DK3790567T3 - Leverspecifik tropisme hos adenoassocierede vira - Google Patents
Leverspecifik tropisme hos adenoassocierede viraInfo
- Publication number
- DK3790567T3 DK3790567T3 DK19799988.1T DK19799988T DK3790567T3 DK 3790567 T3 DK3790567 T3 DK 3790567T3 DK 19799988 T DK19799988 T DK 19799988T DK 3790567 T3 DK3790567 T3 DK 3790567T3
- Authority
- DK
- Denmark
- Prior art keywords
- adeno
- liver
- associated viruses
- specific tropism
- tropism
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14145—Special targeting system for viral vectors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862670543P | 2018-05-11 | 2018-05-11 | |
| US201962841179P | 2019-04-30 | 2019-04-30 | |
| PCT/US2019/031851 WO2019217911A1 (en) | 2018-05-11 | 2019-05-10 | Liver-specific tropism of adeno-associated viruses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3790567T3 true DK3790567T3 (da) | 2025-11-03 |
Family
ID=68468421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19799988.1T DK3790567T3 (da) | 2018-05-11 | 2019-05-10 | Leverspecifik tropisme hos adenoassocierede vira |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11987801B2 (da) |
| EP (1) | EP3790567B1 (da) |
| JP (2) | JP7438981B2 (da) |
| KR (1) | KR102946842B1 (da) |
| CN (1) | CN112368391A (da) |
| AU (1) | AU2019264991B2 (da) |
| BR (1) | BR112020022858A2 (da) |
| CA (1) | CA3100006A1 (da) |
| DK (1) | DK3790567T3 (da) |
| ES (1) | ES3050313T3 (da) |
| IL (1) | IL278598B2 (da) |
| SA (1) | SA520420518B1 (da) |
| WO (1) | WO2019217911A1 (da) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3100006A1 (en) | 2018-05-11 | 2019-11-14 | Massachusetts Eye And Ear Infirmary | Altering tissue tropism of adeno-associated viruses |
| EP3715358A1 (en) * | 2019-03-28 | 2020-09-30 | Universität zu Köln | Mutated adeno-associated virus capsid proteins, aav particle comprising the same and liver directed aav vector gene therapy |
| CA3153972A1 (en) | 2019-09-09 | 2021-03-18 | Massachusetts Eye And Ear Infirmary | Methods and compositions for modulating the interaction between adeno-associated virus (aav) and the aav receptor (aavr) for altered bio-distribution of aav |
| AU2020368539A1 (en) | 2019-10-16 | 2022-04-28 | Massachusetts Institute Of Technology | Engineered muscle targeting compositions |
| WO2021222831A2 (en) * | 2020-05-01 | 2021-11-04 | The Broad Institute, Inc. | Engineered central nervous system compositions |
| CN111876432B (zh) * | 2020-07-29 | 2022-10-28 | 舒泰神（北京）生物制药股份有限公司 | 一组肝靶向新型腺相关病毒的获得及其应用 |
| AU2021378075B2 (en) | 2020-11-11 | 2025-03-27 | Borea Therapeutics S.R.L. | Modified viral particles for gene therapy |
| WO2022150634A2 (en) | 2021-01-08 | 2022-07-14 | Massachusetts Eye And Ear Infirmary | Methods and compositions for modulating the interaction between adeno-associated virus (aav) and the aav receptor (aavr) for altered bio-distribution of aav |
| US20240115734A1 (en) * | 2021-02-09 | 2024-04-11 | Affinia Therapeutics Inc. | Recombinant aavs with improved tropism and specificity |
| US20240352077A1 (en) * | 2021-08-25 | 2024-10-24 | Children's Medical Research Institute | Modified aav capsids and vectors |
| WO2023039480A2 (en) * | 2021-09-08 | 2023-03-16 | The Broad Institute, Inc. | Engineered central nervous system compositions |
| KR20240095539A (ko) | 2021-10-08 | 2024-06-25 | 디노 테라퓨틱스, 인코포레이티드 | 캡시드 변이체 및 이의 사용 방법 |
| WO2024238807A2 (en) | 2023-05-16 | 2024-11-21 | Affinia Therapeutics Inc. | Recombinant aavs with improved tropism and specificity |
| WO2025059678A1 (en) * | 2023-09-15 | 2025-03-20 | Ohio State Innovation Foundation | Novel engineered capsid serotypes of recombinant adeno-associated viral vectors with reduced liver tropism |
| WO2025137378A1 (en) * | 2023-12-20 | 2025-06-26 | Aavantibio, Inc. | Aav capsid engineering for cardiac and/or musculoskeletal gene therapy |
| US20250276095A1 (en) | 2024-03-04 | 2025-09-04 | Kate Therapeutics, Inc. | Adeno-associated virus compositions for the treatment of duchenne muscular dystrophy |
| WO2025194042A1 (en) | 2024-03-14 | 2025-09-18 | Affinia Therapeutics Inc. | Plasmid system for production of recombinant adenoassociated virus |
| WO2025226842A1 (en) | 2024-04-24 | 2025-10-30 | Kate Therapeutics, Inc. | Expression control by drg-expressed mirnas |
| WO2025226841A1 (en) | 2024-04-24 | 2025-10-30 | Kate Therapeutics, Inc. | Gene therapy approach for treating disorders associated with tnnt2 |
| WO2025227063A1 (en) | 2024-04-26 | 2025-10-30 | Affinia Therapeutics Inc. | Recombinant aavs with improved tropism and specificity |
| WO2025235491A1 (en) | 2024-05-07 | 2025-11-13 | Affinia Therapeutics Inc. | Recombinant aav for treatment of cardiac diseases |
| WO2026011008A1 (en) | 2024-07-02 | 2026-01-08 | Kate Therapeutics, Inc. | Expression control by skeletal muscle-expressed mirnas |
| WO2026011009A1 (en) | 2024-07-02 | 2026-01-08 | Kate Therapeutics, Inc. | Compositions and methods for muscle disorders |
| WO2026030242A1 (en) | 2024-07-29 | 2026-02-05 | Kate Therapeutics, Inc. | Adeno-associated virus compositions for the treatment of facioscapulohumeral muscular dystrophy |
| WO2026030244A1 (en) | 2024-07-30 | 2026-02-05 | Kate Therapeutics, Inc. | Adeno-associated virus compositions for the treatment of limb girdle muscular dystrophy 2a |
| WO2026050402A1 (en) | 2024-08-29 | 2026-03-05 | Kate Therapeutics, Inc. | Liver de-targeted muscle tropic capsids |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2345731B1 (en) | 2003-09-30 | 2015-10-21 | The Trustees of the University of Pennsylvania | Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses thereof |
| JP5136766B2 (ja) * | 2004-12-15 | 2013-02-06 | ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | キメラベクター |
| WO2010093784A2 (en) * | 2009-02-11 | 2010-08-19 | The University Of North Carolina At Chapel Hill | Modified virus vectors and methods of making and using the same |
| CN105755044A (zh) * | 2011-04-22 | 2016-07-13 | 加利福尼亚大学董事会 | 具有变异衣壳的腺相关病毒病毒体及其使用方法 |
| JP5915467B2 (ja) | 2012-08-30 | 2016-05-11 | 株式会社島津製作所 | 液体クロマトグラフ検出器用送液管及び液体クロマトグラフ |
| ES2926774T3 (es) | 2013-03-15 | 2022-10-28 | Univ North Carolina Chapel Hill | Métodos y composiciones para vectores AAV de doble unión de glicano |
| EP3003391B1 (en) * | 2013-05-31 | 2021-09-22 | The Regents of The University of California | Adeno-associated virus variants and methods of use thereof |
| WO2015048534A1 (en) | 2013-09-26 | 2015-04-02 | University Of Florida Research Foundation, Inc. | Synthetic combinatorial aav capsid library for targeted gene therapy |
| CN106232618A (zh) | 2013-10-11 | 2016-12-14 | 马萨诸塞眼科耳科诊所 | 预测祖先病毒序列的方法及其用途 |
| US9474181B2 (en) | 2013-12-23 | 2016-10-18 | Dell Products, L.P. | Combined power and management module for use in a rack-configured information handling system |
| WO2015164757A1 (en) * | 2014-04-25 | 2015-10-29 | Oregon Health & Science University | Methods of viral neutralizing antibody epitope mapping |
| JP6475998B2 (ja) | 2015-02-10 | 2019-02-27 | デクセリアルズ株式会社 | タッチパッド用アンテナ装置、及び電子機器 |
| CN108603235A (zh) | 2015-07-30 | 2018-09-28 | 马萨诸塞眼科耳科诊所 | 祖先病毒序列及其用途 |
| EP3384034B1 (en) | 2015-12-02 | 2020-07-08 | The Board of Trustees of the Leland Stanford Junior University | Novel recombinant adeno-associated virus capsids with enhanced human skeletal muscle tropism |
| SG10201913266UA (en) * | 2015-12-11 | 2020-02-27 | Massachusetts Eye & Ear Infirmary | Materials and methods for delivering nucleic acids to cochlear and vestibular cells |
| JP6947739B2 (ja) | 2016-02-16 | 2021-10-13 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 既存のヒト中和抗体に対して耐性である新規組換えアデノ随伴ウイルスカプシド |
| JP6936788B2 (ja) | 2016-04-01 | 2021-09-22 | 株式会社カネカ | 軽量化及びリブ設計が可能な樹脂組成物による表面性が良好な射出発泡成形体 |
| IL305149A (en) * | 2016-07-26 | 2023-10-01 | Biomarin Pharm Inc | Novel adeno-associated virus capsid proteins |
| AU2017341849B2 (en) | 2016-10-13 | 2024-03-21 | University Of Massachusetts | AAV capsid designs |
| US11905312B2 (en) | 2017-02-15 | 2024-02-20 | The University Of North Carolina At Chapel Hill | Methods and compositions for gene transfer across the vasculature |
| CA3061968A1 (en) | 2017-05-10 | 2018-11-15 | Massachusetts Eye And Ear Infirmary | Methods and compositions for modifying assembly-activating protein (aap)-dependence of viruses |
| US11247659B2 (en) | 2017-08-08 | 2022-02-15 | Aisin Seiki Kabushiki Kaisha | Vehicle control apparatus |
| CN111770999A (zh) | 2017-11-27 | 2020-10-13 | 4D分子治疗有限公司 | 腺相关病毒变体衣壳和用于抑制血管生成的应用 |
| CA3100006A1 (en) | 2018-05-11 | 2019-11-14 | Massachusetts Eye And Ear Infirmary | Altering tissue tropism of adeno-associated viruses |
| WO2020041498A1 (en) | 2018-08-21 | 2020-02-27 | Massachusetts Eye And Ear Infirmary | Compositions and methods for modulating transduction efficiency of adeno-associated viruses |
| CA3153972A1 (en) | 2019-09-09 | 2021-03-18 | Massachusetts Eye And Ear Infirmary | Methods and compositions for modulating the interaction between adeno-associated virus (aav) and the aav receptor (aavr) for altered bio-distribution of aav |
| WO2022150634A2 (en) | 2021-01-08 | 2022-07-14 | Massachusetts Eye And Ear Infirmary | Methods and compositions for modulating the interaction between adeno-associated virus (aav) and the aav receptor (aavr) for altered bio-distribution of aav |
-
2019
- 2019-05-10 CA CA3100006A patent/CA3100006A1/en active Pending
- 2019-05-10 IL IL278598A patent/IL278598B2/en unknown
- 2019-05-10 DK DK19799988.1T patent/DK3790567T3/da active
- 2019-05-10 CN CN201980042499.3A patent/CN112368391A/zh active Pending
- 2019-05-10 US US17/053,412 patent/US11987801B2/en active Active
- 2019-05-10 ES ES19799988T patent/ES3050313T3/es active Active
- 2019-05-10 AU AU2019264991A patent/AU2019264991B2/en active Active
- 2019-05-10 BR BR112020022858-3A patent/BR112020022858A2/pt unknown
- 2019-05-10 JP JP2020563602A patent/JP7438981B2/ja active Active
- 2019-05-10 KR KR1020207035395A patent/KR102946842B1/ko active Active
- 2019-05-10 WO PCT/US2019/031851 patent/WO2019217911A1/en not_active Ceased
- 2019-05-10 EP EP19799988.1A patent/EP3790567B1/en active Active
-
2020
- 2020-11-10 SA SA520420518A patent/SA520420518B1/ar unknown
-
2024
- 2024-02-14 JP JP2024020029A patent/JP7727029B2/ja active Active
- 2024-04-12 US US18/633,726 patent/US20240344085A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR102946842B1 (ko) | 2026-04-01 |
| JP2021522827A (ja) | 2021-09-02 |
| BR112020022858A2 (pt) | 2021-02-23 |
| EP3790567A4 (en) | 2021-12-01 |
| AU2019264991B2 (en) | 2025-12-04 |
| EP3790567B1 (en) | 2025-08-06 |
| KR20210010491A (ko) | 2021-01-27 |
| CA3100006A1 (en) | 2019-11-14 |
| SA520420518B1 (ar) | 2024-03-17 |
| IL278598B2 (en) | 2025-11-01 |
| EP3790567A1 (en) | 2021-03-17 |
| JP7727029B2 (ja) | 2025-08-20 |
| WO2019217911A1 (en) | 2019-11-14 |
| US11987801B2 (en) | 2024-05-21 |
| AU2019264991A1 (en) | 2020-11-26 |
| ES3050313T3 (en) | 2025-12-19 |
| IL278598B1 (en) | 2025-07-01 |
| JP2024073426A (ja) | 2024-05-29 |
| JP7438981B2 (ja) | 2024-02-27 |
| IL278598A (da) | 2021-03-01 |
| US20230051611A1 (en) | 2023-02-16 |
| US20240344085A1 (en) | 2024-10-17 |
| CN112368391A (zh) | 2021-02-12 |
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