HRP20211070T1/hr unknown
- 2016-06-08 PT PT168075307T patent/PT3309149T/pt unknown
- 2016-06-08 WO PCT/JP2016/067114 patent/WO2016199824A1/ja not_active Ceased
- 2016-06-08 US US15/580,731 patent/US10266501B2/en active Active
- 2016-06-08 CN CN202510238014.5A patent/CN120081794A/zh active Pending
- 2016-06-08 HK HK18107817.6A patent/HK1248236A1/zh unknown
- 2016-06-08 JP JP2017523678A patent/JP6705817B2/ja active Active
- 2016-06-08 ES ES16807530T patent/ES2865296T3/es active Active
- 2016-06-08 PL PL16807530T patent/PL3309149T3/pl unknown
- 2016-06-08 EP EP16807530.7A patent/EP3309149B1/en active Active
- 2016-06-08 HU HUE16807530A patent/HUE054654T2/hu unknown
- 2016-06-08 DK DK16807530.7T patent/DK3309149T3/da active
-
2019
- 2019-03-05 US US16/293,100 patent/US10519117B2/en active Active
-
2021
- 2021-05-26 CY CY20211100457T patent/CY1124180T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SI3309149T1 (sl) | 2021-09-30 |
| US10519117B2 (en) | 2019-12-31 |
| HK1248236A1 (zh) | 2018-10-12 |
| JPWO2016199824A1 (ja) | 2018-03-29 |
| US20180141920A1 (en) | 2018-05-24 |
| JP6705817B2 (ja) | 2020-06-03 |
| EP3309149B1 (en) | 2021-04-07 |
| PL3309149T3 (pl) | 2021-10-25 |
| LT3309149T (lt) | 2021-06-25 |
| HRP20211070T1 (hr) | 2021-10-01 |
| CN120081794A (zh) | 2025-06-03 |
| HUE054654T2 (hu) | 2021-09-28 |
| CY1124180T1 (el) | 2022-05-27 |
| CN107635976A (zh) | 2018-01-26 |
| PT3309149T (pt) | 2021-05-14 |
| US20190194146A1 (en) | 2019-06-27 |
| EP3309149A1 (en) | 2018-04-18 |
| US10266501B2 (en) | 2019-04-23 |
| EP3309149A4 (en) | 2019-01-09 |
| ES2865296T3 (es) | 2021-10-15 |
| WO2016199824A1 (ja) | 2016-12-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3280441T3 (da) | Anti-sortilin-antistoffer og fremgangsmåder til anvendelse deraf | |
| DK3185868T3 (da) | Hidtil ukendte ULK1-inhibitorer og fremgangsmåder til anvendelse af samme | |
| DK3102673T3 (da) | Fremgangsmåder og sammensætninger til behandling af beta-talassæmi | |
| DK3134149T3 (da) | Mikrokanyler og fremgangsmåder til fremstilling deraf | |
| DK3303395T3 (da) | Anti-cd40-antistoffer og anvendelser deraf | |
| DK2924093T3 (da) | Multicarboxylat-sammensætninger og fremgangsmåde til fremstilling af disse | |
| DK3265947T3 (da) | Fremgangsmåde og system til kryptering | |
| DK3286311T3 (da) | Fremgangsmåde til behandling af maligniteter | |
| DK3137605T3 (da) | Sammensætninger og fremgangsmåder til modulering af angiopoietin-lignende-3-ekspression | |
| DK3129912T3 (da) | Fremgangsmåde og system til sikring af data | |
| DK3316909T3 (da) | Anti-ntb-a-antistoffer og relaterede sammensætninger og fremgangsmåder | |
| DK3134130T3 (da) | Sammensætninger og fremgangsmåder til behandling af hæmoglobinopatier | |
| DK3285544T3 (da) | Fremgangsmåde og indretning til behandling af indretning-til-indretning-synkroniseringssekvens | |
| DK3394065T3 (da) | Tetrahydropyranyl-amino-pyrrolopyrimidinon og fremgangsmåder til anvendelse deraf | |
| DK3242947T3 (da) | Genterapi og elektroporese til behandling af maligniteter | |
| DK3210961T3 (da) | Fremgangsmåde til fremstilling af methanol og indretning til fremstilling af methanol | |
| DK3178324T3 (da) | Mikrobicid og fremgangsmåde til fremstilling af samme | |
| DK3393655T3 (da) | Fenfluramin-sammensætninger og fremgangsmåder til fremstilling af samme | |
| DK3167076T3 (da) | Fremgangsmåder og produkter til kvantificering af RNA-transkriptvarianter | |
| DK3151943T3 (da) | Filterpanel og fremgangsmåde til fremstilling heraf | |
| DK3110446T3 (da) | Fremgangsmåder og sammensætninger til behandling af Siglec-8-associerede sygdomme | |
| DK3265443T3 (da) | Pyrrolidincarboxamidderivater og fremgangsmåde til fremstilling og anvendelse af samme | |
| DK3380213T3 (da) | Filtreringsmateriale og fremgangsmåde til fremstilling af dette | |
| DK3323485T3 (da) | Krystalliseringssøjle og krystalliseringsfremgangsmåde | |
| DK3274143T3 (da) | Fremgangsmåde til fremstilling af lignocellulosematerialer |