DK3436593T3 - Fremgangsmåder til varmeinaktivering af adenovirus - Google Patents
Fremgangsmåder til varmeinaktivering af adenovirus Download PDFInfo
- Publication number
- DK3436593T3 DK3436593T3 DK17776462.8T DK17776462T DK3436593T3 DK 3436593 T3 DK3436593 T3 DK 3436593T3 DK 17776462 T DK17776462 T DK 17776462T DK 3436593 T3 DK3436593 T3 DK 3436593T3
- Authority
- DK
- Denmark
- Prior art keywords
- adenovirus
- methods
- heat inactivation
- inactivation
- heat
- Prior art date
Links
- 230000002779 inactivation Effects 0.000 title 1
- 241000701161 unidentified adenovirus Species 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/761—Adenovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2523/00—Culture process characterised by temperature
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10361—Methods of inactivation or attenuation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662314116P | 2016-03-28 | 2016-03-28 | |
| PCT/US2017/024545 WO2017172772A1 (en) | 2016-03-28 | 2017-03-28 | Methods of heat inactivation of adenovirus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3436593T3 true DK3436593T3 (da) | 2023-02-20 |
Family
ID=59966403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17776462.8T DK3436593T3 (da) | 2016-03-28 | 2017-03-28 | Fremgangsmåder til varmeinaktivering af adenovirus |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US11013774B2 (da) |
| EP (2) | EP4159867A1 (da) |
| JP (3) | JP7356224B2 (da) |
| KR (1) | KR102389674B1 (da) |
| CN (1) | CN109196106A (da) |
| AU (1) | AU2017241777B2 (da) |
| CA (1) | CA3018380A1 (da) |
| DK (1) | DK3436593T3 (da) |
| ES (1) | ES2938833T3 (da) |
| FI (1) | FI3436593T3 (da) |
| HU (1) | HUE061100T2 (da) |
| IL (1) | IL261914B2 (da) |
| LT (1) | LT3436593T (da) |
| PL (1) | PL3436593T3 (da) |
| PT (1) | PT3436593T (da) |
| SG (1) | SG11201808183PA (da) |
| WO (1) | WO2017172772A1 (da) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107106689A (zh) | 2014-11-05 | 2017-08-29 | 沃雅戈治疗公司 | 用于治疗帕金森病的aadc多核苷酸 |
| IL292999A (en) | 2014-11-14 | 2022-07-01 | Voyager Therapeutics Inc | Compositions and methods of treating amyotrophic lateral sclerosis (als) |
| CN112410338A (zh) | 2014-11-14 | 2021-02-26 | 沃雅戈治疗公司 | 调节性多核苷酸 |
| WO2016094783A1 (en) | 2014-12-12 | 2016-06-16 | Voyager Therapeutics, Inc. | Compositions and methods for the production of scaav |
| SG11201809699XA (en) | 2016-05-18 | 2018-12-28 | Voyager Therapeutics Inc | Modulatory polynucleotides |
| JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
| US12460196B2 (en) | 2018-04-27 | 2025-11-04 | Qiagen Gmbh | Method for isolating nucleic acids from plant samples |
| US20210238580A1 (en) * | 2018-05-11 | 2021-08-05 | Qiagen Gmbh | Lysis method for plant samples |
| EP3794126A1 (en) | 2018-05-15 | 2021-03-24 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of parkinson's disease |
| CN113383010B (zh) | 2018-09-28 | 2025-09-09 | 沃雅戈治疗公司 | 具有经工程化改造的启动子的共济蛋白表达构建体及其使用方法 |
| DK3898981T5 (da) | 2018-12-18 | 2024-08-05 | Ultragenyx Pharmaceutical Inc | Fremgangsmåder og sammensætninger til behandling af glykogenlagringssygdomme |
| JP7560475B2 (ja) | 2019-04-12 | 2024-10-02 | ウルトラジェニックス ファーマシューティカル インコーポレイテッド | 操作された産生細胞株ならびにそれを作製および使用する方法 |
| JP2023031782A (ja) * | 2021-08-25 | 2023-03-09 | 株式会社東芝 | ウィルス検出方法 |
| JP2025509328A (ja) | 2022-03-07 | 2025-04-11 | ウルトラジェニックス ファーマシューティカル インコーポレイテッド | 改良されたバッチａａｖ産生システムおよび方法 |
| JP2024020941A (ja) * | 2022-08-02 | 2024-02-15 | 株式会社東芝 | ウイルス不活性化装置およびウイルス不活性化方法 |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5436146A (en) | 1989-09-07 | 1995-07-25 | The Trustees Of Princeton University | Helper-free stocks of recombinant adeno-associated virus vectors |
| US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
| US5387484A (en) | 1992-07-07 | 1995-02-07 | International Business Machines Corporation | Two-sided mask for patterning of materials with electromagnetic radiation |
| US5658785A (en) | 1994-06-06 | 1997-08-19 | Children's Hospital, Inc. | Adeno-associated virus materials and methods |
| JP4216350B2 (ja) | 1994-09-19 | 2009-01-28 | 大日本住友製薬株式会社 | 動物細胞感染用の組換えｄｎａウイルスベクター |
| US5872005A (en) | 1994-11-03 | 1999-02-16 | Cell Genesys Inc. | Packaging cell lines for adeno-associated viral vectors |
| US6924128B2 (en) | 1994-12-06 | 2005-08-02 | Targeted Genetics Corporation | Packaging cell lines for generation of high titers of recombinant AAV vectors |
| CA2207927A1 (en) | 1994-12-06 | 1996-06-13 | Targeted Genetics Corporation | Packaging cell lines for generation of high titers of recombinant aav vectors |
| IL116816A (en) | 1995-01-20 | 2003-05-29 | Rhone Poulenc Rorer Sa | Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof |
| US5741683A (en) | 1995-06-07 | 1998-04-21 | The Research Foundation Of State University Of New York | In vitro packaging of adeno-associated virus DNA |
| US5688676A (en) * | 1995-06-07 | 1997-11-18 | Research Foundation Of State University Of New York | In vitro packaging of adeno-associated virus DNA |
| US6027931A (en) | 1995-08-03 | 2000-02-22 | Avigen, Inc. | High-efficiency AA V helper functions |
| ES2099678B1 (es) * | 1995-11-03 | 1998-02-16 | Grifols Grupo Sa | Procedimiento para la inactivacion de virus en proteinas. |
| US6004797A (en) | 1995-11-09 | 1999-12-21 | Avigen, Inc. | Adenovirus helper-free recombinant AAV Virion production |
| US6541258B2 (en) | 1996-12-18 | 2003-04-01 | Targeted Genetics Corporation | AAV split-packaging genes and cell lines comprising such genes for use in the production of recombinant AAV vectors |
| US6156303A (en) | 1997-06-11 | 2000-12-05 | University Of Washington | Adeno-associated virus (AAV) isolates and AAV vectors derived therefrom |
| US6989264B2 (en) | 1997-09-05 | 2006-01-24 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
| US6566118B1 (en) | 1997-09-05 | 2003-05-20 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
| CA2303768C (en) | 1997-09-19 | 2009-11-24 | The Trustees Of The University Of Pennsylvania | Methods and vector constructs useful for production of recombinant aav |
| IT1297074B1 (it) | 1997-11-21 | 1999-08-03 | Angeletti P Ist Richerche Bio | Forme ormone-dipendenti delle proteine rep del virus adeno-associato (aav-2), sequenze di dna codificanti per esse, vettori che le |
| CA2340682A1 (en) | 1998-08-14 | 2000-02-24 | Aventis Pharmaceuticals Products Inc. | Adenovirus formulations for gene therapy |
| EP1124976A1 (en) | 1998-10-27 | 2001-08-22 | Crucell Holland B.V. | Improved aav vector production |
| DE19905501B4 (de) | 1999-02-10 | 2005-05-19 | MediGene AG, Gesellschaft für molekularbiologische Kardiologie und Onkologie | Verfahren zur Herstellung eines rekombinanten Adeno-assoziierten Virus, geeignete Mittel hierzu sowie Verwendung zur Herstellung eines Arzneimittels |
| JP2002541792A (ja) * | 1999-04-09 | 2002-12-10 | アベンテイス・フアルマ・ソシエテ・アノニム | 感染性の組換えアデノウイルスの保存用組成物 |
| US20040235173A1 (en) | 2000-07-03 | 2004-11-25 | Gala Design, Inc. | Production of host cells containing multiple integrating vectors by serial transduction |
| DE10061533B4 (de) | 2000-12-11 | 2006-05-04 | Amphenol-Tuchel Electronics Gmbh | Selbsttragende Kontaktfeder, insbesondere für einen Smartcard-Connector |
| US6492327B2 (en) * | 2000-12-19 | 2002-12-10 | Sulzer Biologics Inc. | Isolation of purified TGF- β1 and TGF -β2 from bone tissue |
| US6723551B2 (en) | 2001-11-09 | 2004-04-20 | The United States Of America As Represented By The Department Of Health And Human Services | Production of adeno-associated virus in insect cells |
| AU2002360355B2 (en) | 2001-11-09 | 2005-07-07 | Government Of The United States Of America, Department Of Health And Human Services | Production of adeno-associated virus in insect cells |
| CA2369985A1 (en) | 2002-01-18 | 2003-07-18 | Duke University | Generation of recombinant adeno-associated viral vectors by a complete adenovirus-mediated approach |
| US7622562B2 (en) * | 2002-06-26 | 2009-11-24 | Zimmer Orthobiologics, Inc. | Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue |
| WO2004075861A2 (en) | 2003-02-26 | 2004-09-10 | Children's Hospital, Inc. | Recombinant adeno-associated virus production |
| BRPI0511764B8 (pt) * | 2004-06-01 | 2021-05-25 | Avigen Inc | método de prevenção de agregação de vírions de vírus adeno-associado recombinante (raav) em uma preparação purificada de virions raav |
| US7195394B2 (en) | 2004-07-19 | 2007-03-27 | Vijay Singh | Method for resonant wave mixing in closed containers |
| US8980247B2 (en) | 2004-10-21 | 2015-03-17 | The Penn State Research Foundation | Parvovirus methods and compositions for killing neoplastic cells |
| AU2006304997B2 (en) | 2005-10-20 | 2012-03-01 | Uniqure Ip B.V. | Improved AAV vectors produced in insect cells |
| CN101472941B (zh) * | 2006-03-31 | 2017-08-08 | 沃弗-威斯康星校友研究基金会 | 用于疫苗的高滴度重组流感病毒 |
| ES2785223T3 (es) | 2006-06-21 | 2020-10-06 | Uniqure Ip Bv | Células de insecto para la producción de vectores de AAV |
| GB0706638D0 (en) | 2007-04-04 | 2007-05-16 | Mbda Uk Ltd | A high-dielectric material |
| US9404150B2 (en) * | 2007-08-29 | 2016-08-02 | Sequenom, Inc. | Methods and compositions for universal size-specific PCR |
| US8580755B2 (en) | 2008-02-19 | 2013-11-12 | University Of Rochester | Methods and compositions for treating inflammatory conditions |
| US20110251547A1 (en) | 2008-11-07 | 2011-10-13 | Intelligentnano Inc. | Transfection with magnetic nanoparticles and ultrasound |
| KR101812813B1 (ko) * | 2009-06-16 | 2017-12-27 | 젠자임 코포레이션 | 재조합 ａａｖ 벡터에 대한 개선된 정제 방법 |
| WO2013096955A1 (en) | 2011-12-23 | 2013-06-27 | Case Western Reserve University | Targeted gene modification using hybrid recombinant adeno-associated virus |
| BR122020002822B1 (pt) | 2013-01-08 | 2023-04-18 | Genzyme Corporation | Método para cultivar um vetor de hsv-1 d27.1 |
-
2017
- 2017-03-28 LT LTEPPCT/US2017/024545T patent/LT3436593T/lt unknown
- 2017-03-28 SG SG11201808183PA patent/SG11201808183PA/en unknown
- 2017-03-28 FI FIEP17776462.8T patent/FI3436593T3/fi active
- 2017-03-28 CA CA3018380A patent/CA3018380A1/en active Pending
- 2017-03-28 ES ES17776462T patent/ES2938833T3/es active Active
- 2017-03-28 CN CN201780033212.1A patent/CN109196106A/zh active Pending
- 2017-03-28 DK DK17776462.8T patent/DK3436593T3/da active
- 2017-03-28 WO PCT/US2017/024545 patent/WO2017172772A1/en not_active Ceased
- 2017-03-28 KR KR1020187030706A patent/KR102389674B1/ko active Active
- 2017-03-28 PT PT177764628T patent/PT3436593T/pt unknown
- 2017-03-28 JP JP2018550814A patent/JP7356224B2/ja active Active
- 2017-03-28 EP EP22199443.7A patent/EP4159867A1/en active Pending
- 2017-03-28 EP EP17776462.8A patent/EP3436593B1/en active Active
- 2017-03-28 HU HUE17776462A patent/HUE061100T2/hu unknown
- 2017-03-28 AU AU2017241777A patent/AU2017241777B2/en active Active
- 2017-03-28 US US16/085,177 patent/US11013774B2/en active Active
- 2017-03-28 PL PL17776462.8T patent/PL3436593T3/pl unknown
-
2018
- 2018-09-20 IL IL261914A patent/IL261914B2/en unknown
-
2021
- 2021-02-01 JP JP2021014329A patent/JP2021072838A/ja not_active Withdrawn
- 2021-04-23 US US17/238,743 patent/US11944658B2/en active Active
-
2022
- 2022-08-25 JP JP2022134006A patent/JP7682837B2/ja active Active
-
2024
- 2024-02-29 US US18/591,746 patent/US20240252562A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20180130531A (ko) | 2018-12-07 |
| IL261914A (en) | 2018-10-31 |
| IL261914B1 (en) | 2023-03-01 |
| PT3436593T (pt) | 2023-01-31 |
| JP2019509747A (ja) | 2019-04-11 |
| JP2021072838A (ja) | 2021-05-13 |
| IL261914B2 (en) | 2023-07-01 |
| US11944658B2 (en) | 2024-04-02 |
| US20240252562A1 (en) | 2024-08-01 |
| CA3018380A1 (en) | 2017-10-05 |
| KR102389674B1 (ko) | 2022-04-21 |
| EP3436593A4 (en) | 2019-10-16 |
| AU2017241777A1 (en) | 2018-10-11 |
| AU2017241777B2 (en) | 2022-02-03 |
| BR112018069703A2 (pt) | 2019-02-05 |
| US20190083554A1 (en) | 2019-03-21 |
| US11013774B2 (en) | 2021-05-25 |
| SG11201808183PA (en) | 2018-10-30 |
| US20220072073A1 (en) | 2022-03-10 |
| PL3436593T3 (pl) | 2023-03-27 |
| FI3436593T3 (fi) | 2023-03-16 |
| CN109196106A (zh) | 2019-01-11 |
| LT3436593T (lt) | 2023-03-10 |
| EP3436593B1 (en) | 2022-11-23 |
| JP2022166304A (ja) | 2022-11-01 |
| EP3436593A1 (en) | 2019-02-06 |
| JP7682837B2 (ja) | 2025-05-26 |
| HUE061100T2 (hu) | 2023-05-28 |
| ES2938833T3 (es) | 2023-04-17 |
| JP7356224B2 (ja) | 2023-10-04 |
| WO2017172772A1 (en) | 2017-10-05 |
| EP4159867A1 (en) | 2023-04-05 |
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