DK344488A - Hexacycliske forbindelser - Google Patents
Hexacycliske forbindelserInfo
- Publication number
- DK344488A DK344488A DK344488A DK344488A DK344488A DK 344488 A DK344488 A DK 344488A DK 344488 A DK344488 A DK 344488A DK 344488 A DK344488 A DK 344488A DK 344488 A DK344488 A DK 344488A
- Authority
- DK
- Denmark
- Prior art keywords
- compound
- hexacyclic compounds
- antitumour
- camptothecin
- chem
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- -1 aminoketone compound Chemical class 0.000 abstract 2
- 230000000259 anti-tumor effect Effects 0.000 abstract 2
- 238000006928 Friedlaender synthesis reaction Methods 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Luminescent Compositions (AREA)
- Lubricants (AREA)
- Fats And Perfumes (AREA)
- Liquid Crystal Substances (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15699087 | 1987-06-24 | ||
| JP550388 | 1988-01-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK344488D0 DK344488D0 (da) | 1988-06-23 |
| DK344488A true DK344488A (da) | 1989-02-24 |
Family
ID=26339454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK344488A DK344488A (da) | 1987-06-24 | 1988-06-23 | Hexacycliske forbindelser |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US4939255A (da) |
| EP (1) | EP0296597B1 (da) |
| KR (1) | KR960002853B1 (da) |
| AT (1) | ATE111913T1 (da) |
| AU (1) | AU610189B2 (da) |
| CA (1) | CA1304370C (da) |
| DE (1) | DE3851577T2 (da) |
| DK (1) | DK344488A (da) |
| ES (1) | ES2064329T3 (da) |
| FI (1) | FI91872C (da) |
| IE (1) | IE61281B1 (da) |
| NO (1) | NO167738C (da) |
| PH (1) | PH27557A (da) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4939255A (en) * | 1987-06-24 | 1990-07-03 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic camptothecin derivatives |
| US5552154A (en) * | 1989-11-06 | 1996-09-03 | The Stehlin Foundation For Cancer Research | Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof |
| US5658920A (en) * | 1991-01-16 | 1997-08-19 | Daiichi Pharmaceutical Co., Ltd. | Substituted 1H,12H-benz-[DE]pyrano[3',4':6,7] indolizino[1,2-B]quinoline-10,13(9H,15H)-dione compound |
| JP3008226B2 (ja) * | 1991-01-16 | 2000-02-14 | 第一製薬株式会社 | 六環性化合物 |
| US6407115B1 (en) * | 1991-01-16 | 2002-06-18 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic compound |
| US6080751A (en) * | 1992-01-14 | 2000-06-27 | The Stehlin Foundation For Cancer Research | Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof |
| US5446047A (en) * | 1992-07-23 | 1995-08-29 | Sloan-Kettering Institute For Cancer Research | Camptothecin analogues |
| US5391745A (en) * | 1992-07-23 | 1995-02-21 | Sloan-Kettering Institute For Cancer Research | Methods of preparation of camptothecin analogs |
| US6504029B1 (en) | 1995-04-10 | 2003-01-07 | Daiichi Pharmaceutical Co., Ltd. | Condensed-hexacyclic compounds and a process therefor |
| US5663177A (en) * | 1995-05-31 | 1997-09-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs |
| US5670500A (en) * | 1995-05-31 | 1997-09-23 | Smithkline Beecham Corporation | Water soluble camptothecin analogs |
| EP0835303A4 (en) * | 1995-06-07 | 2000-09-13 | Univ Jefferson | Anti-fungal agents and methods of identifying and using the same |
| SG50747A1 (en) * | 1995-08-02 | 1998-07-20 | Tanabe Seiyaku Co | Comptothecin derivatives |
| SG103322A1 (en) * | 1996-10-30 | 2004-04-29 | Tanabe Seiyaku Co | S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof |
| KR19980076076A (ko) * | 1997-04-04 | 1998-11-16 | 유현식 | 전선용 발포성 수지조성물 |
| US6046209A (en) * | 1997-05-27 | 2000-04-04 | Smithkline Beecham Corporation | Water soluble camptothecin analogs |
| IN189180B (da) | 1997-07-09 | 2003-01-04 | Chong Kun Dang Corp | |
| JP4094710B2 (ja) | 1997-11-06 | 2008-06-04 | 株式会社ヤクルト本社 | 新規なカンプトテシン誘導体 |
| AU775373B2 (en) | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| FR2801309B1 (fr) * | 1999-11-18 | 2002-01-04 | Adir | Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| ATE398131T1 (de) * | 2001-11-30 | 2008-07-15 | Chugai Pharmaceutical Co Ltd | Kondensierte camptothecine als antitumormittel |
| US7563810B2 (en) | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
| US8034831B2 (en) | 2002-11-06 | 2011-10-11 | Celgene Corporation | Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies |
| US7595400B2 (en) | 2003-02-21 | 2009-09-29 | Chugai Seiyaku Kabushiki Kaisha | Process for the preparation of hexacyclic compounds |
| TWI351284B (en) | 2004-04-09 | 2011-11-01 | Chugai Pharmaceutical Co Ltd | Novel water-soluble prodrugs |
| TW200744603A (en) | 2005-08-22 | 2007-12-16 | Chugai Pharmaceutical Co Ltd | Novel anticancer concomitant drug |
| CN102060713A (zh) * | 2010-12-09 | 2011-05-18 | 中华人民共和国嘉兴出入境检验检疫局 | 用于检测偶氮类染料的芳香胺半抗原及其制备方法 |
| MX2021011812A (es) | 2019-03-29 | 2021-10-22 | Medimmune Ltd | Compuestos y conjugados de estos. |
| EP4093439A1 (en) | 2020-01-22 | 2022-11-30 | MedImmune Limited | Compounds and conjugates thereof |
| TW202140076A (zh) * | 2020-01-22 | 2021-11-01 | 英商梅迪繆思有限公司 | 化合物及其軛合物 |
| TW202320858A (zh) | 2021-07-19 | 2023-06-01 | 美商薩諾管理公司 | 免疫接合物及方法 |
| US11806405B1 (en) | 2021-07-19 | 2023-11-07 | Zeno Management, Inc. | Immunoconjugates and methods |
| CA3241157A1 (en) * | 2021-12-16 | 2023-06-22 | Wei Zhou | Camptothecin compound and conjugate thereof |
| IL315366A (en) | 2022-03-23 | 2024-11-01 | Synaffix Bv | Antibody pairs for targeting PTK7-expressing tumors |
| US20250205353A1 (en) | 2022-03-23 | 2025-06-26 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing nectin-4 |
| CA3253220A1 (en) | 2022-03-23 | 2023-09-28 | Synaffix B.V. | ANTIBODIES CONJUGATED FOR TARGETING TUMORS EXPRESSING TROP-2 |
| KR20250024741A (ko) | 2022-03-23 | 2025-02-19 | 시나픽스 비.브이. | 암배아성 항원을 발현하는 종양을 표적화하기 위한 항체-컨쥬게이트 |
| EP4644395A1 (en) * | 2022-12-30 | 2025-11-05 | Changchun Genescience Pharmaceutical Co., Ltd. | Camptothecin derivative, pharmaceutical composition, and preparation method and use therefor |
| CN119630672B (zh) * | 2023-02-23 | 2026-01-30 | 一线医药（杭州）有限公司 | 喜树碱衍生物及其偶联物以及其制备方法和医药用途 |
| AU2024271903A1 (en) * | 2023-05-12 | 2025-10-09 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Linker compounds and ligand-drug conjugates, preparation methods and uses thereof |
| WO2025021152A1 (zh) * | 2023-07-26 | 2025-01-30 | 上海医药集团股份有限公司 | 喜树碱类小分子及其抗体药物偶联物、制备方法和应用 |
| WO2025167743A1 (zh) * | 2024-02-06 | 2025-08-14 | 四川科伦博泰生物医药股份有限公司 | 抗体药物偶联物及其制备方法和用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US32518A (en) * | 1861-06-11 | Improvement in city railroads | ||
| JPS51288A (ja) * | 1974-06-18 | 1976-01-05 | Tamura Seisakusho Kk | Hanshakyoshinhoshasochi |
| US4399282A (en) | 1979-07-10 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives |
| US4399276A (en) * | 1981-01-09 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | 7-Substituted camptothecin derivatives |
| US4473692A (en) * | 1981-09-04 | 1984-09-25 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives and process for preparing same |
| JPS5839685A (ja) * | 1981-09-04 | 1983-03-08 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体及びその製造法 |
| JPS58154582A (ja) * | 1982-03-10 | 1983-09-14 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体およびその製造法 |
| JPS6019790A (ja) * | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
| DE3682874D1 (de) * | 1985-10-21 | 1992-01-23 | Daiichi Seiyaku Co | Pyranoindolizinderivate und verfahren zu ihrer herstellung. |
| US4939255A (en) * | 1987-06-24 | 1990-07-03 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic camptothecin derivatives |
| US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
| JPH0615547B2 (ja) * | 1988-01-20 | 1994-03-02 | 株式会社ヤクルト本社 | 新規なカンプトテシン誘導体 |
-
1988
- 1988-06-16 US US07/207,718 patent/US4939255A/en not_active Expired - Fee Related
- 1988-06-20 IE IE186088A patent/IE61281B1/en not_active IP Right Cessation
- 1988-06-21 CA CA000569969A patent/CA1304370C/en not_active Expired - Lifetime
- 1988-06-23 DK DK344488A patent/DK344488A/da not_active Application Discontinuation
- 1988-06-23 NO NO882785A patent/NO167738C/no unknown
- 1988-06-23 ES ES88110044T patent/ES2064329T3/es not_active Expired - Lifetime
- 1988-06-23 AT AT88110044T patent/ATE111913T1/de not_active IP Right Cessation
- 1988-06-23 EP EP88110044A patent/EP0296597B1/en not_active Expired - Lifetime
- 1988-06-23 FI FI883050A patent/FI91872C/fi not_active IP Right Cessation
- 1988-06-23 DE DE3851577T patent/DE3851577T2/de not_active Expired - Fee Related
- 1988-06-24 AU AU18349/88A patent/AU610189B2/en not_active Ceased
- 1988-06-24 KR KR1019880007643A patent/KR960002853B1/ko not_active Expired - Fee Related
- 1988-07-22 PH PH37104A patent/PH27557A/en unknown
-
1989
- 1989-12-27 US US07/457,921 patent/US5061795A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US4939255A (en) | 1990-07-03 |
| NO882785L (no) | 1988-12-27 |
| AU610189B2 (en) | 1991-05-16 |
| IE61281B1 (en) | 1994-10-19 |
| KR960002853B1 (ko) | 1996-02-27 |
| FI91872B (fi) | 1994-05-13 |
| NO882785D0 (no) | 1988-06-23 |
| EP0296597B1 (en) | 1994-09-21 |
| DK344488D0 (da) | 1988-06-23 |
| EP0296597A3 (en) | 1991-07-31 |
| FI883050A0 (fi) | 1988-06-23 |
| AU1834988A (en) | 1989-01-05 |
| NO167738B (no) | 1991-08-26 |
| US5061795A (en) | 1991-10-29 |
| EP0296597A2 (en) | 1988-12-28 |
| IE881860L (en) | 1988-12-24 |
| ATE111913T1 (de) | 1994-10-15 |
| DE3851577D1 (de) | 1994-10-27 |
| FI883050L (fi) | 1988-12-25 |
| DE3851577T2 (de) | 1995-04-27 |
| NO167738C (no) | 1991-12-04 |
| PH27557A (en) | 1993-08-18 |
| KR890000489A (ko) | 1989-03-15 |
| ES2064329T3 (es) | 1995-02-01 |
| CA1304370C (en) | 1992-06-30 |
| FI91872C (fi) | 1994-08-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHS | Application shelved for other reasons than non-payment |