DK3390412T3 - Vandopløselige derivater af 3,5-diphenyl-diazolforbindelser - Google Patents

Vandopløselige derivater af 3,5-diphenyl-diazolforbindelser Download PDF

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Publication number
DK3390412T3
DK3390412T3 DK16809425.8T DK16809425T DK3390412T3 DK 3390412 T3 DK3390412 T3 DK 3390412T3 DK 16809425 T DK16809425 T DK 16809425T DK 3390412 T3 DK3390412 T3 DK 3390412T3
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DK
Denmark
Prior art keywords
diphenyl
water
soluble derivatives
diazole compounds
diazole
Prior art date
Application number
DK16809425.8T
Other languages
English (en)
Inventor
Christian Griesinger
Sergey Ryazanov
Armin Giese
Felix Schmidt
Andrei Leonov
Original Assignee
Max Planck Gesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft filed Critical Max Planck Gesellschaft
Application granted granted Critical
Publication of DK3390412T3 publication Critical patent/DK3390412T3/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/11—Esters of phosphoric acids with hydroxyalkyl compounds without further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK16809425.8T 2015-12-14 2016-12-14 Vandopløselige derivater af 3,5-diphenyl-diazolforbindelser DK3390412T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15199972 2015-12-14
PCT/EP2016/081084 WO2017102893A1 (en) 2015-12-14 2016-12-14 Water-soluble derivatives of 3,5-diphenyl-diazole compounds

Publications (1)

Publication Number Publication Date
DK3390412T3 true DK3390412T3 (da) 2021-06-21

Family

ID=54850017

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16809425.8T DK3390412T3 (da) 2015-12-14 2016-12-14 Vandopløselige derivater af 3,5-diphenyl-diazolforbindelser

Country Status (21)

Country Link
US (1) US10308671B2 (da)
EP (1) EP3390412B1 (da)
JP (1) JP6898931B2 (da)
KR (1) KR102671166B1 (da)
CN (1) CN108473516B (da)
AU (1) AU2016372408B2 (da)
BR (1) BR112018011994B1 (da)
CA (1) CA3008334C (da)
CL (1) CL2018001570A1 (da)
DK (1) DK3390412T3 (da)
ES (1) ES2873510T3 (da)
HU (1) HUE054815T2 (da)
IL (1) IL260011B (da)
MX (1) MX379522B (da)
NZ (1) NZ742979A (da)
PH (1) PH12018501276A1 (da)
PL (1) PL3390412T3 (da)
PT (1) PT3390412T (da)
RU (1) RU2764131C2 (da)
WO (1) WO2017102893A1 (da)
ZA (1) ZA201803865B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH713150A2 (fr) * 2016-11-23 2018-05-31 Eta Sa Mft Horlogere Suisse Mécanisme régulateur à résonateur rotatif à guidage flexible entretenu par un échappement libre à ancre.
US10368502B2 (en) 2017-09-25 2019-08-06 Multiple Energy Technologies Llc Bioceramic and carbon-based hydroponic systems, methods and devices
KR20220104000A (ko) 2019-11-19 2022-07-25 모다크 게엠베하 알파-시누클레인의 응집과 관련된 질병의 진단, 치료 및 예방을 위한 신규한 화합물
CA3231484A1 (en) 2021-10-01 2023-04-06 Qinwen Mao Pathologic tdp-43 as a biomarker for the diagnosis of tdp-43 proteinopathy
US20250161273A1 (en) * 2022-03-01 2025-05-22 Modag Gmbh Pharmaceutical composition comprising diphenyldiazole derivatives and methods of use
CN115337301A (zh) * 2022-07-22 2022-11-15 汕头大学医学院第一附属医院 Anle138b在制备改善饮食诱导胰岛素抵抗药物中的应用
CN116399983B (zh) * 2023-06-09 2023-08-15 天津辰欣药物研究有限公司 一种利用gc-ms法检测二叔丁基氯甲基磷酸酯残留量的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7745625B2 (en) * 2004-03-15 2010-06-29 Bristol-Myers Squibb Company Prodrugs of piperazine and substituted piperidine antiviral agents
CA2612344A1 (en) * 2005-06-16 2006-12-28 Cv Therapeutics, Inc. Prodrugs of a2b adenosine receptor antagonists
WO2009123241A1 (ja) * 2008-03-31 2009-10-08 株式会社レナサイエンス プラスミノーゲンアクチベーターインヒビター-1阻害剤
ES2714453T3 (es) * 2008-06-09 2019-05-28 Univ Muenchen Ludwig Maximilians Fármacos para inhibir la agregación de proteínas implicadas en enfermedades relacionadas con enfermedades neurodegenerativas y/o agregación de proteínas
JP6069661B2 (ja) * 2010-06-24 2017-02-01 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 種々のアミロイドβペプチドアロフォームレベルの調節における組成物及びその使用
LT2864292T (lt) * 2012-06-08 2017-07-10 Theravance Biopharma R&D Ip, Llc Neprilizino inhibitoriai

Also Published As

Publication number Publication date
CL2018001570A1 (es) 2018-12-28
CN108473516A (zh) 2018-08-31
IL260011B (en) 2021-12-01
KR20180089511A (ko) 2018-08-08
PL3390412T3 (pl) 2021-10-25
RU2018125590A (ru) 2020-01-20
RU2018125590A3 (da) 2020-04-21
JP6898931B2 (ja) 2021-07-07
MX379522B (es) 2025-03-10
BR112018011994B1 (pt) 2022-07-19
EP3390412A1 (en) 2018-10-24
PH12018501276A1 (en) 2019-01-28
RU2764131C2 (ru) 2022-01-13
CA3008334A1 (en) 2017-06-22
ZA201803865B (en) 2019-04-24
HUE054815T2 (hu) 2021-10-28
NZ742979A (en) 2022-05-27
BR112018011994A2 (pt) 2018-12-04
IL260011A (en) 2018-07-31
US10308671B2 (en) 2019-06-04
WO2017102893A1 (en) 2017-06-22
EP3390412B1 (en) 2021-04-14
CA3008334C (en) 2024-01-02
MX2018006877A (es) 2018-09-18
PT3390412T (pt) 2021-06-22
AU2016372408B2 (en) 2021-05-13
AU2016372408A1 (en) 2018-06-21
KR102671166B1 (ko) 2024-05-31
JP2019501167A (ja) 2019-01-17
US20180370997A1 (en) 2018-12-27
CN108473516B (zh) 2021-06-18
ES2873510T3 (es) 2021-11-03

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