DK342189A - Fremgangsmaade til fremstilling af 02,2'-anhydro-1-(beta-d-arabinofuranosyl)thymin og mellemprodukter derved - Google Patents

Fremgangsmaade til fremstilling af 02,2'-anhydro-1-(beta-d-arabinofuranosyl)thymin og mellemprodukter derved Download PDF

Info

Publication number: DK342189A
Authority: DK; Denmark
Prior art keywords: beta; arabinofuranosyl; anhydro; thymine; intermediates
Prior art date: 1988-07-12

Application number

DK342189A

Other languages

English (en)

Other versions

DK342189D0 (da

Inventor

Charles William Murtiashaw

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-07-12

Filing date

1989-07-11

Publication date

1990-01-15

1989-07-11 Application filed by Pfizer filed Critical Pfizer

1989-07-11 Publication of DK342189D0 publication Critical patent/DK342189D0/da

1990-01-15 Publication of DK342189A publication Critical patent/DK342189A/da

Links

239000000543 intermediate Substances 0.000 title abstract 2
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
YAXGBZDYGZBRBQ-UHFFFAOYSA-N 4,5-dihydro-1,3-oxazol-2-amine Chemical class NC1=NCCO1 YAXGBZDYGZBRBQ-UHFFFAOYSA-N 0.000 abstract 1
230000003197 catalytic effect Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
PSHKMPUSSFXUIA-UHFFFAOYSA-N n,n-dimethylpyridin-2-amine Chemical compound CN(C)C1=CC=CC=N1 PSHKMPUSSFXUIA-UHFFFAOYSA-N 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/09—Pyrimidine radicals with arabinosyl as the saccharide radical

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Virology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

DK342189A 1988-07-12 1989-07-11 Fremgangsmaade til fremstilling af 02,2'-anhydro-1-(beta-d-arabinofuranosyl)thymin og mellemprodukter derved DK342189A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/217,906 US5008384A (en)	1988-07-12	1988-07-12	Process for the production of O.sup. 2,2'-anhydro-1-(β-D-arabinofuranosyl)thymine

Publications (2)

Publication Number	Publication Date
DK342189D0 DK342189D0 (da)	1989-07-11
DK342189A true DK342189A (da)	1990-01-15

Family

ID=22812966

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK342189A DK342189A (da)	1988-07-12	1989-07-11	Fremgangsmaade til fremstilling af 02,2'-anhydro-1-(beta-d-arabinofuranosyl)thymin og mellemprodukter derved

Country Status (21)

Country	Link
US (1)	US5008384A (da)
EP (1)	EP0351126B1 (da)
JP (1)	JPH075626B2 (da)
KR (1)	KR910008112B1 (da)
CN (1)	CN1039423A (da)
AT (1)	ATE117314T1 (da)
AU (1)	AU603042B2 (da)
CA (1)	CA1315776C (da)
DD (2)	DD292003A5 (da)
DE (1)	DE68920648T2 (da)
DK (1)	DK342189A (da)
ES (1)	ES2066853T3 (da)
FI (1)	FI893364A7 (da)
GR (1)	GR3015293T3 (da)
HU (1)	HUT50843A (da)
IE (1)	IE65735B1 (da)
IL (1)	IL90884A0 (da)
NO (1)	NO892821L (da)
PT (1)	PT91113B (da)
YU (1)	YU138789A (da)
ZA (1)	ZA895259B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3065350B2 (ja) *	1990-11-30	2000-07-17	ヤマサ醤油株式会社	１―（２，３―ジデオキシ―β―Ｄ―グリセロ―ペント―２―エノフラノシル）チミンの製造法
DE69415506T2 (de) *	1994-05-20	1999-08-12	Council Of Scientific And Industrial Research, New Delhi	Verfahren zur Herstellung von Beta-Thymidine
DE60144573D1 (de)	2000-11-29	2011-06-16	Mitsui Chemicals Inc	Verfahren und Zwischenprodukte bei der Synthese von L-Thymidin
US6870048B2 (en) *	2001-03-30	2005-03-22	Triangle Pharmaceuticals	Process for the preparation of 2'-halo-β-L-arabinofuranosyl nucleosides
DE10216426A1 (de) *	2002-04-12	2003-10-23	Boehringer Ingelheim Pharma	Verfahren zur Herstellung von beta-L-2'Deoxy-Thymidin
KR20060015542A (ko)	2003-04-28	2006-02-17	이데닉스 (케이만) 리미티드	산업 규모의 뉴클레오시드 합성
WO2005003374A2 (en)	2003-06-30	2005-01-13	Idenix (Cayman) Limited	SYNTHESIS OF β-L-2-DEOXY NUCLEOSIDES
MX2008011719A (es)	2006-03-15	2008-09-24	Novartis Ag	Proceso para preparar derivados de acido b-nucleico e intermediarios de los mismos.
CN102014919B (zh)	2008-03-03	2015-02-25	托斯克公司	减少毒性的甲氨蝶呤佐剂及其使用方法
US11446303B2 (en)	2019-06-21	2022-09-20	Tosk, Inc.	Uridine phosphorylase (UPase) inhibitors for treatment of liver conditions

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3322747A (en) *	1965-04-01	1967-05-30	Merck & Co Inc	Thionocarbonate nucleosides
US3463850A (en) *	1967-01-03	1969-08-26	Merck & Co Inc	Arabinofuranosyl 2-thiopyrimidines and pharmaceutical compositions thereof
US3658788A (en) *	1969-06-06	1972-04-25	Salk Inst For Biological Studi	Aminooxazolines and products thereof and processes for synthesizing same
US3812098A (en) *	1970-03-19	1974-05-21	Syntex Inc	O2,2'-anhydro-1-(beta-d-arabinofuranosyl)-cytosine derivatives and methods of making and related procedures
US3709874A (en) *	1970-03-19	1973-01-09	Syntex Corp	1-beta-d-arabinofuranosyl cytosine derivatives and methods of preparing
US3792040A (en) *	1970-03-19	1974-02-12	Syntex Corp	Acyl derivatives of o2,2'-anhydro-1-(beta-d-arabinofuranosyl)-cytosines and methods of preparing
US3920630A (en) *	1970-09-24	1975-11-18	Upjohn Co	2,2{40 -Anhydro-ara-cytidine compounds and process of preparation
SE391183B (sv) *	1971-04-15	1977-02-07	Asahi Chemical Ind	2',3'-0-sulfinylcytidin och syraadditionssalter derav till anvendning som mellanprodukt for framstellning av 2,2'-anhydro-(1-beta-d-arabinofuranosyl) cytosin
US3978042A (en) *	1975-01-31	1976-08-31	The Upjohn Company	Process for preparing cyclocytidine derivatives
US4140850A (en) *	1977-08-29	1979-02-20	The Upjohn Company	2,2'-Anhydrotriazine nucleosides and process for preparing the same
JPS5649398A (en) *	1979-09-28	1981-05-02	Yamasa Shoyu Co Ltd	Preparation of 1-beta-d-arabinofuranosyl-2,2'-cyclothymine
JPS636557A (ja) *	1986-06-26	1988-01-12	Sharp Corp	微細パタ−ン形成方法

1988
- 1988-07-12 US US07/217,906 patent/US5008384A/en not_active Expired - Lifetime
1989
- 1989-07-05 AT AT89306820T patent/ATE117314T1/de not_active IP Right Cessation
- 1989-07-05 EP EP89306820A patent/EP0351126B1/en not_active Expired - Lifetime
- 1989-07-05 DE DE68920648T patent/DE68920648T2/de not_active Expired - Fee Related
- 1989-07-05 IL IL90884A patent/IL90884A0/xx unknown
- 1989-07-05 ES ES89306820T patent/ES2066853T3/es not_active Expired - Lifetime
- 1989-07-07 NO NO89892821A patent/NO892821L/no unknown
- 1989-07-10 CN CN89104789A patent/CN1039423A/zh active Pending
- 1989-07-10 PT PT91113A patent/PT91113B/pt not_active IP Right Cessation
- 1989-07-10 JP JP1177876A patent/JPH075626B2/ja not_active Expired - Fee Related
- 1989-07-10 CA CA000605243A patent/CA1315776C/en not_active Expired - Fee Related
- 1989-07-11 DK DK342189A patent/DK342189A/da not_active Application Discontinuation
- 1989-07-11 KR KR1019890009853A patent/KR910008112B1/ko not_active Expired
- 1989-07-11 FI FI893364A patent/FI893364A7/fi not_active Application Discontinuation
- 1989-07-11 DD DD89337873A patent/DD292003A5/de not_active IP Right Cessation
- 1989-07-11 IE IE223389A patent/IE65735B1/en not_active IP Right Cessation
- 1989-07-11 ZA ZA895259A patent/ZA895259B/xx unknown
- 1989-07-11 HU HU893491A patent/HUT50843A/hu unknown
- 1989-07-11 DD DD89330684A patent/DD284024A5/de not_active IP Right Cessation
- 1989-07-11 YU YU01387/89A patent/YU138789A/xx unknown
- 1989-07-11 AU AU38020/89A patent/AU603042B2/en not_active Ceased
1995
- 1995-03-03 GR GR950400471T patent/GR3015293T3/el unknown

Also Published As

Publication number	Publication date
DE68920648D1 (de)	1995-03-02
CN1039423A (zh)	1990-02-07
US5008384A (en)	1991-04-16
ES2066853T3 (es)	1995-03-16
HUT50843A (en)	1990-03-28
DE68920648T2 (de)	1995-05-18
IE65735B1 (en)	1995-11-15
NO892821L (no)	1990-01-15
YU138789A (en)	1990-12-31
JPH075626B2 (ja)	1995-01-25
AU603042B2 (en)	1990-11-01
AU3802089A (en)	1990-04-26
ATE117314T1 (de)	1995-02-15
FI893364A7 (fi)	1990-01-13
FI893364A0 (fi)	1989-07-11
EP0351126A3 (en)	1990-10-24
KR910008112B1 (ko)	1991-10-10
DD284024A5 (de)	1990-10-31
CA1315776C (en)	1993-04-06
EP0351126A2 (en)	1990-01-17
PT91113B (pt)	1995-01-31
KR900001704A (ko)	1990-02-27
EP0351126B1 (en)	1995-01-18
DD292003A5 (de)	1991-07-18
PT91113A (pt)	1990-02-08
JPH0259598A (ja)	1990-02-28
IL90884A0 (en)	1990-02-09
ZA895259B (en)	1991-02-27
NO892821D0 (no)	1989-07-07
IE892233L (en)	1990-01-12
GR3015293T3 (en)	1995-06-30
DK342189D0 (da)	1989-07-11

Legal Events

Date	Code	Title	Description
1998-04-20	ATS	Application withdrawn

Publication	Publication Date	Title
FI852974A0 (fi)	1985-08-01	Nya n-hydroxylgruppen skyddande grupper och framstaellningsfoerfarande foer 3-acylamino-1-hydroxi-2-azetidinoner.
ES2000910A6 (es)	1988-03-16	Procedimiento para preparar piridina-2,3-dicarboxilatos sustituidos y disustituidos
PH27439A (en)	1993-07-02	Process for the preparation of 1-methyl-3-methylthio-4-quinolone and the sulfinyl and sulfonyl analogs thereof
DK342189A (da)	1990-01-15	Fremgangsmaade til fremstilling af 02,2'-anhydro-1-(beta-d-arabinofuranosyl)thymin og mellemprodukter derved
ATE35417T1 (de)	1988-07-15	Verfahren zur herstellung von phosphorhaltigen cyanhydrinderivaten.
DK288287D0 (da)	1987-06-04	Heterocycliske forbindelser samt farmaceutiske praeparater til behandling af allergiske eller inflammatoriske tilstande
IT1225484B (it)	1990-11-14	Procedimento di sintesi dell'amikacina
ATE67199T1 (de)	1991-09-15	Benzoxazin-derivate und verfahren zu ihrer herstellung.
DK466786D0 (da)	1986-09-30	Fremgangsmaade til fremstilling af n-substituerede dihydrolysergsyre-derivater
FI922097A0 (fi)	1992-05-08	Asymmetrisk syntes av 3-substituerade furanosidfoereningar.
DK0391673T3 (da)	1993-06-28	Fremstilling af glutarsyrederivater
DE69410073D1 (de)	1998-06-10	Verfahren zur Herstellung von 2-Perfluoroalkyl-3-oxazolin-5-one
DK0614890T3 (da)	1997-10-13	Fremgangsmåde til fremstilling af eventuelt 2-substituerede 5-chlorimidazoler.
DK24088A (da)	1988-07-06	Fremgangsmaade og mellemprodukter til fremstilling af thiazolobenzimidazoler
DK248287D0 (da)	1987-05-14	Fremgangsmaade til fremstilling af chephalosporinderivater
KR850004748A (ko)	1985-07-27	N-(4- 메톡시-2- 메틸페닐)-3-(5-니트로-2-퓨라닐) 프로펜아미드의 제조방법 및 그 구충약제 조성물
DK0455304T3 (da)	1995-02-13	Fremgangsmåde til fremstilling af cykliske ketoner
DK0557519T3 (da)	1997-06-23	Fremgangsmåde til fremstilling af sulfonamidderivater af norbornan
ATE46145T1 (de)	1989-09-15	Verfahren zur herstellung von 2-isocyanato-2,3dehydrocarbon-saeureestern.
DK452684A (da)	1985-03-23	Fremgangsmaade til fremstilling af quinolin-4-oner
FI882956L (fi)	1988-06-21	4-piperidyl-substituerade karboxylsyraderivat och foerfarande foer deras framstaellning.
KR830006284A (ko)	1983-09-20	5-치환된 옥사졸리딘-2,4-디온의 제조방법