DK3722436T3 - Fixed-bed-bioreaktor med pumpe/rør-system med konstant flow - Google Patents

Fixed-bed-bioreaktor med pumpe/rør-system med konstant flow

Info

Publication number
DK3722436T3
DK3722436T3 DK20176020.4T DK20176020T DK3722436T3 DK 3722436 T3 DK3722436 T3 DK 3722436T3 DK 20176020 T DK20176020 T DK 20176020T DK 3722436 T3 DK3722436 T3 DK 3722436T3
Authority
DK
Denmark
Prior art keywords
fixed
constant flow
pipe system
flow pump
bed bioreactor
Prior art date
Application number
DK20176020.4T
Other languages
English (en)
Inventor
Hanna P Lesch
Piia Kristiina Valonen
Tarja Hannele Tuunanen
Milla Jonna Karoliina Karnaattu
Minna Kristiina Karhinen
Achim Müller
Seppo Yla-Herttuala
Eva Kristiina Räsänen
Original Assignee
Ferring Ventures Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring Ventures Ltd filed Critical Ferring Ventures Ltd
Application granted granted Critical
Publication of DK3722436T3 publication Critical patent/DK3722436T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00Apparatus for enzymology or microbiology
    • C12M1/02Apparatus for enzymology or microbiology with agitation means; with heat exchange means
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/16Particles; Beads; Granular material; Encapsulation
    • C12M25/18Fixed or packed bed
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10Perfusion
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/18External loop; Means for reintroduction of fermented biomass or liquid percolate
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/15011Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15051Methods of production or purification of viral material

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK20176020.4T 2016-04-14 2017-04-03 Fixed-bed-bioreaktor med pumpe/rør-system med konstant flow DK3722436T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662322651P 2016-04-14 2016-04-14
EP17782838.1A EP3442986A4 (en) 2016-04-14 2017-04-03 FIXED BAYOR ACTUATOR WITH CONSTANT FLOW PUMP / PIPING SYSTEM

Publications (1)

Publication Number Publication Date
DK3722436T3 true DK3722436T3 (da) 2025-12-15

Family

ID=60042678

Family Applications (2)

Application Number Title Priority Date Filing Date
DK20176020.4T DK3722436T3 (da) 2016-04-14 2017-04-03 Fixed-bed-bioreaktor med pumpe/rør-system med konstant flow
DK20176019.6T DK3722435T3 (da) 2016-04-14 2017-04-03 Fixed-bed-bioreaktor med pumpe/rør-system med konstant flow

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK20176019.6T DK3722435T3 (da) 2016-04-14 2017-04-03 Fixed-bed-bioreaktor med pumpe/rør-system med konstant flow

Country Status (9)

Country Link
US (1) US11781102B2 (da)
EP (4) EP3604547A1 (da)
KR (1) KR102535013B1 (da)
CN (1) CN109071594A (da)
CA (1) CA3021070A1 (da)
DK (2) DK3722436T3 (da)
PT (1) PT3722435T (da)
SG (1) SG11201808698TA (da)
WO (1) WO2017180341A2 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116144500A (zh) 2016-04-14 2023-05-23 崔泽尔有限公司 具有恒流泵/管道系统的固定床生物反应器
EP3604547A1 (en) 2016-04-14 2020-02-05 Trizell Ltd. Fixed-bed bioreactor with constant-flow pump/tubing system
BE1026108B1 (fr) * 2018-03-16 2019-10-14 Univercells S.A. Échantillonneur à lit fixe et procédés associés
JP2022532498A (ja) * 2019-05-02 2022-07-15 アレフ ファームス リミテッド 培養システムおよび培養食品の大量生産方法
US20220403307A1 (en) * 2019-11-06 2022-12-22 I Peace, Inc. Cell culture device
CN113832112A (zh) * 2020-06-24 2021-12-24 重庆精准生物技术有限公司 一种制备慢病毒的混合方法及混合系统
US20230146372A1 (en) * 2021-11-07 2023-05-11 Univercells Technologies S.A. Sampling apparatus for cell culture bed and related methods

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63313576A (ja) * 1987-06-13 1988-12-21 Rikagaku Kenkyusho チユ−ブラ−バイオリアクタ−
US5622857A (en) * 1995-08-08 1997-04-22 Genespan Corporation High performance cell culture bioreactor and method
WO1998022588A2 (en) * 1996-11-20 1998-05-28 Introgen Therapeutics, Inc. An improved method for the production and purification of adenoviral vectors
ZA200406921B (en) * 2002-03-12 2006-10-25 Ark Therapeutics Ltd Engineered baculoviruses and their use
CA2557046A1 (en) * 2004-03-05 2005-10-13 John Crowley Process for cell culturing by continuous perfusion and alternating tangential flow
US20110189764A1 (en) * 2011-03-27 2011-08-04 Nathan Starbard Single use device incorporating a container and scaffold
US20140315294A1 (en) * 2011-11-24 2014-10-23 Genethon Scalable lentiviral vector production system compatible with industrial pharmaceutical applications
HUE042094T2 (hu) * 2013-02-22 2019-06-28 Genzyme Corp Mikrokarrier-perfúziós tenyésztési eljárások és alkalmazásuk
AU2014226126B2 (en) * 2013-03-08 2019-02-14 Genzyme Corporation Continuous purification of therapeutic proteins
GB201417042D0 (en) * 2014-09-29 2014-11-12 Fkd Therapies Oy Method
CN116144500A (zh) 2016-04-14 2023-05-23 崔泽尔有限公司 具有恒流泵/管道系统的固定床生物反应器
EP3604547A1 (en) 2016-04-14 2020-02-05 Trizell Ltd. Fixed-bed bioreactor with constant-flow pump/tubing system

Also Published As

Publication number Publication date
EP3722435A1 (en) 2020-10-14
WO2017180341A3 (en) 2017-11-23
PT3722435T (pt) 2025-09-22
EP3722436B1 (en) 2025-09-24
CA3021070A1 (en) 2017-10-19
WO2017180341A4 (en) 2018-01-11
SG11201808698TA (en) 2018-11-29
KR102535013B1 (ko) 2023-05-22
KR20180133487A (ko) 2018-12-14
EP3442986A4 (en) 2019-11-13
US11781102B2 (en) 2023-10-10
WO2017180341A2 (en) 2017-10-19
US20200165557A1 (en) 2020-05-28
EP3722436A1 (en) 2020-10-14
DK3722435T3 (da) 2025-11-17
EP3722435B1 (en) 2025-09-03
EP3442986A2 (en) 2019-02-20
CN109071594A (zh) 2018-12-21
EP3604547A1 (en) 2020-02-05

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