DK3536333T3 - Depotsystem der omfatter glatirameracetat - Google Patents

Depotsystem der omfatter glatirameracetat Download PDF

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Publication number
DK3536333T3
DK3536333T3 DK18205308.2T DK18205308T DK3536333T3 DK 3536333 T3 DK3536333 T3 DK 3536333T3 DK 18205308 T DK18205308 T DK 18205308T DK 3536333 T3 DK3536333 T3 DK 3536333T3
Authority
DK
Denmark
Prior art keywords
system containing
glatiramer acetate
depot system
containing glatiramer
depot
Prior art date
Application number
DK18205308.2T
Other languages
English (en)
Inventor
Ehud Marom
Shai Rubnov
Original Assignee
Mapi Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mapi Pharma Ltd filed Critical Mapi Pharma Ltd
Application granted granted Critical
Publication of DK3536333T3 publication Critical patent/DK3536333T3/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Epoxy Resins (AREA)
  • Epoxy Compounds (AREA)
DK18205308.2T 2010-01-04 2010-08-19 Depotsystem der omfatter glatirameracetat DK3536333T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29192810P 2010-01-04 2010-01-04
EP10840699.2A EP2398488B1 (en) 2010-01-04 2010-08-19 Depot system comprising glatiramer acetate

Publications (1)

Publication Number Publication Date
DK3536333T3 true DK3536333T3 (da) 2022-10-24

Family

ID=44226217

Family Applications (2)

Application Number Title Priority Date Filing Date
DK10840699.2T DK2398488T3 (da) 2010-01-04 2010-08-19 Depotsystem omfattende glatirameracetat
DK18205308.2T DK3536333T3 (da) 2010-01-04 2010-08-19 Depotsystem der omfatter glatirameracetat

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK10840699.2T DK2398488T3 (da) 2010-01-04 2010-08-19 Depotsystem omfattende glatirameracetat

Country Status (21)

Country Link
US (1) US8796226B2 (da)
EP (2) EP2398488B1 (da)
JP (2) JP5916622B2 (da)
CN (3) CN107661490B (da)
AU (1) AU2010337822B2 (da)
BR (1) BR112012016459B1 (da)
CA (1) CA2784394C (da)
CY (1) CY1120975T1 (da)
DK (2) DK2398488T3 (da)
ES (2) ES2699692T3 (da)
HK (1) HK1244430A1 (da)
HR (2) HRP20221208T1 (da)
HU (2) HUE060304T2 (da)
LT (2) LT3536333T (da)
MX (3) MX374215B (da)
PL (2) PL2398488T3 (da)
PT (2) PT3536333T (da)
SI (1) SI2398488T1 (da)
SM (2) SMT202200422T1 (da)
TR (1) TR201818858T4 (da)
WO (1) WO2011080733A1 (da)

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US8377885B2 (en) 2010-01-04 2013-02-19 Mapi Pharma Ltd. Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
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CN109982712A (zh) * 2016-08-31 2019-07-05 Mapi医药公司 包含醋酸格拉替雷的储库系统
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WO2019002228A1 (en) 2017-06-26 2019-01-03 Institut Pasteur TREATMENTS TO REMOVE HIV RESERVOIRS AND REDUCE VIRAL LOAD
WO2022003662A1 (en) * 2020-06-29 2022-01-06 Mapi Pharma Ltd. Low burst-release liraglutide depot systems
JP2023550545A (ja) * 2020-11-02 2023-12-01 シムハ・アイエル－１８・インコーポレイテッド インターロイキン－１８バリアントおよび使用の方法
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JP7837538B2 (ja) 2021-01-29 2026-03-31 ティオンラボ・セラピューティクス 初期放出制御されたデポー組成物及びその製造方法
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JP2024529009A (ja) 2021-07-06 2024-08-01 マーク・ヘースルトン セロトニン再取り込み阻害剤離脱症候群の治療
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Also Published As

Publication number Publication date
HRP20221208T1 (hr) 2022-12-09
MX374215B (es) 2025-03-04
TR201818858T4 (tr) 2019-01-21
SMT202200422T1 (it) 2022-11-18
MX349162B (es) 2017-07-14
BR112012016459A2 (pt) 2017-10-03
ES2699692T3 (es) 2019-02-12
CA2784394C (en) 2016-12-13
HUE040390T2 (hu) 2019-03-28
EP2398488B1 (en) 2018-11-14
BR112012016459B1 (pt) 2020-01-14
MX2012007760A (es) 2012-08-01
PT2398488T (pt) 2018-12-20
DK2398488T3 (da) 2019-01-28
CN107661490B (zh) 2021-12-31
AU2010337822A1 (en) 2012-07-12
AU2010337822B2 (en) 2016-03-17
EP2398488A4 (en) 2014-06-11
HK1244430A1 (zh) 2018-08-10
WO2011080733A1 (en) 2011-07-07
HRP20182076T1 (hr) 2019-02-08
JP2016074696A (ja) 2016-05-12
JP2013516403A (ja) 2013-05-13
LT3536333T (lt) 2022-11-10
MX392126B (es) 2025-03-21
PL3536333T3 (pl) 2022-12-05
CN102686235A (zh) 2012-09-19
ES2928900T3 (es) 2022-11-23
CN107661490A (zh) 2018-02-06
EP3536333A1 (en) 2019-09-11
SMT201900020T1 (it) 2019-02-28
US8796226B2 (en) 2014-08-05
MX2020003805A (es) 2022-05-05
JP5916622B2 (ja) 2016-05-11
CN107184954A (zh) 2017-09-22
CA2784394A1 (en) 2011-07-07
PT3536333T (pt) 2022-11-11
EP3536333B1 (en) 2022-08-03
SI2398488T1 (sl) 2019-02-28
US20120015891A1 (en) 2012-01-19
PL2398488T3 (pl) 2019-03-29
CY1120975T1 (el) 2019-12-11
HUE060304T2 (hu) 2023-02-28
LT2398488T (lt) 2019-01-25
EP2398488A1 (en) 2011-12-28
HK1245667A1 (zh) 2018-08-31

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