DK3331886T3 - Dopamin-d3-receptorantagonister med en bicyclo-del - Google Patents
Dopamin-d3-receptorantagonister med en bicyclo-del Download PDFInfo
- Publication number
- DK3331886T3 DK3331886T3 DK16757355.9T DK16757355T DK3331886T3 DK 3331886 T3 DK3331886 T3 DK 3331886T3 DK 16757355 T DK16757355 T DK 16757355T DK 3331886 T3 DK3331886 T3 DK 3331886T3
- Authority
- DK
- Denmark
- Prior art keywords
- dopamin
- bicyclo
- receptor antagonists
- antagonists
- receptor
- Prior art date
Links
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Addiction (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1513871.2A GB201513871D0 (en) | 2015-08-05 | 2015-08-05 | Bicyclo dopamine D3 receptor antagonists |
| GBGB1518125.8A GB201518125D0 (en) | 2015-10-13 | 2015-10-13 | Dopamine D3 receptor antagonist having a bicyclo moiety |
| PCT/IB2016/054708 WO2017021920A1 (en) | 2015-08-05 | 2016-08-04 | Dopamine d3 receptor antagonists having a bicyclo moiety |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3331886T3 true DK3331886T3 (da) | 2020-08-24 |
Family
ID=56801657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16757355.9T DK3331886T3 (da) | 2015-08-05 | 2016-08-04 | Dopamin-d3-receptorantagonister med en bicyclo-del |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10273244B2 (da) |
| EP (1) | EP3331886B1 (da) |
| AU (1) | AU2016303558B2 (da) |
| CA (1) | CA2992820C (da) |
| DK (1) | DK3331886T3 (da) |
| ES (1) | ES2821896T3 (da) |
| HK (1) | HK1250029A1 (da) |
| IL (1) | IL256914B (da) |
| NZ (1) | NZ739139A (da) |
| WO (1) | WO2017021920A1 (da) |
| ZA (1) | ZA201800483B (da) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3331886B1 (en) | 2015-08-05 | 2020-07-15 | Indivior UK Limited | Dopamine d3 receptor antagonists having a bicyclo moiety |
| WO2018021447A1 (ja) * | 2016-07-28 | 2018-02-01 | 塩野義製薬株式会社 | ドーパミンd3受容体拮抗作用を有する含窒素縮環化合物 |
| WO2019084075A1 (en) * | 2017-10-24 | 2019-05-02 | The Trustees Of The University Of Pennsylvania | DOPAMINE RECEPTOR SELECTIVE ANTAGONISTS AND METHODS OF USING THE SAME |
| WO2019146740A1 (ja) | 2018-01-26 | 2019-08-01 | 塩野義製薬株式会社 | ドーパミンd3受容体拮抗作用を有する環式化合物 |
| BR112020014875A2 (pt) | 2018-01-26 | 2020-12-08 | Shionogi & Co., Ltd. | Composto cíclico condensado tendo antagonismo de receptor de dopamina d3 |
| CA3129516A1 (en) | 2018-02-28 | 2019-09-06 | The Trustees Of The University Of Pennsylvania | Low affinity poly(ad-ribose) polymerase 1 dependent cytotoxic agents |
| US12448374B2 (en) | 2018-06-07 | 2025-10-21 | Disarm Therapeutics, Inc. | Inhibitors of SARM1 |
| EP3608326A1 (en) | 2018-08-10 | 2020-02-12 | Irbm S.P.A. | Tricyclic inhibitors of hepatitis b virus |
| CN113164508B (zh) | 2018-12-19 | 2025-07-08 | 达萨玛治疗公司 | 与神经保护剂组合的sarm1抑制剂 |
| EP3825318A1 (en) | 2019-11-25 | 2021-05-26 | Promidis S.r.l. | Oxalamido-substituted tricyclic inhibitors of hepatitis b virus |
| EP3741762A1 (en) | 2019-05-23 | 2020-11-25 | Irbm S.P.A. | Oxalamido-substituted tricyclic inhibitors of hepatitis b virus |
| UY38705A (es) | 2019-05-23 | 2020-12-31 | Irbm S P A | Inhibidores tricíclicos sustituidos con oxalamido del virus de hepatitis b |
| CN110684028B (zh) * | 2019-10-28 | 2021-10-26 | 上海阿拉丁生化科技股份有限公司 | 一种2,6-二氮杂双环[3,3,0]辛烷类化合物的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4341403A1 (de) | 1993-12-04 | 1995-06-08 | Basf Ag | N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung |
| US5541217A (en) | 1995-05-17 | 1996-07-30 | Ortho Pharmaceutical Corporation | 4-arylcyclopenta[c]pyrrole analgesics |
| ATE451364T1 (de) * | 2004-02-23 | 2009-12-15 | Glaxo Group Ltd | Als modulatoren des dopamin-d3-rezeptors geeignete azabicycloä3.1.0ühexanderivate |
| GB0507680D0 (en) | 2005-04-15 | 2005-05-25 | Glaxo Group Ltd | Compounds |
| EP3461827B1 (en) * | 2013-09-26 | 2022-02-23 | Cadent Therapeutics, Inc. | Selective octahydro-cyclopenta[c]pyrrole negative modulators of nr2b |
| AU2014369053B2 (en) * | 2013-12-20 | 2019-03-14 | Institute For Drug Discovery, Llc | Substituted amino triazoles, and methods using same |
| EP3331886B1 (en) | 2015-08-05 | 2020-07-15 | Indivior UK Limited | Dopamine d3 receptor antagonists having a bicyclo moiety |
-
2016
- 2016-08-04 EP EP16757355.9A patent/EP3331886B1/en active Active
- 2016-08-04 DK DK16757355.9T patent/DK3331886T3/da active
- 2016-08-04 US US15/750,128 patent/US10273244B2/en active Active
- 2016-08-04 HK HK18109519.3A patent/HK1250029A1/zh unknown
- 2016-08-04 CA CA2992820A patent/CA2992820C/en active Active
- 2016-08-04 NZ NZ739139A patent/NZ739139A/en unknown
- 2016-08-04 AU AU2016303558A patent/AU2016303558B2/en active Active
- 2016-08-04 WO PCT/IB2016/054708 patent/WO2017021920A1/en not_active Ceased
- 2016-08-04 ES ES16757355T patent/ES2821896T3/es active Active
-
2018
- 2018-01-14 IL IL256914A patent/IL256914B/en active IP Right Grant
- 2018-01-23 ZA ZA2018/00483A patent/ZA201800483B/en unknown
-
2019
- 2019-03-04 US US16/292,110 patent/US10584135B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| IL256914B (en) | 2021-03-25 |
| US10584135B2 (en) | 2020-03-10 |
| CA2992820C (en) | 2022-08-16 |
| EP3331886A1 (en) | 2018-06-13 |
| AU2016303558A1 (en) | 2018-02-08 |
| CA2992820A1 (en) | 2017-02-09 |
| AU2016303558B2 (en) | 2020-08-06 |
| WO2017021920A1 (en) | 2017-02-09 |
| IL256914A (en) | 2018-03-29 |
| ES2821896T3 (es) | 2021-04-28 |
| US10273244B2 (en) | 2019-04-30 |
| US20190194225A1 (en) | 2019-06-27 |
| HK1250029A1 (zh) | 2018-11-23 |
| ZA201800483B (en) | 2019-07-31 |
| EP3331886B1 (en) | 2020-07-15 |
| NZ739139A (en) | 2023-01-27 |
| US20180222918A1 (en) | 2018-08-09 |
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