DK3630798T3 - Manipulerede aldolase-polypeptider og deres anvendelser i syntese af beta-hydroxy-alpha-aminosyrer - Google Patents
Manipulerede aldolase-polypeptider og deres anvendelser i syntese af beta-hydroxy-alpha-aminosyrer Download PDFInfo
- Publication number
- DK3630798T3 DK3630798T3 DK18810766.8T DK18810766T DK3630798T3 DK 3630798 T3 DK3630798 T3 DK 3630798T3 DK 18810766 T DK18810766 T DK 18810766T DK 3630798 T3 DK3630798 T3 DK 3630798T3
- Authority
- DK
- Denmark
- Prior art keywords
- beta
- alpha
- hydroxy
- synthesis
- applications
- Prior art date
Links
- 102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 title 1
- 108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/02—Aldehyde-lyases (4.1.2)
- C12Y401/02048—Low-specificity L-threonine aldolase (4.1.2.48)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710386994 | 2017-05-27 | ||
| PCT/CN2018/086227 WO2018219107A1 (en) | 2017-05-27 | 2018-05-09 | Engineered polypeptides and their applications in synthesis of beta-hydroxy-alpha-amino acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK3630798T3 true DK3630798T3 (da) | 2023-02-20 |
| DK3630798T5 DK3630798T5 (da) | 2024-09-02 |
Family
ID=64454353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18810766.8T DK3630798T5 (da) | 2017-05-27 | 2018-05-09 | Manipulerede aldolase-polypeptider og deres anvendelser i syntese af beta-hydroxy-alpha-aminosyrer |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11512303B2 (da) |
| EP (1) | EP3630798B1 (da) |
| JP (1) | JP7402157B2 (da) |
| CN (1) | CN110869383B (da) |
| DK (1) | DK3630798T5 (da) |
| WO (1) | WO2018219107A1 (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110914288B (zh) * | 2017-05-27 | 2023-05-05 | 宁波酶赛生物工程有限公司 | 工程化醛缩酶多肽及其应用 |
| CN109402098B (zh) * | 2018-11-06 | 2021-09-17 | 王喆明 | 苏氨酸醛缩酶、突变体及其在制备取代苯丝氨酸衍生物中的应用 |
| CN110951799B (zh) * | 2019-12-23 | 2021-07-30 | 福州大学 | “一菌多酶”全细胞不对称合成(2s,3r)-对甲砜基苯丝氨酸的方法 |
| CN112301067B (zh) * | 2020-11-06 | 2022-07-05 | 杭州濡湜生物科技有限公司 | 一种制备2-氨基-3-取代苯基-3-羟基丙酸的绿色环保工艺 |
| CN117185938B (zh) * | 2023-09-07 | 2025-08-08 | 宁波酶赛生物工程有限公司 | 一种(1r,2r)-2-氨基-1-(4-硝基苯基)-1,3-丙二醇的制备工艺 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ238342A (en) | 1990-06-04 | 1993-10-26 | Univ Notre Dame Du Lac | Preparation of beta-hydroxy-alphaamino acids useful as intermediates in the preparation of beta-lactam antibiotics |
| KR100741650B1 (ko) * | 2002-08-26 | 2007-07-24 | 아지노모토 가부시키가이샤 | 신규한 알돌라제 및 치환 α-케토산의 제조방법 |
| EP2557160A3 (en) * | 2002-12-09 | 2013-03-27 | Ajinomoto Co., Inc. | Mutated D-aminotransferase and method for producing optically active glutamic acid derivatives using the same |
| MX2007004980A (es) * | 2004-10-25 | 2007-06-14 | Codexis Inc | Alanina 2,3-aminomutasas mejoradas, y polinucleotidos relacionados. |
| JP2006121983A (ja) | 2004-10-29 | 2006-05-18 | Daicel Chem Ind Ltd | 添加物存在下での光学活性β−ヒドロキシアミノ酸の製造方法 |
| RU2338784C2 (ru) * | 2006-03-24 | 2008-11-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | Новая альдолаза, днк, кодирующая альдолазу, клетки, трансформированные днк, способ получения альдолазы и способ получения 4-гидрокси-l-изолейцина (варианты) |
| WO2007118682A1 (en) | 2006-04-13 | 2007-10-25 | Dsm Ip Assets B.V. | Process for the preparation of enantiomeri cally enriched beta-amino alcohols starting from glycine and an aldehyde in the presence of a threonine aldolase and a decarboxylase |
| CN104673814B (zh) | 2015-02-27 | 2018-02-02 | 台州职业技术学院 | 一种来自于阴沟肠杆菌的l‑苏氨酸醛缩酶及其应用 |
| CN110914288B (zh) * | 2017-05-27 | 2023-05-05 | 宁波酶赛生物工程有限公司 | 工程化醛缩酶多肽及其应用 |
-
2018
- 2018-05-09 CN CN201880023566.2A patent/CN110869383B/zh active Active
- 2018-05-09 DK DK18810766.8T patent/DK3630798T5/da active
- 2018-05-09 US US16/615,120 patent/US11512303B2/en active Active
- 2018-05-09 JP JP2020515804A patent/JP7402157B2/ja active Active
- 2018-05-09 WO PCT/CN2018/086227 patent/WO2018219107A1/en not_active Ceased
- 2018-05-09 EP EP18810766.8A patent/EP3630798B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN110869383B (zh) | 2023-06-27 |
| JP7402157B2 (ja) | 2023-12-20 |
| EP3630798A1 (en) | 2020-04-08 |
| EP3630798B1 (en) | 2022-11-23 |
| US20210284987A1 (en) | 2021-09-16 |
| CN110869383A (zh) | 2020-03-06 |
| US11512303B2 (en) | 2022-11-29 |
| EP3630798A4 (en) | 2021-03-10 |
| JP2020521509A (ja) | 2020-07-27 |
| WO2018219107A1 (en) | 2018-12-06 |
| DK3630798T5 (da) | 2024-09-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3494134T3 (da) | Manipulerede polypeptider og deres anvendelse | |
| IL262652A (en) | Gdf15 fusion proteins and uses thereof | |
| DK3601533T3 (da) | Fremgangsmåder til frembringelse af tumorinfiltrerende lymfocytter og anvendelser af samme i immunoterapi | |
| IL268593A (en) | Polypeptide variants and uses thereof | |
| DK3454871T3 (da) | Manipulerede naturlige dræberceller og anvendelser deraf | |
| DK3988117T3 (da) | Terapeutiske antistoffer og deres anvendelser | |
| DK3678668T3 (da) | ENPP1-inhibitorer og deres anvendelse til behandling af kræft | |
| DK3280432T3 (da) | Polypeptider indeholdende de novo-bindingsdomæner og anvendelser deraf | |
| DK3383916T3 (da) | Anti-CD73-antistoffer og anvendelser deraf | |
| PL3368658T3 (pl) | Namnażanie komórek T gamma delta rezydujących w tkankach nie-krwiotwórczych i zastosowania tych komórek | |
| DK3497094T3 (da) | Tlr7/8-antagonister og anvendelser deraf | |
| EP3544628A4 (en) | 4-1BB BINDING PROTEINS AND THEIR USES | |
| HRP20190028T1 (hr) | Interleukin-2 fuzijski proteini i njihove primjene | |
| DK3655401T3 (da) | Tlr7/8-antagonister og anvendelser deraf | |
| DK3480213T3 (da) | Syntac-polypeptider og anvendelser deraf | |
| DK3452485T3 (da) | Arginasehæmmere og deres terapeutiske anvendelser | |
| DK3232806T3 (da) | Opløsning af denatureret ærteprotein og anvendelser deraf til dannelse af mikropartikler | |
| DK3532499T3 (da) | ANTI-IL-33-antistoffer og anvendelser deraf | |
| DK3630798T5 (da) | Manipulerede aldolase-polypeptider og deres anvendelser i syntese af beta-hydroxy-alpha-aminosyrer | |
| DK3402821T3 (da) | Psma-bindende antistof og anvendelser deraf | |
| DK3128005T3 (da) | Sirp-alfa-variantkonstruktioner og anvendelser deraf | |
| DK3092246T3 (da) | Muterede fragmenter af ospa og fremgangsmåder og anvendelser i tilknytning dertil | |
| DK3443010T3 (da) | Nye anti-SIRPa-antistoffer og terapeutiske anvendelser deraf | |
| DK3434737T3 (da) | Modificerede pigmenter og deres anvendelse | |
| DK3356444T3 (da) | Med silikoneharpiks modificerede isocyanatoalkylalkoxysilan-addukter og deres anvendelse |