DK3548492T5 - Cell impermeable coelenterazine analogues - Google Patents

Cell impermeable coelenterazine analogues Download PDF

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Publication number
DK3548492T5
DK3548492T5 DK17829356.9T DK17829356T DK3548492T5 DK 3548492 T5 DK3548492 T5 DK 3548492T5 DK 17829356 T DK17829356 T DK 17829356T DK 3548492 T5 DK3548492 T5 DK 3548492T5
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DK
Denmark
Prior art keywords
cell impermeable
coelenterazine analogues
coelenterazine
analogues
impermeable
Prior art date
Application number
DK17829356.9T
Other languages
English (en)
Other versions
DK3548492T3 (en
Inventor
Rachel Friedman Ohana
Mary Hall
Thomas Kirkland
Poncho Meisenheimer
Anton Shakhmin
Joel R Walker
Wenhui Zhou
Original Assignee
Promega Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Promega Corp filed Critical Promega Corp
Publication of DK3548492T3 publication Critical patent/DK3548492T3/da
Application granted granted Critical
Publication of DK3548492T5 publication Critical patent/DK3548492T5/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/66Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/902Oxidoreductases (1.)
    • G01N2333/90241Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK17829356.9T 2016-12-01 2017-12-01 Cell impermeable coelenterazine analogues DK3548492T5 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662428997P 2016-12-01 2016-12-01
US201762477512P 2017-03-28 2017-03-28
PCT/US2017/064229 WO2018102693A1 (en) 2016-12-01 2017-12-01 Cell impermeable coelenterazine analogues

Publications (2)

Publication Number Publication Date
DK3548492T3 DK3548492T3 (en) 2023-08-07
DK3548492T5 true DK3548492T5 (en) 2024-08-05

Family

ID=60972321

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17829356.9T DK3548492T5 (en) 2016-12-01 2017-12-01 Cell impermeable coelenterazine analogues

Country Status (5)

Country Link
US (2) US10577370B2 (da)
EP (2) EP3548492B1 (da)
JP (1) JP7139330B2 (da)
DK (1) DK3548492T5 (da)
WO (1) WO2018102693A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10577370B2 (en) * 2016-12-01 2020-03-03 Promega Corporation Cell impermeable coelenterazine analogues
JP7036343B2 (ja) * 2017-03-28 2022-03-15 国立大学法人電気通信大学 新規セレンテラジン誘導体
JP7419260B2 (ja) 2018-05-01 2024-01-22 プロメガ コーポレイション NanoLuc自殺基質としてのセレンテラジン化合物
JP7653351B2 (ja) * 2018-08-23 2025-03-28 プロメガ コーポレイション セレンテラジン類似体
CN112996923B (zh) 2018-10-03 2025-02-18 普洛麦格公司 用于稳定腔肠素及其类似物和衍生物的组合物和方法
CN111116594B (zh) * 2019-12-03 2021-05-28 山东大学 一种C-6位改造NanoLuc类型类似物及其制备方法与应用
KR102940072B1 (ko) * 2022-01-10 2026-03-17 주식회사 엘지화학 환상 술폰산에스테르 유도체 화합물의 제조방법
CN116082185B (zh) * 2023-04-06 2023-07-21 佛山职业技术学院 虫酰肼类半抗原、抗原、抗体、检测装置及其制备与应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7268229B2 (en) 2001-11-02 2007-09-11 Promega Corporation Compounds to co-localize luminophores with luminescent proteins
US8883486B2 (en) 2004-05-04 2014-11-11 Universite De Montreal Arrestin biosensor
US20080248511A1 (en) 2007-03-26 2008-10-09 Promega Corporation Methods to quench light from optical reactions
LT3409764T (lt) 2009-05-01 2020-06-10 Promega Corporation Sintetinės oplophorus liuciferazės su sustiprinta šviesos išeiga
BR112013010487B1 (pt) * 2010-11-02 2021-02-02 Promega Corporation compostos de coelenterazina, kit compreendendo ditos compostos e método para detectar luminescência em uma amostra in vitro
WO2012061477A1 (en) 2010-11-02 2012-05-10 Promega Corporation Coelenterazine derivatives and methods of using same
JP6067019B2 (ja) 2011-09-02 2017-01-25 プロメガ コーポレイションPromega Corporation 代謝的に活性な細胞の酸化還元状態を評価するための化合物及び方法、ならびにnad(p)/nad(p)hを測定するための方法
EP2782916B1 (en) 2011-11-21 2018-02-28 Promega Corporation Carboxy x rhodamine analogs
WO2013130761A1 (en) * 2012-03-02 2013-09-06 Pierce Biotechnology, Inc. Indole derivatives as labeling dye for biomolecule
US9927430B2 (en) 2014-01-29 2018-03-27 Promega Corporation Pro-substrates for live cell applications
US9790537B2 (en) 2014-01-29 2017-10-17 Promega Corporation Quinone-masked probes as labeling reagents for cell uptake measurements
CN107922428B (zh) 2015-06-25 2021-02-05 普洛麦格公司 噻吩并吡咯化合物及其作为刺虾源性荧光素酶的抑制剂的用途
EP3416968B1 (en) 2016-02-15 2022-07-27 Promega Corporation Coelenterazine analogues
CN105968114B (zh) * 2016-05-27 2018-11-09 山东大学 一种腔肠素类似物及其制备方法与应用
JP7212612B2 (ja) * 2016-07-28 2023-01-25 プロメガ コーポレイション セレンテラジン類縁体
EP3535270B3 (en) * 2016-11-01 2024-05-29 Promega Corporation Coelenterazine analogues tethered to energy acceptors
US10577370B2 (en) * 2016-12-01 2020-03-03 Promega Corporation Cell impermeable coelenterazine analogues

Also Published As

Publication number Publication date
JP2020510617A (ja) 2020-04-09
DK3548492T3 (en) 2023-08-07
US11192894B2 (en) 2021-12-07
US20200239475A1 (en) 2020-07-30
WO2018102693A1 (en) 2018-06-07
EP4279490A3 (en) 2024-04-10
JP7139330B2 (ja) 2022-09-20
EP3548492A1 (en) 2019-10-09
EP3548492B1 (en) 2023-07-05
EP4279490A2 (en) 2023-11-22
US20180155350A1 (en) 2018-06-07
US10577370B2 (en) 2020-03-03

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