DK3680000T3 - Fremgangsmåder til oprensning af antistoffer - Google Patents

Fremgangsmåder til oprensning af antistoffer Download PDF

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Publication number
DK3680000T3
DK3680000T3 DK19198005.1T DK19198005T DK3680000T3 DK 3680000 T3 DK3680000 T3 DK 3680000T3 DK 19198005 T DK19198005 T DK 19198005T DK 3680000 T3 DK3680000 T3 DK 3680000T3
Authority
DK
Denmark
Prior art keywords
antibodies
purification
methods
Prior art date
Application number
DK19198005.1T
Other languages
English (en)
Inventor
Kent E Goklen
Eric J Suda
Antonio Raul Ubiera
Original Assignee
Glaxosmithkline Ip Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50391244&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3680000(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Ip Dev Ltd filed Critical Glaxosmithkline Ip Dev Ltd
Application granted granted Critical
Publication of DK3680000T3 publication Critical patent/DK3680000T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/22Affinity chromatography or related techniques based upon selective absorption processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804Affinity chromatography
    • B01D15/3809Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065Purification, fragmentation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
DK19198005.1T 2013-03-15 2014-03-13 Fremgangsmåder til oprensning af antistoffer DK3680000T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361787309P 2013-03-15 2013-03-15
EP14713926.5A EP2969098B1 (en) 2013-03-15 2014-03-13 Methods for purifying antibodies

Publications (1)

Publication Number Publication Date
DK3680000T3 true DK3680000T3 (da) 2024-04-02

Family

ID=50391244

Family Applications (2)

Application Number Title Priority Date Filing Date
DK19198005.1T DK3680000T3 (da) 2013-03-15 2014-03-13 Fremgangsmåder til oprensning af antistoffer
DK14713926.5T DK2969098T3 (da) 2013-03-15 2014-03-13 Fremgangsmåder til oprensning af antistoffer

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK14713926.5T DK2969098T3 (da) 2013-03-15 2014-03-13 Fremgangsmåder til oprensning af antistoffer

Country Status (15)

Country Link
US (3) US10676503B2 (da)
EP (3) EP4371996A3 (da)
JP (2) JP6599773B2 (da)
KR (1) KR102114021B1 (da)
CN (1) CN105188872B (da)
AU (1) AU2014229280B2 (da)
BR (1) BR112015022321A2 (da)
CA (1) CA2902287A1 (da)
DK (2) DK3680000T3 (da)
ES (2) ES2765206T3 (da)
IL (1) IL240753B (da)
RU (1) RU2651483C2 (da)
SG (1) SG11201506494XA (da)
TW (1) TWI625335B (da)
WO (1) WO2014141150A1 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI625335B (zh) 2013-03-15 2018-06-01 Glaxosmithkline Intellectual Property (No. 2) Limited 純化抗體的方法
JP2016519145A (ja) 2013-05-15 2016-06-30 メディミューン リミテッド 組換え産生ポリペプチドの精製
ES2857582T3 (es) 2014-04-30 2021-09-29 Novo Nordisk As Métodos para la purificación de proteínas mediante el uso de ácido caprílico
WO2016121701A1 (ja) 2015-01-26 2016-08-04 株式会社カネカ 免疫グロブリンκ鎖可変領域含有タンパク質精製用アフィニティー分離マトリックス
CN108064286A (zh) 2015-01-26 2018-05-22 株式会社钟化 突变型免疫球蛋白κ链可变区结合性肽
WO2017195638A1 (ja) 2016-05-09 2017-11-16 株式会社カネカ 抗体またはκ鎖可変領域含有抗体断片の精製方法
RU2759909C2 (ru) 2016-09-07 2021-11-18 Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед Способы очистки антител
CN106939045B (zh) * 2017-05-01 2020-03-31 深圳市国创纳米抗体技术有限公司 一种单克隆抗体细胞培养液澄清的方法
CN108085358A (zh) * 2018-02-08 2018-05-29 保定冀中药业有限公司 一种犬细小病毒单克隆抗体IgG2b-Fab片段的制备方法
TW202000891A (zh) * 2018-03-07 2020-01-01 英商葛蘭素史克智慧財產發展有限公司 純化抗體之方法
TW202003555A (zh) * 2018-03-07 2020-01-16 英商葛蘭素史克智慧財產發展有限公司 用於純化重組多肽之方法
CN116234619A (zh) * 2020-08-18 2023-06-06 赛多利斯比亚分离有限责任公司 宿主细胞dna的金属亲和提取
CN114133446A (zh) * 2021-12-31 2022-03-04 方坦思(上海)生物医药有限公司 单克隆抗体的纯化方法
CN116179582A (zh) * 2022-09-27 2023-05-30 南京医事达生物科技有限公司 一种通用型基因重组蛋白质a亲和纯化填料制备方法和应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57106673A (en) 1980-12-24 1982-07-02 Chugai Pharmaceut Co Ltd Dibenzo(b,f)(1,4)oxazepin derivative
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5429746A (en) * 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
US6955917B2 (en) 1997-06-20 2005-10-18 Bayer Healthcare Llc Chromatographic method for high yield purification and viral inactivation of antibodies
IL127127A0 (en) 1998-11-18 1999-09-22 Peptor Ltd Small functional units of antibody heavy chain variable regions
EP1584242B1 (en) * 2001-06-01 2010-01-20 Upfront Chromatography A/S Fractionation of protein containing mixtures
CA2457636C (en) 2001-08-10 2012-01-03 Aberdeen University Antigen binding domains
CN100403028C (zh) 2002-05-31 2008-07-16 印度农业研究委员会 Bt-cry毒素的迅速检测
ES2407380T5 (es) * 2004-02-27 2017-07-07 Octapharma Ag Procedimiento para proporcionar una preparación de anticuerpos purificada, sin riesgo respecto a virus
EP1786827A4 (en) * 2004-05-14 2008-10-29 Kirin Holdings Kk PROCESS FOR IMMUNOGLOBULINE CLEANING
US8263750B2 (en) * 2006-03-16 2012-09-11 Amgen Inc. Method for purifying a protein using protein-A affinity chromatography using an intermediate wash step
AR062711A1 (es) 2006-09-08 2008-11-26 Wyeth Corp Lavado de arginina en l a purificacion de proteinas usando cromatografia de afinidad
WO2008085988A1 (en) * 2007-01-05 2008-07-17 Amgen Inc. Methods of purifying proteins
JP6147726B2 (ja) * 2011-03-29 2017-06-14 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーGlaxoSmithKline LLC タンパク質精製のためのバッファー系
TWI625335B (zh) * 2013-03-15 2018-06-01 Glaxosmithkline Intellectual Property (No. 2) Limited 純化抗體的方法
JP2016519145A (ja) 2013-05-15 2016-06-30 メディミューン リミテッド 組換え産生ポリペプチドの精製
EP3683232A1 (en) 2013-09-13 2020-07-22 F. Hoffmann-La Roche AG Methods and compositions comprising purified recombinant polypeptides

Also Published As

Publication number Publication date
EP4371996A3 (en) 2024-08-14
JP2016519052A (ja) 2016-06-30
ES2765206T3 (es) 2020-06-08
EP3680000B1 (en) 2024-03-13
EP2969098A1 (en) 2016-01-20
JP6599773B2 (ja) 2019-10-30
DK2969098T3 (da) 2020-01-27
IL240753A0 (en) 2015-10-29
SG11201506494XA (en) 2015-09-29
JP7002511B2 (ja) 2022-02-21
US12358945B2 (en) 2025-07-15
TW201522365A (zh) 2015-06-16
KR20150131235A (ko) 2015-11-24
EP4371996A2 (en) 2024-05-22
ES2978309T3 (es) 2024-09-10
CN105188872B (zh) 2019-01-15
EP3680000A1 (en) 2020-07-15
US10676503B2 (en) 2020-06-09
JP2020019795A (ja) 2020-02-06
CN105188872A (zh) 2015-12-23
US20250353878A1 (en) 2025-11-20
AU2014229280B2 (en) 2017-01-05
BR112015022321A2 (pt) 2017-07-18
IL240753B (en) 2021-01-31
AU2014229280A1 (en) 2015-10-01
TWI625335B (zh) 2018-06-01
US20200277330A1 (en) 2020-09-03
WO2014141150A1 (en) 2014-09-18
RU2651483C2 (ru) 2018-04-19
KR102114021B1 (ko) 2020-05-22
CA2902287A1 (en) 2014-09-18
US20160024146A1 (en) 2016-01-28
RU2015136860A (ru) 2017-04-28
EP2969098B1 (en) 2019-10-30

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