DK349688A - Bomologe af humant aprotinin, vaertsstamme samt ekspressionsvektorer til deres fremstilling og deres anvendelse som laegemidler - Google Patents

Bomologe af humant aprotinin, vaertsstamme samt ekspressionsvektorer til deres fremstilling og deres anvendelse som laegemidler

Info

Publication number: DK349688A
Authority: DK; Denmark
Prior art keywords: bomologist; humant; aprotinin; medicines; preparation
Prior art date: 1987-06-27

Application number

DK349688A

Other languages

English (en)

Other versions

DK349688D0 (da

Inventor

Wolfgang Bruns

Juergen Ebbers

Hans Dietrich Hoerlein

Eugen Schnabel

Werner Schroeder

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-06-27

Filing date

1988-06-24

Publication date

1988-12-28

1988-06-24 Application filed by Bayer Ag filed Critical Bayer Ag

1988-06-24 Publication of DK349688D0 publication Critical patent/DK349688D0/da

1988-12-28 Publication of DK349688A publication Critical patent/DK349688A/da

Links

108010039627 Aprotinin Proteins 0.000 title 1
229960004405 aprotinin Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
239000013604 expression vector Substances 0.000 title 1
ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Oncology (AREA)
Biochemistry (AREA)
Communicable Diseases (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Gastroenterology & Hepatology (AREA)
Virology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK349688A 1987-06-27 1988-06-24 Bomologe af humant aprotinin, vaertsstamme samt ekspressionsvektorer til deres fremstilling og deres anvendelse som laegemidler DK349688A (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3721240		1987-06-27
DE19873724570 DE3724570A1 (de)	1987-06-27	1987-07-24	Human-aprotinin, dessen lys-rest in position 15 gegen einen anderen protogenen aminosaeurerest ausgetauscht ist

Publications (2)

Publication Number	Publication Date
DK349688D0 DK349688D0 (da)	1988-06-24
DK349688A true DK349688A (da)	1988-12-28

Family

ID=25857006

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK349688A DK349688A (da)	1987-06-27	1988-06-24	Bomologe af humant aprotinin, vaertsstamme samt ekspressionsvektorer til deres fremstilling og deres anvendelse som laegemidler

Country Status (5)

Country	Link
EP (1)	EP0297362A3 (da)
JP (1)	JPH02439A (da)
DE (1)	DE3724570A1 (da)
DK (1)	DK349688A (da)
IL (1)	IL86852A0 (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5223482A (en) *	1986-11-17	1993-06-29	Scios Nova Inc.	Recombinant Alzheimer's protease inhibitory amyloid protein and method of use
GB2208511A (en) *	1987-08-07	1989-04-05	Bayer Ag	Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology
US5591603A (en) *	1987-08-28	1997-01-07	Novo Nordisk A/S	Process for preparing aprotinin and aprotinin analogs in yeast cells
DK225488D0 (da) *	1988-04-26	1988-04-26	Novo Industri As	Polypeptid
US5223409A (en) *	1988-09-02	1993-06-29	Protein Engineering Corp.	Directed evolution of novel binding proteins
DE3912638A1 (de) *	1989-04-18	1990-10-31	Bayer Ag	Gentechnologisch hergestellte homologe des alzheimer protease inhibitors, wirtstaemme sowie expressionsvektoren fuer ihre herstellung und ihre verwendung als arzneimittel
US7413537B2 (en)	1989-09-01	2008-08-19	Dyax Corp.	Directed evolution of disulfide-bonded micro-proteins
IL99585A0 (en) *	1990-10-01	1992-08-18	Novo Nordisk As	Aprotinin analogues,their production and pharmaceutical compositions containing them
EP0575485A1 (en)	1991-03-01	1993-12-29	Dyax Corp.	Process for the development of binding mini-proteins
IL104314A0 (en) *	1992-01-07	1993-05-13	Novo Nordisk As	Human kunitz-type protease inhibitor and variants thereof,their production and pharmaceutical compositions containing them
KR101409877B1 (ko) *	2011-11-14	2014-06-20	엘지전자 주식회사	합금주철 및 그를 이용한 로터리 압축기용 베인의 제조방법
WO2016042131A1 (en) *	2014-09-18	2016-03-24	The Provost, Fellows, Foundation Scholars, & The Other Members Of Board, Of The College Of The Holy & Undiv. Trinity Of Queen Elizabeth Near Dublin	Use of inhibitors of il-36 proteolytic processing for the treatment and/or reduction of inflammation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU560584B2 (en) *	1983-07-28	1987-04-09	Bayer Aktiengesellschaft	Homologues of aprotinin
DE3523701A1 (de) *	1985-07-03	1987-01-08	Bayer Ag	Verfahren zur herstellung von proteinen und polypeptiden
GB2188322A (en) *	1986-03-26	1987-09-30	Bayer Ag	Aprotinin and analogues thereof produced by a recombinant host
GB2188933A (en) *	1986-04-10	1987-10-14	Bayer Ag	Expression vectors for production of polypeptides, method for enhanced expression of polypeptides, hosts containing the expression vectors, products manufactured thereby

1987
- 1987-07-24 DE DE19873724570 patent/DE3724570A1/de not_active Withdrawn
1988
- 1988-06-16 EP EP88109617A patent/EP0297362A3/de not_active Withdrawn
- 1988-06-24 IL IL86852A patent/IL86852A0/xx unknown
- 1988-06-24 DK DK349688A patent/DK349688A/da not_active Application Discontinuation
- 1988-06-27 JP JP63159055A patent/JPH02439A/ja active Pending

Also Published As

Publication number	Publication date
EP0297362A2 (de)	1989-01-04
JPH02439A (ja)	1990-01-05
EP0297362A3 (de)	1990-05-30
IL86852A0 (en)	1988-11-30
DE3724570A1 (de)	1989-01-05
DK349688D0 (da)	1988-06-24

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Legal Events

Date	Code	Title	Description
1993-04-13	ATS	Application withdrawn