DK3655532T3 - Tokomponent vektorbibliotek til hurtig sammensætning og diversificering af åbne t-cellereceptorlæserammer i fuld længde - Google Patents
Tokomponent vektorbibliotek til hurtig sammensætning og diversificering af åbne t-cellereceptorlæserammer i fuld længde Download PDFInfo
- Publication number
- DK3655532T3 DK3655532T3 DK18743749.6T DK18743749T DK3655532T3 DK 3655532 T3 DK3655532 T3 DK 3655532T3 DK 18743749 T DK18743749 T DK 18743749T DK 3655532 T3 DK3655532 T3 DK 3655532T3
- Authority
- DK
- Denmark
- Prior art keywords
- diversification
- length
- cell receptor
- reading frames
- component vector
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17181798 | 2017-07-18 | ||
| PCT/EP2018/069333 WO2019016175A1 (en) | 2017-07-18 | 2018-07-17 | TWO-COMPONENT VECTOR LIBRARY SYSTEM FOR RAPID ASSEMBLY AND DIVERSIFICATION OF FULL-LENGTH T-CELL RECEPTOR OPEN READER FRAMES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3655532T3 true DK3655532T3 (da) | 2021-11-08 |
Family
ID=59387893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18743749.6T DK3655532T3 (da) | 2017-07-18 | 2018-07-17 | Tokomponent vektorbibliotek til hurtig sammensætning og diversificering af åbne t-cellereceptorlæserammer i fuld længde |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20200231974A1 (da) |
| EP (1) | EP3655532B1 (da) |
| JP (1) | JP7335224B2 (da) |
| KR (1) | KR102652494B1 (da) |
| CN (1) | CN111315883B (da) |
| AU (1) | AU2018303164B2 (da) |
| CA (1) | CA3067124A1 (da) |
| DK (1) | DK3655532T3 (da) |
| ES (1) | ES2897202T3 (da) |
| WO (1) | WO2019016175A1 (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3038917A1 (en) | 2016-11-07 | 2018-05-11 | Genovie Ab | An engineered multi-component system for identification and characterisation of t-cell receptors and t-cell antigens |
| CN116144706A (zh) | 2018-08-13 | 2023-05-23 | 根路径基因组学公司 | 成对的二分免疫受体多核苷酸的高通量克隆及其应用 |
| IL282290B1 (en) | 2018-10-16 | 2026-04-01 | Blueallele Llc | Methods for directing the insertion of DNA into genes |
| EP3947436A4 (en) * | 2019-04-05 | 2022-12-28 | Rootpath Genomics, Inc. | COMPOSITIONS AND METHODS FOR ASSEMBLING T LYMPHOCYTE RECEPTOR GENE |
| JP7756639B2 (ja) | 2019-11-08 | 2025-10-20 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｘ連鎖性若年網膜分離療法のためのｃｒｉｓｐｒおよびａａｖ戦略 |
| CN112739833B (zh) * | 2020-04-25 | 2024-08-30 | 黄婉秋 | 利用巢式RPA技术检测SARS-CoV-2的引物对、探针、试剂盒及其应用 |
| AU2021265124A1 (en) | 2020-04-27 | 2022-11-03 | Genovie Ab | Methods to generate vaccine compositions that prime human leukocyte antigen class I restricted CD8 T-cell responses against viral non-virion-integral derived epitopes |
| KR20240036508A (ko) * | 2021-05-13 | 2024-03-20 | 포지 바이올로직스, 인크. | 아데노바이러스성 헬퍼 플라스미드 |
| MX2024003870A (es) * | 2021-09-27 | 2024-09-11 | Aldevron Llc | Produccion sintetica de vectores de adn circular. |
| WO2025125590A2 (en) | 2023-12-15 | 2025-06-19 | Genovie Ab | Tcr recognizing g12v mutated ras and uses thereof |
| CN119979614A (zh) * | 2024-10-22 | 2025-05-13 | 特赛免疫(广州)科技有限公司 | αβ型TCR分子文库及其构建方法与应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170039316A1 (en) * | 2003-11-12 | 2017-02-09 | Yuriy Fofanov | Compositions, processes and algorithms for microbial detection |
| US20100291633A1 (en) * | 2007-09-03 | 2010-11-18 | Thorsten Selmer | Method of cloning at least one nucleic acid molecule of interest using type iis restriction endonucleases, and corresponding cloning vectors, kits and system using type iis restriction endonucleases |
| EP2395087A1 (en) * | 2010-06-11 | 2011-12-14 | Icon Genetics GmbH | System and method of modular cloning |
| DK2831238T3 (da) * | 2012-03-27 | 2018-04-03 | Dsm Ip Assets Bv | Kloningsfremgangsmåde |
| EP2834357B1 (en) * | 2012-04-04 | 2017-12-27 | Life Technologies Corporation | Tal-effector assembly platform, customized services, kits and assays |
| JP6126804B2 (ja) | 2012-07-25 | 2017-05-10 | 国立大学法人富山大学 | Ｔ細胞受容体のクローニング方法 |
| EP2877489A4 (en) * | 2012-07-27 | 2016-04-13 | Univ Illinois | MANIPULATION OF T-CELL RECEPTORS |
| CN114634950A (zh) * | 2012-12-12 | 2022-06-17 | 布罗德研究所有限公司 | 用于序列操纵的crispr-cas组分系统、方法以及组合物 |
| JP2017511151A (ja) * | 2014-03-14 | 2017-04-20 | イムノコア リミテッド | Ｔｃｒライブラリ |
| GB201407852D0 (en) * | 2014-05-02 | 2014-06-18 | Iontas Ltd | Preparation of libraries od protein variants expressed in eukaryotic cells and use for selecting binding molecules |
| WO2016145084A1 (en) * | 2015-03-09 | 2016-09-15 | Novozymes A/S | Methods of introducing multiple expression constructs into a eukaryotic cell |
| NZ737400A (en) * | 2015-06-01 | 2019-09-27 | Medigene Immunotherapies Gmbh | T cell receptor library |
| CA3039420A1 (en) | 2016-11-07 | 2018-05-11 | Genovie Ab | A two-part device for t-cell receptor synthesis and stable genomic integration to tcr-presenting cells |
| US20190359937A1 (en) * | 2016-11-17 | 2019-11-28 | Innovative Targeting Solutions Inc. | Chimeric receptors, biosensor host cells and methods/uses thereof |
-
2018
- 2018-07-17 DK DK18743749.6T patent/DK3655532T3/da active
- 2018-07-17 CA CA3067124A patent/CA3067124A1/en active Pending
- 2018-07-17 ES ES18743749T patent/ES2897202T3/es active Active
- 2018-07-17 JP JP2020502407A patent/JP7335224B2/ja active Active
- 2018-07-17 KR KR1020207003522A patent/KR102652494B1/ko active Active
- 2018-07-17 AU AU2018303164A patent/AU2018303164B2/en active Active
- 2018-07-17 CN CN201880047571.7A patent/CN111315883B/zh active Active
- 2018-07-17 WO PCT/EP2018/069333 patent/WO2019016175A1/en not_active Ceased
- 2018-07-17 US US16/632,301 patent/US20200231974A1/en active Pending
- 2018-07-17 EP EP18743749.6A patent/EP3655532B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3655532B1 (en) | 2021-08-18 |
| NZ759372A (en) | 2023-11-24 |
| JP2020530769A (ja) | 2020-10-29 |
| US20200231974A1 (en) | 2020-07-23 |
| WO2019016175A9 (en) | 2020-04-02 |
| JP7335224B2 (ja) | 2023-08-29 |
| ES2897202T3 (es) | 2022-02-28 |
| KR20200028415A (ko) | 2020-03-16 |
| AU2018303164A1 (en) | 2019-12-12 |
| EP3655532A1 (en) | 2020-05-27 |
| KR102652494B1 (ko) | 2024-03-28 |
| WO2019016175A1 (en) | 2019-01-24 |
| CN111315883B (zh) | 2024-06-18 |
| AU2018303164B2 (en) | 2024-09-19 |
| CN111315883A (zh) | 2020-06-19 |
| CA3067124A1 (en) | 2019-01-24 |
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