DK3642227T3 - Hundeantistofbiblioteker - Google Patents

Hundeantistofbiblioteker Download PDF

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Publication number
DK3642227T3
DK3642227T3 DK18731127.9T DK18731127T DK3642227T3 DK 3642227 T3 DK3642227 T3 DK 3642227T3 DK 18731127 T DK18731127 T DK 18731127T DK 3642227 T3 DK3642227 T3 DK 3642227T3
Authority
DK
Denmark
Prior art keywords
antibody libraries
canine antibody
canine
libraries
antibody
Prior art date
Application number
DK18731127.9T
Other languages
English (en)
Inventor
Ralf Strohner
Kathrin Ladetzki-Baehs
Josef Prassler
Thomas Tiller
Markus Waldhuber
Original Assignee
Adivo Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adivo Gmbh filed Critical Adivo Gmbh
Application granted granted Critical
Publication of DK3642227T3 publication Critical patent/DK3642227T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/10Libraries containing peptides or polypeptides, or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • C40B30/04Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK18731127.9T 2017-06-22 2018-06-21 Hundeantistofbiblioteker DK3642227T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17177322 2017-06-22
PCT/EP2018/066563 WO2018234438A1 (en) 2017-06-22 2018-06-21 Canine antibody libraries

Publications (1)

Publication Number Publication Date
DK3642227T3 true DK3642227T3 (da) 2024-09-02

Family

ID=59152686

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18731127.9T DK3642227T3 (da) 2017-06-22 2018-06-21 Hundeantistofbiblioteker

Country Status (14)

Country Link
US (4) US11014978B2 (da)
EP (2) EP3642227B1 (da)
JP (1) JP7290581B2 (da)
KR (2) KR20230148857A (da)
CN (2) CN117587524A (da)
AU (1) AU2018288525B2 (da)
CA (1) CA3064798A1 (da)
DK (1) DK3642227T3 (da)
ES (1) ES2988673T3 (da)
FI (1) FI3642227T3 (da)
IL (1) IL270698B2 (da)
PL (1) PL3642227T3 (da)
PT (1) PT3642227T (da)
WO (1) WO2018234438A1 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230148857A (ko) 2017-06-22 2023-10-25 모르포시스 아게 개과 항체 라이브러리
GB2578867A (en) * 2018-10-09 2020-06-03 Genome Res Ltd Animal models and therapeutic molecules
WO2021165417A1 (en) 2020-02-19 2021-08-26 Adivo Gmbh Modified fc regions
GB202107372D0 (en) 2021-05-24 2021-07-07 Petmedix Ltd Animal models and therapeutics molecules
US12342776B1 (en) * 2021-12-09 2025-07-01 Pioneer Hi-Bred International, Inc. Sorghum inbred 2PQCS69A
US12342777B1 (en) * 2021-12-09 2025-07-01 Pioneer Hi-Bred International, Inc. Sorghum inbred 2PWBB63A
US12532827B1 (en) * 2021-12-13 2026-01-27 Pioneer Hi-Bred International, Inc. Sorghum hybrid XSW7611
JP2025508603A (ja) 2022-02-18 2025-03-26 アディヴォ ゲゼルシャフト ミット ベシュレンクテル ハフツング ネコ抗体ライブラリー
US20260028399A1 (en) * 2022-02-24 2026-01-29 Abnomx Bv Human-like target-binding proteins
GB202209247D0 (en) 2022-06-23 2022-08-10 Petmedix Ltd Animal models and therapeutic molecules
GB202217978D0 (en) 2022-11-30 2023-01-11 Petmedix Ltd Rodents expressing a common light chain
US12457953B1 (en) * 2022-12-21 2025-11-04 Pioneer Hi-Bred International, Inc. Sorghum inbred 2PVPJ27A
JP2026508149A (ja) * 2023-02-13 2026-03-10 インターベット インターナショナル ベー. フェー. イヌil-13に対するイヌ抗体
EP4688848A1 (en) 2023-03-27 2026-02-11 Zoetis Services LLC Anti-canine pd-l1 antibodies
CN119979614A (zh) * 2024-10-22 2025-05-13 特赛免疫(广州)科技有限公司 αβ型TCR分子文库及其构建方法与应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5169775A (en) 1987-04-30 1992-12-08 The Wistar Institute Monoclonal antibodies against lymphoma-associated antigens, hybrid cell lines producing these antibodies
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
EP1958962A3 (en) 1997-06-12 2013-05-01 Novartis International Pharmaceutical Ltd. Artificial antibody polypeptides
US8722587B2 (en) 2008-04-09 2014-05-13 The Trustees Of The University Of Pennsylvania Single chain fragment variable antibody libraries and uses thereof
ES2551871T3 (es) * 2010-01-29 2015-11-24 Morphosys Ag Genotecas combinatorias de anticuerpos de roedor
CN104017080B (zh) * 2014-06-13 2016-09-28 华南农业大学 一种犬源单链抗体及其构建方法和应用
KR20230148857A (ko) 2017-06-22 2023-10-25 모르포시스 아게 개과 항체 라이브러리

Also Published As

Publication number Publication date
PL3642227T3 (pl) 2024-11-12
US20210317190A1 (en) 2021-10-14
CN110799532A (zh) 2020-02-14
EP3642227B1 (en) 2024-08-07
CN110799532B (zh) 2023-11-03
US20200223904A1 (en) 2020-07-16
PT3642227T (pt) 2024-10-08
EP4442706A3 (en) 2024-12-25
JP2020528736A (ja) 2020-10-01
AU2018288525A1 (en) 2019-11-14
IL270698B1 (en) 2024-02-01
ES2988673T3 (es) 2024-11-21
US20230399381A1 (en) 2023-12-14
FI3642227T3 (fi) 2024-10-09
NZ758530A (en) 2025-09-26
JP7290581B2 (ja) 2023-06-13
KR20200020819A (ko) 2020-02-26
EP3642227A1 (en) 2020-04-29
US11702463B2 (en) 2023-07-18
WO2018234438A1 (en) 2018-12-27
CN117587524A (zh) 2024-02-23
KR102637804B1 (ko) 2024-02-22
US20250340619A1 (en) 2025-11-06
IL270698A (en) 2020-01-30
EP4442706A2 (en) 2024-10-09
US12344659B2 (en) 2025-07-01
US11014978B2 (en) 2021-05-25
AU2018288525B2 (en) 2025-04-17
CA3064798A1 (en) 2018-12-27
KR20230148857A (ko) 2023-10-25
IL270698B2 (en) 2024-06-01

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