DK3649109T3 - Ethynylforbindelser, deres fremstilling og deres terapeutiske anvendelse til behandling af malaria - Google Patents

Ethynylforbindelser, deres fremstilling og deres terapeutiske anvendelse til behandling af malaria Download PDF

Info

Publication number
DK3649109T3
DK3649109T3 DK18734258.9T DK18734258T DK3649109T3 DK 3649109 T3 DK3649109 T3 DK 3649109T3 DK 18734258 T DK18734258 T DK 18734258T DK 3649109 T3 DK3649109 T3 DK 3649109T3
Authority
DK
Denmark
Prior art keywords
malaria
preparation
treatment
therapeutic use
ethynyl compounds
Prior art date
Application number
DK18734258.9T
Other languages
English (en)
Inventor
Cécile Pascal
Alain Pellet
Gilles Courtemanche
Simon Campbell
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Application granted granted Critical
Publication of DK3649109T3 publication Critical patent/DK3649109T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK18734258.9T 2017-07-04 2018-07-04 Ethynylforbindelser, deres fremstilling og deres terapeutiske anvendelse til behandling af malaria DK3649109T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17305866 2017-07-04
PCT/EP2018/068079 WO2019008027A1 (en) 2017-07-04 2018-07-04 ETHYNYL COMPOUNDS, THEIR PREPARATION AND THEIR THERAPEUTIC USE IN THE TREATMENT OF MALARIA

Publications (1)

Publication Number Publication Date
DK3649109T3 true DK3649109T3 (da) 2021-11-22

Family

ID=59350831

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18734258.9T DK3649109T3 (da) 2017-07-04 2018-07-04 Ethynylforbindelser, deres fremstilling og deres terapeutiske anvendelse til behandling af malaria

Country Status (18)

Country Link
US (1) US11078160B2 (da)
EP (1) EP3649109B1 (da)
JP (1) JP7065898B2 (da)
CN (1) CN110869350B (da)
BR (1) BR112020000034B1 (da)
CA (1) CA3069046A1 (da)
CY (1) CY1124530T1 (da)
DK (1) DK3649109T3 (da)
ES (1) ES2894657T3 (da)
HR (1) HRP20211806T1 (da)
HU (1) HUE056766T2 (da)
LT (1) LT3649109T (da)
PL (1) PL3649109T3 (da)
PT (1) PT3649109T (da)
RS (1) RS62656B1 (da)
SI (1) SI3649109T1 (da)
SM (1) SMT202100683T1 (da)
WO (1) WO2019008027A1 (da)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0577024T3 (da) * 1992-07-01 1997-02-24 Hoechst Ag
DE19737463A1 (de) * 1997-08-28 1999-03-04 Hoechst Marion Roussel De Gmbh Verwendung von Inhibitoren des Natrium-Wasserstoff-Austauschers zur Herstellung eines Arzneimittels zur Behandlung von Erkrankungen, die durch Protozoen verursacht werden
EP1399414B1 (en) 2001-04-24 2010-01-13 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
DE10338554A1 (de) 2003-08-22 2005-03-31 Aventis Pharma Deutschland Gmbh Pentafluorosulfanylphenyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US20110263901A1 (en) * 2008-01-23 2011-10-27 Dhananjay Govind Sathe Process of Preparation of Proguanil
AU2009276744A1 (en) * 2008-07-28 2010-02-04 Polymedix, Inc. Anti-malarial compounds
WO2012149093A1 (en) 2011-04-26 2012-11-01 THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF ARMY 2-guanidino-4-oxo-imidazoline derivatives as antimalarial agents, synthesis and methods of use thereof
EP2727911B1 (en) 2012-10-31 2016-12-21 Medizinische Hochschule Hannover Novel means and methods for treating malaria and other parasitic disorders

Also Published As

Publication number Publication date
HRP20211806T1 (hr) 2022-02-18
CN110869350B (zh) 2023-05-02
RS62656B1 (sr) 2021-12-31
SMT202100683T1 (it) 2022-01-10
BR112020000034A2 (pt) 2020-09-29
US20200281909A1 (en) 2020-09-10
US11078160B2 (en) 2021-08-03
JP2020525496A (ja) 2020-08-27
PL3649109T3 (pl) 2022-01-31
CN110869350A (zh) 2020-03-06
LT3649109T (lt) 2021-09-27
HUE056766T2 (hu) 2022-03-28
EP3649109B1 (en) 2021-09-01
SI3649109T1 (sl) 2021-11-30
BR112020000034B1 (pt) 2023-10-10
JP7065898B2 (ja) 2022-05-12
PT3649109T (pt) 2021-09-10
WO2019008027A1 (en) 2019-01-10
EP3649109A1 (en) 2020-05-13
CY1124530T1 (el) 2022-07-22
CA3069046A1 (en) 2019-01-10
ES2894657T3 (es) 2022-02-15

Similar Documents

Publication Publication Date Title
DK3678668T3 (da) ENPP1-inhibitorer og deres anvendelse til behandling af kræft
DK3558997T3 (da) Aminotriazolopyridinforbindelser og deres anvendelse til behandling af cancer
DK3889145T3 (da) 8-cyano-5-piperidino-quinoliner som TLR7/8-antagonister og anvendelser deraf til behandling af immunsygdomme
DK4234581T3 (da) Terapeutiske antistoffer og deres anvendelse
DK3612517T3 (da) Bicykliske forbindelser og deres anvendelse ved behandling af cancer
DK3672954T3 (da) Forbindelser og salte deraf og deres anvendelse til behandling af sygdomme
DK3439663T3 (da) Fremgangsmåder til behandling af pædiatriske cancere
DK3215511T3 (da) Substituerede pyrazolo(1,5-a)pyrimidiner og deres anvendelse i behandlingen af medicinske lidelser
DK3134125T3 (da) Antistof-lægemiddel-konjugat og anvendelse deraf til behandling af cancer
DK3325509T3 (da) Anti-tfr antistoffer og deres anvendelse i behandling af proliferative og inflammatoriske lidelser
DK3882250T3 (da) Tetrahydropyranyl-amino-pyrrolopyrimidinon til anvendelse i behandling af btk-medierede forstyrrelser
DK3160470T3 (da) Analoger af pridopidin, fremstilling og anvendelse heraf
DK4335517T3 (da) Indgivelse og dosering af diaminofenothiaziner
DK3328864T3 (da) Terapeutiske forbindelser og sammensætninger til behandling af sociale forstyrrelser og stofmisbrugsforstyrrelser
DK3137168T3 (da) Substituerede 4-phenylpiperidiner, deres fremstilling og anvendelse
DK3481846T3 (da) 11-substituerede 24-hydroxysteroler til anvendelse til behandling af nmda-relaterede tilstande
DK3371179T3 (da) Hidtil ukendte cryptophycin-forbindelser og konjugater, deres fremstilling og terapeutisk anvendelse heraf
SI3346995T1 (sl) Terapevtski sestavek za zdravljenje virusa človeške imunske pomanjkljivosti
DK3362066T3 (da) Kombinationsterapi til behandling af maligniteter
DK3160234T3 (da) Sammensætning til anvendelse til forebyggelse og behandling af oftalmisk-, hånd- eller fodbiofilmvækst
DK3331879T3 (da) Benzazolforbindelser og fremgangsmåder til fremstilling og anvendelse af forbindelserne
BR112016018062A2 (pt) compostos terapêuticos, composição farmacêutica e usos
DK3790879T3 (da) Triazolopyrimidinforbindelser og deres anvendelse til behandling af kræft
IL249061A0 (en) Combination, composition, and method of administering the combination or composition to animals
DK3723739T3 (da) Isoxazolin-parasiticidformuleringer og deres anvendelse til behandling af blepharitis