DK340889A - Pyridazinonderivater - Google Patents

Pyridazinonderivater Download PDF

Info

Publication number: DK340889A
Authority: DK; Denmark
Prior art keywords: alkyl; heart; improve; vasodilator; substituents
Prior art date: 1988-07-11

Application number

DK340889A

Other languages

English (en)

Other versions

DK340889D0 (da

Inventor

James Redpath

Robert Thomas Logan

Robert Gibson Roy

George Mccarry

Original Assignee

Akzo Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-07-11

Filing date

1989-07-10

Publication date

1990-01-12

1989-07-10 Application filed by Akzo Nv filed Critical Akzo Nv

1989-07-10 Publication of DK340889D0 publication Critical patent/DK340889D0/da

1990-01-12 Publication of DK340889A publication Critical patent/DK340889A/da

Links

AAILEWXSEQLMNI-UHFFFAOYSA-N 1h-pyridazin-6-one Chemical compound OC1=CC=CN=N1 AAILEWXSEQLMNI-UHFFFAOYSA-N 0.000 title abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
230000002685 pulmonary effect Effects 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
229940124549 vasodilator Drugs 0.000 abstract 2
239000003071 vasodilator agent Substances 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
230000017531 blood circulation Effects 0.000 abstract 1
210000001772 blood platelet Anatomy 0.000 abstract 1
229940124630 bronchodilator Drugs 0.000 abstract 1
230000003177 cardiotonic effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
-1 methylenedioxy group Chemical group 0.000 abstract 1
230000004118 muscle contraction Effects 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
230000009885 systemic effect Effects 0.000 abstract 1
238000009423 ventilation Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Diabetes (AREA)
Hematology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK340889A 1988-07-11 1989-07-10 Pyridazinonderivater DK340889A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP88306295		1988-07-11

Publications (2)

Publication Number	Publication Date
DK340889D0 DK340889D0 (da)	1989-07-10
DK340889A true DK340889A (da)	1990-01-12

Family

ID=8200131

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK340889A DK340889A (da)	1988-07-11	1989-07-10	Pyridazinonderivater

Country Status (16)

Country	Link
US (1)	US4952571A (da)
EP (1)	EP0350990B1 (da)
JP (1)	JPH0285281A (da)
KR (1)	KR900001691A (da)
AT (1)	ATE128135T1 (da)
AU (1)	AU617489B2 (da)
CA (1)	CA1308413C (da)
DE (1)	DE68924308T2 (da)
DK (1)	DK340889A (da)
ES (1)	ES2080064T3 (da)
FI (1)	FI97295C (da)
GR (1)	GR3018356T3 (da)
IE (1)	IE68680B1 (da)
NZ (1)	NZ229876A (da)
PT (1)	PT91117B (da)
ZA (1)	ZA895087B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL94394A (en) *	1989-05-17	1994-10-21	Nissan Chemical Ind Ltd	History of pyridazinone, process for their preparation and preparations for controlling and / or preventing insects, mites, nematodes and mollusks
KR100226053B1 (ko) *	1996-06-18	1999-10-15	권태웅	공장제어 시스템의 비데오 카피어 인터페이스 모듈
US6276721B1 (en) *	2000-03-14	2001-08-21	Simula, Inc.	Pivoting seat belt upper anchor point attachment
FR2829977B1 (fr) *	2001-09-24	2003-12-12	Valeo Vision	Projecteur d'eclairage ou de signalisation a controleur integre pour vehicule et systeme d'eclairage ou de signalisation equipe d'au moins un tel projecteur
RS62410B1 (sr)	2016-10-04	2021-10-29	Merck Sharp & Dohme	Benzo[b]tiofenska jedinjenja kao agonisti sting
JP2020530838A (ja) *	2017-08-04	2020-10-29	メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋＳｈａｒｐ＆ＤｏｈｍｅＣｏｒｐ．	がん治療のためのベンゾ［ｂ］チオフェンＳＴＩＮＧアゴニスト
WO2019027857A1 (en)	2017-08-04	2019-02-07	Merck Sharp & Dohme Corp.	COMBINATIONS OF PD-1 ANTAGONISTS AND STING BENZO [B] THIOPHENIC AGONISTS FOR THE TREATMENT OF CANCER
WO2019195063A1 (en) *	2018-04-03	2019-10-10	Merck Sharp & Dohme Corp.	Aza-benzothiophene compounds as sting agonists
WO2019195124A1 (en) *	2018-04-03	2019-10-10	Merck Sharp & Dohme Corp.	Benzothiophenes and related compounds as sting agonists
CN113861161A (zh) *	2020-06-30	2021-12-31	上海海和药物研究开发股份有限公司	一种芳基并芳杂环衍生物及其制备方法和用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES8101067A1 (es) *	1978-08-25	1980-12-01	Thomae Gmbh Dr K	Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona
US4225711A (en) *	1978-10-02	1980-09-30	Schering Corporation	Substituted 2-[(methylsulfinyl)acetyl]-3-heterocyclicindoles and their use as immunosuppressants
DE3129447A1 (de) *	1981-07-25	1983-02-10	Dr. Karl Thomae Gmbh, 7950 Biberach	"neue benztriazole, ihre herstellung und ihre verwendung als arzneimittel"
CA1199027A (en) *	1981-11-12	1986-01-07	Stuart D. Mills	Heterocyclic derivatives of pyridazinone, thiadiazinone, oxadiazinone and triazinone
US4666902A (en) *	1983-06-20	1987-05-19	Cassella Aktiengesellschaft	Tetrahydropyridazinone derivatives, processes for their preparation and their use
US4647564A (en) *	1984-05-14	1987-03-03	Eli Lilly And Company	Inotropic agents
DE3511110A1 (de) *	1985-03-27	1986-10-02	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue pyridazinone, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3631085A1 (de) *	1986-09-12	1988-03-24	Boehringer Mannheim Gmbh	Heterocyclisch substituierte indolinone, verfahren zu ihrer herstellung, arzneimittel sowie zwischenprodukte

1989
- 1989-06-29 EP EP89201716A patent/EP0350990B1/en not_active Expired - Lifetime
- 1989-06-29 AT AT89201716T patent/ATE128135T1/de not_active IP Right Cessation
- 1989-06-29 ES ES89201716T patent/ES2080064T3/es not_active Expired - Lifetime
- 1989-06-29 DE DE68924308T patent/DE68924308T2/de not_active Expired - Fee Related
- 1989-07-03 IE IE214889A patent/IE68680B1/en not_active IP Right Cessation
- 1989-07-04 ZA ZA895087A patent/ZA895087B/xx unknown
- 1989-07-07 NZ NZ229876A patent/NZ229876A/en unknown
- 1989-07-07 AU AU37967/89A patent/AU617489B2/en not_active Ceased
- 1989-07-10 CA CA000605216A patent/CA1308413C/en not_active Expired - Lifetime
- 1989-07-10 PT PT91117A patent/PT91117B/pt not_active IP Right Cessation
- 1989-07-10 DK DK340889A patent/DK340889A/da not_active Application Discontinuation
- 1989-07-10 FI FI893345A patent/FI97295C/fi not_active IP Right Cessation
- 1989-07-10 JP JP1177872A patent/JPH0285281A/ja active Pending
- 1989-07-10 KR KR1019890009773A patent/KR900001691A/ko not_active Ceased
- 1989-07-11 US US07/378,342 patent/US4952571A/en not_active Expired - Fee Related
1995
- 1995-12-11 GR GR950403477T patent/GR3018356T3/el unknown

Also Published As

Publication number	Publication date
FI97295C (fi)	1996-11-25
ZA895087B (en)	1990-03-28
FI97295B (fi)	1996-08-15
EP0350990B1 (en)	1995-09-20
IE68680B1 (en)	1996-07-10
US4952571A (en)	1990-08-28
DE68924308T2 (de)	1996-04-04
AU3796789A (en)	1990-01-11
DK340889D0 (da)	1989-07-10
FI893345A0 (fi)	1989-07-10
GR3018356T3 (en)	1996-03-31
ES2080064T3 (es)	1996-02-01
PT91117A (pt)	1990-02-08
KR900001691A (ko)	1990-02-27
ATE128135T1 (de)	1995-10-15
NZ229876A (en)	1991-03-26
CA1308413C (en)	1992-10-06
IE892148L (en)	1990-01-11
JPH0285281A (ja)	1990-03-26
FI893345A7 (fi)	1990-01-12
DE68924308D1 (de)	1995-10-26
PT91117B (pt)	1995-07-06
AU617489B2 (en)	1991-11-28
EP0350990A1 (en)	1990-01-17

Legal Events

Date	Code	Title	Description
1999-05-03	AHB	Application shelved due to non-payment

Publication	Publication Date	Title
ATE37179T1 (de)	1988-09-15	Dihydropyridazinone.
NO934792D0 (no)	1993-12-23	Xantinderivater
UA27031A1 (uk)	2000-02-28	Похідhі 3(2h)піридазиhоhу або їх фармацевтичhо прийhятhі солі, що мають протитромботичhу, позитивhу іhотропhу, судиhорозширювальhу дію й аhтиалергічhу активhість та фармацевтичhа композиція hа їх осhові
NO20034595L (no)	2003-12-19	Kinolin- og kinazolinderivater med azolylgruppe
FI892787A0 (fi)	1989-06-07	Analogiamenetelmä terapeuttisesti käyttökelpoisten 1-indolyylialkyyli-4-(substituoitu pyridinyyli)piperatsiinien valmistamiseksi
BR9915401A (pt)	2001-08-14	Derivados de pirimidinilbenzimidazol e triazinilbenzimidazol e fungicida agrìcola/hortìcola
EP0254259A3 (en)	1989-11-23	P-aminophenol derivatives
DK340889D0 (da)	1989-07-10	Pyridazinonderivater
FI903939A0 (fi)	1990-08-09	Benzopyranfoereningar, foerfaranden foer deras framstaellning och farmaceutiska kompositioner.
KR910007883A (ko)	1991-05-30	퀴놀린 유도체, 그의 제조방법 및 용도
EP0138505A3 (en)	1986-06-18	Dihydropyridine derivatives, their production and use
JPS56115784A (en)	1981-09-11	Novel pyridinecarboxamide derivative and its preparation
IE39359B1 (en)	1978-09-27	Coumarin derivatives
ATE71619T1 (de)	1992-02-15	Pyridazinon-derivate.
IE861633L (en)	1987-01-11	Carboxamide indole derivatives
DK0470686T3 (da)	1996-08-26	(Benzhydryloxyethylpiperidyl)alifatiske syrederivater og deres anvendelse til behandling af allergier og astma
KR860000286A (ko)	1986-01-27	디히드로피리딘 유도체의 제조방법
DE3588094D1 (de)	1996-04-25	Antihypertensive Derivate
ATE58135T1 (de)	1990-11-15	1,3-oxathianderivate.
EP0205299A3 (en)	1988-01-20	Isatin derivatives, compositions containing the same, and the use thereof for ulcer diseases
IE36865L (en)	1973-02-16	Imidazolines
JPS5651465A (en)	1981-05-09	Benzothiazine derivative
DK416084A (da)	1985-03-01	Flaven- og thioflavenderivater og salte deraf samt deres fremstilling og anvendelse
JPS6472A (en)	1989-01-05	4-substituted 2,6-diphenylpyrodine derivative, production thereof and herbicide containing said derivative as active ingredient
EP0461264A4 (en)	1992-02-19	Ethynylphenyl derivative, production thereof, and remedy for diseases of circulatory organs containing the same as active ingredient