DK356085A - Reninhaemmende peptid eller et farmaceutisk acceptabelt syreadditionssalt deraf - Google Patents

Reninhaemmende peptid eller et farmaceutisk acceptabelt syreadditionssalt deraf Download PDF

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Publication number
DK356085A
DK356085A DK356085A DK356085A DK356085A DK 356085 A DK356085 A DK 356085A DK 356085 A DK356085 A DK 356085A DK 356085 A DK356085 A DK 356085A DK 356085 A DK356085 A DK 356085A
Authority
DK
Denmark
Prior art keywords
acid addition
addition salt
acceptable acid
pharmaceutical acceptable
inhibition
Prior art date
Application number
DK356085A
Other languages
English (en)
Other versions
DK356085D0 (da
Inventor
Jr Jackson Boling Hester
Donald Theodore Pals
Hossain Hassain Saneii
Tomi Kim Sawyer
Heinrich Josef Schostarez
Ruth Elizabeth Tenbrink
Suvit Thaisrivongs
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of DK356085D0 publication Critical patent/DK356085D0/da
Publication of DK356085A publication Critical patent/DK356085A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96472—Aspartic endopeptidases (3.4.23)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Furan Compounds (AREA)
DK356085A 1984-08-06 1985-08-05 Reninhaemmende peptid eller et farmaceutisk acceptabelt syreadditionssalt deraf DK356085A (da)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US63804184A 1984-08-06 1984-08-06
US63802584A 1984-08-06 1984-08-06
US63802784A 1984-08-06 1984-08-06
US63802384A 1984-08-06 1984-08-06
US66302784A 1984-10-19 1984-10-19
US66309384A 1984-10-19 1984-10-19
US66302684A 1984-10-19 1984-10-19
US66302884A 1984-10-19 1984-10-19
US75319885A 1985-07-09 1985-07-09

Publications (2)

Publication Number Publication Date
DK356085D0 DK356085D0 (da) 1985-08-05
DK356085A true DK356085A (da) 1986-02-07

Family

ID=27578888

Family Applications (1)

Application Number Title Priority Date Filing Date
DK356085A DK356085A (da) 1984-08-06 1985-08-05 Reninhaemmende peptid eller et farmaceutisk acceptabelt syreadditionssalt deraf

Country Status (4)

Country Link
EP (2) EP0486478A3 (da)
JP (2) JPH05222063A (da)
DK (1) DK356085A (da)
FI (1) FI88400C (da)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4613676A (en) * 1983-11-23 1986-09-23 Ciba-Geigy Corporation Substituted 5-amino-4-hydroxyvaleryl derivatives
JPS60163899A (ja) * 1984-02-03 1985-08-26 Sankyo Co Ltd レニン阻害ペプチド類
EP0181110A3 (en) * 1984-10-22 1988-05-11 Kissei Pharmaceutical Co. Ltd. Histidine derivatives as renin inhibitors
US4727060A (en) * 1984-11-13 1988-02-23 Ciba-Geigy Corporation Novel 5-amino-4-hydroxyvaleryl derivatives
EP0190891A3 (en) * 1985-01-31 1988-04-20 Kissei Pharmaceutical Co. Ltd. Novel amino acid derivatives
FI865196A7 (fi) 1985-04-19 1986-12-18 Upjohn Co Halostatiinisubstituoituja reniini-inhibiittoreita.
US4882420A (en) * 1985-04-19 1989-11-21 The Upjohn Company Dihalo-statine substituted renin inhibitors
EP0206807A3 (en) * 1985-06-28 1988-01-20 Kissei Pharmaceutical Co. Ltd. Novel amino acid derivatives
CA1290097C (en) * 1985-07-24 1991-10-01 Merck & Co., Inc. Peptide enzyme inhibitors
US4729985A (en) * 1985-08-09 1988-03-08 Pfizer Inc. Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues
US4853463A (en) * 1985-09-04 1989-08-01 Kissei Pharmaceutical Co., Ltd. Amino acid derivatives
WO1987002986A1 (en) * 1985-11-15 1987-05-21 The Upjohn Company Novel renin inhibiting polypeptide analogs containing s-aryl-d- or l- or dl-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties
US4894437A (en) * 1985-11-15 1990-01-16 The Upjohn Company Novel renin inhibiting polypeptide analogs containing S-aryl-D- or L- or DL-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties
NZ218937A (en) * 1986-01-16 1990-03-27 Abbott Lab Functionalised peptidyl aminodiols and -triols as renin inhibitors and pharmaceutical compositions
EP0236734A3 (de) * 1986-02-07 1988-05-11 Ciba-Geigy Ag Durch schwefelhaltigen Gruppen substituierte 5-Amino-4-hydroxyvalerylderivate
CA1309555C (en) * 1986-02-27 1992-10-27 Upjohn Company (The) Inhibiting peptides having a dihydroxyethylene isostere transitionstate insert
US4705846A (en) * 1986-03-27 1987-11-10 The Upjohn Company Novel renin inhibiting peptides having a gamma lactam pseudo dipeptide insert
DE3610593A1 (de) * 1986-03-29 1987-10-01 Hoechst Ag Substituierte 4-amino-3-hydroxybuttersaeure-derivate verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
EP0249096B1 (de) * 1986-06-10 1995-01-11 Merck Patent Gmbh Reninhemmende Aminosäurederivate.
JPS6322081A (ja) * 1986-07-11 1988-01-29 Kissei Pharmaceut Co Ltd 新規なアミノ酸誘導体
DE3627877A1 (de) * 1986-07-30 1988-02-04 Hoechst Ag Renin-hemmende di- und tripeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
GB8619182D0 (en) * 1986-08-06 1986-09-17 Sandoz Ltd Peptides & derivatives
ES2053582T3 (es) * 1986-08-13 1994-08-01 Ciba Geigy Ag Procedimiento para la obtencion de derivados del acido 5-amino-4-hidroxivalerianico.
AU7968687A (en) * 1986-09-30 1988-04-21 Upjohn Company, The Renin inhibitory peptides having novel c-terminal moieties
EP0264106B1 (en) * 1986-10-14 1994-03-16 Banyu Pharmaceutical Co., Ltd. 5-Substituted amino-4-hydroxy-pentanoic acid derivatives and their use
EP0278158A3 (en) * 1986-11-12 1990-05-23 Merck & Co. Inc. Renin inhibitors containing phenylalanyl-histidine replacements
US4743585A (en) * 1986-11-21 1988-05-10 Warner-Lambert Company Renin inhibitors
US4895834A (en) * 1986-12-15 1990-01-23 Warner-Lambert Company Renin inhibitors III
EP0344189A1 (en) * 1986-12-22 1989-12-06 The Upjohn Company Renin-inhibitory peptides having an epoxide or glycol moiety
SE8605573D0 (sv) * 1986-12-29 1986-12-29 Haessle Ab Novel compounds
US5032577A (en) * 1986-12-31 1991-07-16 Abbott Laboratories Peptidylaminodiols
GB2200115B (en) * 1987-01-21 1990-11-14 Sandoz Ltd Novel peptide derivatives, their production and use
US4758584A (en) * 1987-02-05 1988-07-19 Ciba-Geigy Corporation Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups
EP0349570A1 (en) * 1987-03-09 1990-01-10 The Upjohn Company Renin inhibitors containing a cyclopropyl amino acid and/or a cycloalkyl transition-state analogue
JPH02504509A (ja) * 1987-08-07 1990-12-20 ジ・アップジョン・カンパニー 非ペプチド結合を有するレニン抑制ペプチド
JPH03500772A (ja) * 1987-10-21 1991-02-21 ジ・アップジョン・カンパニー （１‐アミノ‐２‐ヒドロキシ‐２‐ヘテロサイクリック）エチル基を含有するレニン抑制物質類
GB8728560D0 (en) * 1987-12-07 1988-01-13 Glaxo Group Ltd Chemical compounds
GB8728561D0 (en) * 1987-12-07 1988-01-13 Glaxo Group Ltd Chemical compounds
EP0326364B1 (en) * 1988-01-26 1994-06-22 Sankyo Company Limited Renin inhibitory oligopeptides, their preparation and use
EP0329295A1 (en) * 1988-02-01 1989-08-23 The Upjohn Company Renin inhibiting peptides with polar end groups
US4981843A (en) * 1988-04-07 1991-01-01 E. R. Squibb & Sons, Inc. N-heterocyclic alcohol derivatives
WO1989010920A1 (en) * 1988-05-03 1989-11-16 The Upjohn Company Renin inhibitory peptides containing a substituted phenoxyacetyle group
DE3815913A1 (de) * 1988-05-10 1989-11-23 Sandoz Ag Neue reninhemmer, verfahren zu deren herstellung und deren verwendung
EP0347987A3 (en) * 1988-06-20 1991-01-02 Merck & Co. Inc. Tripeptide renin inhibitors with n-terminal carbamoyl or acyl groups
EP0423170A1 (en) * 1988-06-30 1991-04-24 The Upjohn Company Dipeptide hydroxy ethylene isostere synthesis and intermediates therefor
US5175298A (en) * 1988-06-30 1992-12-29 The Upjohn Company Dipeptide hydroxy ethylene isostere synthesis and intermediates therefor
WO1990006761A1 (en) * 1988-12-22 1990-06-28 The Upjohn Company Transdermal and intranasal administration of renin inhibitory peptides
WO1990006914A1 (en) * 1988-12-22 1990-06-28 The Upjohn Company N-alkylation of n-alpha-boc-protected amino acids
US5229518A (en) * 1991-03-06 1993-07-20 Abbott Laboratories Isomerically pure 2-piperidone compounds
US5342981A (en) * 1991-03-06 1994-08-30 Abbott Laboratories Substantially isomerically pure hexane or hexene compounds
US5643878A (en) * 1991-09-12 1997-07-01 Ciba-Geigy Corporation 5-amino-4-hydroxyhexanoic acid derivatives
US5413999A (en) * 1991-11-08 1995-05-09 Merck & Co., Inc. HIV protease inhibitors useful for the treatment of AIDS
TW217410B (da) * 1992-04-01 1993-12-11 Ciba Geigy
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
JP3409439B2 (ja) * 1994-06-17 2003-05-26 日産自動車株式会社 左右輪と前後輪の駆動力配分総合制御装置
US6486193B2 (en) 1998-12-31 2002-11-26 Aventis Pharmaceuticals Inc. 3-substituted pyrrolidines useful as inhibitors of matrix metalloproteinases
UA108742C2 (uk) 2009-09-23 2015-06-10 Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO812612L (no) * 1980-08-06 1982-02-08 Ferring Pharma Ltd Enzym-inhibitorer.
CA1258748A (en) * 1981-10-08 1989-08-22 Daniel F. Veber Renin inhibitory peptides
JPS5865260A (ja) * 1981-10-13 1983-04-18 Microbial Chem Res Found ３−アミノ−２−ヒドロキシ−４−フエニル酪酸誘導体および医薬組成物
EP0104041B1 (en) * 1982-09-15 1988-07-27 Aktiebolaget Hässle Enzyme inhibitors
FI843837A7 (fi) * 1983-02-07 1984-09-28 Ab Haessle Entsyymi-inhibiittorit.
EP0144290A3 (de) * 1983-12-01 1987-05-27 Ciba-Geigy Ag Substituierte Aethylendiaminderivate
US4727060A (en) * 1984-11-13 1988-02-23 Ciba-Geigy Corporation Novel 5-amino-4-hydroxyvaleryl derivatives
FI865196A7 (fi) * 1985-04-19 1986-12-18 Upjohn Co Halostatiinisubstituoituja reniini-inhibiittoreita.

Also Published As

Publication number Publication date
JPH0643410B2 (ja) 1994-06-08
EP0486478A2 (en) 1992-05-20
FI853004A0 (fi) 1985-08-05
DK356085D0 (da) 1985-08-05
JPH05222063A (ja) 1993-08-31
EP0486478A3 (en) 1992-08-12
EP0173481A3 (en) 1988-12-21
FI88400C (fi) 1993-05-10
FI853004L (fi) 1986-02-07
FI88400B (fi) 1993-01-29
JPH05194462A (ja) 1993-08-03
EP0173481A2 (en) 1986-03-05

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