DK335686A - Fremgangsmaade til fremstilling af 1-carba-3-cephem-4-carboxylsyrer ogderivater deraf samt mellemprodukter til brug ved fremgangsmaaden - Google Patents

Fremgangsmaade til fremstilling af 1-carba-3-cephem-4-carboxylsyrer ogderivater deraf samt mellemprodukter til brug ved fremgangsmaaden Download PDF

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Publication number
DK335686A
DK335686A DK335686A DK335686A DK335686A DK 335686 A DK335686 A DK 335686A DK 335686 A DK335686 A DK 335686A DK 335686 A DK335686 A DK 335686A DK 335686 A DK335686 A DK 335686A
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procedure
carba
cephem
intermediates
derivatives
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DK335686A
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English (en)
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DK335686D0 (da
DK173456B1 (da
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David Albert Evans
Eric Brian Sjogren
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Harvard College
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK198603356A 1985-07-17 1986-07-15 Fremgangsmåde til fremstilling af cis-enantiomere af 1-carba-3-cephem-4-carboxylsyrer og derivater deraf samt forskellige 3 DK173456B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75598285 1985-07-17
US06/755,982 US4665171A (en) 1985-07-17 1985-07-17 Process and intermediates for β-lactam antibiotics

Publications (3)

Publication Number Publication Date
DK335686D0 DK335686D0 (da) 1986-07-15
DK335686A true DK335686A (da) 1987-02-25
DK173456B1 DK173456B1 (da) 2000-11-27

Family

ID=25041514

Family Applications (2)

Application Number Title Priority Date Filing Date
DK198603356A DK173456B1 (da) 1985-07-17 1986-07-15 Fremgangsmåde til fremstilling af cis-enantiomere af 1-carba-3-cephem-4-carboxylsyrer og derivater deraf samt forskellige 3
DK016096A DK16096A (da) 1985-07-17 1996-02-15 Fremgangsmåde til fremstilling af ciaenantiomere af 1-carba-3-cephem-4-carboxylsyrer og derivater deraf samt N-alkylerede 3beta-beskyttet amino-azetidin-2-on-4beta-propansyre-thioestere, der er mellemprodukter ved fremgangsmåden

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK016096A DK16096A (da) 1985-07-17 1996-02-15 Fremgangsmåde til fremstilling af ciaenantiomere af 1-carba-3-cephem-4-carboxylsyrer og derivater deraf samt N-alkylerede 3beta-beskyttet amino-azetidin-2-on-4beta-propansyre-thioestere, der er mellemprodukter ved fremgangsmåden

Country Status (22)

Country Link
US (1) US4665171A (da)
EP (2) EP0362902B1 (da)
JP (2) JPH0762015B2 (da)
KR (1) KR900005257B1 (da)
CN (1) CN1015178B (da)
AR (1) AR243186A1 (da)
AT (2) ATE133172T1 (da)
AU (2) AU595216B2 (da)
CA (1) CA1310323C (da)
DE (2) DE3650474T2 (da)
DK (2) DK173456B1 (da)
ES (2) ES2000516A6 (da)
GR (1) GR861857B (da)
HK (1) HK1007140A1 (da)
HU (2) HU906465D0 (da)
IE (1) IE58997B1 (da)
IL (1) IL79420A (da)
NZ (1) NZ216871A (da)
PT (1) PT82989B (da)
RU (1) RU1794079C (da)
SU (1) SU1579460A3 (da)
ZA (1) ZA865274B (da)

Families Citing this family (34)

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US4870169A (en) * 1985-07-17 1989-09-26 President And Fellows Of Harvard College Intermediates for beta-lactam antibiotics
US4673737A (en) * 1985-08-02 1987-06-16 Harvard University 7-acylamino-(or 7-amino)-3-trifluoromethylsulfonyloxy-1-carba(1-dethia)-3-cephem-4-carboxylic acids and esters thereof
US4734498A (en) * 1986-07-10 1988-03-29 Eli Lilly And Company 3β-succinimidoazetidinones as chiral intermediates
CA1323370C (en) * 1986-09-12 1993-10-19 Davis H. Crater Fluorochemical oxazolidinones
US4782144A (en) * 1987-09-14 1988-11-01 Eli Lilly And Company 1-carba(dethia)-3-hydroxy-3-cephem ester crystalline and crystalline solvate thereof
US5019571A (en) * 1988-01-25 1991-05-28 Eli Lilly And Company 1-carbacephalosporin antibiotics
US4855418A (en) 1988-03-23 1989-08-08 Eli Lilly And Company Process for production of ceophalosporins
US4820832A (en) * 1988-03-23 1989-04-11 Eli Lilly And Company Process for preparing 3-unsubstituted cephalosporins and 1-carba(dethia)cephalosporins
EP0345998A1 (en) * 1988-06-06 1989-12-13 Eli Lilly And Company Process and intermediates for beta-lactam antibiotics
EP0345999A1 (en) * 1988-06-06 1989-12-13 Eli Lilly And Company Process for intermediates to 1-carba(1-dethia)-3-cephem-4-carboxylic acids
US4885362A (en) * 1988-06-06 1989-12-05 Eli Lilly And Company Azetidinone intermediates for 1-carba(dethia)caphalosporins
ES2063129T3 (es) * 1988-06-22 1995-01-01 Lilly Co Eli Intermedio de la 1-carba(detia)cefalosporina.
US5453503A (en) * 1988-10-11 1995-09-26 Eli Lilly And Company Azetidinone intermediates to carbacephalosporins and process
KR0169096B1 (ko) * 1988-10-11 1999-01-15 리로이 휘테커 카바세팔로스포린의 아제티디논 중간체 화합물 및 제조방법
US4931556A (en) * 1988-10-17 1990-06-05 Eli Lilly And Company Method of resolving cis 3-amino-4-(2-(2-furyl)eth-1-yl)-methoxycarbonylmethyl-azetidin-2-one and malic acid salts thereof
US4931557A (en) * 1988-10-17 1990-06-05 Eli Lilly And Company Method of resolving cis 3-amino-4-(2-furyl)vinyl)-1-methoxycarbonylmethyl-azetidin-2-one and di-p-toluoyl-tartaric acid salts thereof
JPH02252648A (ja) * 1989-03-27 1990-10-11 Naomi Iwagou イオン溶出燒結体
US5106475A (en) * 1989-09-20 1992-04-21 Eli Lilly And Company Process for preparing 4-substituted azetidinones
US4992545A (en) * 1989-09-20 1991-02-12 Eli Lilly And Company Process for preparing 4-substituted azetidinones
US5030725A (en) * 1990-02-06 1991-07-09 Eli Lilly And Company Method of resolving cis 3-amino-4-[2-(2-furyl)eth-1-yl]-1-methoxycarbonylmethyl-azetidin-2-one using (-)-DAG
US5051502A (en) * 1990-06-06 1991-09-24 University Of Notre Dame Du Lac Rhodium catalyzed cyclization process for bicyclic β-lactams
EP0479431B1 (en) * 1990-09-13 1999-12-08 Eli Lilly And Company Intermediates to 1-carbacephalosporins and process for preparation thereof
US5089610A (en) * 1991-04-25 1992-02-18 Eli Lilly And Company Ring-closure method for 1-carbacephalosporin six-membered ring
US5521307A (en) * 1992-02-18 1996-05-28 Eli Lilly And Company Methods and compounds for the preparation of carbacephems
US6204260B1 (en) 1996-02-23 2001-03-20 Eli Lilly And Company Non-peptidyl vasopressin V1a antagonists
AU4224699A (en) 1999-01-27 2000-08-18 Pharmacia & Upjohn Company Assays for modulators of elongation factor p activity
JP4916929B2 (ja) * 2007-03-23 2012-04-18 ヤマハ発動機株式会社 直交型ロボット
CA2711957C (en) 2007-10-11 2019-03-19 The Regents Of The University Of California Use of inhibitors of n-acylethanolamine-hydrolyzing acid amidase as anti-inflamatory medicaments
AU2011272738B2 (en) 2010-07-01 2015-08-20 Azevan Pharmaceuticals, Inc. Methods for treating post traumatic stress disorder
WO2014144547A2 (en) 2013-03-15 2014-09-18 The Regents Of The University Of California Amide derivatives of lactam based n-acylethanolamine acid amidase (naaa) inhibitors
WO2014144836A2 (en) 2013-03-15 2014-09-18 The Regents Of The University Of California Carbamate derivatives of lactam based n-acylethanolamine acid amidase (naaa) inhibitors
BR112016022575A2 (pt) 2014-03-28 2017-08-15 Azevan Pharmaceuticals Inc Composições e métodos para o tratamento de doenças neurodegenerativas
US20190321363A1 (en) * 2016-06-20 2019-10-24 Dr. Reddy's Laboratories Limited Process for the preparation of elagolix sodium and its polymorph
CN112500361B (zh) * 2020-12-27 2023-05-12 甘肃瀚聚药业有限公司 一种(s)-4-苯基-2-恶唑烷酮的制备方法

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US4226866A (en) * 1972-11-06 1980-10-07 Merck & Co., Inc. Novel antibiotic analogues of cephalosporins
US4166816A (en) * 1975-05-05 1979-09-04 Smithkline Corporation Methods and intermediates for preparing cis-4-oxoazetidine intermediates
US4200572A (en) * 1975-09-03 1980-04-29 Smithkline Corporation Substituted azetidinones
ZA766941B (en) * 1975-11-21 1978-06-28 Merck & Co Inc 3-(substituted thio)cephalosporins,derivatives and nuclear analogues thereof
US4174316A (en) * 1978-08-14 1979-11-13 Merck & Co., Inc. 4-Iodomethylazetidin-2-one
US4472576A (en) * 1982-12-03 1984-09-18 Merck & Co., Inc. Processes for the production of antibiotic 1-oxadethiacephalosporins
US4502994A (en) 1982-12-09 1985-03-05 Hoffmann-La Roche Inc. Enantiomeric synthesis of 3-amino-4-carbamoyloxymethyl-2-azetidonone-1-sulfate
US4751299A (en) * 1983-11-18 1988-06-14 Takeda Chemical Industries, Ltd. Optically active β-lactams and method of their production
US4673737A (en) 1985-08-02 1987-06-16 Harvard University 7-acylamino-(or 7-amino)-3-trifluoromethylsulfonyloxy-1-carba(1-dethia)-3-cephem-4-carboxylic acids and esters thereof

Also Published As

Publication number Publication date
US4665171A (en) 1987-05-12
SU1579460A3 (ru) 1990-07-15
EP0362902A3 (en) 1990-08-01
AR243186A1 (es) 1993-07-30
GR861857B (en) 1986-11-18
AU619938B2 (en) 1992-02-06
JPS6242985A (ja) 1987-02-24
EP0362902A2 (en) 1990-04-11
AU595216B2 (en) 1990-03-29
HUT41786A (en) 1987-05-28
JPH07300476A (ja) 1995-11-14
ATE133172T1 (de) 1996-02-15
CN86104783A (zh) 1987-02-04
IL79420A (en) 1992-01-15
EP0362902B1 (en) 1996-01-17
ES2005752A6 (es) 1989-03-16
DE3650474D1 (de) 1996-02-29
IE861900L (en) 1987-01-17
PT82989B (pt) 1989-01-30
DK335686D0 (da) 1986-07-15
ES2000516A6 (es) 1988-03-01
EP0209352A3 (en) 1988-04-20
KR900005257B1 (ko) 1990-07-21
HK1007140A1 (en) 1999-04-01
DE3679002D1 (de) 1991-06-06
ZA865274B (en) 1988-02-24
AU6016686A (en) 1987-01-22
DK173456B1 (da) 2000-11-27
HU906465D0 (en) 1991-04-29
NZ216871A (en) 1989-10-27
HU201931B (en) 1991-01-28
JP2634775B2 (ja) 1997-07-30
ATE63118T1 (de) 1991-05-15
CN1015178B (zh) 1991-12-25
EP0209352B1 (en) 1991-05-02
RU1794079C (ru) 1993-02-07
KR870001193A (ko) 1987-03-12
IE58997B1 (en) 1993-12-15
JPH0762015B2 (ja) 1995-07-05
DE3650474T2 (de) 1996-06-13
DK16096A (da) 1996-02-15
EP0209352A2 (en) 1987-01-21
AU4793490A (en) 1990-05-10
PT82989A (en) 1986-08-01
CA1310323C (en) 1992-11-17

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B1 Patent granted (law 1993)
PUP Patent expired