DK374286A - Serinproteaseinhibitorer og fremgangsmaade til isolering af disse - Google Patents

Serinproteaseinhibitorer og fremgangsmaade til isolering af disse Download PDF

Info

Publication number: DK374286A
Authority: DK; Denmark
Prior art keywords: serine protease; protease inhibitor; inhibitor; ability; inhibit
Prior art date: 1984-12-06

Application number

DK374286A

Other languages

English (en)

Other versions

DK173678B1 (da

DK374286D0 (da

Inventor

Robert C Thompson

Kjell Ohlsson

Original Assignee

Synergen Biolog Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-12-06

Filing date

1986-08-06

Publication date

1986-08-06

1985-12-04 Priority claimed from PCT/US1985/002384 external-priority patent/WO1986003497A1/en

1986-08-06 Application filed by Synergen Biolog Inc filed Critical Synergen Biolog Inc

1986-08-06 Publication of DK374286A publication Critical patent/DK374286A/da

1986-08-06 Publication of DK374286D0 publication Critical patent/DK374286D0/da

2001-06-11 Application granted granted Critical

2001-06-11 Publication of DK173678B1 publication Critical patent/DK173678B1/da

Links

239000003001 serine protease inhibitor Substances 0.000 title abstract 6
238000000034 method Methods 0.000 title abstract 2
101710102218 Serine protease inhibitor Proteins 0.000 abstract 6
229940122055 Serine protease inhibitor Drugs 0.000 abstract 5
238000004925 denaturation Methods 0.000 abstract 2
230000036425 denaturation Effects 0.000 abstract 2
239000003112 inhibitor Substances 0.000 abstract 2
LKDMKWNDBAVNQZ-UHFFFAOYSA-N 4-[[1-[[1-[2-[[1-(4-nitroanilino)-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid Chemical compound OC(=O)CCC(=O)NC(C)C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(C(=O)NC=1C=CC(=CC=1)[N+]([O-])=O)CC1=CC=CC=C1 LKDMKWNDBAVNQZ-UHFFFAOYSA-N 0.000 abstract 1
102000004173 Cathepsin G Human genes 0.000 abstract 1
108090000617 Cathepsin G Proteins 0.000 abstract 1
102000016387 Pancreatic elastase Human genes 0.000 abstract 1
108010067372 Pancreatic elastase Proteins 0.000 abstract 1
102000035195 Peptidases Human genes 0.000 abstract 1
108091005804 Peptidases Proteins 0.000 abstract 1
102000004142 Trypsin Human genes 0.000 abstract 1
108090000631 Trypsin Proteins 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
150000001413 amino acids Chemical group 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000002779 inactivation Effects 0.000 abstract 1
230000003993 interaction Effects 0.000 abstract 1
230000001590 oxidative effect Effects 0.000 abstract 1
210000003681 parotid gland Anatomy 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1
239000012588 trypsin Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK198603742A 1984-12-06 1986-08-06 Farmaceutiske præparater indeholdende en serinproteaseinhibitor DK173678B1 (da)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US67882384A	1984-12-06	1984-12-06
US67882384		1984-12-06
US06/803,423 US4760130A (en)	1984-12-06	1985-12-02	Serine protease inhibitors and methods for isolation of same
US80342385		1985-12-02
US8502384		1985-12-04
PCT/US1985/002384 WO1986003497A1 (en)	1984-12-06	1985-12-04	Serine protease inhibitors and methods for isolation of same

Publications (3)

Publication Number	Publication Date
DK374286A true DK374286A (da)	1986-08-06
DK374286D0 DK374286D0 (da)	1986-08-06
DK173678B1 DK173678B1 (da)	2001-06-11

Family

ID=27102097

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198603742A DK173678B1 (da)	1984-12-06	1986-08-06	Farmaceutiske præparater indeholdende en serinproteaseinhibitor

Country Status (6)

Country	Link
US (1)	US4760130A (da)
DK (1)	DK173678B1 (da)
IE (1)	IE61351B1 (da)
IL (1)	IL77226A (da)
MX (1)	MX9203520A (da)
NZ (1)	NZ214457A (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6291662B1 (en)	1984-12-05	2001-09-18	Amgen Inc.	Recombinant methods for production of serine protease inhibitors and DNA sequences
US5871956A (en) *	1984-12-06	1999-02-16	Amgen Inc.	Recombinant methods for production of serine inhibitors and DNA sequences useful for same
US5900400A (en) *	1984-12-06	1999-05-04	Amgen Inc.	Serine protease inhibitor analogs
US6132990A (en) *	1984-12-06	2000-10-17	Amgen Boulder Inc.	Recombinant methods for production of serine protease inhibitors and DNA sequences useful for same
GB2199582A (en) *	1987-01-07	1988-07-13	Bayer Ag	Analogues of pancreatic secretory trypsin inhibitor
US5851983A (en) *	1987-12-28	1998-12-22	Teijin Limited	Elastase inhibitory polypeptide and process for production thereof by recombinant gene technology
WO1990004409A1 (en) *	1988-10-27	1990-05-03	University Of Kentucky Research Foundation	Human leukocyte elastase inhibitors and methods of producing and using same
DE3841873A1 (de) *	1988-12-13	1990-06-21	Gruenenthal Gmbh	Neue serinprotease-inhibitor-proteine, diese enthaltende arzneimittel, dna-sequenzen, die fuer diese proteine codieren und verfahren zur herstellung dieser proteine, arzneimittel und dna-sequenzen
US5591431A (en) *	1990-03-09	1997-01-07	G.D. Searle & Co.	Enhancement of clot lysis
AU8941691A (en) *	1990-10-31	1992-05-26	Loram Maintenance Of Way, Inc.	Ballast distribution, regulation and reclaiming railroad maintenance device
US6869925B1 (en) *	1992-09-09	2005-03-22	Amgen Inc.	Inhibition of retrovirus infection
FI951078L (fi) *	1992-09-09	1995-03-08	Amgen Boulder Inc	Retrovirusinfektion inhibitio
US5462870A (en) *	1993-04-23	1995-10-31	Wayne State University	Human diploid salivary gland epithelial cell lines
FR2711371B1 (fr) *	1993-10-18	1995-12-29	Aetsrn	Procédé de préparation d'un concentré d'inter-alpha-trypsine inhibiteur à usage thérapeutique et concentré obtenu.
US6017880A (en) *	1994-03-09	2000-01-25	Amgen Inc.	Inhibition of retrovirus infection
NZ282488A (en) *	1994-03-23	1999-09-29	Tokyo Tanabe Co	Therapeutic or prophylactic medicament for viral disease containing antileukoprotease (serine protease inhibitor)
US5633227A (en) *	1994-09-12	1997-05-27	Miles, Inc.	Secretory leukocyte protease inhibitor as an inhibitor of tryptase
BR9711540A (pt)	1996-09-24	2001-06-19	Protector & Gamble Company	Inibidores de protease proteìnico estabilizados e variantes dos mesmos
US6849605B1 (en) *	1999-03-05	2005-02-01	The Trustees Of University Technology Corporation	Inhibitors of serine protease activity, methods and compositions for treatment of viral infections
AU3864000A (en) *	1999-03-05	2000-09-21	Trustees Of University Technology Corporation, The	Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses
US6489308B1 (en)	1999-03-05	2002-12-03	Trustees Of University Of Technology Corporation	Inhibitors of serine protease activity, methods and compositions for treatment of nitric-oxide-induced clinical conditions
AU2001274566A1 (en) *	2000-06-21	2002-01-02	Takeda Chemical Industries Ltd.	Novel protein and dna thereof
US7247704B2 (en) *	2000-12-18	2007-07-24	Arriva Pharmaceuticals, Inc.	Multifunctional protease inhibitors and their use in treatment of disease
CA2451955C (en)	2001-06-26	2015-09-29	Abgenix, Inc.	Antibodies to opgl
WO2003002187A2 (en) *	2001-06-26	2003-01-09	Photomed Technologies, Inc.	Multiple wavelength illuminator
WO2003018620A2 (en) *	2001-08-27	2003-03-06	Les Laboratoires Aeterna Inc.	Serine protease inhibitor and processes for the preparation thereof
US20040220242A1 (en) *	2003-05-02	2004-11-04	Leland Shapiro	Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions
PL2520654T3 (pl)	2003-08-26	2017-08-31	The Regents Of The University Of Colorado, A Body Corporate	Inhibitory aktywności proteazy serynowej i ich zastosowanie w sposobach i kompozycjach do leczenia zakażeń bakteryjnych
AR056806A1 (es)	2005-11-14	2007-10-24	Amgen Inc	Moleculas quimericas de anticuerpo rankl- pth/ pthrp
ES2799153T3 (es)	2013-03-29	2020-12-15	Univ Colorado Regents	Alfa 1 antitripsina para uso en la preparación de un sujeto para trasplante

1985
- 1985-12-02 US US06/803,423 patent/US4760130A/en not_active Expired - Lifetime
- 1985-12-04 IL IL77226A patent/IL77226A/xx not_active IP Right Cessation
- 1985-12-05 IE IE308285A patent/IE61351B1/en not_active IP Right Cessation
- 1985-12-06 NZ NZ214457A patent/NZ214457A/xx unknown
1986
- 1986-08-06 DK DK198603742A patent/DK173678B1/da not_active IP Right Cessation
1992
- 1992-06-26 MX MX9203520A patent/MX9203520A/es unknown

Also Published As

Publication number	Publication date
US4760130A (en)	1988-07-26
DK173678B1 (da)	2001-06-11
IE61351B1 (en)	1994-11-02
IE853082L (en)	1986-06-06
DK374286D0 (da)	1986-08-06
NZ214457A (en)	1989-04-26
MX9203520A (es)	1992-08-01
IL77226A (en)	1993-02-21

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Legal Events

Date	Code	Title	Description
2005-12-19	PUP	Patent expired