DK3625263T3 - Anti-galectin- 9-antistoffer og anvendelser deraf - Google Patents

Anti-galectin- 9-antistoffer og anvendelser deraf

Info

Publication number
DK3625263T3
DK3625263T3 DK18870270.8T DK18870270T DK3625263T3 DK 3625263 T3 DK3625263 T3 DK 3625263T3 DK 18870270 T DK18870270 T DK 18870270T DK 3625263 T3 DK3625263 T3 DK 3625263T3
Authority
DK
Denmark
Prior art keywords
galectin
antibodies
Prior art date
Application number
DK18870270.8T
Other languages
English (en)
Inventor
Shohei Koide
George Miller
Akiko Koide
Aleksandra Filipovic
Eric Elenko
Joseph Bolen
Linxiao Chen
Original Assignee
Univ New York
Puretech Lyt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=66246040&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3625263(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ New York, Puretech Lyt Inc filed Critical Univ New York
Application granted granted Critical
Publication of DK3625263T3 publication Critical patent/DK3625263T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
DK18870270.8T 2017-10-27 2018-10-29 Anti-galectin- 9-antistoffer og anvendelser deraf DK3625263T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762578111P 2017-10-27 2017-10-27
US201862665175P 2018-05-01 2018-05-01
US201862736317P 2018-09-25 2018-09-25
PCT/US2018/058028 WO2019084553A1 (en) 2017-10-27 2018-10-29 ANTI-GALECTIN-9 ANTIBODIES AND USES THEREOF

Publications (1)

Publication Number Publication Date
DK3625263T3 true DK3625263T3 (da) 2025-06-30

Family

ID=66246040

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18870270.8T DK3625263T3 (da) 2017-10-27 2018-10-29 Anti-galectin- 9-antistoffer og anvendelser deraf

Country Status (14)

Country Link
US (5) US10344091B2 (da)
EP (2) EP3625263B8 (da)
JP (5) JP6873445B2 (da)
KR (1) KR102162129B1 (da)
CN (2) CN115261392B (da)
AU (3) AU2018355588C1 (da)
CA (1) CA3080120C (da)
DK (1) DK3625263T3 (da)
ES (1) ES3032734T3 (da)
IL (3) IL280648B2 (da)
PT (1) PT3625263T (da)
SG (1) SG11202003652QA (da)
WO (1) WO2019084553A1 (da)
ZA (3) ZA202002246B (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202003652QA (en) * 2017-10-27 2020-05-28 Univ New York Anti-galectin-9 antibodies and uses thereof
CN111256416B (zh) * 2018-11-30 2025-09-09 海尔智家股份有限公司 风冷冰箱
CA3134942A1 (en) * 2019-03-25 2020-10-01 New York University Anti-galectin-9 antibodies and uses thereof
CN114026126B (zh) * 2019-05-01 2024-09-27 纽约大学 抗半乳糖凝集素-9抗体及其用途
CN114025797A (zh) * 2019-05-31 2022-02-08 昆士兰医学研究所理事会 抗Gal9免疫抑制性结合分子
WO2020243623A1 (en) * 2019-05-31 2020-12-03 The Council Of The Queensland Institute Of Medical Research Activating anti-gal9 binding molecules
CA3140249A1 (en) * 2019-06-24 2020-12-30 Upm-Kymmene Corporation Transplantable cell composition comprising eukaryotic cells in a nanofibrillar cellulose hydrogel, method for preparing thereof and use of nanofibrillar cellulose
WO2021007503A1 (en) * 2019-07-11 2021-01-14 Dana-Farber Cancer Institute, Inc. Targeting galectin-9 as a therapeutic strategy for t-cell exhaustion in t-cell acute lymphoblastic leukemia
AU2020319899A1 (en) * 2019-08-01 2022-02-24 New York University Combined cancer therapy of anti-galectin-9 antibodies and chemotherapeutics
MX2022001947A (es) * 2019-08-14 2022-06-14 Modmab Therapeutics Inc Anticuerpos que se unen a las proteinas lrp5 y metodos de uso.
WO2021139682A1 (en) * 2020-01-07 2021-07-15 Hifibio (Hk) Limited Anti-galectin-9 antibody and uses thereof
WO2022020745A1 (en) * 2020-07-23 2022-01-27 Emory University Galectin-9 specific binding agents for use in treating cancer
AU2021320658A1 (en) * 2020-08-04 2023-03-02 Exelixis, Inc. CD47 binding agents and uses thereof
CN116390951A (zh) * 2020-08-04 2023-07-04 埃克塞里艾克西斯公司 Pd-l1结合剂及其用途
AU2021322114A1 (en) * 2020-08-04 2023-03-02 Exelixis, Inc. Multispecific binding agents and uses thereof
EP4232089A4 (en) * 2020-10-26 2024-09-04 PureTech LYT, Inc. ANTI-GALECTIN-9 ANTIBODIES AND USES THEREOF IN THE TREATMENT OF OCULAR MELANOMAS
WO2022109299A1 (en) * 2020-11-20 2022-05-27 New York University Anti-galectin-9 antibodies and therapeutic uses thereof
US20240043543A1 (en) * 2020-11-20 2024-02-08 New York University Anti-galectin-9 antibodies and therapeutic uses thereof
JP2024513651A (ja) * 2021-02-26 2024-03-27 ニューヨーク ユニバーシティ 共有結合性ペプチドコンジュゲートに結合する抗体を含む組成物及び方法
AU2022264597A1 (en) * 2021-04-30 2023-11-09 Puretech Lyt, Inc. Combination of anti-galectin-9 antibodies and chemotherapeutics for use in cancer therapy
EP4351736A4 (en) * 2021-06-11 2025-08-27 Univ California ANTIBODIES THAT STIMULATE NK CELL-MEDIATED CYTOTOXICITY
EP4413048A4 (en) * 2021-10-06 2026-02-11 Univ Chicago Survivin-targeting polypeptides for cancer detection and treatment
WO2023112454A1 (ja) * 2021-12-16 2023-06-22 学校法人東京理科大学 腸管腫瘍抑制剤、ｐｇｅ２産生抑制剤、及びｉｌ－２２ｂｐ産生促進剤
WO2023245021A2 (en) * 2022-06-14 2023-12-21 Invenra Inc. Multispecific binding agents that target cd25 and/or ctla4 and uses thereof
JP2025522729A (ja) * 2022-06-29 2025-07-17 ピュアテック・エル・ワイ・ティ・インコーポレイテッド ガレクチン－９を阻害する抗体を用いた悪性血液疾患の処置
US20240277122A1 (en) * 2023-02-16 2024-08-22 Dongguan Casekey Industry Co., Ltd Card fixation assembly for card holder and card holder
UY40783A (es) 2023-06-12 2024-12-31 Amgen Inc Proteínas de unión a agonistas del receptor beta de linfotoxina
WO2025014933A1 (en) * 2023-07-10 2025-01-16 Northwestern University Targeting tim-3 in mapk-driven glioma
WO2025085792A1 (en) * 2023-10-19 2025-04-24 Puretech Lyt, Inc. Treatment of hematological malignancies with antibodies inhibiting galectin-9
WO2025129249A1 (en) * 2023-12-22 2025-06-26 Commonwealth Scientific And Industrial Research Organisation Identifying sequence functionality

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US4777127A (en) 1985-09-30 1988-10-11 Labsystems Oy Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US4868103A (en) 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
US4704692A (en) 1986-09-02 1987-11-03 Ladner Robert C Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
GB8702816D0 (en) 1987-02-07 1987-03-11 Al Sumidaie A M K Obtaining retrovirus-containing fraction
US5219740A (en) 1987-02-13 1993-06-15 Fred Hutchinson Cancer Research Center Retroviral gene transfer into diploid fibroblasts for gene therapy
US5422120A (en) 1988-05-30 1995-06-06 Depotech Corporation Heterovesicular liposomes
AP129A (en) 1988-06-03 1991-04-17 Smithkline Biologicals S A Expression of retrovirus gag protein eukaryotic cells
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
EP1997891A1 (en) 1988-09-02 2008-12-03 Dyax Corporation Generation and selection of recombinant varied binding proteins
US5750373A (en) 1990-12-03 1998-05-12 Genentech, Inc. Enrichment method for variant proteins having altered binding properties, M13 phagemids, and growth hormone variants
WO1990007936A1 (en) 1989-01-23 1990-07-26 Chiron Corporation Recombinant therapies for infection and hyperproliferative disorders
EP0465529B1 (en) 1989-03-21 1998-04-29 Vical, Inc. Expression of exogenous polynucleotide sequences in a vertebrate
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
EP0845537A1 (en) 1989-08-18 1998-06-03 Chiron Corporation Recombinant retroviruses delivering vector constructs to target cells
US5585362A (en) 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
ZA911974B (en) 1990-03-21 1994-08-22 Res Dev Foundation Heterovesicular liposomes
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
EP0585287B1 (en) 1990-07-10 1999-10-13 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
DK1820858T3 (da) 1991-03-01 2009-11-02 Dyax Corp Kimært protein omfatende mikroprotein med to eller flere disulfidbindinger og udförelsesformer deraf
WO1992018619A1 (en) 1991-04-10 1992-10-29 The Scripps Research Institute Heterodimeric receptor libraries using phagemids
DE4122599C2 (de) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid zum Screenen von Antikörpern
DK0648271T3 (da) 1991-08-20 2003-07-21 Us Gov Health & Human Serv Adenovirusmedieret overførsel af gener til mave-/tarmkanal
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
WO1993010218A1 (en) 1991-11-14 1993-05-27 The United States Government As Represented By The Secretary Of The Department Of Health And Human Services Vectors including foreign genes and negative selective markers
GB9125623D0 (en) 1991-12-02 1992-01-29 Dynal As Cell modification
CA2087413A1 (en) 1992-01-17 1993-07-18 Joseph R. Lakowicz Fluorescent energy transfer immunoassay
FR2688514A1 (fr) 1992-03-16 1993-09-17 Centre Nat Rech Scient Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant.
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
EP0650370A4 (en) 1992-06-08 1995-11-22 Univ California METHODS AND COMPOSITIONS TARGETED ON SPECIFIC TISSUES.
WO1993025698A1 (en) 1992-06-10 1993-12-23 The United States Government As Represented By The Vector particles resistant to inactivation by human serum
SE9201984D0 (sv) 1992-06-29 1992-06-29 Pharmacia Biosensor Ab Improvement in optical assays
GB2269175A (en) 1992-07-31 1994-02-02 Imperial College Retroviral vectors
CA2145641C (en) 1992-12-03 2008-05-27 Richard J. Gregory Pseudo-adenovirus vectors
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
DK0695169T3 (da) 1993-04-22 2003-03-17 Skyepharma Inc Multivesikulære liposomer med indkapslet cyclodextrin og farmakologisk aktive forbindelser samt fremgangsmåder til anvendelse af disse
CA2166118C (en) 1993-06-24 2007-04-17 Frank L. Graham Adenovirus vectors for gene therapy
US6015686A (en) 1993-09-15 2000-01-18 Chiron Viagene, Inc. Eukaryotic layered vector initiation systems
WO1995007994A2 (en) 1993-09-15 1995-03-23 Viagene, Inc. Recombinant alphavirus vectors
ES2256842T4 (es) 1993-10-25 2007-02-01 Canji, Inc. Vector de adenovirus recombinante y metodos de uso.
CN1099868C (zh) 1993-11-16 2003-01-29 斯卡法玛公司 具有控制释放活性成分作用的囊
EP0772689B1 (en) 1994-05-09 2007-12-19 Oxford Biomedica (UK) Limited Retroviral vectors having a reduced recombination rate
WO1996017072A2 (en) 1994-11-30 1996-06-06 Chiron Viagene, Inc. Recombinant alphavirus vectors
US6265150B1 (en) 1995-06-07 2001-07-24 Becton Dickinson & Company Phage antibodies
EP0953052B1 (en) 1996-05-06 2009-03-04 Oxford BioMedica (UK) Limited Crossless retroviral vectors
PT971946E (pt) 1997-01-21 2006-11-30 Gen Hospital Corp Selecção de proteínas utilizando fusões arn-proteína
GB9809951D0 (en) 1998-05-08 1998-07-08 Univ Cambridge Tech Binding molecules
WO2000053211A2 (en) 1999-03-09 2000-09-14 University Of Southern California Method of promoting myocyte proliferation and myocardial tissue repair
JP3950050B2 (ja) 2000-11-01 2007-07-25 株式会社ガルファーマ ガン転移能検出剤
WO2003029456A1 (en) 2001-10-01 2003-04-10 Dyax Corp. Multi-chain eukaryotic display vectors and uses thereof
KR20050103474A (ko) * 2003-01-24 2005-10-31 가르파마 컴퍼니 리미티드 갈렉틴 9 함유 의약
JP2004244411A (ja) * 2003-01-24 2004-09-02 Galpharma Co Ltd ガレクチン９含有医薬
JP5021309B2 (ja) 2003-10-16 2012-09-05 ステファン ジョン ラルフ 免疫調節性組成物およびその使用方法
JP2008526205A (ja) 2004-12-31 2008-07-24 ジェネンテック・インコーポレーテッド Ｂｒ３に結合するポリペプチド及びその使用
EP1973951A2 (en) 2005-12-02 2008-10-01 Genentech, Inc. Binding polypeptides with restricted diversity sequences
JP5523345B2 (ja) 2008-01-18 2014-06-18 ジェネンテック， インコーポレイテッド Ｋ６３結合型ポリユビキチンを標的とする方法と組成物
ES2337224B1 (es) 2008-06-11 2011-02-17 Consejo Superior De Investigaciones Cientificas (Csic) (40%) Anticuerpo anti-dectin-1 humano, hibridoma productor de dicho anticuerpo y sus aplicaciones.
CN102165075A (zh) 2008-07-18 2011-08-24 奥洁克公司 用于检测和治疗结肠直肠癌的组合物
WO2011159877A2 (en) 2010-06-18 2011-12-22 The Brigham And Women's Hospital, Inc. Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions
EA201390669A1 (ru) 2010-11-10 2013-11-29 Дженентек, Инк. Способы и композиции для иммунотерапии заболеваний нервной системы
CN103314102A (zh) 2010-12-09 2013-09-18 株式会社嘉尔药物 分泌半乳糖凝集素9的细胞、其制造方法及其用途
WO2012177788A1 (en) 2011-06-20 2012-12-27 La Jolla Institute For Allergy And Immunology Modulators of 4-1bb and immune responses
WO2013056352A1 (en) 2011-10-19 2013-04-25 University Health Network Antibodies and antibody fragments targeting sirp-alpha and their use in treating hematologic cancers
US20140378531A1 (en) 2012-02-01 2014-12-25 New York University Inhibition of pattern recognition receptors in pancreatic cancer treatment using tlr inhibitors
WO2015035112A1 (en) 2013-09-05 2015-03-12 The Johns Hopkins University Cancer therapy via a combination of epigenetic modulation and immune modulation
JP2017518737A (ja) 2014-04-21 2017-07-13 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ＳＹＫ標的治療薬のための抗ｐＳＹＫ抗体分子及びその使用
FR3021970B1 (fr) * 2014-06-06 2018-01-26 Universite Sciences Technologies Lille Anticorps dirige contre la galectine 9 et inhibiteur de l'activite suppressive des lymphocytes t regulateurs
AU2015291783B2 (en) 2014-07-14 2018-07-26 The Council Of The Queensland Institute Of Medical Research Galectin immunotherapy
EP4368205A1 (en) 2014-09-16 2024-05-15 Innate Pharma Neutralization of inhibitory pathways in lymphocytes
US10640549B2 (en) * 2014-10-17 2020-05-05 University Of Virginia Patent Foundation Recombinant antibodies that recognize the C-terminal domains of Ebola virus nucleoprotein
CA2966040A1 (en) 2014-11-04 2016-05-12 Dana-Farber Cancer Institute, Inc. Anti-galectin antibody biomarkers predictive of anti-immune checkpoint and anti-angiogenesis responses
US20160209425A1 (en) 2015-01-16 2016-07-21 New York University Use of dectin-1 activators for treatment of liver disorders
WO2017044308A1 (en) 2015-09-10 2017-03-16 Albert Einstein College Of Medicine, Inc. Synthetic antibodies to bax and uses thereof
US20190292259A1 (en) 2016-05-24 2019-09-26 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of non small cell lung cancer (nsclc) that coexists with chronic obstructive pulmonary disease (copd)
CA3032305A1 (en) 2016-07-29 2018-02-01 New York University Treating solid tumor by targeting dectin-1 signaling
CA3034105A1 (en) 2016-09-23 2018-03-29 Csl Limited Coagulation factor binding proteins and uses thereof
SG11202003652QA (en) 2017-10-27 2020-05-28 Univ New York Anti-galectin-9 antibodies and uses thereof
EP3820480A4 (en) 2018-07-11 2022-03-09 Arrys Therapeutics, Inc. POLYMORPHIC COMPOUNDS AND USES THEREOF
CA3134942A1 (en) 2019-03-25 2020-10-01 New York University Anti-galectin-9 antibodies and uses thereof
CN114026126B (zh) 2019-05-01 2024-09-27 纽约大学 抗半乳糖凝集素-9抗体及其用途

Also Published As

Publication number Publication date
JP7092317B2 (ja) 2022-06-28
ZA202002246B (en) 2025-04-30
AU2020294364A1 (en) 2021-02-18
SG11202003652QA (en) 2020-05-28
CA3080120A1 (en) 2019-05-02
PT3625263T (pt) 2025-06-20
AU2018355588B2 (en) 2020-10-15
IL312910A (en) 2024-07-01
AU2018355588C1 (en) 2023-04-27
US20220340666A1 (en) 2022-10-27
CN115261392A (zh) 2022-11-01
JP2021153585A (ja) 2021-10-07
EP4597112A3 (en) 2026-04-01
EP3625263B1 (en) 2025-04-09
EP4597112A2 (en) 2025-08-06
ES3032734T3 (en) 2025-07-24
CN115261392B (zh) 2025-05-13
US10344091B2 (en) 2019-07-09
IL274152A (en) 2020-06-30
NZ764590A (en) 2020-12-18
CA3080120C (en) 2023-11-21
CN111511765B (zh) 2022-05-27
US20190127472A1 (en) 2019-05-02
US20220332830A1 (en) 2022-10-20
JP7523084B2 (ja) 2024-07-26
IL274152B (en) 2021-02-28
JP2022116325A (ja) 2022-08-09
EP3625263A4 (en) 2021-05-05
WO2019084553A1 (en) 2019-05-02
AU2023285898A1 (en) 2024-01-18
KR102162129B1 (ko) 2020-10-06
US11414492B2 (en) 2022-08-16
IL280648A (en) 2021-03-25
JP2024133590A (ja) 2024-10-02
JP2023116789A (ja) 2023-08-22
US11629191B2 (en) 2023-04-18
ZA202303412B (en) 2024-09-25
JP7800872B2 (ja) 2026-01-16
EP3625263B8 (en) 2025-05-28
US20190256604A1 (en) 2019-08-22
EP3625263A1 (en) 2020-03-25
AU2018355588A1 (en) 2020-06-11
IL312910B1 (en) 2026-02-01
US10450374B2 (en) 2019-10-22
US20200010551A1 (en) 2020-01-09
JP2021501120A (ja) 2021-01-14
ZA202102905B (en) 2023-04-26
IL280648B1 (en) 2024-06-01
JP7307443B2 (ja) 2023-07-12
CN111511765A (zh) 2020-08-07
AU2020294364B2 (en) 2023-09-21
KR20200064150A (ko) 2020-06-05
IL280648B2 (en) 2024-10-01
JP6873445B2 (ja) 2021-05-19
KR102162129B9 (ko) 2023-02-08

Similar Documents

Publication Publication Date Title
DK3625263T3 (da) Anti-galectin- 9-antistoffer og anvendelser deraf
DK3383916T3 (da) Anti-CD73-antistoffer og anvendelser deraf
IL272183A (en) Anti-cd8 antibodies and uses thereof
IL272330A (en) Anti-cd47 antibodies and uses thereof
DK3596125T3 (da) Anti-PAR2-antistoffer og anvendelser deraf
IL262095A (en) Anti-pacap antibodies and uses thereof
DK3468990T3 (da) Anti-C5-antistoffer og anvendelser deraf
EP3740224A4 (en) ANTI-LILRB ANTIBODIES AND THEIR USES
DK3458479T3 (da) Anti-b7-h3-antistoffer og antistof-lægemiddelkonjugater
DK3443009T3 (da) Anti-tim-3-antistoffer og sammensætninger
DK3532499T3 (da) ANTI-IL-33-antistoffer og anvendelser deraf
DK3402821T3 (da) Psma-bindende antistof og anvendelser deraf
DK3350220T3 (da) Anti-pro/latente-myostatin-antistoffer og anvendelser deraf
DK3610005T3 (da) Peptidligase og anvendelse deraf
DK3504242T3 (da) Anti-ox40-antistoffer og anvendelse deraf
DK3390444T3 (da) Anti-tl1a-antigenbindende proteiner og anvendelser deraf
DK3347379T5 (da) Anti-tigit-antistoffer, anti-pvrig-antistoffer og kombinationer deraf
DK3283106T3 (da) Terapeutiske antistoffer og anvendelser deraf
DK3333191T3 (da) Anti-C10ORF54-antistoffer og anvendelser deraf
DK3126388T3 (da) Anti-EGFRvIII-antistoffer og anvendelser deraf
DK3365368T3 (da) Tgfbeta1-bindende immunoglobuliner og anvendelse deraf
DK3307274T3 (da) Anti-cd123-antistoffer og konjugater deraf
DK3463435T3 (da) Alpha-synuklein-antistoffer og anvendelser deraf
DK3274370T3 (da) Anti-ceacam6-antistoffer og anvendelser deraf
EP3904382A4 (en) ANTI-IL-23P19 ANTIBODIES AND ITS USES