DK3717452T3 - Fremgangsmåde til fremstilling af acylerede amphetaminderivater - Google Patents

Fremgangsmåde til fremstilling af acylerede amphetaminderivater Download PDF

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Publication number
DK3717452T3
DK3717452T3 DK18883053.3T DK18883053T DK3717452T3 DK 3717452 T3 DK3717452 T3 DK 3717452T3 DK 18883053 T DK18883053 T DK 18883053T DK 3717452 T3 DK3717452 T3 DK 3717452T3
Authority
DK
Denmark
Prior art keywords
acylated
preparation
amphetamine derivatives
amphetamine
derivatives
Prior art date
Application number
DK18883053.3T
Other languages
English (en)
Inventor
Brian Orr
Kevin Roesch
Joel Mcclenaghan
Original Assignee
SpecGx LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SpecGx LLC filed Critical SpecGx LLC
Application granted granted Critical
Publication of DK3717452T3 publication Critical patent/DK3717452T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/08—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK18883053.3T 2017-11-30 2018-11-27 Fremgangsmåde til fremstilling af acylerede amphetaminderivater DK3717452T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762592503P 2017-11-30 2017-11-30
PCT/US2018/062624 WO2019108542A1 (en) 2017-11-30 2018-11-27 Process for preparing acylated amphetamine derivatives

Publications (1)

Publication Number Publication Date
DK3717452T3 true DK3717452T3 (da) 2024-08-19

Family

ID=66634896

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18883053.3T DK3717452T3 (da) 2017-11-30 2018-11-27 Fremgangsmåde til fremstilling af acylerede amphetaminderivater

Country Status (12)

Country Link
US (1) US10927068B2 (da)
EP (1) EP3717452B1 (da)
JP (1) JP7263350B2 (da)
AU (1) AU2018374838B2 (da)
CA (1) CA3081841A1 (da)
DK (1) DK3717452T3 (da)
ES (1) ES2984183T3 (da)
HU (1) HUE068303T2 (da)
MX (1) MX2020005151A (da)
PL (1) PL3717452T3 (da)
PT (1) PT3717452T (da)
WO (1) WO2019108542A1 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2023366473A1 (en) * 2022-10-28 2025-05-08 Macfarlan Smith Limited Process for the preparation of lisdexamfetamine
WO2026047284A1 (en) 2024-08-28 2026-03-05 Fermion Oy Method for the preparation of lisdexamfetamine

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7659253B2 (en) * 2002-02-22 2010-02-09 Shire Llc Abuse-resistant amphetamine prodrugs
WO2010042120A1 (en) 2008-10-09 2010-04-15 Archimica, Inc. Process for the synthesis of amphetamine derivatives
US8614346B2 (en) * 2009-06-19 2013-12-24 Cambrex Charles City, Inc. Methods and compositions for preparation of amphetamine conjugates and salts thereof
US8779191B2 (en) 2010-12-20 2014-07-15 Cambrex Charles City, Inc. Methods and compositions for preparing lisdexamfetamine and salts thereof
WO2013011526A1 (en) * 2011-07-20 2013-01-24 Ind-Swift Laboratories Limited Process for preparation of lisdexamphetamine and salts thereof
JP2014521641A (ja) * 2011-07-29 2014-08-28 ケムファーム, インコーポレイテッド ホモアルギニンプロドラッグおよび/またはアンフェタミンおよび他の興奮剤の抱合体、ならびに同物を作製および使用するためのプロセス
US10544434B2 (en) * 2015-06-29 2020-01-28 Noramco, Inc. Process for the preparation of lisdexamfetamine and related derivatives

Also Published As

Publication number Publication date
JP7263350B2 (ja) 2023-04-24
ES2984183T3 (es) 2024-10-29
BR112020010650A2 (pt) 2020-11-17
EP3717452B1 (en) 2024-06-05
PT3717452T (pt) 2024-08-28
CA3081841A1 (en) 2019-06-06
EP3717452A1 (en) 2020-10-07
HUE068303T2 (hu) 2024-12-28
PL3717452T3 (pl) 2024-10-14
US20190161435A1 (en) 2019-05-30
JP2021504324A (ja) 2021-02-15
US10927068B2 (en) 2021-02-23
EP3717452A4 (en) 2021-08-25
WO2019108542A1 (en) 2019-06-06
AU2018374838A1 (en) 2020-05-28
MX2020005151A (es) 2020-08-20
AU2018374838B2 (en) 2023-10-05

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