DK388679A - Fluoreringsproces der er anvendelig i syntesen af gluor-anloge til hydrocodon og oxycodon - Google Patents

Fluoreringsproces der er anvendelig i syntesen af gluor-anloge til hydrocodon og oxycodon

Info

Publication number: DK388679A
Authority: DK; Denmark
Prior art keywords: gluor; hydrocodon; fluoration; oxycodon; synthesis
Prior art date: 1978-09-19

Application number

DK388679A

Other languages

English (en)

Inventor

G A Boswell

R M K Henderson

Original Assignee

Du Pont

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-09-19

Filing date

1979-09-18

Publication date

1980-03-20

1978-09-19 Priority claimed from US05/944,198 external-priority patent/US4236008A/en

1979-07-02 Priority claimed from US06/054,225 external-priority patent/US4241065A/en

1979-09-18 Application filed by Du Pont filed Critical Du Pont

1980-03-20 Publication of DK388679A publication Critical patent/DK388679A/da

Links

BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 title 1
229960000240 hydrocodone Drugs 0.000 title 1
238000000034 method Methods 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK388679A 1978-09-19 1979-09-18 Fluoreringsproces der er anvendelig i syntesen af gluor-anloge til hydrocodon og oxycodon DK388679A (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US94419778A	1978-09-19	1978-09-19
US05/944,198 US4236008A (en)	1978-09-19	1978-09-19	Fluorination of precursors for fluorine analogs of hydrocodone and oxycodone
US06/054,225 US4241065A (en)	1979-07-02	1979-07-02	Fluoro analogs of hydrocodone and oxycodone useful as analgesics, narcotic antagonists or both

Publications (1)

Publication Number	Publication Date
DK388679A true DK388679A (da)	1980-03-20

Family

ID=27368595

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK388679A DK388679A (da)	1978-09-19	1979-09-18	Fluoreringsproces der er anvendelig i syntesen af gluor-anloge til hydrocodon og oxycodon

Country Status (4)

Country	Link
EP (1)	EP0009227B1 (da)
CA (1)	CA1143376A (da)
DE (1)	DE2963614D1 (da)
DK (1)	DK388679A (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4613668A (en) *	1983-12-22	1986-09-23	The United States Of America As Represented By The Department Of Health And Human Services	Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl
EP2580201B1 (en)	2010-06-11	2017-08-02	Rhodes Technologies	Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3137701A (en) *	1962-04-19	1964-06-16	Upjohn Co	Process for the preparation of 6-deoxy-6-fluoromorphines, 6-deoxy-6-fluorocodeines, and related compounds

1979
- 1979-09-17 EP EP19790103475 patent/EP0009227B1/en not_active Expired
- 1979-09-17 CA CA000335799A patent/CA1143376A/en not_active Expired
- 1979-09-17 DE DE7979103475T patent/DE2963614D1/de not_active Expired
- 1979-09-18 DK DK388679A patent/DK388679A/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP0009227A1 (en)	1980-04-02
EP0009227B1 (en)	1982-09-01
DE2963614D1 (en)	1982-10-28
CA1143376A (en)	1983-03-22

Similar Documents

Publication	Publication Date	Title
DK396079A (da)	1980-03-23	Tekstilline og fremgangsmaade til fremstilling deraf
DK421879A (da)	1980-04-23	Formstofnet og fremgangsmaade til fremstilling af dette
DK160079A (da)	1979-10-20	Selvaftaetnende tilslutningsstykke for kanyler og karkatetre
DK508077A (da)	1978-05-17	Hidtil ukendte spirolactoner og fremgangsmaade til fremstilling deraf
DK304781A (da)	1982-01-11	Formdel og fremgansmaade til fremstolling heraf
DK421979A (da)	1980-04-17	Formstofnet og fremgangsmaade til fremstilling af dette
DK36079A (da)	1979-08-04	Saek isaer til meballering og isolering
DK439077A (da)	1978-04-06	1-aryloxy-2-hydroxy-3-alkylenaminopropaner og fremgangsmaade til fremstilling deraf
SE7607403L (sv)	1977-02-21	Radioimmunologisk analysmetod
DK149842C (da)	1987-06-15	Fremgangsmaade til fremstilling af d-camphorat af l-carnitinamid og d-camphorat af d-carnitinamid
DK461778A (da)	1979-04-29	Fremgangsmaade og anordning til fremstilling af myseprodukter
DK132779A (da)	1979-10-01	Fremgangsmaade til fremstilling af cishexahydrodibenzoepyranoner og tetrahydrobenzoxoiner
MX159597A (es)	1989-07-11	Mejoras en aparato surtidor de sujetadores
DK6179A (da)	1979-08-01	Fremgangsmaade til fremstilling af prostaglandinderivater og midler indeholdende disse
DK147914C (da)	1985-08-26	Lithiumpseudomonat og fremgangsmaade til fremstilling deraf
DK101779A (da)	1979-09-14	Brandhaemmende polymere materialer og fremgangsmaade til fremstilling deraf
JPS533515A (en)	1978-01-13	Analysis of phlegm
DK268478A (da)	1978-12-16	Mercaptoacylamidobenzoylglycin og fremgangsmaade til fremstilling deraf
DK81380A (da)	1980-08-28	Fremgangsmaade til indramning
DK314679A (da)	1980-02-01	Apparat til afretning og eller profilering af slibeskiver
DK121279A (da)	1979-09-25	Demethylmaytansinoider og fremgangsmaade til fremstilling deraf
DK343479A (da)	1980-02-26	N-phenethylamidforbindelser og fremgangsmaade til fremstilling deraf
DK570178A (da)	1979-06-25	Sulfonanilider fremgangsmaade til fremstilling heraf og midler indeholdende disse forbindelser
DK536979A (da)	1980-06-30	Chromogent materiale og fremgangsmaade til fremstilling deraf
DE3140623A1 (de)	1982-04-29	Virus-inhibiting substance and process for preparing the same

Legal Events

Date	Code	Title	Description
1984-01-28	ATS	Application withdrawn