DK3732468T3 - Anordning med reduceret fluorescensområde-støj og metode - Google Patents

Anordning med reduceret fluorescensområde-støj og metode Download PDF

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Publication number
DK3732468T3
DK3732468T3 DK18896064.5T DK18896064T DK3732468T3 DK 3732468 T3 DK3732468 T3 DK 3732468T3 DK 18896064 T DK18896064 T DK 18896064T DK 3732468 T3 DK3732468 T3 DK 3732468T3
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Denmark
Prior art keywords
fluorescence area
reduced fluorescence
area noise
noise
reduced
Prior art date
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DK18896064.5T
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English (en)
Inventor
Tracy H Fung
Poorya Sabounchi
Bernard Hirschbein
Joseph Pinto
Tarun Khurana
Randall Smith
Wenyi Feng
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Illumina Inc
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Publication of DK3732468T3 publication Critical patent/DK3732468T3/da

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6452Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G01N21/6454Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6486Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6402Atomic fluorescence; Laser induced fluorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B19/00Condensers, e.g. light collectors or similar non-imaging optics
    • G02B19/0004Condensers, e.g. light collectors or similar non-imaging optics characterised by the optical means employed
    • G02B19/0019Condensers, e.g. light collectors or similar non-imaging optics characterised by the optical means employed having reflective surfaces only (e.g. louvre systems, systems with multiple planar reflectors)
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B19/00Condensers, e.g. light collectors or similar non-imaging optics
    • G02B19/0033Condensers, e.g. light collectors or similar non-imaging optics characterised by the use
    • G02B19/0076Condensers, e.g. light collectors or similar non-imaging optics characterised by the use for use with a detector
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B5/00Optical elements other than lenses
    • G02B5/20Filters
    • G02B5/22Absorbing filters
    • G02B5/223Absorbing filters containing organic substances, e.g. dyes, inks or pigments
    • HELECTRICITY
    • H10SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10FINORGANIC SEMICONDUCTOR DEVICES SENSITIVE TO INFRARED RADIATION, LIGHT, ELECTROMAGNETIC RADIATION OF SHORTER WAVELENGTH OR CORPUSCULAR RADIATION
    • H10F39/00Integrated devices, or assemblies of multiple devices, comprising at least one element covered by group H10F30/00, e.g. radiation detectors comprising photodiode arrays
    • H10F39/10Integrated devices
    • H10F39/12Image sensors
    • H10F39/18Complementary metal-oxide-semiconductor [CMOS] image sensors; Photodiode array image sensors
    • HELECTRICITY
    • H10SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10FINORGANIC SEMICONDUCTOR DEVICES SENSITIVE TO INFRARED RADIATION, LIGHT, ELECTROMAGNETIC RADIATION OF SHORTER WAVELENGTH OR CORPUSCULAR RADIATION
    • H10F39/00Integrated devices, or assemblies of multiple devices, comprising at least one element covered by group H10F30/00, e.g. radiation detectors comprising photodiode arrays
    • H10F39/80Constructional details of image sensors
    • H10F39/805Coatings
    • H10F39/8053Colour filters
    • HELECTRICITY
    • H10SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10FINORGANIC SEMICONDUCTOR DEVICES SENSITIVE TO INFRARED RADIATION, LIGHT, ELECTROMAGNETIC RADIATION OF SHORTER WAVELENGTH OR CORPUSCULAR RADIATION
    • H10F39/00Integrated devices, or assemblies of multiple devices, comprising at least one element covered by group H10F30/00, e.g. radiation detectors comprising photodiode arrays
    • H10F39/80Constructional details of image sensors
    • H10F39/806Optical elements or arrangements associated with the image sensors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N2021/6463Optics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N2021/6463Optics
    • G01N2021/6471Special filters, filter wheel
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00Features of devices classified in G01N21/00
    • G01N2201/08Optical fibres; light guides

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  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Optical Measuring Cells (AREA)
  • Optical Filters (AREA)
DK18896064.5T 2017-12-28 2018-11-30 Anordning med reduceret fluorescensområde-støj og metode DK3732468T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762611464P 2017-12-28 2017-12-28
US201862644804P 2018-03-19 2018-03-19
PCT/US2018/063395 WO2019133182A1 (en) 2017-12-28 2018-11-30 Detector with reduced fluorescence range noise

Publications (1)

Publication Number Publication Date
DK3732468T3 true DK3732468T3 (da) 2022-02-14

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US (6) US10551317B2 (da)
EP (2) EP3978908B1 (da)
JP (1) JP6827570B2 (da)
KR (2) KR102261632B1 (da)
CN (3) CN109975255B (da)
AU (2) AU2018397465A1 (da)
BR (1) BR112019028286B1 (da)
CA (2) CA3191105C (da)
CL (1) CL2019003784A1 (da)
CO (1) CO2019014476A2 (da)
CR (1) CR20190584A (da)
DK (1) DK3732468T3 (da)
ES (1) ES2906809T3 (da)
IL (1) IL271293B (da)
MX (1) MX381250B (da)
MY (1) MY194752A (da)
NZ (1) NZ778619A (da)
PE (1) PE20200893A1 (da)
PH (1) PH12019502900A1 (da)
RU (1) RU2738311C1 (da)
SA (1) SA519410862B1 (da)
SG (1) SG11201912255RA (da)
TW (1) TWI698638B (da)
WO (1) WO2019133182A1 (da)
ZA (1) ZA201908274B (da)

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ES2906809T3 (es) 2022-04-20
US20250044228A1 (en) 2025-02-06
KR102583715B1 (ko) 2023-10-04
EP3978908B1 (en) 2025-05-07
KR102261632B1 (ko) 2021-06-07
CN109975255A (zh) 2019-07-05
CA3191105A1 (en) 2019-07-04
AU2018397465A1 (en) 2020-01-16
SG11201912255RA (en) 2020-01-30
PH12019502900A1 (en) 2020-09-14
US20190204226A1 (en) 2019-07-04
CA3191105C (en) 2025-10-14
IL271293A (en) 2020-01-30
US20210003505A1 (en) 2021-01-07
KR20210066028A (ko) 2021-06-04
ZA201908274B (en) 2021-04-28
EP3978908A1 (en) 2022-04-06
MX381250B (es) 2025-03-12
JP6827570B2 (ja) 2021-02-10
EP3732468A1 (en) 2020-11-04
TW201930878A (zh) 2019-08-01
US20220260492A1 (en) 2022-08-18
WO2019133182A1 (en) 2019-07-04
CR20190584A (es) 2020-03-06
BR112019028286B1 (pt) 2021-10-26
US20200166461A1 (en) 2020-05-28
JP2020531797A (ja) 2020-11-05
SA519410862B1 (ar) 2022-09-05
US10883937B2 (en) 2021-01-05
RU2738311C1 (ru) 2020-12-11
KR20200017431A (ko) 2020-02-18
TWI698638B (zh) 2020-07-11
NZ778619A (en) 2024-11-29
EP3978908C0 (en) 2025-05-07
CL2019003784A1 (es) 2020-07-10
MX2019015855A (es) 2021-04-07
CN109975255B (zh) 2022-04-19
IL271293B (en) 2021-03-25
NZ759983A (en) 2021-08-27
CO2019014476A2 (es) 2020-04-13
CN209624391U (zh) 2019-11-12
US12123833B2 (en) 2024-10-22
CN115078317A (zh) 2022-09-20
CN115078317B (zh) 2025-11-14
PE20200893A1 (es) 2020-09-07
EP3732468A4 (en) 2020-12-02
US11852586B2 (en) 2023-12-26
US10551317B2 (en) 2020-02-04
MY194752A (en) 2022-12-15
EP3732468B1 (en) 2021-12-15
CA3067249A1 (en) 2019-07-04
US11333604B2 (en) 2022-05-17
AU2021203297A1 (en) 2021-06-17
AU2021203297B2 (en) 2023-05-18
US20240094125A1 (en) 2024-03-21
BR112019028286A2 (pt) 2020-07-14
CA3067249C (en) 2023-04-25

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