DK385686D0 - Hybridplasminogenaktivator, vektorer og dna-enheder, som koder derfor samt aktivatorens anvendelse - Google Patents

Hybridplasminogenaktivator, vektorer og dna-enheder, som koder derfor samt aktivatorens anvendelse

Info

Publication number
DK385686D0
DK385686D0 DK385686A DK385686A DK385686D0 DK 385686 D0 DK385686 D0 DK 385686D0 DK 385686 A DK385686 A DK 385686A DK 385686 A DK385686 A DK 385686A DK 385686 D0 DK385686 D0 DK 385686D0
Authority
DK
Denmark
Prior art keywords
activator
vectors
code
dna units
hybrid plasminogen
Prior art date
Application number
DK385686A
Other languages
English (en)
Other versions
DK385686A (da
DK175420B1 (da
Inventor
Paul Porwen Hung
Narender Kumar Kalyan
Shawguang Lin Lee
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of DK385686D0 publication Critical patent/DK385686D0/da
Publication of DK385686A publication Critical patent/DK385686A/da
Application granted granted Critical
Publication of DK175420B1 publication Critical patent/DK175420B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DK198603856A 1985-08-14 1986-08-13 Hybridplasminogenaktivator, DNA-enhed, kloningsvektor plasmid, mikroorganisme eller cellekultur transformeret med vektoren, fremgangsmåde til fremstilling af plasminogenaktivatioren samt farmaceutisk præparat indeholdende denne DK175420B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US76616385A 1985-08-14 1985-08-14
US76616385 1985-08-14
US06/884,835 US4916071A (en) 1985-08-14 1986-07-11 Poly-kringle plasminogen activator
US88483586 1986-07-11

Publications (3)

Publication Number Publication Date
DK385686D0 true DK385686D0 (da) 1986-08-13
DK385686A DK385686A (da) 1987-02-15
DK175420B1 DK175420B1 (da) 2004-10-04

Family

ID=27117699

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198603856A DK175420B1 (da) 1985-08-14 1986-08-13 Hybridplasminogenaktivator, DNA-enhed, kloningsvektor plasmid, mikroorganisme eller cellekultur transformeret med vektoren, fremgangsmåde til fremstilling af plasminogenaktivatioren samt farmaceutisk præparat indeholdende denne

Country Status (15)

Country Link
US (1) US4916071A (da)
EP (1) EP0213794B1 (da)
JP (2) JPH0829086B2 (da)
KR (1) KR900007649B1 (da)
AU (1) AU596369B2 (da)
CA (1) CA1341449C (da)
DE (1) DE3676760D1 (da)
DK (1) DK175420B1 (da)
GB (1) GB2179948B (da)
GR (1) GR862076B (da)
HU (1) HU200795B (da)
IE (1) IE59380B1 (da)
IL (1) IL79644A (da)
PH (1) PH26199A (da)
PT (1) PT83170B (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5112755A (en) * 1982-04-15 1992-05-12 Genentech, Inc. Preparation of functional human urokinase proteins
GB8334498D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Compounds
US4880776A (en) * 1983-12-24 1989-11-14 Beecham Group P.L.C. Plasmin A-chain urokinase B-chain hybrid protein
JP2581668B2 (ja) * 1985-11-27 1997-02-12 三井東圧化学株式会社 ヒト正常細胞由来のヒト組織プラスミノ−ゲン活性化因子をコ−ドする新しいｄｎａ配列とそれを含むベクタ−及び細胞
EP0231624B1 (en) * 1985-12-20 1993-01-27 The Upjohn Company Tissue plasminogen activator (tpa) analogs
US5204255A (en) * 1986-01-31 1993-04-20 Sagami Chemical Research Center Hybrid tissue plasminogen activator/urokinase polypeptides
ATE70301T1 (de) * 1986-02-17 1991-12-15 Stichting Centraal Lab Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen.
US5047241A (en) * 1986-07-11 1991-09-10 American Home Products Corporation Tris-Kringle plasminogen activator with novel K2 insert
US5580559A (en) * 1986-12-05 1996-12-03 Ciba-Geigy Corporation Hybrid plasminogen activator
US5242819A (en) * 1986-12-05 1993-09-07 Ciba-Geigy Corporation DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase
FI100106B (fi) * 1986-12-05 1997-09-30 Novartis Ag Menetelmä plasminogeenin yksisäikeisen yhdistelmäaktivaattorin valmist amiseksi
EP0299053A1 (en) * 1987-01-30 1989-01-18 American Home Products Corporation Des-epidermal growth factor plasminogen activators
GB8705377D0 (en) * 1987-03-07 1987-04-08 Beecham Group Plc Compounds
GB8711957D0 (en) * 1987-05-20 1987-06-24 Beecham Group Plc Compounds
EP0292009A1 (en) * 1987-05-22 1988-11-23 Zymogenetics, Inc. Fibrinolytic proteins
ZA884012B (en) * 1987-06-04 1989-02-22 Zymogenetics Inc Tissue plasminogen activator analogs having modified growth factor domains
ATE118815T1 (de) * 1987-06-04 1995-03-15 Zymogenetics Inc Gewebs-plasminogen-aktivator-analoge mit modifizierten wachstumsfaktordomänen.
US5149533A (en) * 1987-06-04 1992-09-22 Zymogenetics, Inc. Modified t-PA with kringle-/replaced by another kringle
US5302390A (en) * 1987-07-01 1994-04-12 Beecham Group Plc Hybrid proteins of human plasminogen and human t-PA, pharmaceutical compositions and methods of treatment
EP0297882B1 (en) * 1987-07-01 1993-08-25 Beecham Group Plc Hybrid plasminogen activators
EP0394261A4 (en) * 1987-07-06 1991-09-11 Genetics Institute, Inc. Novel thrombolytic proteins
JP2708749B2 (ja) * 1987-08-10 1998-02-04 エーザイ株式会社 修飾型ｔＰＡ含有注射用組成物
US5244676A (en) * 1987-10-09 1993-09-14 Monsanto Company Modified tissue plasminogen activator with modified glycosylation site
US5100666A (en) * 1987-10-09 1992-03-31 Monsanto Company Modified tissue plasminogen activator K2K2SP
AU3410289A (en) * 1988-04-22 1989-11-24 Collaborative Research Inc. Plasminogen activators with increased fibrin selectivity
GB8826975D0 (en) * 1988-11-18 1988-12-21 Beecham Group Plc Novel compounds
US5326700A (en) * 1990-11-06 1994-07-05 Eli Lilly And Company DNA sequences encoding t-PA derivatives with cleavable sites
WO2003087393A2 (en) * 2002-04-09 2003-10-23 Global Biotech Inc. Human tissue urokinase type plasminogen activator production
WO2009086552A1 (en) * 2008-01-02 2009-07-09 The Trustees Of The University Of Pennsylvania Targeting recombinant therapeutics to circulating red blood cells
US11629198B2 (en) 2017-12-05 2023-04-18 The Trustees Of The University Of Pennsylvania Fusion proteins and antibodies targeting human red blood cell antigens

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR78180B (da) * 1982-04-15 1984-09-26 Genentech Inc
SU1662352A3 (ru) * 1982-05-05 1991-07-07 Генентек, Инк (Фирма) Штамм бактерий ЕSснеRIснIа coLI - продуцент активатора плазминогена тканевого типа
AR241654A1 (es) 1982-05-05 1992-10-30 Genentech Inc Procedimiento para producir activador de plasminogeno de tejido humano.
US4766075A (en) * 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
GB8334498D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Compounds
EP0231883B1 (en) * 1986-01-31 1992-09-02 Sagami Chemical Research Center Hybrid plasminogen activator-like polypeptide

Also Published As

Publication number Publication date
JP2610783B2 (ja) 1997-05-14
GB2179948B (en) 1989-08-16
JPH0829086B2 (ja) 1996-03-27
KR870002264A (ko) 1987-03-30
DK385686A (da) 1987-02-15
HUT41443A (en) 1987-04-28
DE3676760D1 (de) 1991-02-14
PH26199A (en) 1992-03-18
CA1341449C (en) 2003-12-09
GB8619154D0 (en) 1986-09-17
HU200795B (en) 1990-08-28
EP0213794B1 (en) 1991-01-09
GR862076B (en) 1986-12-24
IE59380B1 (en) 1994-02-23
KR900007649B1 (ko) 1990-10-17
US4916071A (en) 1990-04-10
AU6110286A (en) 1987-02-19
AU596369B2 (en) 1990-05-03
IL79644A (en) 1991-06-10
IE862178L (en) 1987-02-14
DK175420B1 (da) 2004-10-04
GB2179948A (en) 1987-03-18
JPH07147984A (ja) 1995-06-13
JPS62104577A (ja) 1987-05-15
PT83170A (en) 1986-09-01
IL79644A0 (en) 1986-11-30
EP0213794A1 (en) 1987-03-11
PT83170B (pt) 1988-07-29

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