DK3440192T3 - Fremstilling af fuldt funktionsdygtige modne betaceller fra menneskelige bugspytkirtelforstadier - Google Patents

Fremstilling af fuldt funktionsdygtige modne betaceller fra menneskelige bugspytkirtelforstadier Download PDF

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DK3440192T3
DK3440192T3 DK17779928.5T DK17779928T DK3440192T3 DK 3440192 T3 DK3440192 T3 DK 3440192T3 DK 17779928 T DK17779928 T DK 17779928T DK 3440192 T3 DK3440192 T3 DK 3440192T3
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Denmark
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production
beta cells
fully functional
human pancreatic
pancreatic progenitors
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DK17779928.5T
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English (en)
Inventor
Matthias Hebrok
Holger Andreas Russ
Gopika G Nair
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Univ California
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0678—Stem cells; Progenitor cells; Precursor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases [EC 2.]
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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    • C12N2535/00—Supports or coatings for cell culture characterised by topography

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  • Gynecology & Obstetrics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK17779928.5T 2016-04-08 2017-04-07 Fremstilling af fuldt funktionsdygtige modne betaceller fra menneskelige bugspytkirtelforstadier DK3440192T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662320185P 2016-04-08 2016-04-08
US201762463561P 2017-02-24 2017-02-24
PCT/US2017/026651 WO2017177163A1 (en) 2016-04-08 2017-04-07 Production of fully functional mature beta cells from human pancreatic progenitors

Publications (1)

Publication Number Publication Date
DK3440192T3 true DK3440192T3 (da) 2024-10-28

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DK17779928.5T DK3440192T3 (da) 2016-04-08 2017-04-07 Fremstilling af fuldt funktionsdygtige modne betaceller fra menneskelige bugspytkirtelforstadier

Country Status (6)

Country Link
US (1) US11299711B2 (da)
EP (2) EP4497472A3 (da)
DK (1) DK3440192T3 (da)
ES (1) ES3002713T3 (da)
MA (1) MA45329A (da)
WO (1) WO2017177163A1 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020527956A (ja) * 2017-07-21 2020-09-17 センマ・セラピューティクス・インコーポレーテッド 幹細胞由来の膵臓ベータ細胞の再凝集
WO2019099725A1 (en) * 2017-11-15 2019-05-23 Semma Therapeutics, Inc. Islet cell manufacturing compositions and methods of use
US11951136B2 (en) 2017-12-12 2024-04-09 The Regents Of The University Of California Preservation of pancreatic islet grafts in the extrahepatic space
WO2019169351A1 (en) * 2018-03-02 2019-09-06 Semma Therapeutics, Inc. Methods of enhancing stem cell differentiation into beta cells
EP3833365A4 (en) 2018-08-10 2022-05-11 Vertex Pharmaceuticals Incorporated Stem cell derived islet differentiation
TWI862513B (zh) * 2018-09-19 2024-11-21 日商千紙鶴治療公司 包含胰島素產生細胞之細胞集團、包含該細胞集團之醫藥、其用途及製造方法
EP3868870B1 (en) * 2018-10-15 2025-12-03 Evia Life Sciences Inc. Method for producing stem/precursor cells, by using low molecular weight compound, from cells derived from endodermal tissue or organ
WO2021051256A1 (en) * 2019-09-17 2021-03-25 Center For Excellence In Molecular Cell Science, Chinese Academy Of Sciences Pancreatic pro-endocrine progenitor cells and use thereof
WO2021072390A1 (en) * 2019-10-10 2021-04-15 The Regents Of The University Of Colorado, A Body Corporate Use of entpd3 for identification, isolation, and enhancing mature stem cell derived insulin-producing cells
JP7705448B2 (ja) 2020-07-31 2025-07-09 バーテックス ファーマシューティカルズ インコーポレイテッド 膵内分泌細胞の分化
JP2024542041A (ja) 2021-11-01 2024-11-13 バーテックス ファーマシューティカルズ インコーポレイテッド 幹細胞由来の膵臓島分化
EP4569086A1 (en) * 2022-08-08 2025-06-18 Spiber Technologies AB 3d islet formation from endocrine progenitor cells
WO2024243236A2 (en) * 2023-05-22 2024-11-28 Sana Biotechnology, Inc. Methods of delivery of islet cells and related methods
IL328729A (en) 2023-12-01 2026-07-01 Sigilon Therapeutics Inc Methods for producing stem cell-derived islet-like cells, as well as populations and compositions comprising them

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8008075B2 (en) 2008-11-04 2011-08-30 Viacyte, Inc. Stem cell aggregate suspension compositions and methods of differentiation thereof
US9109245B2 (en) * 2009-04-22 2015-08-18 Viacyte, Inc. Cell compositions derived from dedifferentiated reprogrammed cells
DK2844739T3 (da) * 2012-04-30 2019-09-30 Univ Health Network FREMGANGSMÅDER OG SAMMENSÆTNINGER TIL GENERERING AF PANCREATISKE PROGENITORER OG FUNKTIONELLE BETA-CELLER UD FRA hPSC'ER
KR102084561B1 (ko) 2012-12-31 2020-03-04 얀센 바이오테크 인코포레이티드 췌장 내분비 세포로의 분화를 위한 공기-액체 계면에서의 인간 배아 줄기세포의 배양
AU2014278178B2 (en) * 2013-06-11 2021-01-21 President And Fellows Of Harvard College SC-beta cells and compositions and methods for generating the same
SG11201609473XA (en) * 2014-05-16 2016-12-29 Janssen Biotech Inc Use of small molecules to enhance mafa expression in pancreatic endocrine cells
US10975355B2 (en) 2015-04-23 2021-04-13 The Regents Of The University Of California Controlled induction of human pancreatic progenitors produces functional beta-like cells
US11332716B2 (en) 2015-07-27 2022-05-17 The Regents Of The University Of California Methods and compositions for producing pancreatic beta cells

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Publication number Publication date
EP4497472A3 (en) 2025-04-23
US11299711B2 (en) 2022-04-12
MA45329A (fr) 2019-02-13
EP3440192A4 (en) 2019-10-23
ES3002713T3 (en) 2025-03-07
US20190177697A1 (en) 2019-06-13
EP3440192A1 (en) 2019-02-13
WO2017177163A1 (en) 2017-10-12
EP3440192B1 (en) 2024-10-02
EP4497472A2 (en) 2025-01-29

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