DK3712152T3 - 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridin og 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepinderivater som janus kinase-inhibitorer - Google Patents

4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridin og 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepinderivater som janus kinase-inhibitorer Download PDF

Info

Publication number
DK3712152T3
DK3712152T3 DK20171633.9T DK20171633T DK3712152T3 DK 3712152 T3 DK3712152 T3 DK 3712152T3 DK 20171633 T DK20171633 T DK 20171633T DK 3712152 T3 DK3712152 T3 DK 3712152T3
Authority
DK
Denmark
Prior art keywords
chinase
hexahydroimidazo
janus
imidazo
tetrahydro
Prior art date
Application number
DK20171633.9T
Other languages
English (en)
Inventor
Matthew Colin Thor Fyfe
Original Assignee
Topivert Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1519381.6A external-priority patent/GB201519381D0/en
Application filed by Topivert Pharma Ltd filed Critical Topivert Pharma Ltd
Application granted granted Critical
Publication of DK3712152T3 publication Critical patent/DK3712152T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK20171633.9T 2015-11-03 2016-11-02 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridin og 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepinderivater som janus kinase-inhibitorer DK3712152T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1519381.6A GB201519381D0 (en) 2015-11-03 2015-11-03 Kinase inhibitors
GB201606968 2016-04-21
EP16793973.5A EP3371184A1 (en) 2015-11-03 2016-11-02 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors

Publications (1)

Publication Number Publication Date
DK3712152T3 true DK3712152T3 (da) 2021-03-22

Family

ID=57256356

Family Applications (1)

Application Number Title Priority Date Filing Date
DK20171633.9T DK3712152T3 (da) 2015-11-03 2016-11-02 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridin og 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepinderivater som janus kinase-inhibitorer

Country Status (8)

Country Link
US (1) US10851097B2 (da)
EP (3) EP3371184A1 (da)
CA (1) CA3037243A1 (da)
DK (1) DK3712152T3 (da)
ES (1) ES2864035T3 (da)
PL (1) PL3712152T3 (da)
PT (1) PT3712152T (da)
WO (1) WO2017077283A1 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3371185T (pt) 2015-11-03 2020-12-28 Topivert Pharma Ltd Derivados de 4,5,6,7-tetrahidro-1h-imidazo[4,5-c]piridina e 1,4,5,6,7,8-hexahidroimidazo[4,5-d]azepina como inibidores de janus quinase
KR20180073687A (ko) 2015-11-03 2018-07-02 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 호흡기 질환의 치료를 위한 jak 키나제 저해제 화합물
AU2018231032B2 (en) 2017-03-09 2021-08-19 Theravance Biopharma R&D Ip, Llc JAK inhibitors containing a 4-membered heterocyclic amide
MX389014B (es) 2017-05-01 2025-03-20 Theravance Biopharma R&D Ip Llc Formas cristalinas de un compuesto inhibidor de jak
KR102568333B1 (ko) 2017-05-01 2023-08-18 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 Jak 저해제 화합물을 사용하는 치료 방법
AR111495A1 (es) 2017-05-01 2019-07-17 Theravance Biopharma R&D Ip Llc Compuestos de imidazo-piperidina fusionada como inhibidores de jak
EP3652169A1 (en) 2017-08-01 2020-05-20 Theravance Biopharma R&D IP, LLC Pyrazolo and triazolo bicyclic compounds as jak kinase inhibitors
JP7383696B2 (ja) 2018-09-04 2023-11-20 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー Ｊａｋ阻害剤としての５員～７員の複素環アミド
EP3837253B1 (en) * 2018-09-04 2023-06-07 Theravance Biopharma R&D IP, LLC Process for preparing jak inhibitors and intermediates thereof
DK3837258T3 (da) 2018-09-04 2024-07-22 Theravance Biopharma R&D Ip Llc Dimethyl amino azetidine amides as jak inhibitors
SG11202103042XA (en) * 2018-10-29 2021-04-29 Theravance Biopharma R&D Ip Llc 2-azabicyclo hexane compound as jak inhibitor
JP2022518741A (ja) 2019-01-23 2022-03-16 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ＪＡＫキナーゼ阻害剤としてのイミダゾ［１，５－ａ］ピリジン、１，２，４－トリアゾロ［４，３－ａ］ピリジンおよびイミダゾ［１，５－ａ］ピラジン
WO2020173400A1 (zh) * 2019-02-25 2020-09-03 河南迈英诺医药科技有限公司 Jak抑制剂化合物及其用途
CN114075200A (zh) * 2020-08-14 2022-02-22 河南迈英诺医药科技有限公司 用于治疗重症肺炎的jak抑制剂化合物
CN114075199B (zh) * 2020-08-14 2026-03-10 河南迈英诺医药科技有限公司 Jak抑制剂化合物及其用途
TW202144343A (zh) 2020-03-02 2021-12-01 美商施萬生物製藥研發 Ip有限責任公司 Jak抑制劑化合物之結晶水合物
EP4357347B1 (en) * 2021-06-21 2024-12-11 Henan Medinno Pharmaceutical Technology Co., Ltd. Trk kinase inhibitor compound and use thereof
TW202317550A (zh) 2021-06-25 2023-05-01 美商施萬生物製藥研發 Ip有限責任公司 作為jak抑制劑之咪唑吲唑化合物
JP2025525428A (ja) * 2022-07-04 2025-08-05 メディノ ファーマスーティカル テクノロジー （チューハイ） カンパニー リミテッド Ｔｒｋ阻害剤及び／又はｒｅｔ阻害剤としての化合物及びその使用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2691914C (en) 2007-07-11 2012-06-26 Pfizer Inc. Pharmaceutical compositions and methods of treating dry eye disorders
US8575336B2 (en) * 2011-07-27 2013-11-05 Pfizer Limited Indazoles
FR2981917B1 (fr) 2011-10-26 2013-11-15 Cadorit Ag Recipient pour emballer un premier fluide et un deuxieme fluide
JP6248103B2 (ja) 2012-06-22 2017-12-13 ミメトゲン ファーマシュウティカルズ インコーポレイテッドＭｉｍｅｔｏｇｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． β−ターン環式ペプチド模倣化合物の合成
CN106459048A (zh) 2014-05-14 2017-02-22 辉瑞公司 吡唑并吡啶类和吡唑并嘧啶类
KR20180011272A (ko) 2015-05-28 2018-01-31 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 Jak 키나제 저해제로서 나프티리딘 화합물
KR20180073687A (ko) 2015-11-03 2018-07-02 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 호흡기 질환의 치료를 위한 jak 키나제 저해제 화합물
PT3371185T (pt) 2015-11-03 2020-12-28 Topivert Pharma Ltd Derivados de 4,5,6,7-tetrahidro-1h-imidazo[4,5-c]piridina e 1,4,5,6,7,8-hexahidroimidazo[4,5-d]azepina como inibidores de janus quinase
US10435428B2 (en) 2015-11-24 2019-10-08 Theravance Biopharma R&D Ip, Llc Prodrugs of a JAK inhibitor compound for treatment of gastrointestinal inflammatory disease
TWI726094B (zh) 2016-04-28 2021-05-01 美商施萬生物製藥研發Ｉｐ有限責任公司 作為jak激酶抑制劑之嘧啶化合物

Also Published As

Publication number Publication date
EP3712152B1 (en) 2021-01-13
EP3865481A1 (en) 2021-08-18
US20180319791A1 (en) 2018-11-08
ES2864035T3 (es) 2021-10-13
WO2017077283A1 (en) 2017-05-11
CA3037243A1 (en) 2017-05-11
EP3712152A1 (en) 2020-09-23
US10851097B2 (en) 2020-12-01
EP3371184A1 (en) 2018-09-12
PL3712152T3 (pl) 2021-08-02
PT3712152T (pt) 2021-04-15

Similar Documents

Publication Publication Date Title
DK3371185T3 (da) 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridin og 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepinderivater som janus-kinase-inhibitorer
PT3712152T (pt) Derivados de 4,5,6,7-tetrahidro-1h-imidazo[4,5-c]piridina e 1,4,5,6,7,8-hexahidroimidazo[4,5-d]azepina como inibidores de janus quinase
DK3558990T3 (da) Tetrahydroimidazo[4,5-c]pyridinderivater som pd-l1 internaliseringsinducere
DK3478681T3 (da) 1h-pyrazolo[4,3-b]pyridiner som pde1-inhibitorer
KR102161364B9 (ko) LRRK2 억제제로서 이미다조[4,5-c]퀴놀린 및 이미다조[4,5-c][1,5]나프티리딘 유도체
LT3555097T (lt) Imidazo[4,5-d]pirolo[2,3-b]piridino junginiai kaip janus kinazės inhibitoriai
DK3322706T3 (da) Substituerede pyrazolo[1,5-a]pyridin-forbindelser som ret-kinaseinhibitorer
DK3523301T3 (da) Substituerede pyrazolo[1,5-A]pyridin-forbindelser som RET-kinase-inhibitorer
DK3523302T3 (da) Substituerede pyrazolo[1,5-A]pyridin-forbindelser som RET-kinase-inhibitorer
DK3481827T3 (da) Imidazo[1,2-a]pyridinderivater, fremgangsmåder til fremstilling og anvendelse deraf
DK3194388T3 (da) Imidazo[4,5-c]pyridin afledte ssao-inhibitorer
DK3466955T3 (da) Fremgangsmåde til fremstilling af oxazol[4,5-b]pyridin og thiazol[4,5-b]pyridinderivater som irak4-hæmmere til behandling af cancer
DK3237423T3 (da) Thieno[2,3-c]pyrrol-4-on-derivater som erk-inhibitorer
CR20160449A (es) Inhibidores de la jak1 para el tratamiento de síndromes mielodisplásicos
DK2970260T3 (da) Imidazo-[4,5-c]pyridin- og pyrrolo-[2,3-c]pyridinderivater som ssao-inhibitorer
IL253284B (en) History of 4h-pyrrolo[2,3-c]pyridine-4-one
IL258341A (en) New imidazo[4,5-b]pyridine derivatives as dual dyrk1/clk1 inhibitors
IL269214B (en) Novel imidazo[5,4-c]quinoline derivatives as lrrk2 inhibitors
DK3347356T3 (da) Tricyclic forbundet pyridin-2-one-derivater og deres anvendelse som brd4-hæmmere
SI2991983T1 (sl) DERIVATI 2-FENIL ALI 2-HETARIL IMIDAZOL(1,2-a)PIRIDINA
HUE057202T2 (hu) Kombinációs kezelések 1H-pirazolo[4,3-b]piridinek alkalmazásával
IL251166A0 (en) Imidazo-[4,5-c]pyridine derivatives as inhibitors of ssao
DK3472160T3 (da) Bicykliske pyridin-, pyrazin- og pyrimidinderivater som pi3k-beta-inhibitorer