DK3440192T3 - Fremstilling af fuldt funktionsdygtige modne betaceller fra menneskelige bugspytkirtelforstadier - Google Patents

Fremstilling af fuldt funktionsdygtige modne betaceller fra menneskelige bugspytkirtelforstadier Download PDF

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DK3440192T3
DK3440192T3 DK17779928.5T DK17779928T DK3440192T3 DK 3440192 T3 DK3440192 T3 DK 3440192T3 DK 17779928 T DK17779928 T DK 17779928T DK 3440192 T3 DK3440192 T3 DK 3440192T3
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production
beta cells
fully functional
human pancreatic
pancreatic progenitors
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DK17779928.5T
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English (en)
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Matthias Hebrok
Holger Andreas Russ
Gopika G Nair
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Univ California
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0678—Stem cells; Progenitor cells; Precursor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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DK17779928.5T 2016-04-08 2017-04-07 Fremstilling af fuldt funktionsdygtige modne betaceller fra menneskelige bugspytkirtelforstadier DK3440192T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662320185P 2016-04-08 2016-04-08
US201762463561P 2017-02-24 2017-02-24
PCT/US2017/026651 WO2017177163A1 (en) 2016-04-08 2017-04-07 Production of fully functional mature beta cells from human pancreatic progenitors

Publications (1)

Publication Number Publication Date
DK3440192T3 true DK3440192T3 (da) 2024-10-28

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Application Number Title Priority Date Filing Date
DK17779928.5T DK3440192T3 (da) 2016-04-08 2017-04-07 Fremstilling af fuldt funktionsdygtige modne betaceller fra menneskelige bugspytkirtelforstadier

Country Status (6)

Country Link
US (1) US11299711B2 (da)
EP (2) EP3440192B1 (da)
DK (1) DK3440192T3 (da)
ES (1) ES3002713T3 (da)
MA (1) MA45329A (da)
WO (1) WO2017177163A1 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111246864A (zh) * 2017-07-21 2020-06-05 森玛治疗公司 干细胞衍生的胰腺β细胞的重聚
EP3710021A4 (en) 2017-11-15 2021-08-11 Semma Therapeutics, Inc. ISLAND CELL MANUFACTURING COMPOSITIONS AND METHOD OF USE
US11951136B2 (en) 2017-12-12 2024-04-09 The Regents Of The University Of California Preservation of pancreatic islet grafts in the extrahepatic space
EP3758719A4 (en) * 2018-03-02 2021-12-08 Vertex Pharmaceuticals Inc. METHODS FOR IMPROVING THE DIFFERENTIATION OF STEM CELLS INTO BETA CELLS
WO2020033879A1 (en) 2018-08-10 2020-02-13 Semma Therapeutics, Inc. Stem cell derived islet differentiation
WO2020059892A1 (ja) * 2018-09-19 2020-03-26 武田薬品工業株式会社 インスリン産生細胞
ES3062949T3 (en) * 2018-10-15 2026-04-14 Evia Life Sciences Inc Method for producing stem/precursor cells, by using low molecular weight compound, from cells derived from endodermal tissue or organ
WO2021051256A1 (en) * 2019-09-17 2021-03-25 Center For Excellence In Molecular Cell Science, Chinese Academy Of Sciences Pancreatic pro-endocrine progenitor cells and use thereof
AU2020361709A1 (en) * 2019-10-10 2022-05-26 The Regents Of The University Of Colorado, A Body Corporate Use of ENTPD3 for identification, isolation, and enhancing mature stem cell derived insulin-producing cells
WO2022026932A2 (en) 2020-07-31 2022-02-03 Vertex Pharmaceuticals Incorporated Differentiation of pancreatic endocrine cells
CA3232971A1 (en) 2021-11-01 2023-05-04 George Harb Stem cell derived pancreatic islet differentiation
CN119923461A (zh) * 2022-08-08 2025-05-02 思百博技术股份公司 从内分泌祖细胞的3d胰岛形成
EP4716541A2 (en) * 2023-05-22 2026-04-01 Sana Biotechnology, Inc. Methods of delivery of islet cells and related methods
WO2025117331A1 (en) 2023-12-01 2025-06-05 Eli Lilly And Company Methods of making stem cell-derived islet-like cells, as well as populations and compositions including the same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8008075B2 (en) 2008-11-04 2011-08-30 Viacyte, Inc. Stem cell aggregate suspension compositions and methods of differentiation thereof
US9109245B2 (en) 2009-04-22 2015-08-18 Viacyte, Inc. Cell compositions derived from dedifferentiated reprogrammed cells
HRP20191677T1 (hr) 2012-04-30 2019-12-13 Univ Health Network POSTUPCI I SASTAVI ZA GENERIRANJE PANKREASNIH PROGENITORA I FUNKCIONALNIH BETA STANICA IZ hPSC
ES2837763T3 (es) * 2012-12-31 2021-07-01 Janssen Biotech Inc Cultivo de células madre embrionarias humanas en la interconexión aire-líquido para la diferenciación en células endocrinas pancreáticas
CN120796168A (zh) * 2013-06-11 2025-10-17 哈佛学院校长同事会 SC-β细胞以及用于产生其的组合物和方法
WO2015175307A1 (en) * 2014-05-16 2015-11-19 Janssen Biotech, Inc. Use of small molecules to enhance mafa expression in pancreatic endocrine cells
EP3286563B1 (en) * 2015-04-23 2022-11-02 The Regents of The University of California Controlled induction of human pancreatic progenitors produces functional beta-like cells
EP3328404A4 (en) 2015-07-27 2018-12-26 The Regents of The University of California Methods and compositions for producing pancreatic beta cells

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Publication number Publication date
EP3440192A1 (en) 2019-02-13
EP4497472A3 (en) 2025-04-23
US20190177697A1 (en) 2019-06-13
EP3440192A4 (en) 2019-10-23
ES3002713T3 (en) 2025-03-07
WO2017177163A1 (en) 2017-10-12
US11299711B2 (en) 2022-04-12
MA45329A (fr) 2019-02-13
EP3440192B1 (en) 2024-10-02
EP4497472A2 (en) 2025-01-29

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