DK3739061T3 - Methyleringsmønsteranalyse af haplotyper i væv i DNA-blanding - Google Patents
Methyleringsmønsteranalyse af haplotyper i væv i DNA-blanding Download PDFInfo
- Publication number
- DK3739061T3 DK3739061T3 DK20183986.7T DK20183986T DK3739061T3 DK 3739061 T3 DK3739061 T3 DK 3739061T3 DK 20183986 T DK20183986 T DK 20183986T DK 3739061 T3 DK3739061 T3 DK 3739061T3
- Authority
- DK
- Denmark
- Prior art keywords
- haplotypes
- tissues
- pattern analysis
- dna mixture
- methylation pattern
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562194702P | 2015-07-20 | 2015-07-20 | |
| EP16827235.9A EP3325663B1 (en) | 2015-07-20 | 2016-07-20 | Methylation pattern analysis of haplotypes in tissues in dna mixture |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3739061T3 true DK3739061T3 (da) | 2022-04-19 |
Family
ID=57833669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK20183986.7T DK3739061T3 (da) | 2015-07-20 | 2016-07-20 | Methyleringsmønsteranalyse af haplotyper i væv i DNA-blanding |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10689706B2 (da) |
| EP (3) | EP3325663B1 (da) |
| CN (2) | CN115287348A (da) |
| AU (2) | AU2016295712B2 (da) |
| CA (1) | CA2993588A1 (da) |
| DK (1) | DK3739061T3 (da) |
| ES (1) | ES2911613T3 (da) |
| HU (1) | HUE059407T2 (da) |
| PT (1) | PT3739061T (da) |
| TW (2) | TWI798718B (da) |
| WO (1) | WO2017012544A1 (da) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI895765B (zh) | 2014-07-18 | 2025-09-01 | 香港中文大學 | Dna混合物中之組織甲基化模式分析 |
| DK3739061T3 (da) | 2015-07-20 | 2022-04-19 | Univ Hong Kong Chinese | Methyleringsmønsteranalyse af haplotyper i væv i DNA-blanding |
| CA3039685A1 (en) | 2016-11-30 | 2018-06-07 | The Chinese University Of Hong Kong | Analysis of cell-free dna in urine and other samples |
| ES2990117T3 (es) | 2017-01-25 | 2024-11-28 | Univ Hong Kong Chinese | Aplicaciones de diagnóstico que utilizan fragmentos de ácido nucleico |
| SG11201911538YA (en) * | 2017-06-20 | 2020-01-30 | Illumina Inc | Methods and systems for decomposition and quantification of dna mixtures from multiple contributors of known or unknown genotypes |
| ES2959360T3 (es) | 2017-07-26 | 2024-02-23 | Univ Hong Kong Chinese | Mejora del cribado del cáncer mediante ácidos nucleicos víricos acelulares |
| EP4741515A2 (en) * | 2018-02-18 | 2026-05-13 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Cell free dna deconvolution and use thereof |
| AU2019249422B2 (en) | 2018-04-02 | 2025-09-25 | Grail, Inc. | Methylation markers and targeted methylation probe panels |
| EP3788172B1 (en) | 2018-05-03 | 2025-04-02 | The Chinese University Of Hong Kong | Size-tagged preferred ends and orientation-aware analysis for measuring properties of cell-free mixtures |
| KR102873073B1 (ko) * | 2018-05-16 | 2025-10-17 | 트윈스트랜드 바이오사이언시스, 인코포레이티드 | 핵산 혼합물 및 혼합된 세포 집단을 해상하기 위한 방법 및 시약 및 관련 응용 |
| IL281741B2 (en) | 2018-09-27 | 2026-04-01 | Grail Inc | Methylation markers and a targeted methylation detection panel |
| US20200385813A1 (en) * | 2018-12-18 | 2020-12-10 | Grail, Inc. | Systems and methods for estimating cell source fractions using methylation information |
| EP3938534A4 (en) * | 2019-03-13 | 2023-03-29 | Grail, LLC | SYSTEMS AND METHODS FOR ENCOURAGEMENT OF CANCER DERIVATIVE FRAGMENTS BY FRAGMENT SIZE |
| SG11202101070QA (en) * | 2019-08-16 | 2021-03-30 | Univ Hong Kong Chinese | Determination Of Base Modifications Of Nucleic Acids |
| CN114746559A (zh) * | 2019-10-18 | 2022-07-12 | 华盛顿大学 | 用于测量细胞状态的方法和系统 |
| JP7311934B2 (ja) * | 2020-02-05 | 2023-07-20 | ザ チャイニーズ ユニバーシティ オブ ホンコン | 妊娠中の無細胞断片を使用する分子分析 |
| CN114566220B (zh) * | 2020-11-27 | 2025-01-21 | 深圳华大生命科学研究院 | 基于dna甲基化水平确定样本类型的系统、可读介质及其应用 |
| WO2025213273A1 (en) * | 2024-04-10 | 2025-10-16 | University Health Network | Panels and methods for identifying cell origin of cell free dna |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12180549B2 (en) | 2007-07-23 | 2024-12-31 | The Chinese University Of Hong Kong | Diagnosing fetal chromosomal aneuploidy using genomic sequencing |
| HUE061020T2 (hu) | 2007-07-23 | 2023-05-28 | Univ Hong Kong Chinese | Nukleinsav-szekvencia kiegyensúlyozatlanságának meghatározására |
| US8563242B2 (en) * | 2009-08-11 | 2013-10-22 | The Chinese University Of Hong Kong | Method for detecting chromosomal aneuploidy |
| SMT202300034T1 (it) * | 2009-11-05 | 2023-03-17 | Sequenom Inc | Analisi genomica fetale da un campione biologico materno |
| EA034241B1 (ru) | 2009-11-06 | 2020-01-21 | Те Чайниз Юниверсити Ов Гонконг | Способ пренатальной диагностики дисбаланса последовательности |
| SG10202008532PA (en) | 2010-11-30 | 2020-10-29 | Univ Hong Kong Chinese | Detection of genetic or molecular aberrations associated with cancer |
| CN103620055A (zh) * | 2010-12-07 | 2014-03-05 | 利兰·斯坦福青年大学托管委员会 | 在全基因组规模非侵入性确定亲本单倍型的胎儿遗传 |
| JP6105485B2 (ja) * | 2011-01-05 | 2017-04-05 | ザ・チャイニーズ・ユニバーシティー・オブ・ホンコンＴｈｅ Ｃｈｉｎｅｓｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｈｏｎｇ Ｋｏｎｇ | 胎児の性染色体遺伝子型の非侵襲的出生前同定 |
| EP2682887A2 (en) * | 2011-02-24 | 2014-01-08 | The Chinese University Of Hong Kong | Determining fetal DNA percentage for twins |
| US11261494B2 (en) | 2012-06-21 | 2022-03-01 | The Chinese University Of Hong Kong | Method of measuring a fractional concentration of tumor DNA |
| US9732390B2 (en) | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| PL3354747T3 (pl) * | 2012-09-20 | 2021-07-26 | The Chinese University Of Hong Kong | Nieinwazyjne określanie metylomu guza z wykorzystaniem osocza |
| KR20150132216A (ko) | 2013-03-15 | 2015-11-25 | 더 차이니즈 유니버시티 오브 홍콩 | 다태 임신에 대한 태아 게놈의 결정 |
| US20150004601A1 (en) | 2013-06-28 | 2015-01-01 | Ariosa Diagnostics, Inc. | Massively parallel sequencing of random dna fragments for determination of fetal fraction |
| CA2938451C (en) | 2014-01-30 | 2023-10-17 | The Regents Of The University Of California | Methylation haplotyping for non-invasive diagnosis (monod) |
| WO2015159293A2 (en) | 2014-04-14 | 2015-10-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | A method and kit for determining the tissue or cell origin of dna |
| TWI895765B (zh) | 2014-07-18 | 2025-09-01 | 香港中文大學 | Dna混合物中之組織甲基化模式分析 |
| DK3739061T3 (da) | 2015-07-20 | 2022-04-19 | Univ Hong Kong Chinese | Methyleringsmønsteranalyse af haplotyper i væv i DNA-blanding |
-
2016
- 2016-07-20 DK DK20183986.7T patent/DK3739061T3/da active
- 2016-07-20 EP EP16827235.9A patent/EP3325663B1/en active Active
- 2016-07-20 PT PT201839867T patent/PT3739061T/pt unknown
- 2016-07-20 ES ES20183986T patent/ES2911613T3/es active Active
- 2016-07-20 AU AU2016295712A patent/AU2016295712B2/en active Active
- 2016-07-20 US US15/214,998 patent/US10689706B2/en active Active - Reinstated
- 2016-07-20 EP EP20183986.7A patent/EP3739061B1/en active Active
- 2016-07-20 CN CN202210931079.4A patent/CN115287348A/zh active Pending
- 2016-07-20 WO PCT/CN2016/090642 patent/WO2017012544A1/en not_active Ceased
- 2016-07-20 CN CN201680054736.4A patent/CN108138233B/zh active Active
- 2016-07-20 TW TW110121521A patent/TWI798718B/zh active
- 2016-07-20 TW TW105122965A patent/TWI732771B/zh active
- 2016-07-20 HU HUE20183986A patent/HUE059407T2/hu unknown
- 2016-07-20 CA CA2993588A patent/CA2993588A1/en active Pending
- 2016-07-20 EP EP22162789.6A patent/EP4063517B1/en active Active
-
2020
- 2020-05-14 US US16/874,215 patent/US12416049B2/en active Active
-
2022
- 2022-08-18 AU AU2022218555A patent/AU2022218555B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2993588A1 (en) | 2017-01-26 |
| HK1248283A1 (en) | 2018-10-12 |
| TWI798718B (zh) | 2023-04-11 |
| US12416049B2 (en) | 2025-09-16 |
| CN108138233B (zh) | 2022-08-26 |
| EP4063517B1 (en) | 2026-01-07 |
| TW202205300A (zh) | 2022-02-01 |
| EP3739061B1 (en) | 2022-03-23 |
| AU2016295712A1 (en) | 2018-02-08 |
| US20200270707A1 (en) | 2020-08-27 |
| EP3325663A4 (en) | 2018-07-25 |
| EP3739061A1 (en) | 2020-11-18 |
| TW201718871A (zh) | 2017-06-01 |
| TWI732771B (zh) | 2021-07-11 |
| CN115287348A (zh) | 2022-11-04 |
| EP3325663A1 (en) | 2018-05-30 |
| US10689706B2 (en) | 2020-06-23 |
| AU2022218555B2 (en) | 2025-04-24 |
| AU2016295712B2 (en) | 2022-06-02 |
| HK1252222A1 (zh) | 2019-05-24 |
| EP4063517A1 (en) | 2022-09-28 |
| CN108138233A (zh) | 2018-06-08 |
| US20170029900A1 (en) | 2017-02-02 |
| PT3739061T (pt) | 2022-04-05 |
| ES2911613T3 (es) | 2022-05-20 |
| WO2017012544A1 (en) | 2017-01-26 |
| HUE059407T2 (hu) | 2022-11-28 |
| EP3325663B1 (en) | 2020-08-19 |
| AU2022218555A1 (en) | 2022-09-15 |
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