DK3732468T3 - Anordning med reduceret fluorescensområde-støj og metode - Google Patents

Anordning med reduceret fluorescensområde-støj og metode Download PDF

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Publication number
DK3732468T3
DK3732468T3 DK18896064.5T DK18896064T DK3732468T3 DK 3732468 T3 DK3732468 T3 DK 3732468T3 DK 18896064 T DK18896064 T DK 18896064T DK 3732468 T3 DK3732468 T3 DK 3732468T3
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Denmark
Prior art keywords
fluorescence area
reduced fluorescence
area noise
noise
reduced
Prior art date
Application number
DK18896064.5T
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English (en)
Inventor
Tracy H Fung
Poorya Sabounchi
Bernard Hirschbein
Joseph Pinto
Tarun Khurana
Randall Smith
Wenyi Feng
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Illumina Inc
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Publication of DK3732468T3 publication Critical patent/DK3732468T3/da

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G01N21/6454—Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6402—Atomic fluorescence; Laser induced fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B19/00—Condensers, e.g. light collectors or similar non-imaging optics
    • G02B19/0004—Condensers, e.g. light collectors or similar non-imaging optics characterised by the optical means employed
    • G02B19/0019—Condensers, e.g. light collectors or similar non-imaging optics characterised by the optical means employed having reflective surfaces only (e.g. louvre systems, systems with multiple planar reflectors)
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B19/00—Condensers, e.g. light collectors or similar non-imaging optics
    • G02B19/0033—Condensers, e.g. light collectors or similar non-imaging optics characterised by the use
    • G02B19/0076—Condensers, e.g. light collectors or similar non-imaging optics characterised by the use for use with a detector
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B5/00—Optical elements other than lenses
    • G02B5/20—Filters
    • G02B5/22—Absorbing filters
    • G02B5/223—Absorbing filters containing organic substances, e.g. dyes, inks or pigments
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10F—INORGANIC SEMICONDUCTOR DEVICES SENSITIVE TO INFRARED RADIATION, LIGHT, ELECTROMAGNETIC RADIATION OF SHORTER WAVELENGTH OR CORPUSCULAR RADIATION
    • H10F39/00—Integrated devices, or assemblies of multiple devices, comprising at least one element covered by group H10F30/00, e.g. radiation detectors comprising photodiode arrays
    • H10F39/10—Integrated devices
    • H10F39/12—Image sensors
    • H10F39/18—Complementary metal-oxide-semiconductor [CMOS] image sensors; Photodiode array image sensors
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10F—INORGANIC SEMICONDUCTOR DEVICES SENSITIVE TO INFRARED RADIATION, LIGHT, ELECTROMAGNETIC RADIATION OF SHORTER WAVELENGTH OR CORPUSCULAR RADIATION
    • H10F39/00—Integrated devices, or assemblies of multiple devices, comprising at least one element covered by group H10F30/00, e.g. radiation detectors comprising photodiode arrays
    • H10F39/80—Constructional details of image sensors
    • H10F39/805—Coatings
    • H10F39/8053—Colour filters
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10F—INORGANIC SEMICONDUCTOR DEVICES SENSITIVE TO INFRARED RADIATION, LIGHT, ELECTROMAGNETIC RADIATION OF SHORTER WAVELENGTH OR CORPUSCULAR RADIATION
    • H10F39/00—Integrated devices, or assemblies of multiple devices, comprising at least one element covered by group H10F30/00, e.g. radiation detectors comprising photodiode arrays
    • H10F39/80—Constructional details of image sensors
    • H10F39/806—Optical elements or arrangements associated with the image sensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6471—Special filters, filter wheel
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/08—Optical fibres; light guides

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  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Optical Measuring Cells (AREA)
  • Optical Filters (AREA)
DK18896064.5T 2017-12-28 2018-11-30 Anordning med reduceret fluorescensområde-støj og metode DK3732468T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762611464P 2017-12-28 2017-12-28
US201862644804P 2018-03-19 2018-03-19
PCT/US2018/063395 WO2019133182A1 (en) 2017-12-28 2018-11-30 Detector with reduced fluorescence range noise

Publications (1)

Publication Number Publication Date
DK3732468T3 true DK3732468T3 (da) 2022-02-14

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DK18896064.5T DK3732468T3 (da) 2017-12-28 2018-11-30 Anordning med reduceret fluorescensområde-støj og metode

Country Status (25)

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US (6) US10551317B2 (da)
EP (2) EP3978908B1 (da)
JP (1) JP6827570B2 (da)
KR (2) KR102261632B1 (da)
CN (3) CN115078317B (da)
AU (2) AU2018397465A1 (da)
BR (1) BR112019028286B1 (da)
CA (2) CA3191105C (da)
CL (1) CL2019003784A1 (da)
CO (1) CO2019014476A2 (da)
CR (1) CR20190584A (da)
DK (1) DK3732468T3 (da)
ES (1) ES2906809T3 (da)
IL (1) IL271293B (da)
MX (1) MX381250B (da)
MY (1) MY194752A (da)
NZ (1) NZ778619A (da)
PE (1) PE20200893A1 (da)
PH (1) PH12019502900A1 (da)
RU (1) RU2738311C1 (da)
SA (1) SA519410862B1 (da)
SG (1) SG11201912255RA (da)
TW (1) TWI698638B (da)
WO (1) WO2019133182A1 (da)
ZA (1) ZA201908274B (da)

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IL271293A (en) 2020-01-30
CL2019003784A1 (es) 2020-07-10
US10883937B2 (en) 2021-01-05
US20240094125A1 (en) 2024-03-21
KR102261632B1 (ko) 2021-06-07
US20250044228A1 (en) 2025-02-06
NZ759983A (en) 2021-08-27
MY194752A (en) 2022-12-15
PH12019502900A1 (en) 2020-09-14
EP3732468A1 (en) 2020-11-04
CR20190584A (es) 2020-03-06
EP3978908B1 (en) 2025-05-07
IL271293B (en) 2021-03-25
CA3067249A1 (en) 2019-07-04
KR20210066028A (ko) 2021-06-04
SA519410862B1 (ar) 2022-09-05
CA3191105C (en) 2025-10-14
JP6827570B2 (ja) 2021-02-10
US10551317B2 (en) 2020-02-04
TWI698638B (zh) 2020-07-11
CA3067249C (en) 2023-04-25
BR112019028286B1 (pt) 2021-10-26
ZA201908274B (en) 2021-04-28
TW201930878A (zh) 2019-08-01
US20210003505A1 (en) 2021-01-07
EP3732468A4 (en) 2020-12-02
CN209624391U (zh) 2019-11-12
CN115078317B (zh) 2025-11-14
CN109975255A (zh) 2019-07-05
US12123833B2 (en) 2024-10-22
SG11201912255RA (en) 2020-01-30
CN109975255B (zh) 2022-04-19
RU2738311C1 (ru) 2020-12-11
US11333604B2 (en) 2022-05-17
BR112019028286A2 (pt) 2020-07-14
MX2019015855A (es) 2021-04-07
EP3732468B1 (en) 2021-12-15
US20200166461A1 (en) 2020-05-28
PE20200893A1 (es) 2020-09-07
NZ778619A (en) 2024-11-29
MX381250B (es) 2025-03-12
US20190204226A1 (en) 2019-07-04
KR20200017431A (ko) 2020-02-18
US20220260492A1 (en) 2022-08-18
WO2019133182A1 (en) 2019-07-04
CN115078317A (zh) 2022-09-20
AU2018397465A1 (en) 2020-01-16
AU2021203297B2 (en) 2023-05-18
EP3978908A1 (en) 2022-04-06
US11852586B2 (en) 2023-12-26
JP2020531797A (ja) 2020-11-05
AU2021203297A1 (en) 2021-06-17
ES2906809T3 (es) 2022-04-20
CA3191105A1 (en) 2019-07-04
EP3978908C0 (en) 2025-05-07
CO2019014476A2 (es) 2020-04-13
KR102583715B1 (ko) 2023-10-04

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