DK3801577T3 - Fremgangsmåder og sammensætninger omfattende tankyrasehæmmere til dannelse af insulinproducerende celler - Google Patents

Fremgangsmåder og sammensætninger omfattende tankyrasehæmmere til dannelse af insulinproducerende celler Download PDF

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Publication number
DK3801577T3
DK3801577T3 DK19811896.0T DK19811896T DK3801577T3 DK 3801577 T3 DK3801577 T3 DK 3801577T3 DK 19811896 T DK19811896 T DK 19811896T DK 3801577 T3 DK3801577 T3 DK 3801577T3
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Denmark
Prior art keywords
insulin
compositions
formation
methods
producing cells
Prior art date
Application number
DK19811896.0T
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English (en)
Inventor
Maria Cristina Nostro
Farida Sarangi
Roman Korytnikov
Emily Mcgaugh
Hoi Chun Frankie Poon
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Univ Health Network Uhn
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Publication of DK3801577T3 publication Critical patent/DK3801577T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0678—Stem cells; Progenitor cells; Precursor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DK19811896.0T 2018-05-31 2019-05-30 Fremgangsmåder og sammensætninger omfattende tankyrasehæmmere til dannelse af insulinproducerende celler DK3801577T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862678498P 2018-05-31 2018-05-31
PCT/CA2019/000079 WO2019227198A1 (en) 2018-05-31 2019-05-30 Methods and compositions comprising tankyrase inhibitors for generating insulin producing cells

Publications (1)

Publication Number Publication Date
DK3801577T3 true DK3801577T3 (da) 2025-05-05

Family

ID=68698507

Family Applications (1)

Application Number Title Priority Date Filing Date
DK19811896.0T DK3801577T3 (da) 2018-05-31 2019-05-30 Fremgangsmåder og sammensætninger omfattende tankyrasehæmmere til dannelse af insulinproducerende celler

Country Status (6)

Country Link
US (1) US20210198633A1 (da)
EP (1) EP3801577B1 (da)
JP (1) JP2021525094A (da)
CA (1) CA3101021A1 (da)
DK (1) DK3801577T3 (da)
WO (1) WO2019227198A1 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3710021A4 (en) 2017-11-15 2021-08-11 Semma Therapeutics, Inc. ISLAND CELL MANUFACTURING COMPOSITIONS AND METHOD OF USE
WO2020033879A1 (en) * 2018-08-10 2020-02-13 Semma Therapeutics, Inc. Stem cell derived islet differentiation
US20220411759A1 (en) * 2019-05-21 2022-12-29 President And Fellows Of Harvard College Endocrine differentiation-inducing molecule
CA3232971A1 (en) 2021-11-01 2023-05-04 George Harb Stem cell derived pancreatic islet differentiation
WO2025117331A1 (en) 2023-12-01 2025-06-05 Eli Lilly And Company Methods of making stem cell-derived islet-like cells, as well as populations and compositions including the same

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5994619A (en) 1996-04-01 1999-11-30 University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus Production of chimeric bovine or porcine animals using cultured inner cell mass cells
US5945577A (en) 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells
US8187878B2 (en) 2004-08-13 2012-05-29 University Of Georgia Research Foundation, Inc. Methods for increasing definitive endoderm differentiation of pluripotent human embryonic stem cells with PI-3 kinase inhibitors
JP6110048B2 (ja) 2006-03-02 2017-04-05 ヴィアサイト，インコーポレイテッド 内分泌前駆細胞、膵臓ホルモン発現細胞及びそれらの製造方法
US7989204B2 (en) 2006-04-28 2011-08-02 Viacyte, Inc. Hepatocyte lineage cells
US7695963B2 (en) 2007-09-24 2010-04-13 Cythera, Inc. Methods for increasing definitive endoderm production
HRP20191677T1 (hr) 2012-04-30 2019-12-13 Univ Health Network POSTUPCI I SASTAVI ZA GENERIRANJE PANKREASNIH PROGENITORA I FUNKCIONALNIH BETA STANICA IZ hPSC
EP3178924B1 (en) * 2014-08-04 2019-12-25 Takeda Pharmaceutical Company Limited Method for proliferation of pancreatic progenitor cells
EP3286563B1 (en) 2015-04-23 2022-11-02 The Regents of The University of California Controlled induction of human pancreatic progenitors produces functional beta-like cells
EP3819372A3 (en) * 2015-04-24 2021-10-06 University of Copenhagen Isolation of bona fide pancreatic progenitor cells
US11021687B2 (en) * 2016-01-08 2021-06-01 The Brigham And Women's Hospital, Inc. Production of differentiated enteroendocrine cells and insulin producing cells
JP6879511B2 (ja) * 2016-01-29 2021-06-02 国立大学法人京都大学 血小板産生促進剤及びそれを用いた血小板の製造方法
GB201603569D0 (en) * 2016-03-01 2016-04-13 Koninklijke Nederlandse Akademie Van Wetenschappen Improved differentiation method
WO2020033879A1 (en) * 2018-08-10 2020-02-13 Semma Therapeutics, Inc. Stem cell derived islet differentiation

Also Published As

Publication number Publication date
EP3801577B1 (en) 2025-02-19
US20210198633A1 (en) 2021-07-01
WO2019227198A1 (en) 2019-12-05
CA3101021A1 (en) 2019-12-05
EP3801577A1 (en) 2021-04-14
EP3801577A4 (en) 2021-07-14
JP2021525094A (ja) 2021-09-24

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