DK334884A - Modulering af dyrecellereaktioner med praeparater indeholdende 8-substituerede guaninderivater - Google Patents

Modulering af dyrecellereaktioner med praeparater indeholdende 8-substituerede guaninderivater Download PDF

Info

Publication number: DK334884A
Authority: DK; Denmark
Prior art keywords: animal cell; cell reactions; substituted guanine; preparations containing; guanine derivatives
Prior art date: 1982-11-09

Application number

DK334884A

Other languages

English (en)

Other versions

DK334884D0 (da

DK167898B1 (da

Inventor

Michael G Goodman

William O Weigle

Original Assignee

Scripps Clinic Res

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-11-09

Filing date

1984-07-06

Publication date

1984-07-06

1982-11-09 Priority claimed from US06/439,846 external-priority patent/US4539205A/en

1984-07-06 Application filed by Scripps Clinic Res filed Critical Scripps Clinic Res

1984-07-06 Publication of DK334884D0 publication Critical patent/DK334884D0/da

1984-07-06 Publication of DK334884A publication Critical patent/DK334884A/da

1994-01-03 Application granted granted Critical

1994-01-03 Publication of DK167898B1 publication Critical patent/DK167898B1/da

Links

238000002360 preparation method Methods 0.000 title abstract 5
210000004102 animal cell Anatomy 0.000 title abstract 3
238000006243 chemical reaction Methods 0.000 title abstract 3
UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical class O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 title 1
WJSVJNDMOQTICG-UHFFFAOYSA-N 2-amino-1-[(2-methyl-4-methylidene-5-oxooxolan-2-yl)methyl]-7h-purin-6-one Chemical class NC1=NC=2N=CNC=2C(=O)N1CC1(C)CC(=C)C(=O)O1 WJSVJNDMOQTICG-UHFFFAOYSA-N 0.000 abstract 2
230000036647 reaction Effects 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000013543 active substance Substances 0.000 abstract 1
150000001323 aldoses Chemical group 0.000 abstract 1
125000004429 atom Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
210000004027 cell Anatomy 0.000 abstract 1
238000007865 diluting Methods 0.000 abstract 1
MNQZXJOMYWMBOU-UHFFFAOYSA-N glyceraldehyde Chemical compound OCC(O)C=O MNQZXJOMYWMBOU-UHFFFAOYSA-N 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
230000001939 inductive effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000546 pharmaceutical excipient Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK334884A 1982-11-09 1984-07-06 Fremgangsmaade til forbedring af en antigenspecifik immunreaktion af dyreceller en vitro DK167898B1 (da)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US06/439,846 US4539205A (en)	1982-11-09	1982-11-09	Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives
US43984682		1982-11-09
US06/546,679 US4643992A (en)	1982-11-09	1983-11-01	Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives
US54667983		1983-11-01
US8301722		1983-11-07
PCT/US1983/001722 WO1984001898A1 (en)	1982-11-09	1983-11-07	Modulation of animal cellular responses with compositions containng 8-substituted guanine derivatives

Publications (3)

Publication Number	Publication Date
DK334884D0 DK334884D0 (da)	1984-07-06
DK334884A true DK334884A (da)	1984-07-06
DK167898B1 DK167898B1 (da)	1994-01-03

Family

ID=27032191

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK334884A DK167898B1 (da)	1982-11-09	1984-07-06	Fremgangsmaade til forbedring af en antigenspecifik immunreaktion af dyreceller en vitro

Country Status (15)

Country	Link
US (1)	US4643992A (da)
EP (1)	EP0112632B1 (da)
AU (1)	AU568325B2 (da)
CA (1)	CA1236401A (da)
DE (1)	DE3382156D1 (da)
DK (1)	DK167898B1 (da)
ES (1)	ES527138A0 (da)
FI (1)	FI87733C (da)
GR (1)	GR78733B (da)
IE (1)	IE56701B1 (da)
IL (1)	IL70164A (da)
NO (1)	NO174215C (da)
NZ (1)	NZ206208A (da)
PT (1)	PT77636B (da)
WO (1)	WO1984001898A1 (da)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5476659A (en) *	1982-11-09	1995-12-19	The Scripps Research Institute	Cancerous B cell treatment using substituted nucleoside derivatives
US4849411A (en) *	1982-11-09	1989-07-18	Scripps Clinic And Research Foundation	Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives
US5166141A (en) *	1983-11-01	1992-11-24	Scripps Clinic And Research Foundation	Immunostimulating 7-deaza-7-oxa- and 7-deaza-7-oxo-analogs of 8-substituted-guanine-9-(1'-beta-D-aldoglycosidyl) derivatives and methods of treating test animals
US5093318A (en) *	1983-11-01	1992-03-03	Scripps Clinic And Research Foundation	Immunostimulating guanosine derivatives and their pharmaceutical compositions
US4900675A (en) *	1983-11-01	1990-02-13	Scripps Clinic And Research Foundation	Modulation of animal cellular responses with compositions containing isoxanthopterin-8-(1'-β-aldoglycosidyl) derivatives
FR2560212B1 (fr) *	1984-02-24	1989-12-29	Unicet	Anticorps monoclonaux contre l'interferon a2 et hybridomes produisant de tels anticorps
US5011828A (en) *	1985-11-15	1991-04-30	Michael Goodman	Immunostimulating guanine derivatives, compositions and methods
ZA869297B (en) *	1985-12-13	1987-11-25	Scripps Clinic Res	Modulation of animal cellular responses with compositions containing isoxanthopterin-8-(1'-beta-aldoglycosidyl)derivatives
US7307166B1 (en)	1987-10-28	2007-12-11	Wellstat Therapeutics Corporation	Oxpurine nucleosides and their congeners, and acyl, derivatives thereof, for improvement of hematopoiesis
US4880784A (en) *	1987-12-21	1989-11-14	Brigham Young University	Antiviral methods utilizing ribofuranosylthiazolo[4,5-d]pyrimdine derivatives
US4902985A (en) *	1988-02-25	1990-02-20	Raytheon Company	Microwave reflectiion amplifiers having increased bandwidth
GB2216416B (en) *	1988-03-11	1992-06-24	Sandoz Ltd	Nucleobase source for the stimulation of the immune system
ZA893063B (en) *	1988-04-27	1990-01-31	Immunomedics Inc	Improved radiotherapy
AU5845594A (en) *	1992-11-13	1994-06-08	Scripps Research Institute, The	Cancerous b cell treatment using substituted nucleoside derivatives
US5441942A (en) *	1994-05-27	1995-08-15	The Scripps Research Institute	2'3'-dideoxy-2',3'-didehydro-7,8-disubstituted guanosines and their immunostimulative effect
US5786359A (en) *	1994-05-27	1998-07-28	The Scripps Research Institute	N9 alkyl or aralkyl derivatives of 7, 8-disubstituted guanines
US6338963B1 (en)	1994-07-25	2002-01-15	Neotherapeutics, Inc.	Use of carbon monoxide dependent guanylyl cyclase modifiers to stimulate neuritogenesis
US20030100520A1 (en) *	1997-01-21	2003-05-29	Philip Needleman	Immunological process and constructs for increasing the hdl cholesterol concentration by dna vaccination
US6303617B1 (en)	1998-05-04	2001-10-16	Neotherapeutics, Inc.	Serotonin-like 9-substituted hypoxanthine and methods of use
AU4244400A (en) *	1999-04-15	2000-11-02	Board Of Regents, The University Of Texas System	Ppgpp and pppgpp as immunomodulatory agents
US6288069B1 (en)	1999-11-16	2001-09-11	Neotherapeutics, Inc.	Use of 9-substituted hypoxanthine derivatives to stimulate regeneration of nervous tissue
US6407237B1 (en)	2001-02-21	2002-06-18	Neotherapeutics, Inc.	Crystal forms of 9-substituted hypoxanthine derivatives
US6849735B1 (en) *	2000-06-23	2005-02-01	Merck Eprova Ag	Methods of synthesis for 9-substituted hypoxanthine derivatives
US6630490B2 (en)	2000-07-07	2003-10-07	Neotherapeutics, Inc.	Methods for treatment of disease-induced peripheral neuropathy and related conditions
US20030138769A1 (en) *	2000-08-16	2003-07-24	Birkett Ashley J.	Immunogenic HBc chimer particles having enhanced stability
US6759427B2 (en) *	2001-04-20	2004-07-06	Spectrum Pharmaceuticals, Inc.	Synthesis and methods of use of tetrahydroindolone analogues and derivatives
JP2005509591A (ja) *	2001-06-15	2005-04-14	リバファーム・インコーポレイテッド	ヌクレオシドワクチンアジュバント
US20030055249A1 (en) *	2001-07-17	2003-03-20	Fick David B.	Synthesis and methods of use of pyrimidine analogues and derivatives
US20030175863A1 (en) *	2001-08-15	2003-09-18	Birkett Ashley J.	Influenza immunogen and vaccine
US7361352B2 (en)	2001-08-15	2008-04-22	Acambis, Inc.	Influenza immunogen and vaccine
US7321033B2 (en) *	2001-11-27	2008-01-22	Anadys Pharmaceuticals, Inc.	3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
US7351413B2 (en) *	2002-02-21	2008-04-01	Lorantis, Limited	Stabilized HBc chimer particles as immunogens for chronic hepatitis
EP1667694B1 (en)	2003-09-05	2010-04-28	Anadys Pharmaceuticals, Inc.	Tlr7 ligands for the treatment of hepatitis c
ES2459368T3 (es) *	2004-12-17	2014-05-09	Anadys Pharmaceuticals, Inc.	Compuestos de 3H-oxazolo y 3H-tiazolo[4,5-d]pirimidin-2-ona 3,5-disustituidos y 3,5,7-trisustituidos y profármacos de los mismos
CA2630463C (en)	2005-11-21	2015-01-06	Anadys Pharmaceuticals, Inc.	Novel process for the preparation of 5-amino-3h-thiazolo[4,5-d]pyrimidin-2-one
CA2655904C (en) *	2006-06-22	2014-11-18	Anadys Pharmaceuticals, Inc.	Prodrugs of 5-amino-3-(3'-deoxy-.beta.-d-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione
EP2040712B1 (en)	2006-07-18	2011-03-02	Anadys Pharmaceuticals, Inc.	Carbonate and carbamate prodrugs of thiazolo [4,5-d] pyrimidines
WO2009016639A2 (en)	2007-08-02	2009-02-05	Biondvax Pharmaceuticals Ltd.	Multimeric multiepitope influenza vaccines
AU2008331800A1 (en)	2007-12-03	2009-06-11	President And Fellows Of Harvard College	Chlamydia antigens
JP2012510289A (ja)	2008-12-03	2012-05-10	プロティアワクチンテクノロジーズリミテッド	グルタミルｔＲＮＡ合成酵素（ＧｔＳ）フラグメント
UY32306A (es)	2008-12-09	2010-07-30	Gilead Sciences Inc	Derivados de pteridinona y pirimidinodiazepinona y composiciones farmacéuticas que modulan en forma selectiva los receptores tipo toll, métodos y usos
WO2011067758A2 (en)	2009-12-02	2011-06-09	Protea Vaccine Technologies Ltd.	Immunogenic fragments and multimers from streptococcus pneumoniae proteins
WO2012114323A1 (en)	2011-02-22	2012-08-30	Biondvax Pharmaceuticals Ltd.	Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines
ES2702278T3 (es)	2012-04-01	2019-02-28	Technion Res & Dev Foundation	Péptidos de inductor de metaloproteinasa de matriz extracelular (emmprin) y anticuerpos de unión
US10426828B2 (en)	2014-04-03	2019-10-01	Biondvax Pharmaceuticals Ltd.	Compositions of multimeric-multiepitope influenza polypeptides and their production
SI3166607T1 (sl)	2014-07-11	2023-01-31	Gilead Sciences, Inc.	Modulatorji toličnih receptorjev za zdravljenje HIV-a
CN110305133A (zh)	2014-09-16	2019-10-08	吉利德科学公司	Toll样受体调节剂的固体形式
CN113924114A (zh)	2019-05-22	2022-01-11	吉利德科学公司	Tlr7调节化合物和hiv疫苗的组合

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1174077A (en) *	1967-02-18	1969-12-10	Ajinomoto Kk	Process for Preparing 8-Mercaptopurine Derivatives

1983
- 1983-11-01 US US06/546,679 patent/US4643992A/en not_active Expired - Lifetime
- 1983-11-07 WO PCT/US1983/001722 patent/WO1984001898A1/en not_active Ceased
- 1983-11-07 AU AU23302/84A patent/AU568325B2/en not_active Expired
- 1983-11-08 IL IL70164A patent/IL70164A/xx not_active IP Right Cessation
- 1983-11-08 CA CA000440679A patent/CA1236401A/en not_active Expired
- 1983-11-08 DE DE8383306791T patent/DE3382156D1/de not_active Expired - Lifetime
- 1983-11-08 EP EP83306791A patent/EP0112632B1/en not_active Expired - Lifetime
- 1983-11-08 IE IE2605/83A patent/IE56701B1/en not_active IP Right Cessation
- 1983-11-08 ES ES527138A patent/ES527138A0/es active Granted
- 1983-11-09 NZ NZ206208A patent/NZ206208A/en unknown
- 1983-11-09 GR GR72936A patent/GR78733B/el unknown
- 1983-11-09 PT PT77636A patent/PT77636B/pt unknown
1984
- 1984-07-06 DK DK334884A patent/DK167898B1/da not_active IP Right Cessation
- 1984-07-06 NO NO842765A patent/NO174215C/no not_active IP Right Cessation
- 1984-07-09 FI FI842748A patent/FI87733C/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
IL70164A (en)	1988-06-30
PT77636B (en)	1986-03-19
US4643992A (en)	1987-02-17
FI87733B (fi)	1992-11-13
PT77636A (en)	1983-12-01
CA1236401A (en)	1988-05-10
NO842765L (no)	1984-07-06
DE3382156D1 (de)	1991-03-14
GR78733B (da)	1984-10-02
FI842748A0 (fi)	1984-07-09
FI87733C (fi)	1993-02-25
IE56701B1 (en)	1991-11-06
EP0112632A3 (en)	1985-01-23
NZ206208A (en)	1987-03-31
EP0112632A2 (en)	1984-07-04
DK334884D0 (da)	1984-07-06
NO174215B (no)	1993-12-20
ES8601301A1 (es)	1985-11-01
EP0112632B1 (en)	1991-02-06
ES527138A0 (es)	1985-11-01
AU568325B2 (en)	1987-12-24
IL70164A0 (en)	1984-02-29
AU2330284A (en)	1984-06-04
IE832605L (en)	1984-05-09
NO174215C (no)	1994-03-30
WO1984001898A1 (en)	1984-05-24
FI842748L (fi)	1984-07-09
DK167898B1 (da)	1994-01-03

Legal Events

Date	Code	Title	Description
1994-01-03	B1	Patent granted (law 1993)
2003-12-01	PUP	Patent expired

Publication	Publication Date	Title
ES8601301A1 (es)	1985-11-01	Un metodo para producir celulas cuyas respuestas inmunologicas humorales especificas de antigeno han sido moduladas.
DK274688A (da)	1988-08-04	Aktivering ex vivo af effektor-celler til maalrettet celledrab
DK575184D0 (da)	1984-12-04	Fremgangsmaade til oprensning af factor viii.c samt farmaceutisk praeparat indeholdende denne
ATE29809T1 (de)	1987-10-15	Aus einzelnen baugruppen zusammengesetzte elektrische anlage.
IT7920255A0 (it)	1979-02-16	Procedimento per produrre idrogeno e ossigeno, nonche' cella elettrolitica per attuare tale procedimento.
JPS5693269A (en)	1981-07-28	Cathode current collector for sodium sulfur battery
DE3674236D1 (de)	1990-10-25	Elektrode fuer elektrochemische zelle.
IT1137640B (it)	1986-09-10	Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo
JPS5745197A (en)	1982-03-13	O-alpha-glycoside and manufacture
GR78806B (da)	1984-10-02
ES2001978A6 (es)	1988-07-01	Un procedimiento nuevo para la preparacion de analogos de 7-amino-mitosano
Ricquier et al.	1982	Isolation of the GDP binding protein from brown adipose tissue mitochondria of several animals and amino acid composition study in rat
ATA741779A (de)	1985-10-15	Galvanische zelle
GB2023570B (en)	1982-06-23	Glass electrolyte for sodium/sulphur cells
ES8206855A1 (es)	1982-08-01	Un procedimiento para la preparacion de anticuerpos con especialidad frente a antigenos encontrados en los nucleos y nu-cleolos de las celulas humanas cancerosas.
MX168061B (es)	1993-05-03	Hidrolizado de proteinas mejorado
DE3661918D1 (en)	1989-03-02	Organosilanes containing phenylene groups, process for their preparation
Hackney	1980	Photodynamic action of bilirubin on the inner mitochondrial membrane. Implications for the organization of the mitochondrial ATPase
ES2012519A6 (es)	1990-04-01	Procedimiento para preparar compuestos polifluorados.
ES8305342A1 (es)	1983-04-01	"procedimiento para la preparacion de derivados de tiazolina".
SE7907986L (sv)	1980-06-16	Sett att framstella 3alfa,7beta-dihydroxicholansyra
IT7925016A0 (it)	1979-08-09	Procedimento per produrre idrogeno e acido solforico per decomposizione elettrochimica di un elettrolito, nonche' elettrodo per attuare la decomposizione elettrochimica.
ES526623A0 (es)	1984-07-01	Procedimiento de producir razas estables de celulas de mamiferos
ES500980A0 (es)	1982-01-01	Procedimiento de preparar alcoxi propanolaminas
ATE16139T1 (de)	1985-11-15	Elektrolyt fuer bleiakkumulator und diesen elektrolyt enthaltender akkumulator.