DK3392276T3 - Heterodimermolekyle baseret på strukturel CH3-domæne, og fremgangsmåde til fremstilling samt anvendelse deraf - Google Patents

Heterodimermolekyle baseret på strukturel CH3-domæne, og fremgangsmåde til fremstilling samt anvendelse deraf Download PDF

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Publication number
DK3392276T3
DK3392276T3 DK16874885.3T DK16874885T DK3392276T3 DK 3392276 T3 DK3392276 T3 DK 3392276T3 DK 16874885 T DK16874885 T DK 16874885T DK 3392276 T3 DK3392276 T3 DK 3392276T3
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domain
structural
production
molecule based
heterodimer molecule
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DK16874885.3T
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DK3392276T5 (da
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Ting Xu
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Jiangsu Alphamab Biopharmaceuticals Co Ltd
Suzhou Alphamab Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK16874885.3T 2015-12-16 2016-12-16 Heterodimermolekyle baseret på strukturel CH3-domæne, og fremgangsmåde til fremstilling samt anvendelse deraf DK3392276T5 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201510938995.0A CN106883297B (zh) 2015-12-16 2015-12-16 基于ch3结构域的异二聚体分子、其制备方法及用途
PCT/CN2016/110252 WO2017101828A1 (zh) 2015-12-16 2016-12-16 基于ch3结构域的异二聚体分子、其制备方法及用途

Publications (2)

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DK3392276T3 true DK3392276T3 (da) 2023-05-01
DK3392276T5 DK3392276T5 (da) 2024-09-23

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DK16874885.3T DK3392276T5 (da) 2015-12-16 2016-12-16 Heterodimermolekyle baseret på strukturel CH3-domæne, og fremgangsmåde til fremstilling samt anvendelse deraf

Country Status (9)

Country Link
US (3) US11168149B2 (da)
EP (2) EP3392276B1 (da)
JP (3) JP7103603B2 (da)
CN (4) CN106883297B (da)
CA (1) CA3007427C (da)
DK (1) DK3392276T5 (da)
ES (1) ES2944553T3 (da)
FI (1) FI3392276T3 (da)
WO (1) WO2017101828A1 (da)

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CN110719920B (zh) * 2017-06-14 2024-01-30 苏州丁孚靶点生物技术有限公司 蛋白质异二聚体及其用途
CN111051350B (zh) * 2017-09-07 2022-11-01 苏州丁孚靶点生物技术有限公司 包含信号调节蛋白α的免疫缀合物
JP7710706B2 (ja) * 2017-09-25 2025-07-22 シーフイダ ファーマシューティカル グループ （チーリン） カンパニー リミテッド 癌治療のための方法及び組成物
CN111094356B (zh) * 2017-09-25 2022-11-01 苏州丁孚靶点生物技术有限公司 一种蛋白质异二聚体及其用途

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Publication number Publication date
EP4234584A3 (en) 2023-09-27
FI3392276T3 (fi) 2023-05-05
CN108473592A (zh) 2018-08-31
CA3007427C (en) 2024-04-23
US20220017643A1 (en) 2022-01-20
US12281177B2 (en) 2025-04-22
HK1253248A1 (zh) 2019-06-14
CN115057937A (zh) 2022-09-16
JP7788113B2 (ja) 2025-12-18
WO2017101828A1 (zh) 2017-06-22
CN120842427A (zh) 2025-10-28
ES2944553T3 (es) 2023-06-22
CN115057937B (zh) 2025-07-18
EP4234584C0 (en) 2025-07-16
JP2022130568A (ja) 2022-09-06
JP7103603B2 (ja) 2022-07-20
CN106883297B (zh) 2019-12-13
US11168149B2 (en) 2021-11-09
JP7444381B2 (ja) 2024-03-06
JP2019502701A (ja) 2019-01-31
EP3392276B1 (en) 2023-04-19
EP4234584B1 (en) 2025-07-16
US20250257150A1 (en) 2025-08-14
US20180362668A1 (en) 2018-12-20
DK3392276T5 (da) 2024-09-23
EP3392276A1 (en) 2018-10-24
CA3007427A1 (en) 2017-06-22
CN106883297A (zh) 2017-06-23
EP4234584A2 (en) 2023-08-30
JP2024056829A (ja) 2024-04-23
EP3392276A4 (en) 2019-09-18
CN108473592B (zh) 2022-05-03

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