DK3873472T3 - Nye pyridaziner - Google Patents

Nye pyridaziner Download PDF

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Publication number
DK3873472T3
DK3873472T3 DK19801229.6T DK19801229T DK3873472T3 DK 3873472 T3 DK3873472 T3 DK 3873472T3 DK 19801229 T DK19801229 T DK 19801229T DK 3873472 T3 DK3873472 T3 DK 3873472T3
Authority
DK
Denmark
Prior art keywords
pyridazines
new
new pyridazines
Prior art date
Application number
DK19801229.6T
Other languages
English (en)
Inventor
Gerald Juergen Roth
Tom Bretschneider
Christian Andreas Kuttruff
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Application granted granted Critical
Publication of DK3873472T3 publication Critical patent/DK3873472T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/501Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D237/00Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22Nitrogen and oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK19801229.6T 2018-10-29 2019-10-25 Nye pyridaziner DK3873472T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18203226 2018-10-29
PCT/EP2019/079231 WO2020089098A1 (en) 2018-10-29 2019-10-25 Novel pyridazines

Publications (1)

Publication Number Publication Date
DK3873472T3 true DK3873472T3 (da) 2023-09-04

Family

ID=64048690

Family Applications (1)

Application Number Title Priority Date Filing Date
DK19801229.6T DK3873472T3 (da) 2018-10-29 2019-10-25 Nye pyridaziner

Country Status (20)

Country Link
US (1) US11104665B2 (da)
EP (1) EP3873472B1 (da)
JP (1) JP7214860B2 (da)
KR (1) KR102823014B1 (da)
CN (1) CN112996513B (da)
AR (1) AR116877A1 (da)
AU (1) AU2019373324B2 (da)
BR (1) BR112021005445A2 (da)
CA (1) CA3113712A1 (da)
CL (1) CL2021000930A1 (da)
DK (1) DK3873472T3 (da)
EA (1) EA202191115A1 (da)
ES (1) ES2955723T3 (da)
HU (1) HUE063845T2 (da)
IL (1) IL282425B2 (da)
MX (1) MX2021004860A (da)
PH (1) PH12021550903A1 (da)
PL (1) PL3873472T3 (da)
TW (1) TW202035374A (da)
WO (1) WO2020089098A1 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11485727B2 (en) * 2019-07-22 2022-11-01 Boehringer Ingelheim International Gmbh N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators
US11465982B2 (en) 2019-07-22 2022-10-11 Boehringer Ingelheim International Gmbh Pyridazines
ES2982742T3 (es) 2019-07-22 2024-10-17 Boehringer Ingelheim Int Derivados de N-metil,N-(6-(metoxi)piridazín-3-il)amina como moduladores de autotaxina (ATX) para el tratamiento de enfermedades inflamatorias o fibróticas de las vías respiratorias

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2748656T3 (es) * 2011-10-28 2020-03-17 Inhibitaxin Ltd Derivados de piridazina útiles en terapia
SI2970255T1 (sl) 2013-03-14 2017-12-29 Galapagos Nv Spojine in farmacevtski sestavki le-teh za zdravljenje vnetnih motenj
EP3010922B1 (en) * 2013-06-19 2017-03-15 Galapagos NV Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
US9604974B2 (en) * 2015-01-22 2017-03-28 University Of Mysore Compounds as modulator of JAK-STAT pathway, methods and applications thereof
US11485727B2 (en) 2019-07-22 2022-11-01 Boehringer Ingelheim International Gmbh N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators
US11465982B2 (en) 2019-07-22 2022-10-11 Boehringer Ingelheim International Gmbh Pyridazines
ES2982742T3 (es) * 2019-07-22 2024-10-17 Boehringer Ingelheim Int Derivados de N-metil,N-(6-(metoxi)piridazín-3-il)amina como moduladores de autotaxina (ATX) para el tratamiento de enfermedades inflamatorias o fibróticas de las vías respiratorias

Also Published As

Publication number Publication date
EP3873472A1 (en) 2021-09-08
CL2021000930A1 (es) 2021-11-12
AU2019373324B2 (en) 2024-08-29
JP2022506046A (ja) 2022-01-17
JP7214860B2 (ja) 2023-01-30
PH12021550903A1 (en) 2022-03-21
PL3873472T3 (pl) 2023-12-27
US11104665B2 (en) 2021-08-31
EP3873472B1 (en) 2023-07-12
HUE063845T2 (hu) 2024-02-28
CA3113712A1 (en) 2020-05-07
KR20210084597A (ko) 2021-07-07
BR112021005445A2 (pt) 2021-06-15
AR116877A1 (es) 2021-06-23
US20200131151A1 (en) 2020-04-30
ES2955723T3 (es) 2023-12-05
WO2020089098A1 (en) 2020-05-07
EA202191115A1 (ru) 2021-09-06
CN112996513A (zh) 2021-06-18
AU2019373324A1 (en) 2021-04-22
IL282425B2 (en) 2024-07-01
CN112996513B (zh) 2024-10-15
IL282425B1 (en) 2024-03-01
IL282425A (en) 2021-06-30
KR102823014B1 (ko) 2025-06-20
MX2021004860A (es) 2021-06-15
TW202035374A (zh) 2020-10-01

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