DK356087D0 - Fremgangsmaade til isolering af et antibiotikum - Google Patents

Fremgangsmaade til isolering af et antibiotikum

Info

Publication number: DK356087D0
Authority: DK; Denmark
Prior art keywords: antibiotic; isolating; procedure; chromatography; eluent
Prior art date: 1987-07-09

Application number

DK356087A

Other languages

English (en)

Other versions

DK356087A (da

Inventor

Janos Balint

Zsuzsanna Emri

Jozsef Fazekas

Attila Jakab

Gyoergy Toth

Original Assignee

Biogal Gyogyszergyar

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-07-09

Filing date

1987-07-09

Publication date

1987-07-09

1987-07-09 Application filed by Biogal Gyogyszergyar filed Critical Biogal Gyogyszergyar

1987-07-09 Priority to DK356087A priority Critical patent/DK356087A/da

1987-07-09 Publication of DK356087D0 publication Critical patent/DK356087D0/da

1989-01-10 Publication of DK356087A publication Critical patent/DK356087A/da

Links

239000003242 anti bacterial agent Substances 0.000 title 1
230000003115 biocidal effect Effects 0.000 title 1
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
238000004587 chromatography analysis Methods 0.000 abstract 2
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 2
NAALWFYYHHJEFQ-ZASNTINBSA-N (2s,5r,6r)-6-[[(2r)-2-[[6-[4-[bis(2-hydroxyethyl)sulfamoyl]phenyl]-2-oxo-1h-pyridine-3-carbonyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Chemical compound N([C@@H](C(=O)N[C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C=1C=CC(O)=CC=1)C(=O)C(C(N1)=O)=CC=C1C1=CC=C(S(=O)(=O)N(CCO)CCO)C=C1 NAALWFYYHHJEFQ-ZASNTINBSA-N 0.000 abstract 1
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
239000003463 adsorbent Substances 0.000 abstract 1
235000010633 broth Nutrition 0.000 abstract 1
239000012043 crude product Substances 0.000 abstract 1
229960003109 daunorubicin hydrochloride Drugs 0.000 abstract 1
239000003480 eluent Substances 0.000 abstract 1
238000001704 evaporation Methods 0.000 abstract 1
230000008020 evaporation Effects 0.000 abstract 1
238000000605 extraction Methods 0.000 abstract 1
238000000855 fermentation Methods 0.000 abstract 1
230000004151 fermentation Effects 0.000 abstract 1
235000019253 formic acid Nutrition 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
239000000741 silica gel Substances 0.000 abstract 1
229910002027 silica gel Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK356087A 1987-07-09 1987-07-09 Fremgangsmaade til isolering af et antibiotikum DK356087A (da)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
DK356087A DK356087A (da)	1987-07-09	1987-07-09	Fremgangsmaade til isolering af et antibiotikum

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK356087A DK356087A (da)	1987-07-09	1987-07-09	Fremgangsmaade til isolering af et antibiotikum
EP87110159A EP0306541B1 (de)	1987-07-14	1987-07-14	Verfahren zur Gewinnung von Daunorubicinhydrochlorid aus Fermentbrühe

Publications (2)

Publication Number	Publication Date
DK356087D0 true DK356087D0 (da)	1987-07-09
DK356087A DK356087A (da)	1989-01-10

Family

ID=8197127

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK356087A DK356087A (da)	1987-07-09	1987-07-09	Fremgangsmaade til isolering af et antibiotikum

Country Status (7)

Country	Link
EP (1)	EP0306541B1 (da)
AT (1)	ATE71386T1 (da)
AU (1)	AU7566987A (da)
DE (1)	DE3775928D1 (da)
DK (1)	DK356087A (da)
ES (1)	ES2027662T3 (da)
GR (1)	GR3003833T3 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2356284T3 (es) *	1997-12-05	2011-04-06	Mercian Corporation	Antibiótico de antraciclina cristalino y procedimiento para su producción.
CN103641868B (zh) *	2013-11-18	2015-12-09	宁夏泰瑞制药股份有限公司	一种利用柔红霉素发酵液生产盐酸柔红霉素的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS52148064A (en) *	1976-05-31	1977-12-08	Microbial Chem Res Found	Antitumors
JPS5921394A (ja) *	1982-07-24	1984-02-03	Sanraku Inc	ダウノマイシンの製造法
IT1155446B (it) *	1982-12-23	1987-01-28	Erba Farmitalia	Procedimento per la purificazione di glucosidi antraciclinonici mediante adsobimento selettivo su resine

1987
- 1987-07-09 DK DK356087A patent/DK356087A/da not_active Application Discontinuation
- 1987-07-14 DE DE8787110159T patent/DE3775928D1/de not_active Expired - Lifetime
- 1987-07-14 EP EP87110159A patent/EP0306541B1/de not_active Expired - Lifetime
- 1987-07-14 ES ES198787110159T patent/ES2027662T3/es not_active Expired - Lifetime
- 1987-07-14 AT AT87110159T patent/ATE71386T1/de not_active IP Right Cessation
- 1987-07-15 AU AU75669/87A patent/AU7566987A/en not_active Abandoned
1992
- 1992-02-18 GR GR920400255T patent/GR3003833T3/el unknown

Also Published As

Publication number	Publication date
GR3003833T3 (da)	1993-03-16
ES2027662T3 (es)	1992-06-16
EP0306541A1 (de)	1989-03-15
AU7566987A (en)	1989-01-19
ATE71386T1 (de)	1992-01-15
DE3775928D1 (de)	1992-02-20
DK356087A (da)	1989-01-10
EP0306541B1 (de)	1992-01-08

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Legal Events

Date	Code	Title	Description
1995-04-03	AHB	Application shelved due to non-payment