DK3635101T3 - Manipulerede ligasevarianter - Google Patents
Manipulerede ligasevarianter Download PDFInfo
- Publication number
- DK3635101T3 DK3635101T3 DK18798770.6T DK18798770T DK3635101T3 DK 3635101 T3 DK3635101 T3 DK 3635101T3 DK 18798770 T DK18798770 T DK 18798770T DK 3635101 T3 DK3635101 T3 DK 3635101T3
- Authority
- DK
- Denmark
- Prior art keywords
- ligas
- manipulated
- variants
- manipulated ligas
- ligas variants
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2521/00—Reaction characterised by the enzymatic activity
- C12Q2521/50—Other enzymatic activities
- C12Q2521/501—Ligase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/191—Modifications characterised by incorporating an adaptor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
- C12Q2535/122—Massive parallel sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y605/00—Ligases forming phosphoric ester bonds (6.5)
- C12Y605/01—Ligases forming phosphoric ester bonds (6.5) forming phosphoric ester bonds (6.5.1)
- C12Y605/01001—DNA ligase (ATP) (6.5.1.1)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762503075P | 2017-05-08 | 2017-05-08 | |
| US201762540734P | 2017-08-03 | 2017-08-03 | |
| US201762587030P | 2017-11-16 | 2017-11-16 | |
| PCT/US2018/031376 WO2018208665A1 (en) | 2017-05-08 | 2018-05-07 | Engineered ligase variants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3635101T3 true DK3635101T3 (da) | 2021-09-20 |
Family
ID=64014642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18798770.6T DK3635101T3 (da) | 2017-05-08 | 2018-05-07 | Manipulerede ligasevarianter |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US12344872B2 (da) |
| EP (2) | EP3957723A3 (da) |
| JP (2) | JP7401902B2 (da) |
| KR (1) | KR20200003903A (da) |
| CN (1) | CN110914415B (da) |
| AU (1) | AU2018266606B2 (da) |
| BR (1) | BR112019023337A2 (da) |
| CA (1) | CA3062550A1 (da) |
| DK (1) | DK3635101T3 (da) |
| ES (1) | ES2887078T3 (da) |
| HU (1) | HUE055411T2 (da) |
| MX (1) | MX2019013289A (da) |
| PL (1) | PL3635101T3 (da) |
| SG (1) | SG11201909957TA (da) |
| WO (1) | WO2018208665A1 (da) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10837009B1 (en) | 2017-12-22 | 2020-11-17 | New England Biolabs, Inc. | DNA ligase variants |
| EP3906318A1 (en) | 2019-01-06 | 2021-11-10 | 10X Genomics, Inc. | Methods and systems for enrichment of barcodes |
| EP3947722A1 (en) | 2019-03-27 | 2022-02-09 | 10X Genomics, Inc. | Systems and methods for processing rna from cells |
| CN113774032B (zh) * | 2021-11-12 | 2022-03-01 | 翌圣生物科技(上海)股份有限公司 | 重组t4连接酶突变体、编码dna及ngs建库方法 |
| US20230212550A1 (en) * | 2021-12-02 | 2023-07-06 | Abclonal Science, Inc. | T4 DNA Ligase Variants with Increased Ligation Efficiency |
| US11685913B1 (en) * | 2022-02-18 | 2023-06-27 | Abclonal Science, Inc. | T4 DNA ligase variants with increased resistance to salt |
| US11788082B2 (en) * | 2022-02-22 | 2023-10-17 | Abclonal Science, Inc. | T4 DNA ligase variants with increased thermostability |
| US12416044B2 (en) * | 2022-03-21 | 2025-09-16 | Abclonal Science, Inc. | T4 DNA ligase variants with increased ligation efficiency |
| WO2024123733A1 (en) * | 2022-12-05 | 2024-06-13 | Twist Bioscience Corporation | Enzymes for library preparation |
| CN115896047B (zh) * | 2022-12-12 | 2023-06-16 | 南京诺唯赞生物科技股份有限公司 | 重组t4 dna连接酶突变体、融合蛋白及其应用 |
| WO2024138664A1 (zh) * | 2022-12-30 | 2024-07-04 | 深圳华大生命科学研究院 | 一种核酸连接酶及其应用 |
| CN118291587B (zh) * | 2023-01-03 | 2025-04-11 | 南京诺唯赞生物科技股份有限公司 | 一种组合物及其在核酸纯化中的应用 |
| CN120603937A (zh) * | 2023-01-23 | 2025-09-05 | 科德希思公司 | 工程化dna连接酶变体 |
| EP4709879A1 (en) | 2023-05-12 | 2026-03-18 | Roche Sequencing Solutions, Inc. | Enzymatic conversion of methylated nucleic acids for sequencing |
| CN117946985B (zh) * | 2024-03-27 | 2024-05-28 | 翌圣生物科技(上海)股份有限公司 | 突变型t4 dna连接酶、试剂盒及其在文库构建中的应用 |
| JP2026007482A (ja) * | 2024-07-03 | 2026-01-16 | デンカ株式会社 | キメラリガーゼ |
| CN118895257B (zh) * | 2024-07-31 | 2025-05-23 | 翌圣生物科技(上海)股份有限公司 | T4 dna连接酶突变体及其应用 |
| CN118879647B (zh) * | 2024-07-31 | 2025-05-23 | 翌圣生物科技(上海)股份有限公司 | 突变的t4 dna连接酶及试剂盒 |
| WO2026082489A1 (en) | 2024-10-18 | 2026-04-23 | F. Hoffmann-La Roche Ag | Universal pcr to boost molecule recovery in cell free dna library preparation and target enrichment workflows |
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-
2018
- 2018-05-07 ES ES18798770T patent/ES2887078T3/es active Active
- 2018-05-07 WO PCT/US2018/031376 patent/WO2018208665A1/en not_active Ceased
- 2018-05-07 MX MX2019013289A patent/MX2019013289A/es unknown
- 2018-05-07 JP JP2019561258A patent/JP7401902B2/ja active Active
- 2018-05-07 KR KR1020197036043A patent/KR20200003903A/ko not_active Ceased
- 2018-05-07 US US15/972,919 patent/US12344872B2/en active Active
- 2018-05-07 SG SG11201909957T patent/SG11201909957TA/en unknown
- 2018-05-07 HU HUE18798770A patent/HUE055411T2/hu unknown
- 2018-05-07 EP EP21191485.8A patent/EP3957723A3/en not_active Withdrawn
- 2018-05-07 AU AU2018266606A patent/AU2018266606B2/en active Active
- 2018-05-07 CN CN201880046316.0A patent/CN110914415B/zh active Active
- 2018-05-07 PL PL18798770T patent/PL3635101T3/pl unknown
- 2018-05-07 BR BR112019023337-7A patent/BR112019023337A2/pt unknown
- 2018-05-07 DK DK18798770.6T patent/DK3635101T3/da active
- 2018-05-07 EP EP18798770.6A patent/EP3635101B1/en active Active
- 2018-05-07 CA CA3062550A patent/CA3062550A1/en active Pending
-
2023
- 2023-09-19 JP JP2023150987A patent/JP2023166579A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3635101A1 (en) | 2020-04-15 |
| EP3635101A4 (en) | 2020-09-30 |
| WO2018208665A1 (en) | 2018-11-15 |
| BR112019023337A2 (pt) | 2020-06-16 |
| KR20200003903A (ko) | 2020-01-10 |
| CN110914415B (zh) | 2024-09-17 |
| JP7401902B2 (ja) | 2023-12-20 |
| ES2887078T3 (es) | 2021-12-21 |
| CN110914415A (zh) | 2020-03-24 |
| MX2019013289A (es) | 2020-01-15 |
| CA3062550A1 (en) | 2018-11-15 |
| EP3635101B1 (en) | 2021-08-18 |
| HUE055411T2 (hu) | 2021-11-29 |
| JP2020518278A (ja) | 2020-06-25 |
| US12344872B2 (en) | 2025-07-01 |
| AU2018266606B2 (en) | 2024-09-05 |
| EP3957723A3 (en) | 2022-04-20 |
| SG11201909957TA (en) | 2019-11-28 |
| AU2018266606A1 (en) | 2019-11-14 |
| PL3635101T3 (pl) | 2021-12-13 |
| EP3957723A2 (en) | 2022-02-23 |
| US20180320162A1 (en) | 2018-11-08 |
| JP2023166579A (ja) | 2023-11-21 |
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