DK3653644T5 - Monoklonale antistoffer mod vækst- og differentieringsfaktor 15 (gdf-15) og anvendelser deraf til behandling af kræftrelateret kakeksi og kræft - Google Patents

Monoklonale antistoffer mod vækst- og differentieringsfaktor 15 (gdf-15) og anvendelser deraf til behandling af kræftrelateret kakeksi og kræft Download PDF

Info

Publication number: DK3653644T5
Authority: DK; Denmark
Prior art keywords: cancer; cachesia; gdf; treatment; monoclonal antibodies
Prior art date: 2014-03-26

Application number

DK19205321.3T

Other languages

English (en)

Other versions

DK3653644T3 (da

Inventor

Jörg Wischhusen

Markus Junker

Tina Schäfer

Dirk Pühringer

Original Assignee

Univ Wuerzburg J Maximilians

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-03-26

Filing date

2015-03-26

Publication date

2024-08-26

2014-03-26 Priority claimed from GB1405475.3A external-priority patent/GB2524552B/en

2014-03-26 Priority claimed from GB1405477.9A external-priority patent/GB2524553C/en

2015-03-26 Application filed by Univ Wuerzburg J Maximilians filed Critical Univ Wuerzburg J Maximilians

2023-12-18 Application granted granted Critical

2023-12-18 Publication of DK3653644T3 publication Critical patent/DK3653644T3/da

2024-08-26 Publication of DK3653644T5 publication Critical patent/DK3653644T5/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Microbiology (AREA)
Epidemiology (AREA)
Mycology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Compositions Of Macromolecular Compounds (AREA)
Cosmetics (AREA)

DK19205321.3T 2014-03-26 2015-03-26 Monoklonale antistoffer mod vækst- og differentieringsfaktor 15 (gdf-15) og anvendelser deraf til behandling af kræftrelateret kakeksi og kræft DK3653644T5 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB1405475.3A GB2524552B (en)	2014-03-26	2014-03-26	Monoclonal antibodies to growth and differentiation factor 15 (GDF-15), and use thereof for treating cancer
GB1405477.9A GB2524553C (en)	2014-03-26	2014-03-26	Monoclonal antibodies to growth and differentiation factor 15 (GDF-15), and uses thereof for treating cancer cachexia
EP15712629.3A EP3122775B1 (en)	2014-03-26	2015-03-26	Monoclonal antibodies to growth and differentiation factor 15 (gdf-15), and uses thereof for treating cancer cachexia and cancer

Publications (2)

Publication Number	Publication Date
DK3653644T3 DK3653644T3 (da)	2023-12-18
DK3653644T5 true DK3653644T5 (da)	2024-08-26

Family

ID=52745885

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK19205321.3T DK3653644T5 (da)	2014-03-26	2015-03-26	Monoklonale antistoffer mod vækst- og differentieringsfaktor 15 (gdf-15) og anvendelser deraf til behandling af kræftrelateret kakeksi og kræft
DK15712629.3T DK3122775T3 (da)	2014-03-26	2015-03-26	Monoklonale antistoffer til vækst- og differentieringsfaktor 15 (gdf-15), og anvendelser deraf til behandling af cancer kakeksi og cancer

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK15712629.3T DK3122775T3 (da)	2014-03-26	2015-03-26	Monoklonale antistoffer til vækst- og differentieringsfaktor 15 (gdf-15), og anvendelser deraf til behandling af cancer kakeksi og cancer

Country Status (22)

Country	Link
US (6)	US20170204174A1 (da)
EP (3)	EP3122775B1 (da)
JP (3)	JP6865585B2 (da)
KR (1)	KR102520978B1 (da)
CN (1)	CN106536553B (da)
AU (2)	AU2015238264B2 (da)
BR (1)	BR122023027559A2 (da)
CY (1)	CY1122456T1 (da)
DK (2)	DK3653644T5 (da)
ES (2)	ES2763859T3 (da)
FI (1)	FI3653644T3 (da)
HR (2)	HRP20231514T1 (da)
HU (2)	HUE047398T2 (da)
IL (2)	IL248038B (da)
LT (2)	LT3653644T (da)
NZ (1)	NZ724649A (da)
PL (2)	PL3122775T3 (da)
PT (2)	PT3653644T (da)
RS (1)	RS59700B1 (da)
SI (1)	SI3122775T1 (da)
SM (1)	SMT202000064T1 (da)
WO (1)	WO2015144855A1 (da)

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EP3122775B1 (en)	2014-03-26	2019-11-13	Julius-Maximilians-Universität Würzburg	Monoclonal antibodies to growth and differentiation factor 15 (gdf-15), and uses thereof for treating cancer cachexia and cancer
HUE054670T2 (hu)	2014-09-25	2021-09-28	Aveo Pharmaceuticals Inc	Módszer cachexia visszafordítására és túlélés megnövelésére egy GDF15 modulátor és egy rákellenes szer adagolásával
JP6858181B2 (ja) *	2015-10-02	2021-04-14	ユリウス−マクシミリアン−ウニヴェルシテート・ヴュルツブルク	免疫チェックポイントブロッカーを用いる治療の臨床アウトカムを予測するための診断マーカーとしてのｇｄｆ−１５
JP6925326B2 (ja)	2015-10-02	2021-08-25	ユリウス−マクシミリアン−ウニヴェルシテート・ヴュルツブルク	ヒト成長分化因子１５（ｇｄｆ−１５）の阻害剤及び免疫チェックポイントブロッカーを使用する併用療法
GB201517528D0 (en) *	2015-10-02	2015-11-18	Julius Maximillians Universitãt Würzburg	GDF-15 as a diagnosis marker for melanoma
CN109071647B (zh)	2016-04-27	2022-11-22	诺华股份有限公司	抗生长分化因子15的抗体及其用途
JP7059494B2 (ja) *	2016-07-06	2022-04-26	ナショナルリサーチカウンシルオブカナダ	血液脳関門を通過するヒト化抗体及びその使用
MA46523A (fr) *	2016-10-12	2019-08-21	Janssen Biotech Inc	Procédés de criblage de modulateurs d'une activité biologique de type gdf15
CA3045700A1 (en) *	2016-12-06	2018-06-14	St Vincent's Hospital Sydney Limited	Treatment of obesity and eating disorders
CA3109905A1 (en)	2018-08-20	2020-02-27	Pfizer Inc.	Anti-gdf15 antibodies, compositions and methods of use
IL302646A (en) *	2020-11-10	2023-07-01	Catalym Gmbh	Anti-GDF15 antibody and dosage regimen for cancer treatment
EP4314071A1 (en)	2021-03-31	2024-02-07	Cambridge Enterprise Limited	Therapeutic inhibitors of gdf15 signalling
EP4384545A1 (en)	2021-08-10	2024-06-19	BYOMass Inc.	Anti-gdf15 antibodies, compositions and uses thereof
WO2023122213A1 (en)	2021-12-22	2023-06-29	Byomass Inc.	Targeting gdf15-gfral pathway cross-reference to related applications
CN116535503A (zh) *	2022-01-26	2023-08-04	康源博创生物科技(北京)有限公司	抗生长分化因子15的抗体分子及其应用
AU2022437929A1 (en) *	2022-01-26	2024-08-08	Yunnan Baiyao Group Co., Ltd.	Antibody molecule against growth and differentiation factor 15 and use thereof
CN119487065A (zh)	2022-05-09	2025-02-18	舒泰神（北京）生物制药股份有限公司	特异性识别gdf15的抗体及其应用
CN116462757A (zh) *	2023-03-24	2023-07-21	科兴生物制药股份有限公司	Gdf15的单域抗体及其应用
TW202547861A (zh) *	2024-04-23	2025-12-16	大陸商勁方醫藥科技(上海)股份有限公司	抗gdf-15抗體及其應用
CN118878677A (zh) *	2024-09-29	2024-11-01	江苏凯基生物技术股份有限公司	一种IgM亚型单克隆抗体及其制备方法和应用

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EP0953639A1 (en) *	1998-04-30	1999-11-03	Boehringer Ingelheim International GmbH	FAPalpha-specific antibody with improved producibility
US6465181B2 (en)	1999-03-25	2002-10-15	Abbott Laboratories	Reagents and methods useful for detecting diseases of the prostate
ATE348164T1 (de)	1999-05-17	2007-01-15	Bioph Biotech Entw Pharm Gmbh	Neuroprotektive eigenschaften von gdf-15, ein mitglied der tgf-beta superfamilie
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KR101962483B1 (ko)	2010-11-17	2019-03-29	추가이 세이야쿠 가부시키가이샤	혈액응고 제viii 인자의 기능을 대체하는 기능을 갖는 다중특이성 항원 결합 분자
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CN102321173B (zh)	2011-08-12	2013-04-03	中国医学科学院肿瘤研究所	人源化巨噬细胞抑制因子1单克隆抗体及其应用
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PT2900263T (pt) *	2012-09-26	2019-07-29	Univ Wuerzburg J Maximilians	Anticorpos monoclonais contra o factor de crescimento e diferenciaçao 15 (gdf-15)
CA2896076C (en)	2012-12-21	2022-12-06	Aveo Pharmaceuticals, Inc.	Anti-gdf15 antibodies
EP3122775B1 (en)	2014-03-26	2019-11-13	Julius-Maximilians-Universität Würzburg	Monoclonal antibodies to growth and differentiation factor 15 (gdf-15), and uses thereof for treating cancer cachexia and cancer

2015
- 2015-03-26 EP EP15712629.3A patent/EP3122775B1/en active Active
- 2015-03-26 HR HRP20231514TT patent/HRP20231514T1/hr unknown
- 2015-03-26 PL PL15712629T patent/PL3122775T3/pl unknown
- 2015-03-26 HR HRP20200034TT patent/HRP20200034T1/hr unknown
- 2015-03-26 PL PL19205321.3T patent/PL3653644T3/pl unknown
- 2015-03-26 WO PCT/EP2015/056654 patent/WO2015144855A1/en not_active Ceased
- 2015-03-26 EP EP23203704.4A patent/EP4316596A3/en active Pending
- 2015-03-26 DK DK19205321.3T patent/DK3653644T5/da active
- 2015-03-26 AU AU2015238264A patent/AU2015238264B2/en active Active
- 2015-03-26 RS RS20191652A patent/RS59700B1/sr unknown
- 2015-03-26 CN CN201580027932.8A patent/CN106536553B/zh active Active
- 2015-03-26 LT LTEP19205321.3T patent/LT3653644T/lt unknown
- 2015-03-26 SI SI201531059T patent/SI3122775T1/sl unknown
- 2015-03-26 LT LTEP15712629.3T patent/LT3122775T/lt unknown
- 2015-03-26 SM SM20200064T patent/SMT202000064T1/it unknown
- 2015-03-26 HU HUE15712629A patent/HUE047398T2/hu unknown
- 2015-03-26 KR KR1020167029710A patent/KR102520978B1/ko active Active
- 2015-03-26 ES ES15712629T patent/ES2763859T3/es active Active
- 2015-03-26 ES ES19205321T patent/ES2965626T3/es active Active
- 2015-03-26 EP EP19205321.3A patent/EP3653644B1/en active Active
- 2015-03-26 PT PT192053213T patent/PT3653644T/pt unknown
- 2015-03-26 FI FIEP19205321.3T patent/FI3653644T3/fi active
- 2015-03-26 DK DK15712629.3T patent/DK3122775T3/da active
- 2015-03-26 PT PT157126293T patent/PT3122775T/pt unknown
- 2015-03-26 US US15/128,604 patent/US20170204174A1/en not_active Abandoned
- 2015-03-26 BR BR122023027559-4A patent/BR122023027559A2/pt not_active Application Discontinuation
- 2015-03-26 JP JP2016559286A patent/JP6865585B2/ja active Active
- 2015-03-26 NZ NZ724649A patent/NZ724649A/en unknown
- 2015-03-26 HU HUE19205321A patent/HUE064573T2/hu unknown
2016
- 2016-09-26 IL IL248038A patent/IL248038B/en active IP Right Grant
2018
- 2018-03-05 US US15/912,358 patent/US10604565B2/en active Active
2020
- 2020-01-08 CY CY20201100008T patent/CY1122456T1/el unknown
- 2020-02-19 US US16/794,401 patent/US11634482B2/en active Active
- 2020-02-19 US US16/794,406 patent/US11760795B2/en active Active
- 2020-07-30 IL IL276405A patent/IL276405B/en unknown
- 2020-10-28 AU AU2020260440A patent/AU2020260440B2/en active Active
2021
- 2021-04-06 JP JP2021064572A patent/JP7607498B2/ja active Active
2023
- 2023-04-06 JP JP2023062338A patent/JP2023098966A/ja not_active Withdrawn
- 2023-08-02 US US18/364,173 patent/US20230382987A1/en not_active Abandoned
2025
- 2025-06-13 US US19/237,241 patent/US20260008841A1/en active Pending

Also Published As

Publication number	Publication date
EP3122775B1 (en)	2019-11-13
US11760795B2 (en)	2023-09-19
EP3653644A1 (en)	2020-05-20
EP3653644B1 (en)	2023-11-15
ES2763859T3 (es)	2020-06-01
US20180298091A1 (en)	2018-10-18
AU2020260440A1 (en)	2020-11-26
FI3653644T3 (fi)	2023-12-12
US10604565B2 (en)	2020-03-31
IL276405A (en)	2020-09-30
WO2015144855A1 (en)	2015-10-01
JP2017508475A (ja)	2017-03-30
IL248038A0 (en)	2016-11-30
US20260008841A1 (en)	2026-01-08
AU2015238264A1 (en)	2016-10-20
PT3122775T (pt)	2019-12-26
ES2965626T3 (es)	2024-04-16
US20200308265A1 (en)	2020-10-01
IL276405B (en)	2021-07-29
JP2021119138A (ja)	2021-08-12
US20200308264A1 (en)	2020-10-01
US20170204174A1 (en)	2017-07-20
PL3122775T3 (pl)	2020-05-18
US20230382987A1 (en)	2023-11-30
PT3653644T (pt)	2023-12-19
CA2943694A1 (en)	2015-10-01
KR102520978B1 (ko)	2023-04-11
PL3653644T3 (pl)	2024-03-04
AU2020260440B2 (en)	2024-03-21
HRP20200034T1 (hr)	2020-03-20
SMT202000064T1 (it)	2020-03-13
BR122023027559A2 (pt)	2024-01-30
LT3122775T (lt)	2020-02-10
RS59700B1 (sr)	2020-01-31
SI3122775T1 (sl)	2020-02-28
CY1122456T1 (el)	2021-01-27
JP2023098966A (ja)	2023-07-11
EP4316596A2 (en)	2024-02-07
BR112016022013A2 (pt)	2017-10-31
JP7607498B2 (ja)	2024-12-27
JP6865585B2 (ja)	2021-04-28
EP4316596A3 (en)	2024-04-17
HRP20231514T1 (hr)	2024-03-01
AU2015238264B2 (en)	2020-09-03
CN106536553A (zh)	2017-03-22
HUE047398T2 (hu)	2020-04-28
IL248038B (en)	2020-08-31
HUE064573T2 (hu)	2024-03-28
CN106536553B (zh)	2021-03-12
US11634482B2 (en)	2023-04-25
NZ724649A (en)	2022-07-01
EP3122775A1 (en)	2017-02-01
DK3653644T3 (da)	2023-12-18
KR20160139005A (ko)	2016-12-06
LT3653644T (lt)	2024-01-25
DK3122775T3 (da)	2020-02-03

Publication	Publication Date	Title
DK3653644T3 (da)	2023-12-18	Monoklonale antistoffer mod vækst- og differentieringsfaktor 15 (gdf-15) og anvendelser deraf til behandling af kræftrelateret kakeksi og kræft
IL272470A (en)	2020-03-31	Methods and materials for assessing and treating cancer
HUE053452T2 (hu)	2021-07-28	Anti-PD-1 és anti-LAG3 antitestek rák kezelésére
IL264674B1 (en)	2023-05-01	Antibodies to siglec7 for cancer treatment
DK3307322T3 (da)	2021-04-19	Humaniserede anti-cd40-antistoffer og anvendelser deraf
IL253462A0 (en)	2017-09-28	Cancer treatment with monoclonal antibodies against latency-associated peptide
DK3508502T3 (da)	2023-07-31	Kombination af anti-lag-3-antistoffer og anti-pd-1-antistoffer til behandling af tumorer
EP3426686C0 (en)	2025-10-08	Humanized Anti-PACAP Antibodies and Their Uses
DK3504242T3 (da)	2020-08-17	Anti-ox40-antistoffer og anvendelse deraf
DK3445388T3 (da)	2024-06-03	Materialer og fremgangsmåder til behandling af hæmoglobinopatier
DK3826667T3 (da)	2024-07-22	Claudin6-antistoffer og fremgangsmåder til behandling af kræft
DK3142751T3 (da)	2019-10-14	Anti-B7-H1- og anti-CTLA-4-antistoffer til behandling af ikke-småcellet lungecancer
DK4339615T3 (da)	2025-12-22	Anti-PD-1-antistof til anvendelse i behandlingen af kræft
DK3445785T3 (da)	2022-09-19	Humaniserede anti-clever-1-antistoffer og anvendelse deraf
IL258515A (en)	2018-05-31	Methods of treatment using anti-il-17a/f antibodies
IL262588A (en)	2018-12-31	Humanized anti-basigin antibodies and the use thereof
IL282478A (en)	2021-06-30	Materials and methods for treating cancer
IL250507B (en)	2021-10-31	Anti-ck8 antibodies for use in the treatment of cancers
DK3368567T3 (da)	2025-10-20	Humaniseret anti-dkk2-antistof og anvendelser heraf
DK3349731T3 (da)	2024-01-08	Kombination af topoisomerase-i-inhibitorer med immunoterapi til behandlingen af kræft
DK3313528T3 (da)	2021-09-20	Immunterapeutiske doseringsskemaer omfattende pomalidomid og et anti-cs1-antistof til behandling af cancer
GB2524553C (en)	2017-07-19	Monoclonal antibodies to growth and differentiation factor 15 (GDF-15), and uses thereof for treating cancer cachexia
GB2524552B (en)	2017-07-12	Monoclonal antibodies to growth and differentiation factor 15 (GDF-15), and use thereof for treating cancer