DK342484A - Derivater af synergistiner, deres fremstilling og farmaceutiske praeparater deraf - Google Patents

Derivater af synergistiner, deres fremstilling og farmaceutiske praeparater deraf Download PDF

Info

Publication number: DK342484A
Authority: DK; Denmark
Prior art keywords: azepin; azetidin; pyrrolidin; piperidin; synergistines
Prior art date: 1983-07-13

Application number

DK342484A

Other languages

English (en)

Other versions

DK342484D0 (da

DK170421B1 (da

Inventor

Jean-Pierre Corbet

Claude Cotrel

Daniel Farge

Jean-Marc Paris

Original Assignee

Rhone Poulenc Sante

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-07-13

Filing date

1984-07-12

Publication date

1985-01-14

1984-07-12 Application filed by Rhone Poulenc Sante filed Critical Rhone Poulenc Sante

1984-07-12 Publication of DK342484D0 publication Critical patent/DK342484D0/da

1985-01-14 Publication of DK342484A publication Critical patent/DK342484A/da

1995-08-28 Application granted granted Critical

1995-08-28 Publication of DK170421B1 publication Critical patent/DK170421B1/da

Links

239000000825 pharmaceutical preparation Substances 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
-1 piperidino, azetidin-1-yl Chemical group 0.000 abstract 10
125000000217 alkyl group Chemical group 0.000 abstract 5
125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 2
125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 2
125000004567 azetidin-3-yl group Chemical group N1CC(C1)* 0.000 abstract 2
125000004663 dialkyl amino group Chemical group 0.000 abstract 2
125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 abstract 2
125000004483 piperidin-3-yl group Chemical group N1CC(CCC1)* 0.000 abstract 2
125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 abstract 2
125000004485 2-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])C1([H])* 0.000 abstract 1
108010015791 Streptogramin A Proteins 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
239000004599 antimicrobial Substances 0.000 abstract 1
125000004321 azepin-2-yl group Chemical group [H]N1C([H])=C([H])C([H])=C([H])C([H])=C1* 0.000 abstract 1
125000004273 azetidin-2-yl group Chemical group [H]N1C([H])([H])C([H])([H])C1([H])* 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004574 piperidin-2-yl group Chemical group N1C(CCCC1)* 0.000 abstract 1
JOOMGSFOCRDAHL-XKCHLWDXSA-N pristinamycin-IIB Natural products CC(C)[C@@H]1OC(=O)[C@H]2CCCN2C(=O)c3coc(CC(=O)C[C@@H](O)C=C(C)C=CCNC(=O)C=C[C@H]1C)n3 JOOMGSFOCRDAHL-XKCHLWDXSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06182—Dipeptides with the first amino acid being heterocyclic and Pristinamycin II; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/19—Antibiotic
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Lubricants (AREA)
Orthopedics, Nursing, And Contraception (AREA)
Fixed Capacitors And Capacitor Manufacturing Machines (AREA)

DK342484A 1983-07-13 1984-07-12 Pristinamycin IIB-derivater, fremgangsmåde til deres fremstilling og farmaceutiske præparater deraf DK170421B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8311707		1983-07-13
FR8311707A FR2549065B1 (fr)	1983-07-13	1983-07-13	Nouveaux derives de synergistines, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (3)

Publication Number	Publication Date
DK342484D0 DK342484D0 (da)	1984-07-12
DK342484A true DK342484A (da)	1985-01-14
DK170421B1 DK170421B1 (da)	1995-08-28

Family

ID=9290814

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK342484A DK170421B1 (da)	1983-07-13	1984-07-12	Pristinamycin IIB-derivater, fremgangsmåde til deres fremstilling og farmaceutiske præparater deraf

Country Status (18)

Country	Link
US (1)	US4590004A (da)
EP (1)	EP0135410B1 (da)
JP (1)	JPH0631252B2 (da)
KR (1)	KR910002842B1 (da)
AT (1)	ATE37373T1 (da)
AU (1)	AU567951B2 (da)
CA (1)	CA1222513A (da)
DE (1)	DE3474146D1 (da)
DK (1)	DK170421B1 (da)
ES (1)	ES8504202A1 (da)
FI (1)	FI78106C (da)
FR (1)	FR2549065B1 (da)
GR (1)	GR82382B (da)
IE (1)	IE57550B1 (da)
IL (1)	IL72398A (da)
PT (1)	PT78895B (da)
SU (1)	SU1396968A3 (da)
ZA (1)	ZA845315B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2576022B1 (fr) *	1985-01-11	1987-09-11	Rhone Poulenc Sante	Nouveaux derives de la pristinamycine ii b, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2599036B1 (fr) *	1986-05-22	1988-09-09	Rhone Poulenc Sante	Nouveaux derives de synergistines, leur preparation et les compositions pharmaceutiques qui les contiennent
GB8616768D0 (en) *	1986-07-09	1986-08-13	May & Baker Ltd	Process
US4762923A (en) *	1986-11-21	1988-08-09	Merck & Co. Inc.	Fermentation analogs of virginiamycin M1
US4772595A (en) *	1986-11-21	1988-09-20	Merck & Co., Inc.	Synthetic virginiamycin M1 analogs
US4859690A (en) *	1986-11-21	1989-08-22	Merck & Co., Inc.	Therapeutic virginiamycin M1 analogs
DE3778359D1 (de) *	1987-07-07	1992-05-21	Rhone Poulenc Sante	Verfahren zur herstellung von derivaten von pristinamycin iib.
FR2655343B1 (fr) *	1989-12-05	1992-05-07	Rhone Poulenc Sante	Procede de preparation de synergistine.
FR2664599B1 (fr) *	1990-07-16	1993-06-18	Rhone Poulenc Sante	Vinylsulfonyl pristinamycine et sa preparation.
US5242938A (en) *	1992-08-27	1993-09-07	Merck & Co., Inc.	Derivatives of virginiamycin M1
FR2701709B1 (fr) *	1993-02-17	1995-04-07	Rhone Poulenc Rorer Sa	Forme purifiée de streptograminés, sa préparation et les compositions pharmaceutiques qui la contiennent.
FR2755857B1 (fr) *	1996-11-19	1998-12-24	Rhone Poulenc Rorer Sa	Compositions pharmaceutiques stabilisees, a base de quinupristine et de dalfopristine et leur preparation
FR2766489B1 (fr) *	1997-07-28	1999-08-27	Rhone Poulenc Rorer Sa	Derives de streptogramines, leur preparation et les compositions qui les contiennent
FR2795733B1 (fr) *	1999-06-30	2001-09-07	Aventis Pharma Sa	Derives de streptogramines, leur preparation et les compositions qui les contiennent
FR2818644B1 (fr) *	2000-12-21	2004-10-22	Aventis Pharma Sa	Derives de streptogramines, leur preparation et les compositions qui les contiennent
CN103360463B (zh) *	2012-04-08	2016-06-08	浙江海正药业股份有限公司	一种达福普汀及其中间体的分离纯化方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2549063B1 (fr) *	1983-07-13	1985-10-25	Rhone Poulenc Sante	Nouveaux derives de synergistines, leur preparation et les compositions pharmaceutiques qui les contiennent

1983
- 1983-07-13 FR FR8311707A patent/FR2549065B1/fr not_active Expired
1984
- 1984-07-10 ZA ZA845315A patent/ZA845315B/xx unknown
- 1984-07-10 AU AU30471/84A patent/AU567951B2/en not_active Expired
- 1984-07-11 GR GR75265A patent/GR82382B/el unknown
- 1984-07-11 KR KR1019840004024A patent/KR910002842B1/ko not_active Expired
- 1984-07-11 IE IE1788/84A patent/IE57550B1/en not_active IP Right Cessation
- 1984-07-12 SU SU843760753A patent/SU1396968A3/ru active
- 1984-07-12 IL IL72398A patent/IL72398A/xx not_active IP Right Cessation
- 1984-07-12 FI FI842813A patent/FI78106C/fi not_active IP Right Cessation
- 1984-07-12 EP EP84401480A patent/EP0135410B1/fr not_active Expired
- 1984-07-12 JP JP59145224A patent/JPH0631252B2/ja not_active Expired - Lifetime
- 1984-07-12 US US06/630,284 patent/US4590004A/en not_active Expired - Lifetime
- 1984-07-12 CA CA000458720A patent/CA1222513A/fr not_active Expired
- 1984-07-12 PT PT78895A patent/PT78895B/pt unknown
- 1984-07-12 DK DK342484A patent/DK170421B1/da not_active IP Right Cessation
- 1984-07-12 DE DE8484401480T patent/DE3474146D1/de not_active Expired
- 1984-07-12 AT AT84401480T patent/ATE37373T1/de not_active IP Right Cessation
- 1984-07-13 ES ES534314A patent/ES8504202A1/es not_active Expired

Also Published As

Publication number	Publication date
IE57550B1 (en)	1992-11-18
DK342484D0 (da)	1984-07-12
EP0135410A1 (fr)	1985-03-27
FI842813A7 (fi)	1985-01-14
JPH0631252B2 (ja)	1994-04-27
DK170421B1 (da)	1995-08-28
IL72398A0 (en)	1984-11-30
EP0135410B1 (fr)	1988-09-21
ES534314A0 (es)	1985-04-01
JPS6075483A (ja)	1985-04-27
PT78895A (fr)	1984-08-01
KR910002842B1 (ko)	1991-05-06
FR2549065A1 (fr)	1985-01-18
DE3474146D1 (en)	1988-10-27
AU3047184A (en)	1986-01-16
SU1396968A3 (ru)	1988-05-15
FR2549065B1 (fr)	1985-10-25
ZA845315B (en)	1985-02-27
FI78106C (fi)	1989-06-12
ATE37373T1 (de)	1988-10-15
IL72398A (en)	1987-10-30
US4590004A (en)	1986-05-20
IE841788L (en)	1985-01-13
KR850001216A (ko)	1985-03-16
CA1222513A (fr)	1987-06-02
FI78106B (fi)	1989-02-28
GR82382B (da)	1984-12-13
PT78895B (fr)	1986-08-14
ES8504202A1 (es)	1985-04-01
AU567951B2 (en)	1987-12-10
FI842813A0 (fi)	1984-07-12

Legal Events

Date	Code	Title	Description
1995-08-28	B1	Patent granted (law 1993)
2004-08-02	PUP	Patent expired

Publication	Publication Date	Title
DK342484D0 (da)	1984-07-12	Derivater af synergistiner, deres fremstilling og farmaceutiske praeparater deraf
DK0582788T3 (da)	1999-02-01	7-(Substituerede)-9-[(substitueret glycyl)-amido]-demethyl-6-deoxytetracycliner
IL106672A0 (en)	1993-12-08	9-((substituted glycyl)amino))-6-demethyl-6-deoxytetracyclines
FI882081A7 (fi)	1988-05-04	2-substituerade e-fusionerade (1,2,4) triazolo(1,5-c) pyrimidiner, farmaceutiska kompositioner och deras anvaendning.
FI904604A0 (fi)	1990-09-19	Pyrimidin-4,6 -dikarboxylsyraamider, foerfarande foer deras framstaellning samt deras anvaendning samt pao dessa foereningar baserade laekemedel.
AR007969A1 (es)	1999-11-24	Compuestos derivados de pirroles sustituidos, su utilizacion y composiciones farmaceuticas que contienen tales compuestos
NO984950D0 (no)	1998-10-23	Forbindelser med veksthormonfrigj°rende egenskaper
DK342584A (da)	1985-01-14	Derivater af synergistiner, deres fremstilling og farmaceutiske praeparater deraf
DK0745083T3 (da)	1999-01-25	2-Heteroaryl-5, 11-dihydro-6H-dipyrido[3, 2-b:2', 3'-e][1, 4]diazepiner og deres anvendelse til forebyggelse eller behandli
IL97913A0 (en)	1992-06-21	Heterocyclic compounds,their preparation and pharmaceutical compositions containing them
DK0412058T3 (da)	1994-09-19	1-Acyl-2-pyrrolidinoner som indlærings- og hukommelsesforstærkende midler og farmaceutiske præparater indeholdende disse forbindelser
DE69903974D1 (de)	2002-12-19	Anthraquinone antikrebs-arzneimitteln
NZ222078A (en)	1990-07-26	1,2,4-triazole derivatives and pharmaceutical compositions
KR880007515A (ko)	1988-08-27	신규 피롤 유도체, 그 제조방법 및 그것을 함유한 약제학적 조성물
ATE2786T1 (de)	1983-04-15	1-(2-propynyloxy)-2-amino-3-propanol-aether, ihre herstellung und sie enthaltende pharmazeutische zusammensetzung.