DK3310902T3 - Kontinuerligt, bioprintet flerlagsvævsstruktur - Google Patents

Kontinuerligt, bioprintet flerlagsvævsstruktur Download PDF

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Publication number
DK3310902T3
DK3310902T3 DK16810681.3T DK16810681T DK3310902T3 DK 3310902 T3 DK3310902 T3 DK 3310902T3 DK 16810681 T DK16810681 T DK 16810681T DK 3310902 T3 DK3310902 T3 DK 3310902T3
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DK
Denmark
Prior art keywords
bioprinted
continuous
tissue structure
layer tissue
layer
Prior art date
Application number
DK16810681.3T
Other languages
English (en)
Inventor
Simon Beyer
Tamer Mohamed
Sam Wadsworth
Sheng Pan
Original Assignee
Aspect Biosystems Ltd
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Publication of DK3310902T3 publication Critical patent/DK3310902T3/da

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0697Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/10Processes of additive manufacturing
    • B29C64/106Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B33ADDITIVE MANUFACTURING TECHNOLOGY
    • B33YADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y70/00Materials specially adapted for additive manufacturing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B33ADDITIVE MANUFACTURING TECHNOLOGY
    • B33YADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00Products made by additive manufacturing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14Scaffolds; Matrices
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0658Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5061Muscle cells
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/10Processes of additive manufacturing
    • B29C64/106Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
    • B29C64/118Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B33ADDITIVE MANUFACTURING TECHNOLOGY
    • B33YADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00Processes of additive manufacturing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/50Proteins

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Sustainable Development (AREA)
  • Manufacturing & Machinery (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Rheumatology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Mechanical Engineering (AREA)
  • Optics & Photonics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Materials For Medical Uses (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Prostheses (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
DK16810681.3T 2015-06-16 2016-06-16 Kontinuerligt, bioprintet flerlagsvævsstruktur DK3310902T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562180174P 2015-06-16 2015-06-16
US201662305422P 2016-03-08 2016-03-08
PCT/CA2016/050707 WO2016201577A1 (en) 2015-06-16 2016-06-16 Continuously bioprinted multilayer tissue structure

Publications (1)

Publication Number Publication Date
DK3310902T3 true DK3310902T3 (da) 2022-11-14

Family

ID=57545007

Family Applications (2)

Application Number Title Priority Date Filing Date
DK16810681.3T DK3310902T3 (da) 2015-06-16 2016-06-16 Kontinuerligt, bioprintet flerlagsvævsstruktur
DK22183540.8T DK4130243T3 (da) 2015-06-16 2016-06-16 Kontinuerligt, bioprintet flerlagsvævsstruktur

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK22183540.8T DK4130243T3 (da) 2015-06-16 2016-06-16 Kontinuerligt, bioprintet flerlagsvævsstruktur

Country Status (11)

Country Link
US (2) US11746333B2 (da)
EP (2) EP3310902B1 (da)
JP (1) JP7026040B2 (da)
KR (1) KR20180042220A (da)
CN (1) CN108026508A (da)
AU (1) AU2016279941A1 (da)
CA (1) CA2989679C (da)
DK (2) DK3310902T3 (da)
IL (1) IL256306A (da)
RU (1) RU2018101261A (da)
WO (1) WO2016201577A1 (da)

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JP7026040B2 (ja) 2015-06-16 2022-02-25 アスペクト バイオシステムズ リミティド 連続的にバイオプリントされた多層組織構造体
US10926000B2 (en) 2016-05-13 2021-02-23 Colorado School Of Mines Deposition-conversion method for tunable calcium phosphate coatings on substrates and apparatus prepared thereof
US10073346B2 (en) 2016-07-08 2018-09-11 Cypre, Inc. Apparatus for patterning hydrogels into multi-well plates
US10596757B2 (en) * 2016-12-06 2020-03-24 Northeastern University Three dimensional mineralization printer
WO2018208632A1 (en) 2017-05-12 2018-11-15 Corning Incorporated A cross-linked shear thinning fluid with tunable rheology for 3d bioprinting and drug delivery
US10967570B2 (en) 2018-01-18 2021-04-06 Revotek Co., Ltd Device for printing lumen tissue construct, method for using the same and 3D bioprinter
EP3517273A1 (en) * 2018-01-18 2019-07-31 Revotek Co., Ltd Device for printing lumen tissue construct, method for using the same and 3d bioprinter
KR102083788B1 (ko) 2018-09-04 2020-03-03 주식회사 티앤알바이오팹 인공 혈관 제조용 3d 프린팅 시스템 및 이를 이용한 인공 혈관의 제조 방법
BR112021019402A2 (pt) * 2019-03-29 2021-12-28 Tdbt Ip Inc Substituições de tecidos e órgãos e métodos de fazer os mesmos
AU2020349580B2 (en) * 2019-09-22 2022-06-02 Meatech 3D, Ltd. Physical manipulation of cultured muscle tissue
KR102189959B1 (ko) 2019-11-26 2020-12-11 주식회사 티앤알바이오팹 멀티 3d 프린팅 헤드 및 이를 포함하는 3d 프린터
KR102253727B1 (ko) 2019-11-26 2021-05-20 주식회사 티앤알바이오팹 바이오 클린 벤치 시스템
EP4067051B1 (en) 2019-11-26 2025-03-12 T&R Biofab Co., Ltd. Bio-ink supply system and three-dimensional bioprinting method using same
KR102253724B1 (ko) 2019-11-26 2021-05-20 주식회사 티앤알바이오팹 회전형 3d 프린팅 조형판 및 이를 포함하는 3d 프린터
US20230119663A1 (en) * 2020-03-26 2023-04-20 Osaka University Muscle tissue produced by bioprinting
US11559389B2 (en) * 2020-05-05 2023-01-24 International Business Machines Corporation Bioprinted living tissue with therapy capability
KR102525459B1 (ko) 2021-01-22 2023-04-25 피피에스 주식회사 Cps(cyber physical system)에 연결된 용량미달 불량품 식별 시스템 및 방법
WO2025099487A1 (en) * 2023-11-10 2025-05-15 Aspect Biosystems Ltd. Systems and methods for printing high-density tissue fibers
KR102742822B1 (ko) * 2023-12-26 2024-12-17 바오밥헬스케어 주식회사 3d 바이오 프린팅 통합 클린 시스템

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JP7026040B2 (ja) 2015-06-16 2022-02-25 アスペクト バイオシステムズ リミティド 連続的にバイオプリントされた多層組織構造体
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Also Published As

Publication number Publication date
EP3310902A1 (en) 2018-04-25
US11746333B2 (en) 2023-09-05
CA2989679C (en) 2023-11-28
US20180171304A1 (en) 2018-06-21
WO2016201577A1 (en) 2016-12-22
EP4130243B1 (en) 2024-06-26
CA2989679A1 (en) 2016-12-22
RU2018101261A (ru) 2019-07-16
JP2018524022A (ja) 2018-08-30
EP3310902A4 (en) 2018-12-12
EP4130243A1 (en) 2023-02-08
DK4130243T3 (da) 2024-09-30
KR20180042220A (ko) 2018-04-25
US12553035B2 (en) 2026-02-17
IL256306A (en) 2018-02-28
JP7026040B2 (ja) 2022-02-25
AU2016279941A1 (en) 2018-01-18
CN108026508A (zh) 2018-05-11
US20240158758A1 (en) 2024-05-16
EP3310902B1 (en) 2022-08-10

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