DK3527280T3 - Selektiv modificering af polymerunderenheder til forbedring af nanoporebaseret analyse - Google Patents
Selektiv modificering af polymerunderenheder til forbedring af nanoporebaseret analyse Download PDFInfo
- Publication number
- DK3527280T3 DK3527280T3 DK19151505.5T DK19151505T DK3527280T3 DK 3527280 T3 DK3527280 T3 DK 3527280T3 DK 19151505 T DK19151505 T DK 19151505T DK 3527280 T3 DK3527280 T3 DK 3527280T3
- Authority
- DK
- Denmark
- Prior art keywords
- nanopore
- enhance
- based analysis
- selective modification
- polymer subunits
- Prior art date
Links
- 230000004048 modification Effects 0.000 title 1
- 238000012986 modification Methods 0.000 title 1
- 229920000642 polymer Polymers 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D57/00—Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. B03C
- B01D57/02—Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. B03C by electrophoresis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Electrochemistry (AREA)
- Environmental & Geological Engineering (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- General Chemical & Material Sciences (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361872406P | 2013-08-30 | 2013-08-30 | |
| EP14841122.6A EP3038738B1 (en) | 2013-08-30 | 2014-09-02 | Selective modification of polymer subunits to improve nanopore-based analysis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3527280T3 true DK3527280T3 (da) | 2021-08-30 |
Family
ID=52587420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19151505.5T DK3527280T3 (da) | 2013-08-30 | 2014-09-02 | Selektiv modificering af polymerunderenheder til forbedring af nanoporebaseret analyse |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US10017814B2 (da) |
| EP (3) | EP3527280B1 (da) |
| CN (2) | CN105992634B (da) |
| AU (5) | AU2014312020B2 (da) |
| CA (1) | CA2921700A1 (da) |
| DK (1) | DK3527280T3 (da) |
| ES (1) | ES2896017T3 (da) |
| WO (1) | WO2015031909A1 (da) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010086622A1 (en) | 2009-01-30 | 2010-08-05 | Oxford Nanopore Technologies Limited | Adaptors for nucleic acid constructs in transmembrane sequencing |
| IN2014DN00221A (da) | 2011-07-25 | 2015-06-05 | Oxford Nanopore Tech Ltd | |
| WO2014013259A1 (en) | 2012-07-19 | 2014-01-23 | Oxford Nanopore Technologies Limited | Ssb method |
| GB201314695D0 (en) | 2013-08-16 | 2013-10-02 | Oxford Nanopore Tech Ltd | Method |
| BR112015021788B1 (pt) | 2013-03-08 | 2023-02-28 | Oxford Nanopore Technologies Plc | Métodos para mover uma ou mais helicases imobilizadas, para controlar o movimento de um polinucleotídeo alvo, para caracterizar um polinucleotídeo alvo e para controlar o carregamento de uma ou mais helicases em um polinucleotídeo alvo, uso de um poro de transmembrana e de um potencial aplicado e de um ou mais espaçadores, complexo, e, kit |
| CN106133513B (zh) | 2014-02-19 | 2019-08-13 | 华盛顿大学 | 蛋白质特征的基于纳米孔的分析 |
| GB201403096D0 (en) | 2014-02-21 | 2014-04-09 | Oxford Nanopore Tech Ltd | Sample preparation method |
| GB201418159D0 (en) | 2014-10-14 | 2014-11-26 | Oxford Nanopore Tech Ltd | Method |
| US10760117B2 (en) * | 2015-04-06 | 2020-09-01 | The Regents Of The University Of California | Methods for determining base locations in a polynucleotide |
| GB201609220D0 (en) | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
| US20180164280A1 (en) * | 2016-11-07 | 2018-06-14 | Ibis Biosciences, Inc. | Modified nucleic acids for nanopore analysis |
| CN106609282A (zh) * | 2016-12-02 | 2017-05-03 | 中国科学院上海生命科学研究院 | 一种用于植物基因组定点碱基替换的载体 |
| GB201707138D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Machine learning analysis of nanopore measurements |
| CN111919118B (zh) * | 2018-04-13 | 2025-09-05 | 豪夫迈·罗氏有限公司 | 用于检测和分析分析物的方法和组合物 |
| GB201807793D0 (en) | 2018-05-14 | 2018-06-27 | Oxford Nanopore Tech Ltd | Method |
| GB201814369D0 (en) * | 2018-09-04 | 2018-10-17 | Oxford Nanopore Tech Ltd | Method for determining a polymersequence |
| WO2020168286A1 (en) * | 2019-02-14 | 2020-08-20 | University Of Washington | Systems and methods for improved nanopore-based analysis of nucleic acids |
| CN112179955B (zh) * | 2020-09-27 | 2024-05-10 | 西北工业大学 | 基于聚精氨酸和聚谷氨酸逐层修饰的纳米孔制备pH响应的纳米流体二极管方法 |
| CN116165373A (zh) * | 2021-08-30 | 2023-05-26 | 四川大学 | 一种基于铜离子修饰MspA纳米孔的多肽成分分析方法 |
| CN117238360A (zh) * | 2023-10-11 | 2023-12-15 | 南方科技大学 | 提高生物分子在纳米孔分析时的数据存储稳定性、保密性和数据准确性的方法 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6362002B1 (en) | 1995-03-17 | 2002-03-26 | President And Fellows Of Harvard College | Characterization of individual polymer molecules based on monomer-interface interactions |
| US6500650B1 (en) * | 1998-10-01 | 2002-12-31 | Variagenics, Inc. | Method for identifying polymorphisms |
| US7258838B2 (en) | 1999-06-22 | 2007-08-21 | President And Fellows Of Harvard College | Solid state molecular probe device |
| US6800195B1 (en) | 2002-06-04 | 2004-10-05 | Thermaco, Inc. | Low cost grease removal system |
| AU2003903430A0 (en) * | 2003-07-04 | 2003-07-17 | Johnson & Johnson Research Pty Limited | Method for detection of alkylated cytosine in dna |
| US20050136408A1 (en) * | 2003-12-19 | 2005-06-23 | May Tom-Moy | Methods and systems for characterizing a polymer |
| US7279337B2 (en) * | 2004-03-10 | 2007-10-09 | Agilent Technologies, Inc. | Method and apparatus for sequencing polymers through tunneling conductance variation detection |
| WO2006056480A2 (en) * | 2004-11-29 | 2006-06-01 | Klinikum Der Universität Regensburg | Means and methods for detecting methylated dna |
| US20070117114A1 (en) * | 2005-07-07 | 2007-05-24 | Quanta Biosciences, Inc. | Compositions and methods for increasing amplification efficiency |
| US8889348B2 (en) * | 2006-06-07 | 2014-11-18 | The Trustees Of Columbia University In The City Of New York | DNA sequencing by nanopore using modified nucleotides |
| WO2008124706A2 (en) * | 2007-04-06 | 2008-10-16 | Arizona Board Of Regents Acting For And On Behalf Of Arizona State University | Devices and methods for target molecule characterization |
| WO2009092035A2 (en) * | 2008-01-17 | 2009-07-23 | Sequenom, Inc. | Methods and compositions for the analysis of biological molecules |
| JP2009247260A (ja) | 2008-04-04 | 2009-10-29 | Sumitomo Chemical Co Ltd | Ｄｎａメチル化測定方法 |
| CN102216783B (zh) | 2008-09-22 | 2015-04-01 | 华盛顿大学 | Msp纳米微孔和相关方法 |
| WO2010068289A2 (en) * | 2008-12-11 | 2010-06-17 | Pacific Biosciences Of California, Inc. | Classification of nucleic acid templates |
| EP2483680A4 (en) * | 2009-09-30 | 2014-01-01 | Quantapore Inc | ULTRASOUND SEQUENCING OF BIOLOGICAL POLYMERS WITH THE HELP OF A MARKED NANOPORE |
| US8748091B2 (en) * | 2009-12-18 | 2014-06-10 | The Board Of Trustees Of The University Of Illinois | Characterizing stretched polynucleotides in a synthetic nanopassage |
| US9121823B2 (en) * | 2010-02-19 | 2015-09-01 | The Trustees Of The University Of Pennsylvania | High-resolution analysis devices and related methods |
| WO2011106456A2 (en) | 2010-02-23 | 2011-09-01 | University Of Washington | Artificial mycolic acid membranes |
| US9005425B2 (en) * | 2010-03-05 | 2015-04-14 | University Of Utah Research Foundation | Detection of nucleic acid lesions and adducts using nanopores |
| US8652779B2 (en) * | 2010-04-09 | 2014-02-18 | Pacific Biosciences Of California, Inc. | Nanopore sequencing using charge blockade labels |
| WO2012019320A1 (zh) * | 2010-08-11 | 2012-02-16 | 中国科学院心理研究所 | 一种甲基化dna的高通量测序方法及其应用 |
| EP2652153B1 (en) * | 2010-12-17 | 2017-07-05 | The Trustees of Columbia University in the City of New York | Dna sequencing by synthesis using modified nucleotides and nanopore detection |
| WO2012088339A2 (en) * | 2010-12-22 | 2012-06-28 | Genia Technologies, Inc. | Nanopore-based single dna molecule characterization using speed bumps |
| GB201120910D0 (en) | 2011-12-06 | 2012-01-18 | Cambridge Entpr Ltd | Nanopore functionality control |
| ES2669214T3 (es) * | 2011-12-13 | 2018-05-24 | Oslo Universitetssykehus Hf | Procedimientos y kits para la detección de estado de metilación |
| US9116118B2 (en) * | 2012-06-08 | 2015-08-25 | Pacific Biosciences Of California, Inc. | Modified base detection with nanopore sequencing |
| WO2014071250A1 (en) * | 2012-11-01 | 2014-05-08 | University Of Washington Through Its Center For Commercialization | Methods for detecting and mapping modifications to nucleic acid polymers using nanopore systems |
-
2014
- 2014-09-02 US US14/915,611 patent/US10017814B2/en active Active
- 2014-09-02 EP EP19151505.5A patent/EP3527280B1/en active Active
- 2014-09-02 AU AU2014312020A patent/AU2014312020B2/en active Active
- 2014-09-02 CN CN201480047714.6A patent/CN105992634B/zh active Active
- 2014-09-02 EP EP14841122.6A patent/EP3038738B1/en active Active
- 2014-09-02 ES ES19151505T patent/ES2896017T3/es active Active
- 2014-09-02 DK DK19151505.5T patent/DK3527280T3/da active
- 2014-09-02 WO PCT/US2014/053754 patent/WO2015031909A1/en not_active Ceased
- 2014-09-02 CA CA2921700A patent/CA2921700A1/en active Pending
- 2014-09-02 CN CN201910422919.2A patent/CN110124515B/zh active Active
- 2014-09-02 EP EP21179889.7A patent/EP3936222A1/en active Pending
-
2018
- 2018-07-06 US US16/029,396 patent/US10822652B2/en active Active
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2019
- 2019-01-11 AU AU2019200189A patent/AU2019200189B2/en active Active
-
2020
- 2020-09-22 US US17/028,784 patent/US20210032695A1/en not_active Abandoned
- 2020-11-25 AU AU2020277162A patent/AU2020277162B2/en active Active
-
2023
- 2023-04-19 AU AU2023202390A patent/AU2023202390B2/en active Active
-
2024
- 2024-07-11 US US18/769,519 patent/US20240360502A1/en active Pending
-
2025
- 2025-03-12 AU AU2025201791A patent/AU2025201791A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2020277162A1 (en) | 2020-12-24 |
| AU2025201791A1 (en) | 2025-04-03 |
| EP3038738A1 (en) | 2016-07-06 |
| US20210032695A1 (en) | 2021-02-04 |
| US20240360502A1 (en) | 2024-10-31 |
| CN110124515A (zh) | 2019-08-16 |
| EP3038738B1 (en) | 2019-02-27 |
| EP3038738A4 (en) | 2017-07-05 |
| EP3936222A1 (en) | 2022-01-12 |
| ES2896017T3 (es) | 2022-02-23 |
| AU2020277162B2 (en) | 2023-01-19 |
| EP3527280B1 (en) | 2021-07-28 |
| CN105992634A (zh) | 2016-10-05 |
| AU2019200189B2 (en) | 2020-09-10 |
| AU2019200189A1 (en) | 2019-01-31 |
| CA2921700A1 (en) | 2015-03-05 |
| CN105992634B (zh) | 2019-06-14 |
| WO2015031909A1 (en) | 2015-03-05 |
| US10017814B2 (en) | 2018-07-10 |
| US10822652B2 (en) | 2020-11-03 |
| US20190106740A1 (en) | 2019-04-11 |
| AU2014312020A1 (en) | 2016-02-25 |
| CN110124515B (zh) | 2022-02-11 |
| EP3527280A1 (en) | 2019-08-21 |
| US20160222444A1 (en) | 2016-08-04 |
| AU2014312020B2 (en) | 2018-11-01 |
| AU2023202390A1 (en) | 2023-06-08 |
| AU2023202390B2 (en) | 2024-12-12 |
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