DK3455232T3 - Forbedret kobling af stereodefinerede oxazaphospholidin-phosphoramidit-monomerer til nukleosid eller oligonukleotid - Google Patents
Forbedret kobling af stereodefinerede oxazaphospholidin-phosphoramidit-monomerer til nukleosid eller oligonukleotid Download PDFInfo
- Publication number
- DK3455232T3 DK3455232T3 DK17725886.0T DK17725886T DK3455232T3 DK 3455232 T3 DK3455232 T3 DK 3455232T3 DK 17725886 T DK17725886 T DK 17725886T DK 3455232 T3 DK3455232 T3 DK 3455232T3
- Authority
- DK
- Denmark
- Prior art keywords
- stereodefined
- oxazaphospholidine
- nucleoside
- oligonucleotide
- improved coupling
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16169429 | 2016-05-12 | ||
| EP17163513 | 2017-03-29 | ||
| EP17163604 | 2017-03-29 | ||
| PCT/EP2017/060985 WO2017194498A1 (en) | 2016-05-12 | 2017-05-09 | Enhanced coupling of stereodefined oxazaphospholidine phosphoramidite monomers to nucleoside or oligonucleotide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3455232T3 true DK3455232T3 (da) | 2020-07-06 |
Family
ID=58772850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17725886.0T DK3455232T3 (da) | 2016-05-12 | 2017-05-09 | Forbedret kobling af stereodefinerede oxazaphospholidin-phosphoramidit-monomerer til nukleosid eller oligonukleotid |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11261209B2 (da) |
| EP (1) | EP3455232B1 (da) |
| JP (1) | JP7097820B2 (da) |
| CN (1) | CN109311925B (da) |
| DK (1) | DK3455232T3 (da) |
| WO (1) | WO2017194498A1 (da) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102282155B (zh) | 2008-12-02 | 2017-06-09 | 日本波涛生命科学公司 | 磷原子修饰的核酸的合成方法 |
| RU2612521C2 (ru) | 2009-07-06 | 2017-03-09 | Онтории, Инк. | Новые пролекарства нуклеиновых кислот и способы их применения |
| JP5868324B2 (ja) | 2010-09-24 | 2016-02-24 | 株式会社Wave Life Sciences Japan | 不斉補助基 |
| CN103796657B (zh) | 2011-07-19 | 2017-07-11 | 波涛生命科学有限公司 | 合成官能化核酸的方法 |
| PL2872485T3 (pl) | 2012-07-13 | 2021-05-31 | Wave Life Sciences Ltd. | Asymetryczna grupa pomocnicza |
| KR102213609B1 (ko) | 2012-07-13 | 2021-02-08 | 웨이브 라이프 사이언시스 리미티드 | 키랄 제어 |
| JPWO2015108047A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| BR112016016400A2 (pt) | 2014-01-16 | 2017-10-03 | Wave Life Sciences Ltd | Composições de oligonucleotídeos quiralmente controlados, seu uso, sua composição farmacêutica, e métodos |
| KR20190135494A (ko) * | 2017-03-29 | 2019-12-06 | 로슈 이노베이션 센터 코펜하겐 에이/에스 | 입체한정된 포스포로티오에이트 올리고뉴클레오티드의 제조를 위한 직교 보호기 |
| WO2019002237A1 (en) * | 2017-06-28 | 2019-01-03 | Roche Innovation Center Copenhagen A/S | METHOD OF MULTIPLE COUPLING AND OXIDATION |
| KR102723989B1 (ko) | 2017-12-01 | 2024-11-01 | 더 텍사스 에이 & 엠 유니버시티 시스템 | 엔젤만 증후군 안티센스 치료 |
| WO2020104492A1 (en) * | 2018-11-22 | 2020-05-28 | Roche Innovation Center Copenhagen A/S | Pyridinium salts as activators in the synthesis of stereodefined oligonucleotides |
| US12421268B2 (en) | 2019-04-16 | 2025-09-23 | Roche Innovation Center Copenhagen A/S | Process for preparing nucleotide P(V) monomers |
| EP4047004B1 (en) * | 2019-10-18 | 2024-03-06 | FUJIFILM Wako Pure Chemical Corporation | Phosphoramidite activator |
| IL293327B2 (en) * | 2019-11-27 | 2026-04-01 | Alnylam Pharmaceuticals Inc | Synthesis of 3'-RNA oligonucleotides |
| CN112898363B (zh) * | 2021-01-25 | 2024-06-04 | 苏州金唯智生物科技有限公司 | 一种亚磷酰胺单体组合物及其制备方法和应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007090071A2 (en) | 2006-01-27 | 2007-08-09 | Isis Pharmaceuticals, Inc. | 6-modified bicyclic nucleic acid analogs |
| EP2007888A2 (en) | 2006-04-03 | 2008-12-31 | Santaris Pharma A/S | Pharmaceutical composition comprising anti-mirna antisense oligonucleotides |
| JP2009536222A (ja) * | 2006-05-05 | 2009-10-08 | アイシス ファーマシューティカルズ， インコーポレーテッド | Ｐｃｓｋ９の発現を調節するための化合物および方法 |
| EP2623599B1 (en) | 2007-10-04 | 2019-01-02 | Roche Innovation Center Copenhagen A/S | Micromirs |
| US9290534B2 (en) | 2008-04-04 | 2016-03-22 | Ionis Pharmaceuticals, Inc. | Oligomeric compounds having at least one neutrally linked terminal bicyclic nucleoside |
| DK2356129T3 (da) | 2008-09-24 | 2013-05-13 | Isis Pharmaceuticals Inc | Substituerede alpha-L-bicykliske nukleosider |
| KR102213609B1 (ko) * | 2012-07-13 | 2021-02-08 | 웨이브 라이프 사이언시스 리미티드 | 키랄 제어 |
| PL2872485T3 (pl) * | 2012-07-13 | 2021-05-31 | Wave Life Sciences Ltd. | Asymetryczna grupa pomocnicza |
| PL231078B1 (pl) * | 2012-08-05 | 2019-01-31 | Inst Chemii Bioorganicznej Polskiej Akademii Nauk | Sposób syntezy polifosforanów |
| AU2015217221A1 (en) * | 2014-02-13 | 2016-08-11 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and their uses |
-
2017
- 2017-05-09 EP EP17725886.0A patent/EP3455232B1/en active Active
- 2017-05-09 CN CN201780029201.6A patent/CN109311925B/zh active Active
- 2017-05-09 DK DK17725886.0T patent/DK3455232T3/da active
- 2017-05-09 WO PCT/EP2017/060985 patent/WO2017194498A1/en not_active Ceased
- 2017-05-09 JP JP2018559225A patent/JP7097820B2/ja active Active
- 2017-05-09 US US16/300,309 patent/US11261209B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2019514999A (ja) | 2019-06-06 |
| WO2017194498A1 (en) | 2017-11-16 |
| US11261209B2 (en) | 2022-03-01 |
| EP3455232B1 (en) | 2020-05-06 |
| CN109311925A (zh) | 2019-02-05 |
| CN109311925B (zh) | 2022-06-03 |
| EP3455232A1 (en) | 2019-03-20 |
| JP7097820B2 (ja) | 2022-07-08 |
| US20190153012A1 (en) | 2019-05-23 |
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