DK3737677T3 - Tetrahydroisoquinolinforbindelser - Google Patents

Tetrahydroisoquinolinforbindelser Download PDF

Info

Publication number
DK3737677T3
DK3737677T3 DK19700284.3T DK19700284T DK3737677T3 DK 3737677 T3 DK3737677 T3 DK 3737677T3 DK 19700284 T DK19700284 T DK 19700284T DK 3737677 T3 DK3737677 T3 DK 3737677T3
Authority
DK
Denmark
Prior art keywords
tetrahydroisoquinoline compounds
tetrahydroisoquinoline
compounds
Prior art date
Application number
DK19700284.3T
Other languages
English (en)
Inventor
García Miguel Vega
Muelas Pedro Campos
Romero Esther Carrasco
Pérez Asunción Burguete
Gutiérrez Patricia Gómez
González Juan Jesús Pérez
Peypoch Ángel Messeguer
Sánchez Balbino José Alarcón
Rojo Irene Azhara Arellano
Original Assignee
Allinky Biopharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allinky Biopharma filed Critical Allinky Biopharma
Application granted granted Critical
Publication of DK3737677T3 publication Critical patent/DK3737677T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK19700284.3T 2018-01-10 2019-01-10 Tetrahydroisoquinolinforbindelser DK3737677T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18382010 2018-01-10
PCT/EP2019/050518 WO2019137985A1 (en) 2018-01-10 2019-01-10 Tetrahydroisoquinoline compounds

Publications (1)

Publication Number Publication Date
DK3737677T3 true DK3737677T3 (da) 2022-01-10

Family

ID=62104212

Family Applications (1)

Application Number Title Priority Date Filing Date
DK19700284.3T DK3737677T3 (da) 2018-01-10 2019-01-10 Tetrahydroisoquinolinforbindelser

Country Status (10)

Country Link
US (1) US11466012B2 (da)
EP (1) EP3737677B1 (da)
JP (1) JP2021510699A (da)
CN (1) CN112262137A (da)
CA (1) CA3087888A1 (da)
DK (1) DK3737677T3 (da)
ES (1) ES2905568T3 (da)
MX (1) MX2020007403A (da)
RU (1) RU2020126188A (da)
WO (1) WO2019137985A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2021005688A (es) 2018-11-14 2021-07-07 Allinky Biopharma Compuestos de piridina sulfonamida para el tratamiento contra afecciones relacionadas con interleucina 1 beta.
EP3763711A1 (en) * 2019-07-09 2021-01-13 Allinky Biopharma Tetrahydroisoquinoline compounds
IL299131A (en) 2020-06-18 2023-02-01 Revolution Medicines Inc Methods for delaying, preventing and treating acquired resistance to RAS inhibitors
MX2023002248A (es) 2020-09-03 2023-05-16 Revolution Medicines Inc Uso de inhibidores de sos1 para tratar neoplasias malignas con mutaciones de shp2.
CN118922418A (zh) * 2022-03-09 2024-11-08 思路迪生物医药(上海)有限公司 一类作为泛-kras抑制剂的四氢异喹啉类衍生物及其制备方法和应用
CN114874201B (zh) * 2022-04-08 2023-01-20 思路迪生物医药(上海)有限公司 一类泛-kras抑制剂及其制备和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6369226B1 (en) 1999-06-21 2002-04-09 Agouron Pharmaceuticals, Inc. Substituted benzamide inhibitors of rhinovirus 3C protease
NZ527276A (en) * 2001-03-27 2004-11-26 Actelion Pharmaceuticals Ltd 1,2,3,4-tetrahydroisoquinoline derivatives as urotensin II receptor antagonists
SE0303542D0 (sv) * 2003-12-22 2003-12-22 Astrazeneca Ab 1,2,3,4-Tetrahydroisoquinoline derivaties, preparations thereof and uses thereof
UA91341C2 (ru) * 2004-07-15 2010-07-26 Амр Текнолоджи, Інк. Арил- и гетероарилзамещенные тетрагидроизохинолины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина
BRPI0716715B1 (pt) 2006-08-23 2021-07-06 Xenon Pharmaceuticals, Inc Derivados de 4-(n-azacicloalquil) anilidas como moduladores de canal de potássio, seus usos, produto, composição, comprimido e cápsula
CA2703477C (en) 2007-10-25 2016-10-11 Exelixis, Inc. Pyridinyl substituted tropane compounds and uses thereof
TW201100427A (en) * 2009-03-31 2011-01-01 Arqule Inc Substituted heterocyclic compounds
WO2011017125A1 (en) 2009-07-28 2011-02-10 Anacor Pharmaceuticals, Inc. Trisubstituted boron-containing molecules
EP3080103B9 (en) 2013-12-11 2018-09-19 Biogen MA Inc. Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology
WO2016033105A1 (en) * 2014-08-29 2016-03-03 The Board Of Regents Of The University Of Texas System Novel capsazepine analogs for the treatment of cancer and other proliferative diseases
CN106117182B (zh) * 2016-06-20 2019-08-30 中国药科大学 喹唑啉-n-苯乙基四氢异喹啉类化合物及其制备方法和应用
MX2021005688A (es) 2018-11-14 2021-07-07 Allinky Biopharma Compuestos de piridina sulfonamida para el tratamiento contra afecciones relacionadas con interleucina 1 beta.

Also Published As

Publication number Publication date
EP3737677A1 (en) 2020-11-18
JP2021510699A (ja) 2021-04-30
US11466012B2 (en) 2022-10-11
ES2905568T3 (es) 2022-04-11
CA3087888A1 (en) 2019-07-18
WO2019137985A1 (en) 2019-07-18
RU2020126188A (ru) 2022-02-10
US20200369671A1 (en) 2020-11-26
MX2020007403A (es) 2020-11-11
CN112262137A (zh) 2021-01-22
EP3737677B1 (en) 2021-11-03

Similar Documents

Publication Publication Date Title
FIC20253006I1 (fi) Linvoseltamabi
IL283692A (en) Novel composition
FIC20260010I1 (fi) imlunestrantti
EP3890716A4 (en) COMBINATION THERAPIES
LT3810602T (lt) Junginiai
EP3846674C0 (en) VAGINAL SPECULUM
EP3849534A4 (en) COMBINATION THERAPIES
EP3555124C0 (en) TCR NYESO
DK3810587T3 (da) Substituerede alkoxypyridinylindolsulfonamider
EP3781060A4 (en) CRYOPROBE
EP3784463A4 (en) Fluorosulfones
DK3737677T3 (da) Tetrahydroisoquinolinforbindelser
EP3872558A4 (en) OPTICAL ISOLATOR
EP3810860C0 (en) COUPLER
HUE065134T2 (hu) Vegyületek
DK3808747T3 (da) Imidazopyridinon-forbindelse
EP3792200A4 (en) TANK TANK
LT3867247T (lt) Naujieji junginiai
EP3745904C0 (de) Stockgriff
EP3878374A4 (en) Occlusion device
EP3997086C0 (en) TETRAHYDROISOQUINOLINE COMPOUNDS
EP3721129A4 (en) CRYOSPHERE
HUE056928T2 (hu) Új vegyületek
EP3902806C0 (en) THIENOPYRIDINONE COMPOUNDS
EP3844177A4 (en) COMBINATION THERAPIES