DK3856721T3 - Syntetisk fremgangsmåde til fremstillingen af en 3-[5-amino-4-(3-cyanobenzoyl)-pyrazolforbindelse - Google Patents

Syntetisk fremgangsmåde til fremstillingen af en 3-[5-amino-4-(3-cyanobenzoyl)-pyrazolforbindelse Download PDF

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Publication number
DK3856721T3
DK3856721T3 DK19780305.9T DK19780305T DK3856721T3 DK 3856721 T3 DK3856721 T3 DK 3856721T3 DK 19780305 T DK19780305 T DK 19780305T DK 3856721 T3 DK3856721 T3 DK 3856721T3
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DK
Denmark
Prior art keywords
cyanobenzoyl
amino
preparation
synthetic procedure
pyrazole compound
Prior art date
Application number
DK19780305.9T
Other languages
English (en)
Inventor
Mark Meisenbach
Benjamin Martin
Niek Johannes Ronde
Carmen Ruiz
Original Assignee
Mereo Biopharma 1 Ltd
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Application filed by Mereo Biopharma 1 Ltd filed Critical Mereo Biopharma 1 Ltd
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Publication of DK3856721T3 publication Critical patent/DK3856721T3/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10Hydrazines
    • C07C243/22Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/49Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/56Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK19780305.9T 2018-09-26 2019-09-26 Syntetisk fremgangsmåde til fremstillingen af en 3-[5-amino-4-(3-cyanobenzoyl)-pyrazolforbindelse DK3856721T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1815695.0A GB201815695D0 (en) 2018-09-26 2018-09-26 Synthetic method
PCT/GB2019/052718 WO2020065323A1 (en) 2018-09-26 2019-09-26 Synthetic method for the preparation of a 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol compound

Publications (1)

Publication Number Publication Date
DK3856721T3 true DK3856721T3 (da) 2023-04-24

Family

ID=64024269

Family Applications (1)

Application Number Title Priority Date Filing Date
DK19780305.9T DK3856721T3 (da) 2018-09-26 2019-09-26 Syntetisk fremgangsmåde til fremstillingen af en 3-[5-amino-4-(3-cyanobenzoyl)-pyrazolforbindelse

Country Status (12)

Country Link
US (1) US11649213B2 (da)
EP (1) EP3856721B1 (da)
JP (1) JP7291782B2 (da)
KR (1) KR102711257B1 (da)
CN (1) CN112839928B (da)
AU (1) AU2019350525B2 (da)
CA (1) CA3112993A1 (da)
DK (1) DK3856721T3 (da)
ES (1) ES2943289T3 (da)
GB (1) GB201815695D0 (da)
IL (1) IL281636B2 (da)
WO (1) WO2020065323A1 (da)

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1809386A1 (de) 1968-11-16 1970-06-11 Bayer Ag Verfahren zur Herstellung von 1,5-disubstituierten 4-Cyanopyrazolen
US4686221A (en) * 1985-10-01 1987-08-11 Kanebo, Ltd. Quinolinecarboxylic acid compounds and antimicrobial agent containing the same
US6005109A (en) * 1997-10-30 1999-12-21 Pflizer Inc. Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity
US6103900A (en) * 1992-12-17 2000-08-15 Pfizer Inc Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity
FR2732967B1 (fr) 1995-04-11 1997-07-04 Sanofi Sa 1-phenylpyrazole-3-carboxamides substitues, actifs sur la neurotensine, leur preparation, les compositions pharmaceutiques en contenant
GB9608435D0 (en) * 1996-04-24 1996-06-26 Celltech Therapeutics Ltd Chemical compounds
HRP20000724A2 (en) * 1998-05-05 2001-06-30 Hoffmann La Roche Pyrazole derivatives as p-38 map kinase inhibitors
PL2298743T3 (pl) 2003-06-26 2013-02-28 Novartis Ag Inhibitory kinaz P38 na bazie 5-członowych heterocykli
WO2005007632A1 (en) 2003-07-18 2005-01-27 Pharmacia Corporation Substituted pyridazinones as inhibitors of p38
US7485657B2 (en) 2004-05-12 2009-02-03 Boehringer Ingelheim Pharmaceuticals, Inc. Anti-cytokine heterocyclic compounds
ATE510836T1 (de) 2006-01-19 2011-06-15 Matrix Lab Ltd Umwandlung eines aromatischen diazoniumsalzes in ein arylhydrazin
AU2008281594A1 (en) 2007-08-02 2009-02-05 Generics [Uk] Limited Novel process
WO2009088025A1 (ja) 2008-01-10 2009-07-16 Hokko Chemical Industry Co., Ltd. フェニルトリアゾリノン類の製造法
JP5602387B2 (ja) 2008-05-02 2014-10-08 キヤノン株式会社 インクジェット用インク、インクジェット記録方法、インクカートリッジ、記録ユニット、及びインクジェット記録装置
CN102964270B (zh) 2012-11-21 2015-01-07 合肥星宇化学有限责任公司 一种亚硫酸钠还原重氮盐合成肼的方法
WO2018059533A1 (zh) 2016-09-29 2018-04-05 南京明德新药研发股份有限公司 p38αMAPK激酶抑制剂及其制备方法和应用

Also Published As

Publication number Publication date
WO2020065323A1 (en) 2020-04-02
CN112839928B (zh) 2024-04-30
KR102711257B1 (ko) 2024-09-30
US20210395207A1 (en) 2021-12-23
JP2022502400A (ja) 2022-01-11
EP3856721A1 (en) 2021-08-04
US11649213B2 (en) 2023-05-16
EP3856721B1 (en) 2023-03-29
IL281636B2 (en) 2024-08-01
AU2019350525A1 (en) 2021-04-15
CN112839928A (zh) 2021-05-25
AU2019350525B2 (en) 2024-05-02
IL281636B1 (en) 2024-04-01
JP7291782B2 (ja) 2023-06-15
KR20210069044A (ko) 2021-06-10
IL281636A (en) 2021-05-31
CA3112993A1 (en) 2020-04-02
GB201815695D0 (en) 2018-11-07
ES2943289T3 (es) 2023-06-12

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