DK3768265T3 - Ny centralt aktiv ghrelin-agonist og medicinske anvendelser deraf - Google Patents
Ny centralt aktiv ghrelin-agonist og medicinske anvendelser deraf Download PDFInfo
- Publication number
- DK3768265T3 DK3768265T3 DK19715003.0T DK19715003T DK3768265T3 DK 3768265 T3 DK3768265 T3 DK 3768265T3 DK 19715003 T DK19715003 T DK 19715003T DK 3768265 T3 DK3768265 T3 DK 3768265T3
- Authority
- DK
- Denmark
- Prior art keywords
- medical uses
- centrally active
- ghrelin agonist
- active ghrelin
- novel centrally
- Prior art date
Links
- 102000012004 Ghrelin Human genes 0.000 title 1
- 101800001586 Ghrelin Proteins 0.000 title 1
- 239000000556 agonist Substances 0.000 title 1
- GNKDKYIHGQKHHM-RJKLHVOGSA-N ghrelin Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)COC(=O)CCCCCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CC=CC=C1 GNKDKYIHGQKHHM-RJKLHVOGSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18163425.4A EP3542799A1 (en) | 2018-03-22 | 2018-03-22 | New centrally-active ghrelin agonist and medical uses thereof |
| PCT/EP2019/056438 WO2019179878A1 (en) | 2018-03-22 | 2019-03-14 | New centrally-active ghrelin agonist and medical uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3768265T3 true DK3768265T3 (da) | 2022-07-25 |
Family
ID=61763810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19715003.0T DK3768265T3 (da) | 2018-03-22 | 2019-03-14 | Ny centralt aktiv ghrelin-agonist og medicinske anvendelser deraf |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US12005056B2 (da) |
| EP (2) | EP3542799A1 (da) |
| JP (1) | JP7182638B2 (da) |
| KR (1) | KR102676216B1 (da) |
| CN (3) | CN111902142B (da) |
| CA (1) | CA3089440A1 (da) |
| CY (1) | CY1125432T1 (da) |
| DK (1) | DK3768265T3 (da) |
| ES (1) | ES2918329T3 (da) |
| HR (1) | HRP20220905T8 (da) |
| HU (1) | HUE059248T2 (da) |
| LT (1) | LT3768265T (da) |
| MA (1) | MA52080A (da) |
| MD (1) | MD3768265T2 (da) |
| PL (1) | PL3768265T3 (da) |
| PT (1) | PT3768265T (da) |
| RS (1) | RS63409B1 (da) |
| SI (1) | SI3768265T1 (da) |
| WO (1) | WO2019179878A1 (da) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3542799A1 (en) * | 2018-03-22 | 2019-09-25 | Helsinn Healthcare SA | New centrally-active ghrelin agonist and medical uses thereof |
| WO2022253941A1 (en) | 2021-06-02 | 2022-12-08 | Helsinn Healthcare Sa | Piperidine urea derivatives for use as inotropic agents |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL148052A0 (en) * | 1999-08-10 | 2002-09-12 | Uab Research Foundation | Use of gaba antagonists for treatment of spastic disorders, convulsions, and epilepsy |
| CN101951937A (zh) * | 2007-12-21 | 2011-01-19 | 赫尔辛医疗股份公司 | 使用伊帕瑞林刺激胃肠系统动力的方法 |
| GB201004739D0 (en) * | 2010-03-22 | 2010-05-05 | Prosidion Ltd | Receptor modulators |
| US9187413B2 (en) * | 2010-07-28 | 2015-11-17 | The Regents Of The University Of California | Peripherally restricted FAAH inhibitors |
| WO2012113103A1 (en) | 2011-02-25 | 2012-08-30 | Helsinn Healthcare S.A. | Asymmetric ureas and medical uses thereof |
| TWI703130B (zh) | 2014-03-07 | 2020-09-01 | 瑞士商赫爾辛保健股份有限公司 | 對位取代的不對稱脲及其醫療用途 |
| EP3542799A1 (en) * | 2018-03-22 | 2019-09-25 | Helsinn Healthcare SA | New centrally-active ghrelin agonist and medical uses thereof |
-
2018
- 2018-03-22 EP EP18163425.4A patent/EP3542799A1/en not_active Withdrawn
-
2019
- 2019-03-14 CN CN201980021301.3A patent/CN111902142B/zh active Active
- 2019-03-14 EP EP19715003.0A patent/EP3768265B1/en active Active
- 2019-03-14 LT LTEPPCT/EP2019/056438T patent/LT3768265T/lt unknown
- 2019-03-14 RS RS20220692A patent/RS63409B1/sr unknown
- 2019-03-14 MA MA052080A patent/MA52080A/fr unknown
- 2019-03-14 ES ES19715003T patent/ES2918329T3/es active Active
- 2019-03-14 KR KR1020207029769A patent/KR102676216B1/ko active Active
- 2019-03-14 MD MDE20210098T patent/MD3768265T2/ro unknown
- 2019-03-14 JP JP2020544890A patent/JP7182638B2/ja active Active
- 2019-03-14 PL PL19715003.0T patent/PL3768265T3/pl unknown
- 2019-03-14 HU HUE19715003A patent/HUE059248T2/hu unknown
- 2019-03-14 CN CN202310931935.0A patent/CN116983307A/zh active Pending
- 2019-03-14 SI SI201930261T patent/SI3768265T1/sl unknown
- 2019-03-14 CN CN202310931999.0A patent/CN116983308A/zh active Pending
- 2019-03-14 WO PCT/EP2019/056438 patent/WO2019179878A1/en not_active Ceased
- 2019-03-14 PT PT197150030T patent/PT3768265T/pt unknown
- 2019-03-14 CA CA3089440A patent/CA3089440A1/en active Pending
- 2019-03-14 DK DK19715003.0T patent/DK3768265T3/da active
- 2019-03-14 HR HRP20220905TT patent/HRP20220905T8/hr unknown
- 2019-03-14 US US16/982,107 patent/US12005056B2/en active Active
-
2022
- 2022-07-29 CY CY20221100523T patent/CY1125432T1/el unknown
-
2024
- 2024-05-02 US US18/653,685 patent/US12440485B2/en active Active
-
2025
- 2025-08-15 US US19/300,850 patent/US20250367181A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019179878A1 (en) | 2019-09-26 |
| KR102676216B1 (ko) | 2024-06-17 |
| LT3768265T (lt) | 2022-06-27 |
| US20240293388A1 (en) | 2024-09-05 |
| HUE059248T2 (hu) | 2022-11-28 |
| PL3768265T3 (pl) | 2022-08-29 |
| JP2021516675A (ja) | 2021-07-08 |
| EP3768265A1 (en) | 2021-01-27 |
| US12440485B2 (en) | 2025-10-14 |
| EP3768265B1 (en) | 2022-05-04 |
| US12005056B2 (en) | 2024-06-11 |
| CN111902142B (zh) | 2023-10-20 |
| KR20200135814A (ko) | 2020-12-03 |
| PT3768265T (pt) | 2022-05-19 |
| JP7182638B2 (ja) | 2022-12-02 |
| SI3768265T1 (sl) | 2022-08-31 |
| CA3089440A1 (en) | 2019-09-26 |
| RS63409B1 (sr) | 2022-08-31 |
| HRP20220905T1 (hr) | 2022-10-14 |
| CY1125432T1 (el) | 2025-05-09 |
| MD3768265T2 (ro) | 2022-09-30 |
| HRP20220905T8 (hr) | 2022-12-23 |
| MA52080A (fr) | 2021-06-02 |
| ES2918329T3 (es) | 2022-07-15 |
| EP3542799A1 (en) | 2019-09-25 |
| CN116983308A (zh) | 2023-11-03 |
| US20230158007A1 (en) | 2023-05-25 |
| CN116983307A (zh) | 2023-11-03 |
| US20250367181A1 (en) | 2025-12-04 |
| CN111902142A (zh) | 2020-11-06 |
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