DK3749669T6 - Ahr-modulatorer - Google Patents
Ahr-modulatorer Download PDFInfo
- Publication number
- DK3749669T6 DK3749669T6 DK19706135.1T DK19706135T DK3749669T6 DK 3749669 T6 DK3749669 T6 DK 3749669T6 DK 19706135 T DK19706135 T DK 19706135T DK 3749669 T6 DK3749669 T6 DK 3749669T6
- Authority
- DK
- Denmark
- Prior art keywords
- ahr modulators
- ahr
- modulators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Amplifiers (AREA)
- Supplying Of Containers To The Packaging Station (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862626739P | 2018-02-06 | 2018-02-06 | |
| US201962793260P | 2019-01-16 | 2019-01-16 | |
| PCT/US2019/016705 WO2019156987A1 (en) | 2018-02-06 | 2019-02-05 | AhR MODULATORS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK3749669T3 DK3749669T3 (da) | 2023-06-06 |
| DK3749669T6 true DK3749669T6 (da) | 2024-11-18 |
Family
ID=65494575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19706135.1T DK3749669T6 (da) | 2018-02-06 | 2019-02-05 | Ahr-modulatorer |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US10815250B2 (da) |
| EP (2) | EP4219495A1 (da) |
| JP (1) | JP7382348B2 (da) |
| CN (1) | CN111683950B (da) |
| CA (1) | CA3090150A1 (da) |
| DK (1) | DK3749669T6 (da) |
| ES (1) | ES2946632T7 (da) |
| FI (1) | FI3749669T6 (da) |
| TW (1) | TWI840343B (da) |
| WO (1) | WO2019156987A1 (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019018562A1 (en) * | 2017-07-19 | 2019-01-24 | Ideaya Biosciences, Inc. | AMIDO COMPOUND AS MODULATORS OF AHR |
| US10815250B2 (en) | 2018-02-06 | 2020-10-27 | Ideaya Biosciences, Inc. | AhR modulators |
| WO2021102288A1 (en) * | 2019-11-22 | 2021-05-27 | Senda Biosciences, Inc. | Pyridopyrimidinone derivatives as ahr antagonists |
| CA3178129A1 (en) * | 2020-04-17 | 2021-10-21 | Dong-A St Co., Ltd. | Pyridopyrimidinone derivatives and their use as aryl hydrocarbon receptor modulators |
| US12570638B2 (en) | 2020-05-20 | 2026-03-10 | Sail Biomedicines, Inc. | Fused imidazole derivatives as AHR antagonists |
| CN114181212B (zh) * | 2020-09-15 | 2023-06-06 | 山东轩竹医药科技有限公司 | 哒嗪酮类AhR抑制剂 |
| WO2022081649A1 (en) * | 2020-10-13 | 2022-04-21 | Senda Biosciences, Inc. | Biomarkers related to immune checkpoint inhibitor therapy and methods of using the same |
| CN116745622A (zh) * | 2020-10-13 | 2023-09-12 | 先达生物科技公司 | 与免疫检查点抑制剂疗法相关的生物标志物及其使用方法 |
| WO2023020512A1 (zh) * | 2021-08-16 | 2023-02-23 | 成都奥睿药业有限公司 | 取代的吡啶类似物、其制备方法及作为ahr调节剂的用途 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL145922A0 (en) | 1999-04-28 | 2002-07-25 | Aventis Pharma Gmbh | Di-aryl acid derivatives as ppar receptor ligands |
| EP1430038A1 (en) | 2001-08-13 | 2004-06-23 | Ciba SC Holding AG | Ultraviolet light absorbers |
| US7098222B2 (en) | 2004-05-12 | 2006-08-29 | Abbott Laboratories | Bicyclic-substituted amines having cyclic-substituted monocyclic substituents |
| US20050256118A1 (en) | 2004-05-12 | 2005-11-17 | Altenbach Robert J | Bicyclic-substituted amines having cyclic-substituted monocyclic substituents |
| CR9465A (es) | 2005-03-25 | 2008-06-19 | Surface Logix Inc | Compuestos mejorados farmacocineticamente |
| JP5368792B2 (ja) | 2005-07-29 | 2013-12-18 | レスバーロジックス コーポレイション | 複合疾患の予防および処置のための薬学的組成物および挿入可能な医療用デバイスによるその送達 |
| CA2700988A1 (en) | 2006-09-27 | 2008-05-08 | Surface Logix, Inc. | Rho kinase inhibitors |
| KR20100115789A (ko) | 2008-02-04 | 2010-10-28 | 머큐리 테라퓨틱스, 인코포레이티드 | Ａｍｐｋ 조절자 |
| EA021938B1 (ru) | 2008-05-01 | 2015-10-30 | Сертрис Фармасьютикалз, Инк. | Хинолины и их аналоги в качестве модуляторов сиртуина |
| AU2009260503B2 (en) | 2008-05-27 | 2014-03-27 | The Board Of Regents Of The University Of Texas System | Wnt protein signalling inhibitors |
| EP2406236A4 (en) | 2009-03-09 | 2013-07-24 | Surface Logix Inc | RHO KINASE INHIBITORS |
| US20120283282A1 (en) * | 2009-06-18 | 2012-11-08 | Arleen Rifkind | Photoproducts of Tryptophan, Their Synthesis and Uses Thereof |
| EA035288B1 (ru) * | 2010-07-27 | 2020-05-25 | Трастис Оф Бостон Юниверсити | МОДИФИКАТОРЫ АРИЛУГЛЕВОДОРОДНОГО РЕЦЕПТОРА (AhR) В КАЧЕСТВЕ НОВЫХ ПРОТИВОРАКОВЫХ ТЕРАПЕВТИЧЕСКИХ СРЕДСТВ |
| KR20130065728A (ko) | 2010-10-14 | 2013-06-19 | 임뮤나르 에이비 | Ahr 활성화제로서의 1,2-디히드로-4-히드록시-2-옥소-퀴놀린-3-카르복사닐리드 |
| JP2013545749A (ja) | 2010-11-10 | 2013-12-26 | インフィニティー ファーマシューティカルズ， インコーポレイテッド | 複素環化合物及びその使用 |
| US9249087B2 (en) | 2011-02-01 | 2016-02-02 | The Board Of Trustees Of The University Of Illinois | HDAC inhibitors and therapeutic methods using the same |
| EP2788476B1 (en) | 2011-12-08 | 2019-05-22 | Fred Hutchinson Cancer Research Center | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
| BR112016030690B1 (pt) | 2014-06-27 | 2023-11-14 | Nogra Pharma Limited | Compostos moduladores do receptor de arila, composição farmacêutica compreendendo os mesmos e usos terapêuticos dos ditos compostos |
| EP3313420B1 (en) | 2015-06-25 | 2024-03-13 | The Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance |
| WO2017184547A1 (en) | 2016-04-18 | 2017-10-26 | New York University | Quinoline compounds as modulators of rage activity and uses thereof |
| TWI752155B (zh) | 2017-02-01 | 2022-01-11 | 德商菲尼克斯製藥股份有限公司 | 芳香烴受體(AhR)調節劑化合物 |
| TWI674260B (zh) | 2017-02-01 | 2019-10-11 | 德商菲尼克斯製藥股份有限公司 | 芳基烴受體(AhR)調節劑化合物 |
| TW201835070A (zh) | 2017-02-21 | 2018-10-01 | 德商菲尼克斯製藥股份有限公司 | 芳香烴受體(AhR)調節劑化合物 |
| FI3612030T3 (fi) | 2017-04-21 | 2026-03-20 | Pahr Therapeutics Inc | Ahr:n indoliestäjiä ja niiden käyttötapoja |
| WO2019018562A1 (en) | 2017-07-19 | 2019-01-24 | Ideaya Biosciences, Inc. | AMIDO COMPOUND AS MODULATORS OF AHR |
| US10815250B2 (en) | 2018-02-06 | 2020-10-27 | Ideaya Biosciences, Inc. | AhR modulators |
| WO2019236766A1 (en) | 2018-06-06 | 2019-12-12 | Ideaya Biosciences, Inc. | Methods of culturing and/or expanding stem cells and/or lineage committed progenitor cells using lactam compounds |
-
2019
- 2019-02-05 US US16/268,444 patent/US10815250B2/en active Active
- 2019-02-05 EP EP23160174.1A patent/EP4219495A1/en not_active Withdrawn
- 2019-02-05 CA CA3090150A patent/CA3090150A1/en active Pending
- 2019-02-05 DK DK19706135.1T patent/DK3749669T6/da active
- 2019-02-05 CN CN201980011943.5A patent/CN111683950B/zh active Active
- 2019-02-05 JP JP2020564046A patent/JP7382348B2/ja active Active
- 2019-02-05 EP EP19706135.1A patent/EP3749669B3/en active Active
- 2019-02-05 ES ES19706135T patent/ES2946632T7/es active Active
- 2019-02-05 WO PCT/US2019/016705 patent/WO2019156987A1/en not_active Ceased
- 2019-02-05 FI FIEP19706135.1T patent/FI3749669T6/fi active
- 2019-02-11 TW TW108104425A patent/TWI840343B/zh active
-
2020
- 2020-09-17 US US17/023,980 patent/US11407764B2/en active Active
-
2022
- 2022-06-29 US US17/853,647 patent/US12258354B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20230039955A1 (en) | 2023-02-09 |
| CN111683950B (zh) | 2024-04-16 |
| US12258354B2 (en) | 2025-03-25 |
| CN111683950A (zh) | 2020-09-18 |
| FI3749669T3 (fi) | 2023-05-26 |
| US11407764B2 (en) | 2022-08-09 |
| JP2021512954A (ja) | 2021-05-20 |
| EP3749669A1 (en) | 2020-12-16 |
| US20190270754A1 (en) | 2019-09-05 |
| JP7382348B2 (ja) | 2023-11-16 |
| US20210002297A1 (en) | 2021-01-07 |
| FI3749669T6 (fi) | 2024-11-13 |
| US10815250B2 (en) | 2020-10-27 |
| WO2019156987A1 (en) | 2019-08-15 |
| TWI840343B (zh) | 2024-05-01 |
| DK3749669T3 (da) | 2023-06-06 |
| EP3749669B1 (en) | 2023-03-08 |
| CA3090150A1 (en) | 2019-08-15 |
| TW201945362A (zh) | 2019-12-01 |
| ES2946632T3 (es) | 2023-07-21 |
| ES2946632T7 (es) | 2025-03-04 |
| EP3749669B3 (en) | 2024-09-04 |
| EP4219495A1 (en) | 2023-08-02 |
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